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| 1 | Current status of diagnosis and treatment of hepatic echinococcosis显示文摘Echinococcus granulosus(E.granulosus) and Echinococcus multilocularis(E.multilocularis) infections are the most common parasitic diseases that affect the liver.The disease course is typically slow and the patients tend to remain asymptomatic for many years.Often the diagnosis is incidental.Right upper quadrant abdominal pain,hepatitis,cholangitis,and anaphylaxis due to dissemination of the cyst are the main presenting symptoms.Ultrasonography is important in diagnosis.The World Health Organization classification,based on ultrasonographic findings,is used for staging of the disease and treatment selection.In addition to the imaging methods,immunological investigations are used to support the diagnosis.The available treatment options for E.granulosus infection include open surgery,percutaneous interventions,and pharmacotherapy.Aggressive surgery is the first-choice treatment for E.multilocularis infection,while pharmacotherapy is used as an adjunct to surgery.Due to a paucity of clinical studies,empirical evidence on the treatment of E.granulosus and E.multilocularis infections is largely lacking;there are no prominent and widely accepted clinical algorithms yet.In this article,we review the diagnosis and treatment of E.granulosus and E.multilocularis infections in the light of recent evidence. | Memmet Mihmanli Ufuk Oguz Idiz Cemal Kaya Uygar Demir Ozgur Bostanci Sinan Omeroglu Emre Bozkurt | 2016 | World Journal of Hepatology2016，8，28： | 50 |
| 2 | Possible association of the 5-HTTLPR serotonin transporter promoter gene polymorphism with premature ejaculation in a Turkish population显示文摘我们与早泄(PE ) 在病人评估了血清素 transporter 基因(5-HTT ) 的遗传型在 PE 并且可能的 etiopathogenesis 决定基因因素的角色识别耐心的亚群。70 个 PE 病人和 70 控制的一个总数在这研究被包括。所有人是异性爱的,没有另外的混乱并且是结婚的任何一个或在一种稳定的关系中。PE 被定义为射精发生在阴道插入的 1 min 以内。从病人和控制的 Genomic DNA 用血清素 transporter 基因(5-HTTLPR ) 的倡导者区域的聚合酶链反应,和突变而产生之遗传的变化被分析被决定。5-HTTLPR (血清素 transporter 倡导者基因) 在 PE 病人对控制的遗传型如下被散布:L/L 16% 对 17% , L/S 30% 对 53% 并且 S/S 54% 对 28% 。我们为 5-HTTLPR 基因的三多型性检验了 haplotype 分析:LL, LS 和 SS。在 5-HTTLPR 基因的等位基因频率的适当被 Hardy-Weinberg 平衡用 2 测试分析。5-HTTLPR 基因的短(S) 等位基因是显著地在 PE 病人更经常比在控制(P < 0.05 ) 。我们建议 5-HTTLPR 基因在所有主要 PE 盒子的 pathophysiology 起一个作用。进一步的研究被需要评估在 5-HTTLPR 基因多型性和耐心的亚群之间的关系(例如主要、第二等的 PE ) 对选择血清素举起禁止者以及种族差别的回答。 | Emin Ozbek Ali I. Tasci Volkan Tugcu Yusuf O. Ilbey Abdulmuttalip Simsek Levent Ozcan Emre C. Polat Vedat Koksal | 2009 | Asian Journal of Andrology2009，11，3： | 19 |
| 3 | Intrahepatic biliary cystic neoplasms:Surgical results of 9 patients and literature review显示文摘AIM: To investigate the eligible management of the cystic neplasms of the liver. METHODS: The charts of 9 patients who underwent surgery for intrahepatic biliary cystic liver neoplasms between 2003 and 2008 were reviewed retrospectively. Informed consent was obtained from the patients and approval was obtained from the designated review board of the institution. RESULTS: All patients were female with a median (range) age of 49 (27-60 years). The most frequent symptom was abdominal pain in 6 of the patients. Four patients had undergone previous laparotomy (with other diagnoses) which resulted in incomplete surgery or recurrences. Liver resection (n = 6) or enucleation (n = 3) was performed. The final diagnosis was intrahepaticbiliary cystadenoma in 8 patients and cystadenocarcinoma in 1 patient. All symptoms resolved after surgery. There has been no recurrence during a median (range) 31 (7-72) mo of follow up. CONCLUSION: In spite of the improvement in imaging modalities and increasing recognition of biliary cystadenoma and cystadenocarcinoma, accurate preoperative diagnosis may be difficult. Complete surgical removal (liver resection or enucleation) of these lesions yields satisfying long-term results. | Ali Emre Kür■at Rahmi Serin Ilgin zden Yaman Tekant Orhan Bilge Ayd■n Alper Mine Güllüoglu Koray Güven | 2011 | World Journal of Gastroenterology2011，17，3： | 15 |
