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| 1 | gt-C3N4 coordinated single atom as an efficient electrocatalyst for nitrogen reduction reaction显示文摘The electrochemical reduction of nitrogen to ammonia is a promising way to produce ammonia at mild condition.The design and preparation of an efficient catalyst with high ammonia selectivity is critical for the real applications.In this work,a series of transition metal (TM =Sc,Ti,V,Cr,Mn,Fe,Co,Ni,Cu,Zn,Y,Zr,Nb,Mo,Tc,Ru,Rh,Pd,Ag,and Cd) atoms supported by gt-C3N4 (TM/gt-C3N4) are investigated as electrocatalysts for the nitrogen reduction reaction (NRR) based on density functional calculations.It is found that Mo/gt-C3N4 with a limiting potential of-0.82 V is the best catalyst for standing-on adsorbed N2 cases.While for lying-on adsorbed N2 cases,V/gt-C3N4 with a limiting potential of-0.79 V is berer than other materials.It is believed that this work provides several promising candidates for the non-noble metal electrocatalysts for NRR at mild condition. | Lifu Zhang Wanghui Zhao Wenhua Zhang Jing Chen Zhenpeng Hu | 2019 | Nano Research2019，12，5： | 11 |
| 2 | Helioscopianoids A–Q,bioactive jatrophane diterpenoid esters from Euphorbia helioscopia显示文摘The EtOH extracts of the whole plants of Euphorbia helioscopia afforded 17 new jatrophane diterpenoid esters, helioscopianoids A–Q(1–17), along with eight known compounds(18–25). Their structures were elucidated by extensive spectroscopic methods and Mo_2(OAc)_4-induced ECD analysis,and the structures of compounds 1, 2, and 7 were confirmed by X-ray crystallography. Compounds 1–17 were evaluated for inhibitory effects on P-glycoprotein(P-gp) in an adriamycin(ADM)-resistant human breast adenocarcinoma cell line(MCF-7/ADR) and neuroprotective effects against serum deprivationinduced and rotenone-induced PC12 cell damage. Compounds 8 and 16 increased the accumulation of ADM in MCF-7/ADR cells by approximately 3-fold at a concentration of 20 μmol/L. Compound 8 could attenuate rotenone-induced PC12 cell damage, and compounds 2, 8, and 12 showed neuroprotective activities against serum deprivation-induced PC12 cell damage. | Zhenpeng Mai Gang Ni Yanfei Liu Zhao Zhang Li Li Naihong Chen Dequan Yu | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 2 |
| 3 | Synthesis and biological activities of 2-oxocycloalkylsulfonamides显示文摘 | XINGHAI LI XINLING YANG XIAOMEI LIANG ZHENPENG KAI HUIZU YUAN DEKAIYUAN JIANJUN ZHANG RUIQING WANG FUXIANG RAN SHUHUA QI YUN LING FUHENG CHEN DAOQUAN WANG | | 0，，08： | 1 |
| 4 | Effectiveness and safety of Suxiao Jiuxin pill in treating acute coronary syndrome:a systematic review and Meta-analysis显示文摘OBJECTIVE:To evaluate the effectiveness and safety of Suxiao Jiuxin pill(SX)in acute coronary syndrome(ACS)treatment.METHODS:An extensive search of four English databases(Medline/PubMed,Cochrane Library,Embase,and World Health Organization International Clinical Trials Registration Platform)and four Chinese databases(Chinese National Knowledge Infrastructure,Wanfang,China Science and Technology Journal,and Chinese Biomedical Literature Service System)was performed.Randomized,controlled trials(RCTs)involving SX combined with conventional therapy versus conventional therapy were included.The extracted data included populations,interventions,outcomes,and risk of bias.The cardiovascular events served as the primary outcome.Review Manager 5.3 software was used for data analysis.Relative risks(RRs)with 95%confidence intervals(CIs)were the effect measure.RESULTS:A total of eight RCTs with 979 patients were included.There were 559 patients with unstable angina(UA)in six RCTs and 420 patients with acute myocardial infarction(AMI)in two RCTs.Our review showed that SX plus conventional therapy might reduce the incidence of the total endpoint(RR:0.34,95%CI:0.17,0.68,P=0.002),with no obvious adverse events(RR:1.29,95%CI:0.60,2.77,P=0.52)compared with conventional therapy for patients with UA.Additionally,SX plus conventional therapy also reduced the incidence of the total endpoint(RR:0.35,95%CI:0.18,0.68,P=0.002)compared with conventional therapy in patients