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| 1 | AHA/ASA关于卒中和短暂性脑缺血发作患者卒中预防推荐的更新显示文摘在卒中和短暂性脑缺血发作(transient ischemic attack,TIA)患者卒中预防推荐发表以后,美国心脏协会和美国卒中协会(American Heart Association/American Stroke Association,AHA/ASA)著述委员会对最近的一些试验结果进行了回顾。本文的目的是对这些新资料做简要回顾、更新某些推荐意见并说明进行这些修改的理由。在2个领域已发表了一些新的重要临床试验结果:(1)在非心源性栓塞所致缺血性卒中或TIA患者卒中二级预防中具体抗血小板药的应用;(2)他汀类药物在预防卒中复发中的应用。 | Robert J. Adams Greg Albers Mark J. Alberts Oscar Benavente Karen Furie Larry B. Goldstein Philip Gorelick Jonathan Halperin Robert Harbaugh S. Claiborne Johnston Irene Katzan Margaret Kelly-Hayes Edgar J. Kenton Michael Marks Ralph L. Sacco Lee H. Schwamm 赵洪芹 李海峰 (译) | 2008 | 国际脑血管病杂志2008，16，4： | 123 |
| 2 | Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling显示文摘 | Albert W Cheng Nathaniel Jillette Phoebe Lee Dylan Plaskon Yasuhiro Fuj iwara Wenbo Wang Aziz Taghbalout Haoyi Wang | 2016 | Cell Research2016，26，2： | 19 |
| 3 | Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong显示文摘氨基酸,器官的酸和丰满的酸氧化的新陈代谢(IEM ) 的古典先天的错误的背景数据大部分正在缺乏香港,在集体基于 spectrometry 的扩展新生儿为 IEM 屏蔽没被开始的地方。瞄准在香港评估近似发生,光谱和古典 IEM 的另外的特征的当前的学习,将在开发为实验室血浆氨基酸记录的本地 area.Methods 屏蔽节目的一个扩展新生儿重要,血浆 acylcarnitines 和尿从年 2005~2009 的器官的酸分析在为 IEM 提供生物化学、基因的诊断服务的三个地区性的化学病理实验室包括回顾地 reviewed.Resu 在香港的古典 IEM 的发生粗略地被估计每 1000live 出生每 4122 生活出生,或 0.243 个盒子是至少 1 个盒子。这发生类似于全球报导的那些,包括中国的大陆。hyperphenylalaninemia 的估计的发生在 29 542 实时 births.Conclusions 是 1 我们的数据显示它为在香港的扩展新生的屏蔽节目的介绍是无可争辩的。因为香港是一个大城市的城市,一个全面扩展新生的屏蔽程序和工作分派系统应该是可得到的服务在区域出生的出生不满一月的婴儿。 | Han-Chih Hencher Lee Chloe Miu Mak Ching-Wan Lam Yuet-Ping Yuen, Angel On-Kei Chan Chi-Chung Shek Tak-Shing Siu Chi-Kong Lai Chor-Kwan Ching Wai-Kwan Siu Sammy Pak-Lam Chen Chun-Yiu Law Morris Hok-Leung Tai Sidney Tam Albert Yan-Wo Chan | 2011 | Chinese Medical Journal2011，，7： | 12 |
| 4 | Combination of epidural electrical stimulation with ex vivo triple gene therapy for spinal cord injury:a proof of principle study显示文摘Despite emerging contemporary biotechnological methods such as gene-and stem cell-based therapy,there are no clinically established therapeutic strategies for neural regeneration after spinal cord injury.Our previous studies have demonstrated that transplantation of genetically engineered human umbilical cord blood mononuclear cells producing three recombinant therapeutic molecules,including vascular endothelial growth factor(VEGF),glial cell-line derived neurotrophic factor(GDNF),and neural cell adhesion molecule(NCAM)can improve morpho-functional recovery of injured spinal cord in rats and mini-pigs.To investigate the efficacy of human umbilical cord blood mononuclear cells-mediated triple-gene therapy combined with epidural electrical stimulation in the treatment of spinal cord injury,in this study,rats with moderate spinal cord contusion injury were intrathecally infused with human umbilical cord blood mononuclear cells expressing recombinant genes VEGF165,GDNF,NCAM1 at 4 hours after spinal cord injury.Three days after injury,epidural stimulations were given simultaneously above the lesion site at C5(to stimulate the cervical network related to forelimb functions)and below the lesion site at L2(to activate the central pattern generators)every other day for 4 weeks.Rats subjected to the combined treatment showed a limited functional improvement of the knee joint,high preservation of muscle fiber area in tibialis anterior muscle and increased H/M ratio in gastrocnemius muscle 30 days after spinal cord injury.However,beneficial cellular outcomes such as reduced apoptosis and increased sparing of the gray and white matters,and enhanced expression of heat shock and synaptic proteins were found in rats with spinal cord injury subjected to the combined epidural electrical stimulation with gene therapy.This study presents the first proof of principle study of combination