| 4 | Effects of disease severity and necrosis on pancreatic dysfunction after acute pancreatitis显示文摘AIM:To evaluate the effects of disease severity and necrosis on organ dysfunctions in acute pancreatitis(AP).METHODS:One hundred and nine patients treated as AP between March 2003 and September 2007 with at least 6 mo follow-up were included.Patients were classified according to severity of the disease,necrosis ratio and localization.Subjective clinical evaluation and fecal pancreatic elastase-Ⅰ(FPE-Ⅰ)were used for exocrine dysfunction evaluation,and oral glucose tolerance test was completed for endocrine dysfunction.The correlation of disease severity,necrosis ratio and localization with exocrine and endocrine dysfunction were investigated.RESULTS:There were 58 male and 51 female patients,and mean age was 56.5±15.7.Of the patients,35.8%had severe AP(SAP)and 27.5%had pancreatic necrosis.Exocrine dysfunction was identified in 13.7%of the patients[17.9%were in SAP,11.4%were in mild AP(MAP)]and 34.7%of all of the patients had endocrine dysfunction(56.4%in SAP and 23.2%in MAP).In patients with SAP and necrotizing AP(NAP),FPE-Ⅰlevels were lower than the others(P<0.05 and0.001 respectively)and in patients having pancreatic head necrosis or near total necrosis,FPE-1 levels were lower than 200μg/g stool.Forty percent of the patients who had undergone necrosectomy developed exocrine dysfunction.Endocrine dysfunction was more significant in patients with SAP and NAP(P<0.001).All of the patients in the necrosectomy group had endocrine dysfunction.CONCLUSION:Patients with SAP,NAP,pancreatic head necrosis and necrosectomy should be followed for pancreatic functions. | Gokhan Garip Emre Sarandl Ekrem Kaya | 2013 | World Journal of Gastroenterology2013，19，44： | 12 |
| 5 | Lipoma within inverted Meckel’s diverticulum as a cause of recurrent partial intestinal obstruction and hemorrhage: A case report and review of literature显示文摘Lipoma within an inverted Meckel's diverticulum presen- ting with hemorrhage and partial intestinal obstruction is an exceptional clinical entity. We report a case of 47-year-old male with a history of recurrent episodes of partial intestinal obstruction and melena due to a subserosal lipoma located in the base of an inverted Meckel's diverticulum. According to our knowledge, this is the first case of a lipoma within a Meckel's diverticulum giving rise to this clinical scenario without the existence of heterotrophic gastric or pancreatic tissues. | Güldeniz Karadeniz Cakmak Ali Ugur Emre Oge Tascilar Sibel Bekta■ Bulent Hamdi Uan Oktay Irkorucu Kemal Karakaya Yucel Ustundag Mustafa Comert | 2007 | World Journal of Gastroenterology2007，13，7： | 11 |