with AMI.SX plus conventional therapy also reduced the incidence of ventricular fibrillation(RR:0.23,95%CI:0.10,0.57,P=0.001)compared with conventional therapy in patients with AMI.CONCLUSION:Our results suggest that SX is beneficial for treating patients with UA or AMI.However,our findings should be treated with caution because of the poor methodological quality of the included trials.Therefore,more multicenter,large-sample,high-quality RCTs are required to provide high-quality evidence. | Liu Chao Duan Lian Huang Mingyan Li Jun Xiong Xingjiang Chen Guang He Haoqiang Zhang Zhenpeng Wang Jie | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 1 |
| 5 | Mechanism for negative differential resistence in molecular electronic deveices:local orbital symmetry matching显示文摘 | Chen Lan Hu Zhenpeng Zhao Aidi | 2007 | Phys Rev Lett2007，99，： | 1 |
| 6 | A low-energy ion spectrometer with half-space entrance for three-axis stabilized spacecraft显示文摘A low-energy ion spectrometer(LEIS) for use aboard three-axis stabilized spacecraft has been developed to measure ion energy per charge distribution in three-dimensional space with good energy-, angular-and temporal-resolutions. For the standard top-hat electrostatic analyzer used widely in space plasma detection, three-axis stabilized spacecraft makes it difficult to obtain complete coverage of all possible ion arrival directions. We have designed angular scanning deflectors supplementing to a cylindrically symmetric top-hat electrostatic analyzer to provide a half-space field of view as 360°×90°(–45°–+45°), and fabricated the LEIS flight model for detecting magnetospheric ions in geosynchronous orbit. The performance of this payload has been evaluated in detail by a series of simulation and environmental tests, and the payload has also been calibrated through laboratory experiments using a low-energy ion source. The results show that capabilities of the LEIS payload are in accordance with the requirements of a magnetospheric mission. | HU RenXiang SHAN Xu YUAN GuangYuan WANG ShuWen ZHANG WeiHang QI Wei CAO Zhe LI YiRen CHEN ManMing YANG XiaoPing WANG Bo SHAO SiPei LI Feng ZHONG XiaoQing FAN Dan HAO XinJun FENG ChangQing SU ZhenPeng SHEN ChengLong LI Xin DAI GuYue QIU BingLin PAN ZongHao LIU Kai XU ChunKai LIU ShuBin AN Qi ZHANG TieLong WANG YuMing CHEN XiangJun | 2019 | Science China(Technological Sciences)2019，62，6： | 1 |
| 7 | Direct Derivatization and Quantitation of Ultra-trace Gibberellins in Sub-milligram Fresh Plant Organs显示文摘 | Dongmei Li Zhenpeng Guo Yi Chen | 2016 | Molecular Plant2016，9，1： | 1 |
| 8 | Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression显示文摘Inducible expression systems are indispensable for precise regulation and in-depth analysis of biological process.Binary Tet-On system has been widely employed to regulate transgenic expression by doxycycline.Previous pig models with tetracycline regulatory elements were generated through random integration.This process often resulted in uncertain expression and unpredictable phenotypes,thus hindering their applications.Here,by precise knock-in of binary Tet-On 3G elements into Rosa26 and Hipp11 locus,respectively,a double knock-in reporter pig model was generated.We characterized excellent properties of this system for controllable transgenic expression both in vitro and in vivo.Two att P sites were arranged to flank the td Tomato to switch reporter gene.Single or multiple gene replacement was efficiently and faithfully achieved in fetal fibroblasts and nuclear transfer embryos.To display the flexible application of this system,we generated a pig strain with Dox-inducing h KRASexpression through phiC31 integrase-mediated cassette exchange.After eight months of Dox administration,squamous cell carcinoma developed in the nose,mouth,and scrotum,which indicated this pig strain could serve as an ideal large animal model to study tumorigenesis.Overall,the established pig models with controllable and switchable transgene expression system will provide a facilitating platform for transgenic and biomedical research. | Qin Jin Xiaoyu Yang Shixue Gou Xiaoyi Liu Zhenpeng Zhuang Yanhui Liang Hui Shi Jiayuan Huang Han Wu Yu Zhao Zhen Ouyang Quanjun Zhang Zhaoming Liu Fangbing Chen Weikai Ge Jingke Xie Nan Li Chengdan Lai Xiaozhu Zhao Jiaowei Wang Meng Lian Lei Li Longquan Quan Yinghua Ye Liangxue Lai Kepin Wang | 2022 | Science China(Life Sciences)2022，65，11： | 1 |