of the multisite epidural electrical stimulation with ex vivo triple gene therapy(VEGF,GDNF and NCAM)for treatment of spinal cord injury in rat models.The animal protocols were approved by the Kazan State Medical University Animal Care and Use Committee(approval No.2.20.02.18)on February 20,2018. | Filip Olegovich Fadeev Farid Vagizovich Bashirov Vahe Arshaluysovich Markosyan Andrey Alexandrovich Izmailov Tatyana Vyacheslavovna Povysheva Mikhail Evgenyevich Sokolov Maxim Sergeevich Kuznetsov Anton Alexandrovich Eremeev Ilnur Ildusovich Salafutdinov Albert Anatolyevich Rizvanov Hyun Joon Lee Rustem Robertovich Islamov | 2021 | Neural Regeneration Research2021，16，3： | 4 |
| 5 | The Hemodynamic and Adrenergic Effects of Perioperative Dexmedetomidine Infusion after Vascular Surgery显示文摘 | Pekka Talke Richard Chen Brian Thomas Anil Aggarwall Alexandru Gottlieb Per Thorborg Stephen Heard Albert Cheung Stanley Lee Son Antero Kallio | 2000 | Anesthesia & Analgesia2000，，4： | 3 |
| 6 | Zircon U–Pb geochronology and Hf isotope geochemistry of magmatic and metamorphic rocks from the Hida Belt, southwest Japan显示文摘Zircon U–Pb and Hf isotope data integrated in this study for magmatic and metamorphic rocks fromthe Hida Belt,southwest Japan,lead to a new understanding of the evolution of the Cordilleran arc system along the ancestral margins of present-day Northeast Asia.Ion microprobe data for magmatic zircon domains from eight mafic tointermediate orthogneisses in the Tateyama and Tsunogawa areas yielded weighted mean 206Pb/238U ages spanning the entire Permian period(302–254 Ma).Under cathodoluminescence,primary magmatic growth zones in the zircon crystals were observed to be partially or completely replaced by inward-penetrating,irregularly curved featureless or weakly zoned secondary domains that mostly yielded U–Pb ages of 250–240 Ma and relatively high Th/U ratios(>0.2).These secondary domains are considered to have been formed by solid-state recrystallization during thermal overprints associated with intrusions of Hida granitoids.Available whole-rock geochemical and Sr–Nd isotope data as well as zircon age spectra corroborate that the Hida Belt comprises the Paleozoic–Mesozoic Cordilleran arc system built upon the margin of the North China Craton,together with the YeongnamMassif in southern Korea.The arcmagmatismalong this systemwas commenced in the Carboniferous and culminated in the Permian–Triassic transition period.Highly positiveεHf(t)values(>+12)of late Carboniferous to early Permian detrital zircons in the Hida paragneisses indicate that there was significant input from the depleted asthenospheric mantle and/or its crustal derivatives in the early stage of arc magmatism.On the other hand,near-chondriticεHf(t)values(+5 to−2)of magmatic zircons from late Permian Hida orthogneisses suggest a lithospheric mantle origin.Hf isotopic differences between magmatic zircon cores and the secondary rims observed in some orthogneiss samples clearly indicate that the zircons were chemically open to fluids or melts during thermal overprints.Resumed highly positive zirconεHf(t)values(>+9)shared by Early Jurassic granitoids in the Hida Belt and Yeongnam Massif may reflect reworking of the Paleozoic arc crust. | Deung-Lyong Cho Tae-Ho Lee Yutaka Takahashi Takenori Kato Keewook Yi Shinae Lee Albert Chang-sik Cheong | 2021 | Geoscience Frontiers2021，12，4： | 2 |
| 7 | MRI-guided Biopsy to Correlate Tissue Specimens with MR Elastography Stiffness Readings in Liver Transplants显示文摘 | Ryan B. Perumpail Josh Levitsky Yi Wang Victoria S. Lee Jennifer Karp Ning Jin Guang-Yu Yang Bradley D. Bolster Saurabh Shah Sven Zuehlsdorff Albert A. Nemcek Andrew C. Larson Frank H. Miller Reed A. Omary | 2012 | Academic Radiology2012，，9： | 2 |
