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| 1 | Research progress of the fractional Fourier transform in signal processing显示文摘The fractional Fourier transform is a generalization of the classical Fourier transform, which is introduced from the mathematic aspect by Namias at first and has many applications in optics quickly. Whereas its potential appears to have remained largely unknown to the signal processing community until 1990s. The fractional Fourier transform can be viewed as the chirp-basis expansion directly from its definition, but es-sentially it can be interpreted as a rotation in the time-frequency plane, i.e. the unified time-frequency transform. With the order from 0 increasing to 1, the fractional Fourier transform can show the characteristics of the signal changing from the time domain to the frequency domain. In this research paper, the fractional Fourier transform has been com-prehensively and systematically treated from the signal processing point of view. Our aim is to provide a course from the definition to the applications of the fractional Fourier transform, especially as a reference and an introduction for researchers and interested readers. | TAO Ran DENG Bing WANG Yue | 2006 | Science in China(Series F)2006，49，1： | 99 |
| 2 | Analysis of status and countermeasures of cancer incidence and mortality in China显示文摘Cancer is the leading cause of human deaths in the world and produces serious economic burdens. On September 12, 2018, the academic journal A Cancer Journal for Clinicians published an article about the latest statistics of cancers worldwide, which provided a status report on the global burden of 36 cancers in 185 countries worldwide. Cancer has also become a serious public health problem in China and caused more and more attention of the government and people in recent years. This review analyzes the incidence, mortality and prevalent trend of cancers in China, discusses the reasons behind this status, and reviews the potential countermeasures for cancer prevention and control in China. | Chunchun Wu Mengna Li Hanbing Meng Yukun Liu Weihong Niu Yao Zhou Ran Zhao Yumei Duan Zhaoyang Zeng Xiaoling Li Guiyuan Li Wei Xiong Ming Zhou | 2019 | Science China(Life Sciences)2019，62，5： | 175 |
| 3 | Channel change at Toudaoguai Station and its responses to the operation of upstream reservoirs in the upper Yellow River显示文摘水坝的应用程序创建了输入调节的在上游的愿望变化,包括水和沉积,以前的动态伪平衡由隧道流速及流水量到达了的下游地河的系统,和破坏,因此不可缺少的调整为适应新水和沉积供应的下游的隧道是必要的,导致河的系统恢复它的以前的平衡或到达新平衡。用大约 50-year-long 水文学,沉积、代表性的数据,位于上面的黄河到水库的操作的 Toudaoguai 剖面图的时间的反应进程造了在上游被分析。Toudaoguai 剖面图变化被在上游的水库操作和下游的隧道床 armoring 此后强烈影响的结果表演逐渐地发生了并且在计量车站的 Sanhuhekou 下面延长了到活动范围。而且,推迟的沉积负担的中部的直径经历了起初被增加描绘的一个三阶段的变化,然后减少和增加再最后,它反映在 Qingtongxia 水库开始了然后逐渐地在 Sanhuhekou 剖面图下面下游地发展了到活动范围的隧道床 armoring 的过程。因为 Longyangxia, Liujiaxia 和 Qingtongxia 水库的联合操作策略在 1986 被介绍,当仅仅 Qingtongxia 和 Liujiaxia 水库独自被放进操作时,三阶段的变化趋势在在 1969 和 1986 之间的时间时期变得不比那明显。自从 1987,另外,在剖面图戏剧性地减少了的 Toudaoguai 的侧面的移植和 thalweg 举起变化的程度,代表性的侧面和地点趋于稳定,它对为本地人的正常生活有益。 | RAN Lishan WANG Suiji FAN Xiaoli | 2010 | Journal of Geographical Sciences2010，20，2： | 53 |
| 4 | Local“Land Finance”in China's Urban Expansion:Challenges and Solutions显示文摘这篇论文在中国的快城市的扩大的上下文考虑“本地陆地金融”的问题。在中国 s 陆地请求和公共租借系统的分析,我们主张那便宜陆地获得是发生在中国 s 都市化期间的陆地相关的失真的基本原因。同意农民力量在城市的扩大期间与陆地用户一起直接谈判,与协调陆地税改革结合了巩固本地税底是在城市的扩大完成公平和陆地使用效率的中国的关键。 | Changchun Feng Changchun Feng Ran Tao | 2008 | China & World Economy2008，16，2： | 41 |
