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| 1 | Hepatitis C virus syndrome: A constellation of organ-and non-organ specific autoimmune disorders, B-cell nonHodgkin's lymphoma, and cancer显示文摘The clinical course of chronic hepatitis C virus(HCV)infection is characterized by possible development of both liver and extrahepatic disorders. The tropism of HCV for the lymphoid tissue is responsible for several immune-mediated disorders; a poly-oligoclonal B-lymphocyte expansion, commonly observed in a high proportion of patients with HCV infection, are responsible for the production of different autoantibodies and immune-complexes, such as mixed cryoglobulins. These serological alterations may characterize a variety of autoimmune or neoplastic diseases. Cryoglobulinemic vasculitis due to small-vessel deposition of circulating mixed cryoglobulins is the prototype of HCV-driven immune-mediated and lymphoproliferative disorders; interestingly, in some cases the disease may evolve to frank malignant lymphoma. In addition, HCV shows an oncogenic potential as suggested by several clinicoepidemiological and laboratory studies; in addition to hepatocellular carcinoma that represents the most frequent HCV-related malignancy, a causative role of HCV has been largely demonstrated in a significant percentage of patients with isolated B-cells nonHodgkin's lymphomas. The same virus may be also involved in the pathogenesis of papillary thyroid cancer, a rare neoplastic condition that may complicate HCVrelated thyroid involvement. Patients with HCV infection are frequently asymptomatic or may develop only hepatic alteration, while a limited but clinically relevant number can develop one or more autoimmune and/or neoplastic disorders. Given the large variability of their prevalence among patients' populations from different countries, it is possible to hypothesize a potential role of other co-factors, i.e., genetic and/or environmental, in the pathogenesis of HCV-related extra-hepatic diseases. | Clodoveo Ferri Marco Sebastiani Dilia Giuggioli Michele Colaci Poupak Fallahi Alessia Piluso Alessandro Antonelli Anna Linda Zignego | 2015 | World Journal of Hepatology2015，7，3： | 11 |
| 2 | Hepatitis C virus infection and type 1 and type 2 diabetes mellitus显示文摘Hepatitis C virus(HCV) infection and diabetes mellitus are two major public health problems that cause devastating health and financial burdens worldwide. Diabetes can be classified into two major types: type 1 diabetes mellitus(T1DM) and T2 DM. T2 DM is a common endocrine disorder that encompasses multifactorial mechanisms, and T1 DM is an immunologically mediated disease. Many epidemiological studies have shown an association between T2 DM and chronic hepatitis C(CHC) infection. The processes through which CHC is associated with T2 DM seem to involve direct viral effects, insulin resistance, proinflammatory cytokines, chemokines, and other immunemediated mechanisms. Few data have been reported on the association of CHC and T1 DM and reports on the potential association between T1 DM and acute HCV infection are even rarer. A small number of studies indicate that interferon-α therapy can stimulate pancreatic autoim-munity and in certain cases lead to the development of T1 DM. Diabetes and CHC have important interactions. Diabetic CHC patients have an increased risk of developing cirrhosis and hepatocellular carcinoma compared with nondiabetic CHC subjects. However, clinical trials on HCV-positive patients have reported improvements in glucose metabolism after antiviral treatment. Further studies are needed to improve prevention policies and to foster adequate and cost-effec-tive programmes for the surveillance and treatment of diabetic CHC patients. | Alessandro Antonelli Silvia Martina Ferrari Dilia Giuggioli Andrea Di Domenicantonio Ilaria Ruffilli Alda Corrado Silvia Fabiani Santino Marchi Clodoveo Ferri Ele Ferrannini Poupak Fallahi | 2014 | World Journal of Diabetes2014，5，5： | 7 |
| 3 | Cytokines and HCV-Related Disorders显示文摘 | Poupak Fallahi Clodoveo Ferri Silvia Martina Ferrari Alda Corrado Domenico Sansonno Alessandro Antonelli Jürg Schifferli | 2012 | Clinical and Developmental Immunology2012，，： | 1 |
| 4 | Immunopathogenesis of HCV-related endocrine manifestations in chronic hepatitis and mixed cryoglobulinemia显示文摘 | Alessandro Antonelli Clodoveo Ferri Silvia Martina Ferrari Michele Colaci Poupak Fallahi | 2008 | Autoimmunity Reviews2008，，1： | 1 |