| 6 | A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling显示文摘The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells,which are profoundly moulded by cancer cells.An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs.Here,we profile 233,591 single cells from patients with lung,colorectal,ovary and breast cancer(n=36)and construct a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies.We identify 68 stromal cell populations,of which 46 are shared between cancer types and 22 are unique.We also characterise each population phenotypically by highlighting its marker genes,transcription factors,metabolic activities and tissue-specific expression differences.Resident cell types are characterised by substantial tissue specificity,while tumor-infiltrating cell types are largely shared across cancer types.Finally,by applying the blueprint to melanoma tumors treated with checkpoint immunotherapy and identifying a naive CD4+T-cell phenotype predictive of response to checkpoint immunotherapy,we illustrate how it can serve as a guide to interpret scRNA-seq data.In conclusion,by providing a comprehensive blueprint through an interactive web server,we generate the first panoramic view on the shared complexity of stromal cells in different cancers. | Junbin Qian Siel Olbrecht Bram Boeckx Hanne Vos Damya Laoui Emre Etlioglu Els Wauters Valentina Pomella Sara Verbandt Pieter Busschaert Ayse Bassez Amelie Franken Marlies Vanden Bempt Jieyi Xiong Birgit Weynand Yannick van Herck Asier Antoranz Francesca Maria Bosisio Bernard Thienpont Giuseppe Floris Ignace Vergote Ann Smeets Sabine Tejpar Diether Lambrechts | 2020 | Cell Research2020，30，9： | 11 |
| 7 | Protective effects of erythropoietin against acute lung injury in a rat model of acute necrotizing pancreatitis显示文摘瞄准:为了调查外长的 erythro-poietin (EPO ) 的效果,在钠 taurodeoxycholate- 的一个试验性的模型的尖锐的肺损害(ALI ) 上的管理导致了尖锐引起坏死胰腺炎(ANP ) 。方法:47 只男 Wistar 白鼠随机被划分成 7 个组:假冒的组(n = 5 ) , 3 个 ANP 组(n = 7 各个) 并且 3 个 EPO 组(n = 7 各个) 。ANP 被导致由后退进胆总管的 5% 钠 taurodeoxycholate 的注入。在 EPO 组的老鼠收到了 1000 U/kg 肌内的 EPO 立即在 ANP 的正式就职以后。在 ANP 组的老鼠相反被给 1 mL 生理盐水。所有动物被牺牲在手术后 24 h, 48 h 和 72 h。浆液 amilase, IL-2, IL-6 和肺织物 malondialdehyde (MDA ) 被测量。胸膜渗漏体积和肺 / 身体重量(LW/BW ) 比率是计算的。TNF-alpha, IL-2 和 IL-6 的织物层次组织化学地是屏蔽免疫。另外, ox-LDL 累积与免疫者荧光灯的染色被估计。在肺的组织病理学说的改变也被获得。结果:吝啬的胸膜渗漏体积,计算 LW/BW 比率,浆液 IL-6 和肺织物 MDA 层次比在 ANP 组在 EPO 组是显著地更低的。不,统计上,有效差量在这些组之中在浆液或 IL-2 的织物价值被观察。当时, ox-LDL 的肿瘤坏死 factor-alpha (TNF-alpha ) 和 IL-6 和累积的水平在 ANP 组的肺纸巾是明显的与 EPO 组相比,特别地在 72 h。组织病理学说的评估在外长的 EPO 管理以后在肺损害参数证实了改进,特别地在 48 h 和 72 h。结论:EPO 管理由禁止 polymorphonuclear (PMNL ) 在 ALI 参数导致重要减少累积,减少专业版的层次在每氧化的循环,保存微脉管的内皮房间正直和减少的氧化联系压力的类脂化合物的煽动性的 cytokines 并且因此,能在导致 ANP 的 ALI 被认为是一个 cytoprotective 代理人。 | Oge Tascilar Güldeniz Karadeniz Cakmak Ishak Ozel Tekin Ali Ugur Emre Bulent Hamdi Ucan Burak Bahadir Serefden Acikgoz Oktay Irkorucu Kemal Karakaya Hakan Balbaloglu Gürkan Kertis Handan Ankarali Mustafa Comert | 2007 | World Journal of Gastroenterology2007，13，46： | 8 |
| 8 | Appendiceal mucocele: Case reports and review of current literature显示文摘The mucocele of the appendix is an uncommon disorder which is often asymptomatic but sometimes causes acute appendicitis-like symptoms. Sometimes, patients with mucocele can present with confusing symptoms. Preoperative suspicion and diagnosis of appendiceal mucocele are important. Ultrasonography and computed tomography are useful tools for the diagnosis of appendiceal mucocele. It may be also recognised by colonoscopy as a smooth submucosal lesion of the cecum. Optima management of the mucocele could be achieved through accurate preoperative diagnosis. Preoperative diagnosis is a major component for minimizing intra-operative and post-operative complications. We herein report five cases and discuss the diagnostic methods and surgical treatment. | Kemal Karakaya Figen Barut Ali Ugur Emre Hamdi Bulent Ucan Guldeniz Karadeniz Cakmak Oktay Irkorucu Oge Tascilar Yucel Ustundag Mustafa Comert | 2008 | World Journal of Gastroenterology2008，14，14： | 8 |