| 5 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 6 | A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study显示文摘Fulminant myocarditis(FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen(LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR(81 cases),which includes(i) mechanical life support(positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation),(ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and(iii) application of neuraminidase inhibitors, and those receiving conventional treatment(88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients(26.0%) died in hospitals. Inhospital mortality was 3.7%(3/81) for LSBCTR group and 46.6%(41/88) for traditional treatment(P<0.001). Early application of LSBCTR, mechanical life support, neuraminidase inhibitors, and immunomodulation therapy significantly contributed to reduction in in-hospital mortality. This study describes a novel treatment regimen for FM patients that dramatically reduces inhospital mortality. Its generalization and clinical application will efficiently save lives although further optimization is needed.This study offers an insight that virus infection induced inflammatory waterfall results in cardiac injury and cardiogenic shock and is the therapeutic target. | Sheng Li Shengyong Xu Chenze Li Xiao Ran Guanglin Cui Mengying He Kun Miao Chunxia Zhao Jiangtao Yan Rutai Hui Ning Zhou Yan Wang Jiangang Jiang Jing Zhang Daowen Wang | 2019 | Science China(Life Sciences)2019，62，3： | 43 |
| 7 | Ganoderic acid hinders renal fibrosis via suppressing the TGF- β/Smad and MAPK signaling pathways显示文摘Renal fibrosis is considered as the pathway of almost all kinds of chronic kidney diseases(CKD)to the end stage of renal diseases(ESRD).Ganoderic acid(GA)is a group of lanostane triterpenes isolated from Ganoderma lucidum,which has shown a variety of pharmacological activities.In this study we investigated whether GA exerted antirenal fibrosis effect in a unilateral ureteral obstruction(UUO)mouse model.After UUO surgery,the mice were treated with GA(3.125,12.5,and 50 mg·kg^−1·d^−1,ip)for 7 or 14 days.Then the mice were sacrificed for collecting blood and kidneys.We showed that GA treatment dose-dependently attenuated UUO-induced tubular injury and renal fibrosis;GA(50 mg·kg^−1·d^−1)significantly ameliorated renal disfunction during fibrosis progression.We further revealed that GA treatment inhibited the extracellular matrix(ECM)deposition in the kidney by suppressing the expression of fibronectin,mainly through hindering the over activation of TGF-β/Smad signaling.On the other hand,GA treatment significantly decreased the expression of mesenchymal cell markers alpha-smooth muscle actin(α-SMA)and vimentin,and upregulated E-cadherin expression in the kidney,suggesting the suppression of tubular epithelial-mesenchymal transition(EMT)partially via inhibiting both TGF-β/Smad and MAPK(ERK,JNK,p38)signaling pathways.The inhibitory effects of GA on TGF-β/Smad and MAPK signaling pathways were confirmed in TGF-β1-stimulated HK-2 cell model.GA-A,a GA monomer,was identified as a potent inhibitor on renal fibrosis in vitro.These data demonstrate that GA or GA-A might be developed as a potential therapeutic agent in the treatment of renal fibrosis. | Xiao-qiang Geng Ang Ma Jin-zhao He Liang Wang Ying-li Jia Guang-ying Shao Min Li Hong Zhou Shu-qian Lin Jian-hua Ran Bao-xue Yang | 2020 | Acta Pharmacologica Sinica2020，41，5： | 43 |
| 8 | 藏南沉错湖泊沉积多指标揭示的2万年以来环境变化显示文摘通过对藏南沉错湖芯TC1孔的研究,分析了TC1孔的粒度、TOC、TN、C/N、Fe/Mn、Sr/Ba以及环境磁学参数等环境代用指标,基本上获得了这一地区2万年以来的环境变化记录.结果显示约19800~18000 Cal aBP的温度下降在各指标中具有明显的反映;约16000Cal aBP左右,温度在一次跃动上升之后,随即出现急剧下降;约15200~12000 Cal aBP,是降温之后的缓慢回升过程;约12000~9500Cal aBP,各种指标均显示湖区环境处于不适宜阶段,特别是11600~10400 Cal aBP,湖区环境显著恶化.进入全新世后,湖区环境经历了3次明显的暖期(约9 500~7600 Cal aBP、约6800~5800Cal aBP、约4800~3800 Cal aBP)和2次冷期(约7600~6800 Cal aBP、约5 800~4800 Cal aBP),呈现出暖干/冷湿的交替规律,具有南亚季风(西南季风)区气候变化的特征.沉错湖区2万年来的气候环境变化序列中的某些特征时段与格陵兰冰芯记录和青藏高原其他记录相比具有较好的一致性,反映了湖区及藏南地区的气候环境演变特征具有全球性特征. | 朱立平 王君波 陈玲 杨京蓉 李炳元 朱照宇 Hiroyki Kitagawa Gran Possnert | 2004 | 地理学报2004，59，4： | 38 |