| 8 | Formation and Function of Acute Stroke–Ready Hospitals Within a Stroke System of Care Recommendations From the Brain Attack Coalition显示文摘 | Mark J. Alberts Lawrence R. Wechsler Mary E. Lee Jensen Richard E. Latchaw Todd J. Crocco Mary G. George James Baranski Robert R. Bass Robert L. Ruff Judy Huang Barbara Mancini Tammy Gregory Daryl Gress Marian Emr Margo Warren Michael D. Walker | 2013 | Stroke2013，，12： | 2 |
| 9 | High Density Mapping of Atrial Fibrillation During Vagal Nerve Stimulation in the Canine Heart: Restudying the Moe Hypothesis显示文摘 | SEUNGYUP LEE JAYAKUMAR SAHADEVAN CELEEN M. KHRESTIAN DOMINIQUE M. DURAND ALBERT L. WALDO | 2012 | Journal of Cardiovascular Electrophysiology2012，，3： | 1 |
| 10 | Synthesis of Pyrrole-Imidazole Polyamide显示文摘One simple and versatile method is established for the synthesis of DNA recognition molecules-polyamides containing alternating N-methylpyrrole and N-methylimidazole without necessitating NH2- group protection. | Jun Hua XIAO Gu YUAN Wei Qiang HUANG Fei Li TANG Albert S.C.CHAN K.L.Daniel LEE | 2000 | Chinese Chemical Letters2000，11，3： | 1 |
| 11 | Performance of Delayed-Enhancement Magnetic Resonance Imaging With Gadoversetamide Contrast for the Detection and Assessment of Myocardial Infarction: An International, Multicenter, Double-Blinded, Randomized Trial显示文摘 | Raymond J. Kim Timothy S.E. Albert James H. Wible Michael D. Elliott John C. Allen Jennifer C. Lee Michele Parker Alicia Napoli Robert M. Judd | 2008 | Circulation2008，，5： | 1 |
| 12 | Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell–selectin interaction kinetics显示文摘 | Hao Cheng Marta Byrska-Bishop Cathy T. Zhang Christian J. Kastrup Nathaniel S. Hwang Albert K. Tai Won Woo Lee Xiaoyang Xu Matthias Nahrendorf Robert Langer Daniel G. Anderson | 2012 | Biomaterials2012，，20： | 1 |
| 13 | Stress Response to Hepatectomy in Patients with a Healthy or a Diseased Liver显示文摘 | Albert Kuo-Mao Lan M.D. Hsiang-Ning Luk M.D. Ph.D. Shigeru Goto M.D. Ph.D. Shyr-Ming Sheen Chen M.D. Hock-Liew Eng M.D. Yaw-Sen Chen M.D. Vanessa H. Villa M.D. Ph.D. Chih Chi Wang M.D. Yu-Fen Cheng M.D. Chao-Long Chen M.D. Ju-Hao Lee M.D. Bruno Jawan M | 2003 | World Journal of Surgery2003，，7： | 1 |
| 14 | The Hemodynamic and Adrenergic Effects of Perioperative Dexmedetomidine Infusion after Vascular Surgery显示文摘 | Pekka Talke Richard Chen Brian Thomas Anil Aggarwall Alexandru Gottlieb Per Thorborg Stephen Heard Albert Cheung Stanley Lee Son Antero Kallio | 2000 | Anesthesia & Analgesia2000，，4： | 1 |
| 15 | From Novice to Expert:Confi- dence and Activity Status Determine Heart Failure Self-care Per- formance显示文摘 | Riegel B Lee CS Albert N | 2011 | Nurs Res2011，60，2： | 1 |
| 16 | Antitumor activity and prolonged expression from a TRAIL-expressing adenoviral vector显示文摘 | Lee J Hampl M Albert P | 2002 | Neoplasia2002，4，4： | 1 |
| 17 | In vivo requirement for Atg5 in antigen presentation by dendritic cells显示文摘 | Lee H K Mattei L M Steinberg B E Alberts P Lee Y H Chervonsky A | 2010 | Immunity2010，32，： | 1 |
| 18 | Effects of nurse follow-up on emergency room revisits: a randomized controlled trial显示文摘 | Frances Kam Yuet Wong Susan Chow Katherine Chang Albert Lee Jiexin Liu | 2004 | Social Science & Medicine2004，，11： | 1 |
| 19 | Water Quality Functions of Riparian Forest Buffers in Chesapeake Bay Watersheds显示文摘 | Richard Lowrance Lee S. Altier J. Denis Newbold Ronald R. Schnabel Peter M. Groffman Judith M. Denver David L. Correll J. Wendell Gilliam James L. Robinson Russell B. Brinsfield Kenneth W. Staver William Lucas Albert H. Todd | 1997 | Environmental Management1997，，5： | 1 |
| 20 | Site-specific integration of DNA into wild-type and mutant lox sites placed in the plant genome 显示文摘 | Albert H Dale E C Lee E | 1995 | Plant J1995，7，4： | 1 |
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