| 9 | Evaluation of leukocyte esterase and nitrite strip tests to detect spontaneous bacterial peritonitis in cirrhotic patients显示文摘AIM: To investigate the diagnostic eff icacy of leukocyte esterase and nitrite reagent strips for bedside diagnosis of spontaneous bacterial peritonitis (SBP). METHODS: A total of 63 consecutive patients with cirrhotic ascites (38 male, 25 female) tested between April 2005 and July 2006 were included in the study. Bedside reagent strip testing was performed on ascitic ? uid and the results compared to manual cell counting and ascitic fluid culture. SBP was defined as having a polymorphonuclear ascites count of ≥ 250/mm3. RESULTS: Fifteen samples showed SBP. The sensitivity, specificity, positive and negative predictive values of the leukocyte esterase reagent strips were; 93%, 100%, 100%, and 98%, respectively. The sensitivity, specifi city, positive and negative predictive value of the nitrite reagent strips were 13%, 93%, 40%, and 77%, respectively. The combination of leukocyte esterase and nitrite reagents strips did not yield statistically signif icant effects on diagnostic accuracy. CONCLUSION: Leukocyte esterase reagent strips may provide a rapid, bedside diagnostic test for SBP. | Serkan Torun Enver Dolar Yusuf Yilmaz Murat Keskin Murat Kiyici Melda Sinirtas Emre Sarandol Selim Gurel Selim Giray Nak Macit Gulten | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 10 | A bibliometric analysis of academic publication on diabetic retinopathy disease trends during 1980-2014:a global and medical view显示文摘·AIM: To investigate diabetic retinopathy(DR) literature using the Institute for Scientific Information(ISI) Web of Science(Wo S) database and to analyse the correlation results between socio-economic development datas and number of DR publications.·METHODS: The statistical analysis of the documents published during 1980-2014 was analysed. The data of this study were based on the database of Wo S. 'Diabetic retinopathy' was used as the keywords to search the Wo S database.·RESULTS: The United States ranked first in the DR research with 1840 publications and 24.38% of the world production followed by England and Japan. Besides, the most productive country was Iceland. A high correlation was found between number of publications and 2014 gross domestic product( GDP) values of 81 countries(r =0.800, P <0.001). We found a significant correlation between number of publications and Human Development Index(HDI)(r =0.645, P =0.001). There is a moderate correlation between people with diabetes and number of DR publications for 81 countries(r =0.514, P <0.01). It could be analysed that estimated publication number with DR title will be 445 according to the regression curve constituted with cubic model in 2015(R2=1.000).·CONCLUSION: More DR studies have been published in developed countries, DR and other complications of diabetes have gradually increased in developing countries over recent decades. It can be expected that the number of DR studies will gradually increase in developing countries. | Cagatay Caglar Emre Demir Ferit Kerim Kucukler Mustafa Durmus | 2016 | International Journal of Ophthalmology(English edition)2016，9，11： | 7 |
| 11 | 基于模糊推理的致密砂岩气储集层重复压裂井选择方法显示文摘建立了一种基于人工智能的致密砂岩气储集层重复压裂井筛选方法,并进行了算例分析。该方法以模糊逻辑为基础,通过语言模糊性的数学表示来处理语言的不精确性和主观性,是1个基于模糊集理论、模糊规则和模糊推理的计算系统。用5个指数分别表征与重复压裂井选择问题相关的水力裂缝质量、储集层特征、初始条件、操作参数、产量,每个指数又包含3个相关参数。将每个指数/参数的值划分为低、中、高3个类别,针对每个指数/参数的每个类别定义梯形隶属函数,并定义所有相关规则。先将某个指数的相关参数输入到基于规则的模糊推理系统中,输出该指数的值,再另建1个模糊推理系统,将储集层指数、操作指数、初始条件指数和产量指数作为输入参数,重复压裂潜力指数作为输出参数,从而筛选重复压裂井。利用已发表文献中的数据验证了该方法的有效性。 | ARTUN Emre KULGA Burak | 2020 | 石油勘探与开发2020，47，2： | 7 |