| 9 | Nutrition and physical activity in NAFLD:An overview of the epidemiological evidence显示文摘Nonalcoholic fatty liver disease(NAFLD)has been recognized as a major health burden.The high prevalence of NAFLD is probably due to the contemporary epidemics of obesity,unhealthy dietary pattern,and sedentary lifestyle.The efficacy and safety profile of pharmacotherapy in the treatment of NAFLD remains uncertain and obesity is strongly associated with hepatic steatosis;therefore,the first line of treatment is lifestyle modification.The usual management of NAFLD includes gradual weight reduction and increased physical activity(PA)leading to an improvement in serum liver enzymes,reduced hepatic fatty infiltration,and,in some cases,a reduced degree of hepatic inflammation and fibrosis.Nutrition has been demonstrated to be associated with NAFLD and Non-alcoholic steatohepatitis(NASH)in both animals and humans,and thus serves as a major route of prevention and treatment.However,most human studies are observational and retrospective,allowing limited inference about causal associations.Large prospective studies and clinical trials are now needed to establish a causal relationship.Based on available data,patients should optimally achieve a 5%-10%weight reduction.Setting realistic goals is essential for long-term successful lifestyle modification and more effort must be devoted to informing NAFLD patients of the health benefits of even a modest weight reduction.Furthermore,all NAFLD patients,whether obese or of normal weight,should be informed that a healthy diet has benefits beyond weight reduction.They should be advised to reduce saturated/trans fat and increase polyunsaturated fat,with special emphasize on omega-3 fatty acids.They should reduce added sugar to its minimum,try to avoid soft drinks containing sugar,including fruit juices that contain a lot of fructose,and increase their fiber intake.For the heavy meat eaters,especially those of red and processed meats,less meat and increased fish intake should be recommended.Minimizing fast food intake will also help maintain a healthy diet.PA should be integrated into behavioral therapy in NAFLD,as even small gains in PA and fitness may have significant health benefits.Potentially therapeutic dietary supplements are vitamin E and vitamin D,but both warrant further research.Unbalanced nutrition is not only strongly associated with NAFLD,but is also a risk factor that a large portion of the population is exposed to.Therefore,it is important to identify dietary patterns that will serve as modifiable risk factors for the prevention of NAFLD and its complications. | Shira Zelber-Sagi Ran Oren Zelber-Sagi Vlad Ratziu | 2011 | World Journal of Gastroenterology2011，17，29： | 33 |
| 10 | Experimental Study of the Pressure Fluctuations in a Pump Turbine at Large Partial Flow Conditions显示文摘Frequent shifts of output and operating mode require a pump turbine with excellent stability. Current researches show that large partial flow conditions in pump mode experience positive-slope phenomena with a large head drop. The pressure fluctuation at the positive slope is crucial to the pump turbine unit safety. The operating instabilities at large partial flow conditions for a pump turbine are analyzed. The hydraulic performance of a model pump turbine is tested with the pressure fluctuations measured at unstable operating points near a positive slope in the performance curve. The hydraulic performance tests show that there are two separated positive-slope regions for the pump turbine, with the flow discharge for the first positive slope from 0.85 to 0.91 times that at the maximum efficiency point. The amplitudes of the pressure fluctuations at these unstable large partial flow conditions near the first positive slope are much larger than those at stable operating