| 1 | Genetic distinctions between autoimmune hepatitis in Italy and North America显示文摘AIM: Our goals were to analyze the known genetic predispositions for autoimmune hepatitis (AIH) in AIH Italian population and to compare them with North American counterparts.METHODS: Human leukocyte antigens (HLA) B8, C7, DR3,DR4, DR7, DR11, DR13, DQ2 and the B8-DR3-DQ2phenotype were determined by microlymphocytotoxicity and polymerase chain reaction in 74 Italian patients (57with type 1 and 17 with type 2 AIH) and 149 North American patients with type 1 AIH, and in adequate controls.RESULTS: B8-DR3-DQ2 occurred more frequently in Italian patients with type 1 AIH than in Italian controls (30% vs 7%, P<0.0001), but less frequently than in North American counterparts (30% vs48%, P = 0.02). DR4 occurred less frequently in Italian patients with type 1 AIH (23% vs43%,P= 0.01) and in controls (16% vs34%, P= 0.0003) than in North American counterparts. No differences were found in alleles' frequency between type 1 and type 2Italian AIH patients. DR11 had a frequency lower in type 1 Italian AIH patients than controls (17% vs35%, P= 0.01).CONCLUSION: HLA DR4 is not associated with AIH in Italy. The known HLA risk factors for ATH occur similarly in Italian patients with type 1 and type 2 AIH, and they are less frequent than in North American patients. B8-DR3-DQ2 is the predominant phenotype of type 1 AIH also in Italy, and HLA DR11 may be a regionally distinctive protective factor against type 1 AIH. | Paolo Muratori Albert J.Czaja Luigi Muratori Georgios Pappas Silvana Maccariello Fabio Cassani Alessandro Granito Rodolfo Ferrari Vilma Mantovani Marco Lenzi Francesco B.Bianchi | 2005 | World Journal of Gastroenterology2005，11，12： | 2 |
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