| 12 | Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats显示文摘AIM: To investigate the role of oxidative injury and the effect of exogenous melatonin administration on liver damage induced by bile duct ligation (BDL), and second,to evaluate the role of nitric oxide (NO), a free oxygen radical, in oxidative injury.METHODS: Thirty-two Sprague-Dawley rats were assigned to four groups: sham operation (SO), BDL, BDL+melatonin,and BDL+vehicle. Cholestasis was achieved by double ligature of the common bile duct. Melatonin was injected intraperitoneally 500 μg/(kg.d) for 8 d. Hepatic oxidative stress markers were evaluated by changes in the amount of lipid peroxides, measured as malondialdehyde (MDA),and reduced GSH. Total nitrite (NOx) concentrations were determined in hepatic homogenates. Histopathological examination was performed using a histological scoring system.RESULTS: The histopathological changes including portal inflammation, necrosis, apoptosis, focal inflammation and fibrosis were severe in the BDL and BDL+vehicle groups. There were numerous large areas of coagulation necrosis. Histological Activity Index scores of these groups were significantly higher than that of the SO group. Treatment with melatonin reduced these alterations significantly. The degree of necro-infiammation and fibrosis showed significant difference between the BDL and BDL+melatonin groups. BDL was accompanied by a significant increase in MDA and NOx, and a significant decrease in GSH levels. Mean±SE values of MDA, GSH and NOx levels of SO group were 147.47±6.69, 0.88±0.33 μmol/g and 180.70±6.58 nm/g, respectively. The values of BDL group were 200.14±21.30, 0.65±0.02 μmol/g, and 400.46±48.89 nm/g, respectively, whereas the values of BDL+melatonin group were 115.93±6.8, 0.74±0.02 μmol/g,and 290.38±32.32 nm/g, respectively. Melatonin treatment was associated with a significant recovery of MDA, GSH and NOx levels.CONCLUSION: We have concluded that oxidative stress is associated with the pathogenesis of cholestatic liver damage and NO contributes to oxidative damage. Melatonin,even at low dose, is an efficient agent in reducing negative parameters of cholestasis. | Mukaddes Esrefoglu Mehmet Gül Memet Hanifi Emre Alaattin Polat Mukadder Ayse Selimoglu | 2005 | World Journal of Gastroenterology2005，11，13： | 6 |
| 13 | Effect of acupuncture therapy on fracture healing in rats with femur fractures显示文摘OBJECTIVE: To investigate the effect of acupuncture therapy on fracture healing in rats with femur fractures.METHODS: A total of 10 groups were formed;control group, groups sacrificed on 7 th, 14 th, and 21 st days of fracture formation, groups to which acupuncture was applied for 7, 14, and 21 d, groups to which fracture and acupuncture were applied for 7,14, and 21 d. A transverse fracture line was formed in femurs of rats by using a Gigli saw. The Kirschner wire was driven retrograde down from the fracture line to proximal part of the bone and then, the fracture was fixed towards distal part. Acupuncture was applied to the rats for 7, 14, and 21 d as 4 sessions per week after formation of the fracture.RESULTS: Malondialdehyde(MDA), reduced glutathione(GSH) levels, catalase(CAT), glutathione-Stransferase(GST), superoxide dismutase(SOD), and glucose-6-phosphate dehydrogenase(G6 PD) activities were measured. Despite the increased MDA levels, G6 PD and SOD activities reduced during the fracture healing. There was a statistically significant increase in MDA, GSH levels, and G6 PD activity in fracture groups compared to control group, but CAT, GST, and SOD activities decreased. The use of acupuncture enhanced callus development and bone mineralization during bone healing.CONCLUSION: The acupuncture therapy can affect suppression of the effects of free oxygen radicals and regulation of the antioxidant enzyme activity in fracture healing. Thus, it is suggested that acupuncture treatment would be beneficial for fracture healing in order to eliminate the negative effects induced by oxygen free radicals. | Seval Yilmaz Emre Kaya Erhan Yilmaz Ahmet Kavakli Suleyman Gurbuz Mustafa Ozkaraca | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 6 |