condtions. A dominant frequency is measured at 0.2 times the impeller rotational frequency in the flow passage near the impeller exit, which is believed to be induced by the rotating stall in the flow passage of the wicket gates. The test results also show hysteresis with pressure fluctuations when the pump turbine is operated near the first positive slope. The hysteresis creates different pressure fluctuations for those operation points even though their flow rates and heads are similar respectively. The pressure fluctuation characteristics at large partial flow conditions obtained by the present study will be helpful for the safe operation of pumped storage units. | RAN Hongjuan LUO Xianwu ZHU Lei ZHANG Yao WANG Xin XU Hongyuan | 2012 | Chinese Journal of Mechanical Engineering2012，25，6： | 33 |
| 11 | Backstepping design of missile guidance and control based on adaptive fuzzy sliding mode control显示文摘This paper presents an integrated missile guidance and control law based on adaptive fuzzy sliding mode control. The integrated model is formulated as a block-strict-feedback nonlinear system, in which modeling errors, unmodeled nonlinearities, target maneuvers, etc. are viewed as unknown uncertainties. The adaptive nonlinear control law is designed based on backstepping and sliding mode control techniques. An adaptive fuzzy system is adopted to approximate the coupling nonlinear functions of the system, and for the uncertainties, we utilize an online-adaptive control law to estimate the unknown parameters. The stability analysis of the closed-loop system is also conducted. Simulation results show that, with the application of the adaptive fuzzy sliding mode control, small miss distances and smooth missile trajectories are achieved, and the system is robust against system uncertainties and external disturbances. | Ran Maopeng Wang Qing Hou Delong Dong Chaoyang | 2014 | Chinese Journal of Aeronautics2014，27，3： | 32 |
| 12 | Natural Variation in the Promoter of GSE5 Contributes to Grain Size Diversity in Rice显示文摘自然基因变化的利用极大地在庄稼贡献重要农学的特点的改进。为谷物尺寸的自然变化理解基因基础能帮助 breeders 开发产量很高的米饭变化。在这研究,我们识别以前未被认出的基因,命名 GSE5,与功能的分析在由联合染色体宽的协会控制米饭谷物尺寸的 qSW5/GW5 地点学习。GSE5 编码血浆有 IQ 领域的联系膜的蛋白质,与米饭 calmodulin 蛋白质交往, OsCaM1-1。我们发现 GSE5 功能的损失引起了宽、重的谷物,当 GSE5 的 overexpression 导致了狭窄的谷物时。我们证明 GSE5 由在小穗状花小穗壳影响房间增长主要调整谷物尺寸。GSE5 的三主要 haplotypes (GSE5, GSE5 DEL1+IN1 , 和 GSE5 在栽培米饭的 DEL2 ) 在它的倡导者区域基于删除 / 插入类型被识别。我们表明了那在带 GSE5 在带 GSE5 haplotype 和 1212-bp 删除(DEL2 )> 与 GSE5 的减少的表示联系的 DEL2 haplotype,导致宽谷物。进一步的分析显示野米饭就职包含 GSE5 的所有三 haplotypes,建议在栽培米饭在场的 GSE5 haplotypes 是可能的从在米饭驯服期间的不同野米饭就职发源。一起拿,我们的结果显示在 qSW5/GW5 地点的以前未被认出的 GSE5 基因,被米饭 breeders 广泛地利用,控制谷物缩放,并且表明在 GSE5 的倡导者区域的那个自然变化在米饭贡献谷物尺寸差异。 | Penggen Duan Jinsong Xu Dali Zeng Baolan Zhang Mufan Geng Guozheng Zhang Ke Huang Luojiang Huang Ran Xu Song Ge Qian Qian Yunhai Li | 2017 | Molecular Plant2017，10，5： | 31 |
| 13 | Control of Grain Size and Weight by the OsMKKK10-OsM KK4-OsMAPK6 Signaling Pathway in Rice显示文摘谷物尺寸是在庄稼决定谷物产量的关键农学的特点之一。然而,在庄稼位于谷物尺寸控制下面的机制留下逃犯。这里,我们证明断然表明小径的 OsMKKK10-OsMKK4-OsMAPK6 在米饭调整谷物尺寸和重量。在米饭,当组成地活跃的 OsMKKK10 (CA-OsMKKK10 ) 的 overexpression 导致大、重的谷物,长圆锥花序,和高植物时, OsMKKK10 功能的损失导致小、轻的谷物,短圆锥花序,和半矮子植物。OsMKKK10 交往与并且 phosphorylates OsMKK4。我们识别了 OsMKK4 gain-of-function 异种(large11-1D )? 那生产大、重的谷物。OsMKK4 large11-1D 等位基因编码的 A227T 比 OsMKK4 举办更强壮的 kinase 活动。植物 overexpressing OsMKK4 (OsMKK4-DD ) 的一种组成地活跃的形式也生产大谷物。进一步生物化学、基因的分析表明 OsMKKK10, OsMKK4,和 OsMAPK6 在一条普通小径工作控制谷物尺寸。一起拿,我们的学习在米饭为谷物尺寸和重量的 OsMKKK10-OsMKK4-OsMAPK6 调停串联的控制建立一个重要基因、分子的框架。 | Ran Xu Penggen Duan Haiyue Yu Zhengkui Zhou Baolan Zhang Ruci Wang Jing Li Guozheng Zhang Shangshang Zhuang Jia Lyu Na Li Tuanyao Chai Zhixi Tian Shanguo Yao Yunhai Li | 2018 | Molecular Plant2018，11，6： | 33 |