| 9 | Study on the influence of fracture lengths and fracture angles on residual oil distribution based on the slab model显示文摘After fracturing in the pilot area,channeling occurs at a low fracture angle(15).Based on the resistance-water saturation relationship,three-dimensional physical simulation methods are used in the laboratory to study the effect of different fracture angles and lengths on the residual oil distribution during the displacement process.Meanwhile,recovery percent,displacement efficiency and expanding sweep co-efficient to the improvement of recovery percent are also discussed.The results show that the fracture angle and length are closely related to the oil saturation distribution in these models.As the fracture angle increases,the sweep coefficient decreases(0.2412→0.1463),and the recovery percent also in-creases(46.16→56.88%),but the extent of increase has been reduced(7.96→2.96%).The extension of the fracture length is more prone to have a cross-flow phenomenon;the sweep coefficient is reduced(0.2412→0.1463).Compared to the model with 1/2 oil-water well spacing,the recovery percent is decreased by 14.29%.In different fracture models,the increasable sweep coefficient has a greater impact on oil recovery than the increasable displacement efficiency(71.30→28.70%). | Guihui Lian Zhenhua Ding Liang Chen Xiaoguang Wang Jiru Yang Jigang Zhang Ming Gao Weifeng Lv Zhenpeng Leng | 2022 | Petroleum Research2022，7，4： | 0 |
| 10 | First results of the low energy ion spectrometer onboard a Chinese geosynchronous satellite显示文摘A Chinese geosynchronous satellite was launched on June 23,2020.It carried a plasma detection package to monitor the space environment around the orbit.Here we report the inflight performance of a low energy ion spectrometer(LEIS),one of the primary instruments in the plasma detection package,and its initial observations in flight.Benefiting from the state-of-the-art design of a top-hat electrostatic analyzer cooperated with angular scanning deflectors,three-dimensional measurement of ions in space with a large field of view of 360°×90°and a wide energy range from 50 eV to 25 keV per charge has been achieved.The differential energy flux spectra of ions around the orbit have shown clear signatures of surface charging and storm/substorm ion injections.The occurrence of surface charging could be caused by the lack of photoemission at the Earth's eclipse(near the midnight)or the storm energetic electron injection at the dawn sector.The present results demonstrated a good performance of the LEIS payload in flight for monitoring the space ion environment around the orbit.In situ measurements of the LEIS payload provide us an opportunity to understand the magnetospheric ion dynamics and forecast the associate space weather impacts. | SHAN Xu MIAO Bin CAO Zhe SUN ZhenYu LI YiRen LIU Kai GUO XingYu QU SanBiao SU ZhenPeng SHEN ChengLong PAN ZongHao LI Xin HAO XinJun YANG XiaoPing TIAN Chao JIANG Yu LIU ShuBin AN Qi CHEN XiangJun WANG YuMing | 2023 | Science China(Technological Sciences)2023，66，5： | 0 |
| 11 | Weak Acetylene Adsorption Terminated Carbon-Carbon Coupling Kinetics on Silver Electrocatalysts显示文摘Owing to serious poison of downstream olefin polymerization catalysts from acetylene impurities,selective reduction of acetylene to ethylene is a pivotal process in petrochemical industry.However,during thermocatalytic and electrocatalytic acetylene semihydrogenation,acetylene C-C coupling inevitably occurs on current catalysts.The resultant oligomeric species(particularly long-chain hydrocarbons)block active sites and mass transportation,and eventually decrease catalytic activity and stability.In this work,we report Ag nanowires(NWs)as high-performance electrocatalysts for acetylene semihydrogenation,where the C-C coupling is unprecedentedly