| 14 | Coexistence of acute myocardial infarction with normal coronary arteries and migraine with aura in a female patient显示文摘Acute myocardial infarction with normal coronary arteries is a well known condition,which is typically diagnosed in young patients.Coronary vasospasm,inherited,acquired or malignancy-induced hypercoagulable state,collagen vascular disease and coronary arterial embolism have been considered as underlying etiologic factors.An association between migraine with aura and increased risk of ischemic stroke,angina and myocardial infarction has been demonstrated in studies.Patients with migraine and especially with aura should be followed closely against cardiovascular events even if they are young and do not have traditional risk factors. | Umut Celikyurt Goksel Kahraman Ender Emre | 2011 | World Journal of Cardiology2011，3，7： | 6 |
| 15 | Clinical and hemodynamic profiles of elderly patients with pulmonary arterial hypertension: a single center, prospective study显示文摘sPulmonary 动脉的高血压(哼) 以前被认为主要影响幼仔的病,但是现在,它逐渐地也被认出在老。这研究的目的是比较诊断与的老对更年轻的病人的特征,并且定义影响他们的长期的 survival.MethodsIn 的预示的因素哼这未来的、单个中心研究,临床, echocardiographic ,血液动力学的特征,并且结果更年轻( 18-65 年)并且老( 65 年)有 precapillary 的权威的诊断的病人哼 119 个病人全部的 compared.ResultsA 在这研究被分析;43 是老的(吝啬的年龄:71.5 ? 灡牰灯楲瑡 ? 慣摮摩瑡 ? 景瀠汵潭慮祲愠瑲牥慩? 票数瑲湥楳湯 ? 灳 ' 虝娹娆 _ 敨慲祰椠 ? 汥敤汲 ? 慰楴湥獴眠瑩 ? 異浬湯牡 ? | Ebru Ozpelit Bahri Akdeniz Dilek Sezgin Can Sevinc Kemal Can Tertemiz Mehmet Emre Ozpelit Mustafa Baris Nezihi Baris | 2017 | Journal of Geriatric Cardiology2017，14，1： | 5 |
| 16 | Petrogenesis of the late Cretaceous Turnagol intrusion in the eastern Pontides:Implications for magma genesis in the arc setting显示文摘A series of Cretaceous plutons is present in the eastern Pontides of northeastern Turkey.The Turnagl intrusion is the least studied and,thus,the least understood plutons in the orogen.This intrusion consists of hornblende-biotite granodiorites emplaced at 78 Ma based on LA-ICP-MS U-Pb zircon dating.It is of sub- alkaline affinity,belongs to the medium- to high-K calc-alkaline series,and displays features typical of Itype granites.The rocks of the intrusion are enriched in large-ion lithophile elements and light rare earthelements with negative Eu anomalies(Eu/Eu*= 0.69-0.82),but are deficient in high-field-strength elements.They have a small range of (87Sr/86Sr)i(0.7060-0.7063),εNdi(-2.6 to -3.1),and δ18O(+8.1 to +9.1) values.Their Pb isotopic ratios are 206Pb/204Pb = 18.63-18.65,207Pb/204Pb = 15.62-15.63,and 208Pb/204Pb = 38.53-38.55.The fractionation of plagioclase,hornblende,and Fe-Ti oxides had key functions in the evolution of the Tumagl intrusion.The crystallization temperatures of the melts ranged from 758 to 885℃ as determined by zircon and apatite saturation thermometry.All these characteristics,combined with the low values of K2O/Na2O and(Na2O + K2O)/(FeOt+MgO + TiO2),as well as the high values of (CaO + FeOt + MgO + TiO2).suggest an origin by dehydration melting from a metabasaltic lowercrustal source. | Abdullah Kaygusuz Ferkan Sipahi Nurdane Ilbeyli Mehmet Arslan Bin Chen Emre Aydincakir | 2013 | Geoscience Frontiers2013，4，4： | 4 |
