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| 1 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 2 | China cardiovascular diseases report 2015: a summary显示文摘 | Wei-Wei CHEN Run-Lin GAO Li-Sheng LIU Man-Lu ZHU Wen WANG Yong-Jun WANG Zhao-Su WU Hui-Jun LI Dong-Feng GU Yue-Jin YANG Zhe ZHENG Li-Xin JIANG Sheng-Shou HU | 2017 | Journal of Geriatric Cardiology2017，14，1： | 46 |
| 3 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 4 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 5 | Cancer stem cell markers correlate with early recurrence and survival in hepatocellular carcinoma显示文摘AIM:To investigate whether expression of cancer stem cell(CSC)markers is associated with recurrence and survival in hepatocellular carcinoma(HCC)patients.METHODS:A consecutive series of 90 HCC patients who underwent curative hepatectomy between April2007 and April 2009 were analyzed.Of the 90 patients,38(42%)experienced recurrence within two years of surgery.To adjust for baseline differences between this early recurrence group and the other patients,propensity-score matching was used to generate 25 pairs of patients.Immunohistochemistry was used to compare expression of CD133,CD90,and epithelial cell adhesion molecule(EpCAM)in liver tissues from propensity score-matched patients and from 10 healthy adults.Associations of the three markers with HCC,clinicopathological characteristics,early recurrence,and survival time were explored.RESULTS:The expression of all three CSC markers was significantly higher in HCC tissue than in healthy liver tissue(P<0.001 for all).Among the HCC clinicopathology characteristics examined,the absence of tumor capsule was associated with CD133 expression(P=0.005);higher histopathology grade and larger tumor size were associated with CD90 expression(P=0.010 and 0.034,respectively);and elevated serum alpha-fetoprotein levels were associated with EpCAM expression(P=0.021).Expression of CD90 and EpCAM was significantly higher in the early recurrence group than in other patients(P=0.001 and 0.045,respectively),whereas CD133 expression was not significantly different between the two groups(P=0.440).Multivariate analysis identified only CD90 expression as significantly associated with early recurrence.Log-rank analysis identified expression of both CD90 and EpCAM as significantly associated with survival time of HCC patients.Cox regression identified EpCAM expression as an independent predictor of survival time.CONCLUSION:Expression of CD133,CD90,and EpCAM CSC markers may be linked to HCC tumor onset and/or progression.In addition,EpCAM expression is associated with shorter survival time,while CD90 expression is associated with early HCC recurrence. | Zhe Guo Le-Qun Li Jing-Hang Jiang Chao Ou Li-Xia Zeng Bang-De Xiang | 2014 | World Journal of Gastroenterology2014，20，8： | 18 |
| 6 | Blood neutrophil-lymphocyte ratio predicts survival after hepatectomy for hepatocellular carcinoma: A propensity score-based analysis显示文摘AIM: To investigate whether an elevated preoperative neutrophil-to-lymphocyte ratio(NLR) can predict poor survival in patients with hepatocellular carcinoma(HCC).METHODS: We retrospectively reviewed 526 patients with HCC who underwent surgery between 2004 and 2011.RESULTS: Preoperative NLR ≥ 2.81 was an independent predictor of poor disease-free survival(DFS, P < 0.001) and overall survival(OS, P = 0.044). Compared with patients who showed a preoperative NLR < 2.81 and postoperative increase, patients who showed preoperative NLR ≥ 2.81 and postoperative decrease had worse survival(DFS, P < 0.001; OS, P < 0.001). Among patients with preoperative NLR ≥ 2.81, survival was significantly higher among those showing a postoperative decrease in NLR than among those showing an increase(DFS, P < 0.001; OS, P < 0.001). When elevated, alpha-fetoprotein(AFP) provided no prognostic information, and so preoperative NLR ≥ 2.81 may be a good complementary indicator of poor OS whenever AFP levels are low or high.CONCLUSION: Preoperative NLR ≥ 2.81 may be an indicator of poor DFS and OS in patients with HCC undergoing surgery. Preoperative NLR ≥ 2.81 may be a good complementary indicator of poor OS when elevated AFP levels provide no prognostic information. | Hao-Jie Yang Zhe Guo Yu-Ting Yang Jing-Hang Jiang Ya-Peng Qi Ji-Jia Li Le-Qun Li Bang-De Xiang | 2016 | World Journal of Gastroenterology2016，22，21： | 18 |