| 14 | Parameters of Coseismic Reverse- and Oblique-Slip Surface Ruptures of the 2008 Wenchuan Earthquake,Eastern Tibetan Plateau显示文摘在 2008 年 5 月 12 日, M w 7.9 Wenchuan 地震破裂了同时,, Longmenshan 的中间的片断插入了的 Beichuan, Pengguan 和 Xiaoyudong 差错在西藏的高原的东方边缘系上带子。领域调查抑制与 Wenchuan 地震有关的表面破裂模式,长度和偏移量。Beichuan 差错有趋势 NE 有 240 km 的全部的长度的权利侧面的反向的破裂。重估产出 6.5 ±的最大的垂直偏移量 0.5 m 和 4.9 ±的最大的权利侧面的偏移量为它的北片断的 0.5 m,它最大的偏移量被发现;最大的垂直偏移量是 6.2 ±为它的南部的片断的 0.5 m。Pengguan 差错有趋势 NE 纯反向的破裂与大约 3.5 m 的最大的垂直偏移量长的大约 72 km。Xiaoyudong 差错有在 Beichuan 和 Pengguan 之间长的大约 7 km 指责的 NW 惹人注目的左侧面的反向的破裂,与 3.4 m 的最大的垂直偏移量和 3.5 m 的左侧面的偏移量。多重 co 地震的表面破裂的这个模式在之中最近的大地震和礼品最复杂大得多的危险比如果他们个别地破裂了。破裂长度最长因为反向的指责事件曾经报导了。 | XU Xiwei YU Guihua CHEN Guihua RAN Yongkang LI Chenxia CHEN Yuegau CHANG Chungpai | 2009 | Acta Geologica Sinica(English Edition)2009，83，4： | 30 |
| 15 | Laparoscopic common bile duct exploration with primary closure is safe for management of choledocholithiasis in elderly patients显示文摘Background:Laparoscopic common bile duct exploration(LCBDE)is one of the minimally invasive options for choledocholithiasis.Primary closure of the common bile duct(CBD)upon completion of laparoscopic choledochotomy is safe in selected patients.The present study aimed to evaluate the feasibility and safety of primary closure of CBD after LCBDE in patients aged 70 years or older.Methods:A total of 116 patients(51 males and 65 females)who suffered from choledocholithiasis and underwent primary closure of the CBD(without T-tube drainage)after LCBDE from January 2003 to December 2017 were recruited.They were classified into two groups according to age:group A(≥70 years,n=56),and group B(<70 years,n=60).The preoperative characteristics,intraoperative details,and postoperative outcomes of the two groups were evaluated.Results:The mean operative time was 172.02 min for group A and 169.92 min for group B(P=0.853).The mean hospital stay was 7.40 days for group A and 5.38 days for group B(P<0.001).Bile leakage occurred in two patients in group A and one in group B(3.57%vs 1.67%,P=0.952).There were no significant differences in the rates of postoperative complications and mortality between the two groups.At median follow-up time of 60 months,stone recurrence was detected in one patient in group A and two in group B(1.79%vs 3.33%,P=1.000).Stenosis of CBD was not observed in group A and slight stenosis in one patient in group B(0 vs 1.67%,P=1.000).Conclusion:Primary closure of the CBD upon completion of laparoscopic choledochotomy is safe and feasible in elderly patients≥70 years old. | Xiang Wu Ze-Jian Huang Jin-Yi Zhong Yi-Hong Ran Ming-Lei Ma Hong-Wei Zhang | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，6： | 30 |
| 16 | Rhizospheric microbial communities are driven by Panax ginseng at different growth stages and biocontrol bacteria alleviates replanting mortality显示文摘The cultivation of Panax plants is hindered by replanting problems, which may be caused by plantdriven changes in the soil microbial community. Inoculation with microbial antagonists may efficiently alleviate replanting issues. Through high-throughput sequencing, this study revealed that bacterial diversity decreased,whereas fungal diversity increased, in the rhizosphere soils of adult ginseng plants at the root growth stage under different ages. Few microbial community, such as Luteolibacter, Cytophagaceae, Luteibacter, Sphingomonas,Sphingomonadaceae, and Zygomycota, were observed; the relative abundance of microorganisms, namely,Brevundimonas, Enterobacteriaceae, Pandoraea, Cantharellales, Dendryphion, Fusarium, and Chytridiomycota,increased in the soils of adult ginseng plants compared with those in the soils of 2-year-old seedlings. Bacillus subtilis 50-1, a microbial antagonist against the pathogenic Fusarium oxysporum, was isolated through a dual culture technique. These