| 5 | B-cells and mixed cryoglobulinemia显示文摘 | Clodoveo Ferri Alessandro Antonelli Maria Teresa Mascia Marco Sebastiani Poupak Fallahi Daniela Ferrari Marco Giunti Stefano A. Pileri Anna Linda Zignego | 2007 | Autoimmunity Reviews2007，，2： | 1 |
| 6 | Immunopathogenesis of HCV-related endocrine manifestations in chronic hepatitis and mixed cryoglobulinemia显示文摘 | Alessandro Antonelli Clodoveo Ferri Silvia Martina Ferrari Michele Colaci Poupak Fallahi | 2008 | Autoimmunity Reviews2008，，1： | 1 |
| 7 | B-cells and mixed cryoglobulinemia显示文摘 | Clodoveo Ferri Alessandro Antonelli Maria Teresa Mascia Marco Sebastiani Poupak Fallahi Daniela Ferrari Marco Giunti Stefano A. Pileri Anna Linda Zignego | 2007 | Autoimmunity Reviews2007，，2： | 1 |
| 8 | High Levels of Circulating CXC Chemokine Ligand 10 Are Associated with Chronic Autoimmune Thyroiditis and Hypothyroidism显示文摘 | Alessandro Antonelli Mario Rotondi Poupak Fallahi Paola Romagnani Silvia Martina Ferrari Andrea Buonamano Ele Ferrannini Mario Serio | 2004 | The Journal of Clinical Endocrinology & Metabolism2004，，11： | 1 |
| 9 | Thyroid disorders in chronic hepatitis C显示文摘 | Alessandro Antonelli Clodoveo Ferri Alessandro Pampana Poupak Fallahi Claudia Nesti Martina Pasquini Santino Marchi Ele Ferrannini | 2004 | The American Journal of Medicine2004，，1： | 1 |
| 10 | High circulating N-terminal pro-brain natriuretic peptide and tumor necrosis factor-α in mixed cryoglobulinemia显示文摘AIM: To evaluate serum levels of N-terminal pro-brain natriuretic peptide (NTproBNP) and tumor necrosis factor α (TNF-α) in a large series of patients with hepatitis C associated with mixed cryoglobulinemia (MC+HCV).METHODS: Serum NTproBNP and TNF-α levels were assayed in 50 patients with MC+HCV, and in 50 sex- and age-matched controls. RESULTS: Cryoglobulinemic patients showed signifi cantly higher mean NTproBNP and TNF-α levels than controls (P < 0.001; Mann-Whitney U test). By defining high NTproBNP level as a value higher than 125 pg/mL (the single cut-off point for outpatients under 75 years of age), 30% of MC+HCV and 6% of controls had high NTproBNP (χ2, P < 0.01). With a cut-off point of 300 pg/mL (used to rule out heart failure (HF) in patients under 75 years of age), 8% of MC+HCV and 0 controls had high NTproBNP (χ2, P < 0.04). With a cut-off point of 900 pg/mL (used for ruling in HF in patients aged 50-75 years; such as thepatients of our study), 6% of MC+HCV and 0 controls had high NTproBNP (χ2, P = 0.08).CONCLUSION: The study demonstrates high levels of circulating NTproBNP and TNF-α in MC+HCV patients. The increase of NTproBNP may indicate the presence of a subclinical cardiac dysfunction. | Alessandro Antonelli Clodoveo Ferri Silvia Martina Ferrari Fabio Galetta Ferdinando Franzoni Gino Santoro Salvatore De Marco Emiliano Ghiri Poupak Fallahi | 2009 | World Journal of Gastroenterology2009，15，40： | 1 |
| 11 | Circulating CXCL11 and CXCL10 are increased in hepatitis C-associated cryoglobulinemia in the presence of autoimmune thyroiditis显示文摘 | Alessandro Antonelli Poupak Fallahi Silvia Ferrari Marco Sebastiani Andreina Manfredi Valeria Mazzi Silvia Fabiani Marco Centanni Santino Marchi Clodoveo Ferri | 2012 | Modern Rheumatology2012，，5： | 1 |
| 12 | High Levels of Circulating CXC Chemokine Ligand 10 Are Associated with Chronic Autoimmune Thyroiditis and Hypothyroidism显示文摘 | Alessandro Antonelli Mario Rotondi Poupak Fallahi Paola Romagnani Silvia Martina Ferrari Andrea Buonamano Ele Ferrannini Mario Serio | 2004 | The Journal of Clinical Endocrinology & Metabolism2004，，11： | 1 |
| 13 | Chemokine (C–X–C motif) ligand (CXCL)10 in autoimmune diseases显示文摘 | Alessandro Antonelli Silvia Martina Ferrari Dilia Giuggioli Ele Ferrannini Clodoveo Ferri Poupak Fallahi | 2013 | Autoimmunity Reviews2013，，： | 1 |
| 14 | New Targeted Therapies for Thyroid Cancer显示文摘 | Alessandro Antonelli Poupak Fallahi Silvia M. Ferrari Ilaria Ruffilli Francesca Santini Michele Minuto David Galleri Paolo Miccoli | 2011 | Current Genomics2011，，8： | 1 |
| 15 | Cytokines and HCV-Related Disorders显示文摘 | Poupak Fallahi Clodoveo Ferri Silvia Martina Ferrari Alda Corrado Domenico Sansonno Alessandro Antonelli Jürg Schifferli | 2012 | Clinical and Developmental Immunology2012，，： | 1 |
| 16 | New Targeted Therapies for Thyroid Cancer显示文摘 | Alessandro Antonelli Poupak Fallahi Silvia M. Ferrari Ilaria Ruffilli Francesca Santini Michele Minuto David Galleri Paolo Miccoli | 2011 | Current Genomics2011，，8： | 1 |
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