suppressed by weakening acetylene adsorption.In pure acetylene,1,3-butadiene Faradaic efficiency(FE)of Ag NWs is only 2.1%,which is far lower than 41.2%for Cu nanoparticles at−0.2 V versus reversible hydrsogen electrode.Ethylene partial current density of Ag NWs reaches 217 mA/cm^(2)at 0.85 V,which is considerably higher than those for state-of-the-art Cu-based electrocatalysts.Markedly,no 1,3-butadiene is produced on Ag NWs in a large two-electrode flow cell fed with crude ethylene containing 1 vol%acetylene,presenting thorough termination of acetylene C-C coupling.In situ electrochemical Raman spectroscopy and theoretical investigations reveal that weak acetylene adsorption on Ag surfaces is intrinsically responsible for prohibiting their oligomerization.This work will spark the rapid development of high-performance and stable electrocatalysts for reducing alkynes to olefins. | Rui Bai Jinjin Li Jin Lin Zhenpeng Liu Chen Yan Lei Zhang Jian Zhang | 2023 | CCS Chemistry2023，5，1： | 0 |
| 12 | In-flight calibration of the magnetometer on the Mars orbiter of Tianwen-1显示文摘Mars orbiter magnetometer(MOMAG)is one of seven science payloads onboard Tianwen-1’s orbiter.Unlike most of the satellites,Tianwen-1’s orbiter is not magnetically cleaned,and the boom where placed the magnetometer’s sensors is not long enough.These pose many challenges to the magnetic field data processing.In this study,we introduce the in-flight calibration process of the Tianwen-1/MOMAG.The magnetic interference including spacecraft generated dynamic field and the slowlychanging zero offsets are cleaned in sequence.Then the calibrated magnetic field data are compared with the data from the Mars atmosphere and volatile Evolutio N(MAVEN).We find that some physical structures in the solar wind are consistent between the two data sets,and the distributions of the magnetic field strength in the solar wind are very similar.These results suggest that the in-flight calibration of the MOMAG is successful and the MOMAG provides reliable data for scientific research. | ZOU ZhuXuan WANG YuMing ZHANG TieLong WANG GuoQiang XIAO SuDong PAN ZongHao ZHANG ZhouBin YAN Wei DU Yang CHI YuTian CHENG Long WU ZhiYong HAO XinJun LI YiRen LIU Kai CHEN ManMing SU ZhenPeng SHEN ChengLong XU MengJiao GUO JingNan | 2023 | Science China(Technological Sciences)2023，66，8： | 0 |
| 13 | Deep Segmentation Feature-Based Radiomics Improves Recurrence Prediction of Hepatocellular Carcinoma显示文摘Objective and Impact Statement.This study developed and validated a deep semantic segmentation feature-based radiomics(DSFR)model based on preoperative contrast-enhanced computed tomography(CECT)combined with clinical information to predict early recurrence(ER)of single hepatocellular carcinoma(HCC)after curative resection.ER prediction is of great significance to the therapeutic decision-making and surveillance strategy of HCC.Introduction.ER prediction is important for HCC.However,it cannot currently be adequately determined.Methods.Totally,208 patients with single HCC after curative resection were retrospectively recruited into a model-development cohort(n=180)and an independent validation cohort(n=28).DSFR models based on different CT phases were developed.The optimal DSFR model was incorporated with clinical information to establish a DSFR-C model.An integrated nomogram based on the Cox regression was established.The DSFR signature was used to stratify high-and low-risk ER groups.Results.A portal phase-based DSFR model was selected as the optimal model(area under receiver operating characteristic curve(AUC):development cohort,0.740;validation cohort,0.717).The DSFR-C model achieved AUCs of 0.782 and 0.744 in the development and validation cohorts,respectively.In the development and validation cohorts,the integrated nomogram achieved C-index of 0.748 and 0.741 and time-dependent AUCs of 0.823 and 0.822,respectively,for recurrence-free survival(RFS)prediction.The RFS difference between the risk groups was statistically significant(P<0.0001 and P=0.045 in the development and validation cohorts,respectively).Conclusion.CECT-based DSFR can predict ER in single HCC after curative resection,and its combination with clinical information further improved the performance for ER prediction. | Jifei Wang Dasheng Wu Meili Sun Zhenpeng Peng Yingyu Lin Hongxin Lin Jiazhao Chen Tingyu Long Zi-Ping Li Chuanmiao Xie Bingsheng Huang Shi-Ting Feng | 2022 | Biomedical Engineering Frontiers2022，3，1： | 0 |