bacteria acted with a biocontrol efficacy of 67.8%. The ginseng death rate and Fusarium abundance decreased by 63.3% and 46.1%, respectively, after inoculation with B. subtilis 50-1. Data revealed that microecological degradation could result from ginseng-driven changes in rhizospheric microbial communities;these changes are associated with the different ages and developmental stages of ginseng plants. Biocontrol using microbial antagonists alleviated the replanting problem. | Linlin Dong Jiang Xu Lianjuan Zhang Ruiyang Cheng Guangfei Wei He Su Juan Yang Jun Qian Ran Xu Shilin Chen | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 27 |
| 17 | A meta-analysis of the yield of capsule endoscopy compared to double-balloon enteroscopy in patients with small bowel diseases显示文摘AIM:To compare the diagnostic yield of capsule endoscopy (CE) with that of double-balloon enteroscopy (DBE). METHODS:Pubmed,Embase,Elsevier ScienceDirect,the China Academic Journals Full-text Database,and Cochrane Controlled Trials Register were searched for the trials comparing the yield of CE with that of DBE. Outcome measure was odds ratio (OR) of the yield. Fixed or random model method was used for data analysis. RESULTS:Eight studies (n = 277) which prospectively compared the yield of CE and DBE were collected. The results of meta-analysis indicated that there was no difference between the yield of CE and DBE 170/277 vs 156/277,OR 1.21 (95% CI:0.64-2.29). Based on sub analysis,the yield of CE was significantly higher than that of double-balloon enteroscopy without combination of oral and anal insertion approaches 137/219 vs 110/219,OR 1.67 (95% CI:1.14-2.44),P < 0.01),but not superior to the yield of DBE with combination of the two insertion approaches 26/48 vs 37/48,OR 0.33 (95% CI:0.05-2.21),P > 0.05). A focused meta-analysis of the fully published articles concerning obscure GI bleeding was also performed and showed similar results wherein the yield of CE was significantly higher than that of DBE without combination of oral and anal insertion approaches 118/191 vs 96/191,fixed model:OR 1.61 (95% CI:1.07-2.43),P < 0.05) and the yield of CE was significantly lower than that of DBE by oral and anal combinatory approaches 11/24 vs 21/24,fixed model:OR 0.12 (95% CI:0.03-0.52),P < 0.01). CONCLUSION:With combination of oral and anal approaches,the yield of DBE might be at least as high asthat of CE. Decisions made regarding the initial approach should depend on patient's physical status,technology availability,patient's preferences,and potential for therapeutic endoscopy. | Xiang Chen Zhi-Hua Ran Jin-Lu Tong | 2007 | World Journal of Gastroenterology2007，13，32： | 26 |
| 18 | Programmed death-1 expression is associated with the disease status in hepatitis B virus infection显示文摘AIM: To define the potential role of programmed death-1/programmed death-ligand (PD-1/PD-L) pathway in different hepatitis B virus (HBV) infection disease status; we examined the expression of PD-1 on antigen specific CD8+ T cells in peripheral blood of patients with chronic hepatitis B (CHB) and acute exacerbation of hepatitis B (AEHB) infection. METHODS: The PD-1 level on CD8+ T lymphocytes and the number of HBV specifi c CD8+ T lymphocytes in patients and healthy controls (HCs) were analyzed by staining with pentameric peptide-human leukocyte antigen2 (HLA2) complexes combined with flow cytometry. Real-time quantitative polymerase chain reaction (PCR) was used to measure the serum HBV-DNA levels. RESULTS: The level of PD-1 expression on total CD8+ T cells in CHB patients (13.86% ± 3.38%) was significantly higher than that in AEHB patients (6.80%± 2.19%, P < 0.01) and healthy individuals (4.63% ± 1.23%, P < 0.01). Compared to AEHB patients (0.81% ± 0.73%), lower frequency of HBV-specific