| 17 | Vasospastic myocardial infarction:An even rarer occurrence of a rare entity显示文摘INTRODUCTION Vasospastic angina(VSA)is an important functional cardiac disorder that leads to transient myocardial ischemia and is caused by sudden,intense and reversible coronary artery spasm resulting in subtotal or total occlusion.[1,2]VSA is associated with cardiac conditions such as stable or unstable angina,acute coronary syndromes and lethal arrhythmias.The patients | Cem Ertan Mehmet Emre Ozpelit Onder Limon Dcniz Oray Nihat Pekel | 2017 | World Journal of Emergency Medicine2017，8，1： | 4 |
| 18 | Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin显示文摘The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin diseases.During psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal hyperplasia.Similarly,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the skin.However,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains unknown.Here,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T cells.This activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/LFA-1.Naive T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 cells.In particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/CD2.The latter molecule initiated STAT1 signaling and IFN γproduction in T cells.Costimulation of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin disease.Consequently,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases. | Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta Sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag | 2020 | Cellular & Molecular Immunology2020，17，4： | 4 |
| 19 | Clinical and therapeutic considerations of rectal lymphoma: A case report and literature review显示文摘Primary rectal lymphoma is a rare presentation of gastrointestinal lymphomas. Its clinical presentation is indistinguishable from that of rectal carcinoma. Although surgical resection is often technically feasible, optimal therapy for colorectal lymphoma has not yet been identified.We report a case of primary rectal lymphoma (nonHodgkin's large cell lymphoma of type B) with high-grade features that disappeared completely after chemoradiotherapy. This case underlines that primary treatment with systemic chemotherapy and involved-field radiotherapy can be successful for rectal lymphoma, with surgery reserved for complications and chemotherapy failures. | Yilmaz Bilsel Emre Balik Sumer Yamaner Dursun Bugra | 2005 | World Journal of Gastroenterology2005，11，3： | 4 |
| 20 | Predicting gas and shrinkage porosity in solidification microstructure:A coupled three-dimensional cellular automaton model显示文摘Porosity formation during solidification of aluminum-based alloys,due to hydrogen gas and alloy shrinkage,has been a major issue adversely affecting the performance of solidification products such as castings,welds or additively manufactured components.A three-dimensional cellular automaton(CA)model has been developed,for the first time,to couple the predictions of hydrogen-induced gas porosity and shrinkage porosity during solidification microstructure evolution of a binary Al-Si alloy.The CA simulation results are validated under various cooling rates by porosity measurements in an experimental wedge die casting using X-ray micro computed tomography(XMCT)technique.This validated porosity moel provides a critical link in integrated computation materials engineering(ICME)design and manufacturing of solidification products. | Cheng Gu Colin D.Ridgeway Emre Cinkilic Yan Lu Alan A.Luo | 2020 | Journal of Materials Science & Technology2020，47，14： | 4 |
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