| 14 | Research on recognition for cotton spider mites’damage level based on deep learning显示文摘The changes in cotton leaf characteristics are closely related to the cotton spider mites’damage level.Extracting the distinguishable features of cotton leaves is an effective method to identify the level.However,it faces enormous challenges for the classification due to various factors,such as illumination intensity,background complexity,shooting angle and so on.A recognition model is proposed,which is trained through transfer learning with the two-stage learning rate from 0.01 to 0.001 based on MobileNetV1.The experiments demonstrate that the deep learning model attains the accuracy of 92.29%for the training set and 91.88%for the test set of the mixed data.For testifying the effectiveness of the two-stage training method,the models are trained with the two public datasets,CIFAR-10 and Flowers,and attain the accuracy of 95.46%and 95.57%for the test sets,respectively.The average recognition time for a single cotton leaf image is about 0.015 s.Furthermore,the mobile terminal application is developed with the model embedded,to realize the real-time recognition for cotton spider mites’damage level in the field. | Lili Yang Jun Luo Zhenpeng Wang Yan Chen Caicong Wu | 2019 | International Journal of Agricultural and Biological Engineering2019，12，6： | 0 |
| 15 | Generation of pigs with humanized type Ⅱ collagen by precise human COL2A1 gene knock-in显示文摘Osteoarthritis(OA)is the most common chronic disease,characterized by progressive cartilage breakdown,subchondral bone sclerosis,and aberrant bone outgrowth(Yucesoy et al.,2015;Hussain et al.,2016).OA is one of the leading causes of cartilage damage.Patients with severe cartilage damage require transplantation of articular cartilage to improve their quality of life.Type Ⅱ collagen is a major component of articular cartilage and intervertebral discs and plays an important role in the structure and strength of connective tissues that support muscles and joints(Byers,1994). | Ting Lan Yuling Zheng Yangyang Suo Yuhui Wei Hui Shi Quanmei Yan Zhenpeng Zhuang Huangyao Chen Quanjun Zhang Nana Fan Yu Zhao Zhen Ouyang Chengdan Lai Zhaoming Liu Jizeng Zhou Chengcheng Tang Nam-Hyung Kim Qingjian Zou Xiaomin Wang | 2023 | Journal of Genetics and Genomics2023，50，3： | 0 |
| 16 | Fast and extensive intercalation chemistry in Wadsley-Roth phase based high-capacity electrodes显示文摘Wadsley-Roth (W-R) structured oxides featured with wide channels represent one of the most promising material families showing compelling rate performance for lithium-ion batteries.Herein,we report an indepth study on the fast and extensive intercalation chemistry of phosphorus stabilized W-R phase PNb_(9)O_(25) and its application in high energy and fast-charging devices.We explore the intercalation geometry of PNb_(9)O_(25) and identify two geometrical types of stable insertion sites with the total amount much higher than conventional intercalation-type electrodes.We reveal the ion transportation kinetics that the Li ions initially diffuse along the open type Ⅲ channels and then penetrate to edge sites with low kinetic barriers.During the lithiation,no remarkable phase transition is detected with nearly intact host phosphorous niobium oxide backbone.Therefore,the oxide framework of PNb_(9)O_(25) keeps almost unchanged with all the fast diffusion channels and insertion cavities well-maintained upon cycling,which accomplishes the unconventional electrochemical performance of W-R structured electrodes. | Miao Wang Zhenpeng Yao Qianqian Li Yongfeng Hu Xiuping Yin Aibing Chen Xionggang Lu Jiujun Zhang Yufeng Zhao | 2022 | Journal of Energy Chemistry2022，31，6： | 0 |