CD8+ T cells was detected in chronic hepatitis B patients (0.37% ± 0.43%, P < 0.05). There was an inverse correlation between the strength of HBV-specific CD8+ T-cell response and the level of PD-1 expression. Besides, there was a significant positive correlation between HBV viral load and the percentage of PD-1 expression on CD8+ T cells in CHB and AEHB subjects (R = 0.541, P < 0.01). However, PD-1 expression was not associated with disease flare-ups as indicated by alanine aminotransferase (ALT) levels (R = 0.066, P > 0.05). CONCLUSION: Our results confirm previous reports that HBV specific CD8+ T-cell response in the peripheral blood is more intense in patients with AEHB than in chronic hepatitis B with persistent viral infection. Moreover, there is a negative correlation between the level of PD-1 and the intensity of virus specific CD8+T cell response. | Plan Ye Zhi-Hong Weng Shu-Ling Zhang Jian-Ao Zhang Lei Zhao Ji-Hua Dong Sheng-Hua Jie Ran Pang Rong-Hua Wei | 2008 | World Journal of Gastroenterology2008，14，28： | 25 |
| 19 | Research on the application of 4-weighted fractional Fourier transform in communication system显示文摘The paper reveals the relationship between the weighting coefficients and weighted functions via the research of coefficients matrix and based on the original definition of 4-weighted fractional Fourier transform(4-WFRFT).The multi-parameters expression of weighting coefficients are given.Moreover, the 4-WFRFT of discrete sequences is defined by introducing DFT into it, which makes it suitable for digital communication systems.After analyzing the properties of WFRFT, a typical scheme for modulation/demodulation is proposed, which could make the statistics properties of the real and image part on both of the time and frequency domain and the phase properties have a significant variation.Such a variation could be controlled by the adjustment of transform parameters.If the WFRFT of multi-parameters is implemented, it will be more difficult to intercept and capture the modulated signals than normal. | MEI Lin SHA XueJun RAN QinWen ZHANG NaiTong | 2010 | Science China(Information Sciences)2010，53，6： | 25 |
| 20 | Late Quaternary surface deformation and rupture behavior of strong earthquake on the segment north of Mianning of the Anninghe fault显示文摘The Anninghe fault is an important active fault along the eastern boundary of Sichuan-Yunnan active tectonic block, and the study of its surface deformation and rupture behavior during strong earthquake in the late Quaternary is of fundamental importance for understanding the future seismic risk of the fault zone or even the entire western Sichuan region. Using the methods of detailed geomorphic and geological survey, digital image analysis, total station instrument survey, excavation of combined trench and dating, we analyze the geomorphologic sequences of the offset strata at several sites where the late Quaternary deformation remnants are fairly well preserved and obtain some new results as follows: Strong earthquake events with left-lateral displacements of about 3 m occurred at the two sites of Zimakua and Yejitong at 1634-1811, 1030-1050 and 280-550 a BP, respectively, and the recurrence interval is 520-660 a; The youngest event in the area of Dahaizi-Ganhaizi should be the earthquake of 1536, other events are at 1768-1826, 2755-4108 and 4108-6593 a BP, respectively, with a recurrence interval of 1300-1900 a. The strong earthquake activity shows a clustering character. The possibility of occurrence of a strong earthquake exists on the north segment of the Anninghe fault sometime in the future. | RAN YongKang CHEN LiChun CHENG JianWu GONG HuiLing | 2008 | Science China Earth Sciences2008，51，9： | 25 |
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