| 17 | The Mars orbiter magnetometer of Tianwen-1:in-flight performance and first science results显示文摘The Mars Orbiter MAGnetometer(MOMAG)is a scientific instrument onboard the orbiter of China’s first mission for Mars—Tianwen-1.Since November 13,2021,it has been recording magnetic field data from the solar wind to the magnetic pile-up region surrounding Mars.Here we present its in-flight performance and first science results,based on its first one and one-half months’data.Comparing these early MOMAG observations to the magnetic field data in the solar wind from NASA’s Mars Atmosphere and Volatile EvolutioN(MAVEN)mission,we report that the MOMAG magnetic field data are at the same level in magnitude,and describe the same magnetic structures with similar variations in three components.We recognize 158 clear bow shock(BS)crossings in these MOMAG data;their locations match well statistically with the modeled average BS.We also identify and compare five pairs of datasets collected when Tianwen-1’s orbiter and the MAVEN probe made simultaneous BS crossings.These BS crossings confirm the global shape of modeled BS,as well as the south-north asymmetry of the Martian BS.Two cases presented in this paper suggest that the BS is probably more dynamic at flank than near the nose.So far,MOMAG performs well,and provides accurate magnetic field vectors.MOMAG is continuously scanning the magnetic field surrounding Mars.Data from MOMAG’s measurements complement data from MAVEN and will undoubt edly advance our understanding of the plasma environment of Mars. | YuMing Wang TieLong Zhang GuoQiang Wang SuDong Xiao ZhuXuan Zou Long Cheng ZongHao Pan Kai Liu XinJun Hao YiRen Li ManMing Chen ZhouBin Zhang Wei Yan ZhenPeng Su ZhiYong Wu ChengLong Shen YuTian Chi MengJiao Xu JingNan Guo Yang Du | 2023 | Earth and Planetary Physics2023，7，2： | 0 |
| 18 | Neutron Detector Efficiency in the Energy Range From 10 to 40 MeV显示文摘NeutronDetectorEfficiencyintheEnergyRangeFrom10to40MeVZhouZuying;TangHongqing;QiBujia;ZhouChenwei;DuYanfeng;XiaHaihong;ZhangL... | Zhou Zuying Tang Hongqing Qi Bujia Zhou Chenwei Du Yanfeng Xia Haihong Zhang Lishan Mao XiaoyongRichard. L.Walter Werner Tornow Calvin Howell Richard Braun Chen Zemin Chen Zhenpeng Chen Yingtang(Triangle Universities Nuclear Laboratory and Duk | 1996 | 中国原子能科学研究院年报1996，，1： | 0 |
| 19 | Coupled Shell-Material Point Method for Bird Strike Simulation显示文摘In a bird strike, the bird undergoes large deformation like flows; while most part of the structure is in small deformation, the region near the impact point may experience large deformations, even fail. This paper develops a coupled shell-material point method(CSMPM)for bird strike simulation, in which the bird is modeled by the material point method(MPM)and the aircraft structure is modeled by the Belytschko-Lin-Tsay shell element. The interaction between the bird and the structure is handled by a particle-to-surface contact algorithm. The distorted and failed shell elements will be eroded if a certain criterion is reached. The proposed CSMPM takes full advantages of both the finite element method and the MPM for bird strike simulation and is validated by several numerical examples. | Bo Wu Zhenpeng Chen Xiong Zhang Yan Liu Yanping Lian | 2018 | Acta Mechanica Solida Sinica2018，31，1： | 0 |
| 20 | Improving the Cpf1-mediated base editing system by combining dCas9/dead sgRNA with human APOBEC3A variants显示文摘Base editor-mediated C-to-T base conversion obviates the requirements of double-strand breaks,thereby showing promise as a tool for disease modeling and gene therapy(Gaudelli et al.,2017;Rees and Liu 2018).The most actively used base editor comprises a Cas9 nickase(nCas9)with cytidine deaminase and fused uracil DNA glycosylase inhibitor at the carboxy terminus of nCas9 to inhibit uracil N-glycosylase effects(Pearl,2000;Kunz et al.,2009;Rees and Liu 2018). | Meng Lian Fangbing Chen Xingyun Huang Xiaozhu Zhao Shixue Gou Nan Li Qin Jin Hui Shi Yanhui Liang Jingke Xie Weikai Ge Zhenpeng Zhuang Jiaowei Wang Yinghua Ye Yi Yang Kepin Wang Liangxue Lai Han Wu | 2021 | Journal of Genetics and Genomics2021，48，1： | 0 |
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