| 7 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 8 | SYNERGY OF WALL SHEAR STRESS AND CIRCUMFERENTIAL STRESS IN STRAIGHT ARTERIES显示文摘The Wall Shear Stress (WSS) generated by blood flow and Circumferential Stress (CS) driven by blood pressure have been thought to play an important role in blood flow-dependent phenomena such as angiogenesis, vascular remodeling, and atherosgenesis. The WSS and CS in straight arteries were calculated by measuring the blood pressure, center-line velocity, wall thickness, and radius of vessels. The WSS and CS in the time domain were then decomposed into the amplitude and phase in the frequency domain. The CS amplitude to the WSS amplitude ratio (referred as stress amplitude ratio, Zs) and the phase difference between the CS and the WSS (referred as stress phase difference, SPA) in the frequency domain were calculated to characterize the synergy of the CS and WSS. Numerical results demonstrated that the CS is not in phase with the WSS, a time delay in the time domain or a stress phase difference in the frequency domain between the WSS and the CS exists. Theoretical analysis demonstrated that the Zs and SPA are primarily determined by the local factors (blood viscosity, local inertial effects, local geometry, local elasticity) and the input impedance of whole downstream arterial beds. Because the arterial input impedance has been shown to reflect the physiological and pathological states of whole downstream arterial beds, the stress amplitude ratio Zs and stress phase difference SPA would be thought to be the appropriate indices to reflect the effects of states of whole downstream arterial beds on the local blood flow-dependent phenomena such as angiogenesis, vascular remodeling, and atherosgenesis. | QIN Kai-rong XU Zhe WU Hao JIANG Zong-lai LIU Zhao-rong | 2005 | Journal of Hydrodynamics2005，17，6： | 15 |
| 9 | Comparison of simple discectomy and instrumented posterior lumbar interbody fusion for treatment of lumbar disc herniation combined with Modic endplate changes显示文摘 | Cao Peng Chen Zhe Zheng Yuehuan Wang Yuren Jiang Leisheng Yang Yaoqi Zhuang Chengyu Liang Yu Zheng Tao Gong Yaocheng Zhang Xingkai Wu Wenjian Qiu Shijing | 2014 | Chinese Medical Journal2014，，15： | 15 |
| 10 | High HIV incidence epidemic among men who have sex with men in china: results from a multi-site cross-sectional study显示文摘Background:Recent upsurge of new HIV infections among men who have sex with men(MSM)is a major concern in China.Paucity of national-level information regarding the burden and predictors of this progressive epidemic of new infections called for a multi-centric,timely and comprehensive investigation.Methods:Mixed methods were used to recruit MSM from seven cities in China between 2012 and 2013.Recent and established HIV infections were estimated by Western Blot and BED HIV-1 capture enzyme immunoassay.Syphilis and herpes simplex virus-2(HSV-2)were also tested.Results:A total of 4496 eligible MSM were recruited.The majority was aged≤35 years(77.5%),migrants(60.3%),never married(69.8%),and played receptive role in anal sex(70.5%).The HIV prevalence was 9.9%,and 41.9%were recently infected,with sensitivity/specificity adjusted HIV incidence of 8.9(95%CI:7.6-10.2)/100 Person-Years.The prevalence of history HSV-2 and syphilis were 12.5%and 8.5%,respectively.Recent HIV infection was associated with having multiple male partners(aOR=1.4,95%CI 1.1-1.9),recreational drug use(aOR=2.2,95%CI 1.6-3.0),anal bleeding(aOR=2.1,95%CI 1.4-3.0),syphilis infection(aOR=2.8,95%CI 1.9-4.3)and history HSV-2 infection(aOR=2.3,95%CI 1.5-3.3).Conclusion:High rate of recent HIV infection is potentially resulting in progressive deterioration of the overall HIV epidemic among MSM in China.Targeted interventions to address high-risk MSM including those having multiple partners,history of recreational drug use and syphilis or HSV-2 infection seemed to be the need of the hour. | Jun-Jie Xu Wei-Ming Tang Hua-Chun Zou Tanmay Mahapatra Qing-Hai Hu Geng-Feng Fu Zhe Wang Lin Lu Ming-Hua Zhuang Xi Chen Ji-Hua Fu Yan-Qiu Yu Jin-Xin Lu Yong-Jun Jiang Wen-Qing Geng Xiao-Xu Han Hong Shang | 2016 | Infectious Diseases of Poverty2016，5，1： | 14 |
| 11 | Effects of mowing and nitrogen addition on soil respiration in three patches in an oldfield grassland in Inner Mongolia显示文摘Aims Vegetation type is important in determining variations in soil carbon(C)efflux under grassland managements.This study was conducted to examine the effects of mowing and nitrogen(N)addition on soil respiration and their dependences upon vegetation types in an oldfield grassland of northern China.Methods Soil respiration,temperature,moisture and aboveground net primary productivity(ANPP)and belowground net primary productivity(BNPP)were examined in response to mowing and N addition among the three patches dominated by different species(named as grass,forb and mixed patches,respectively)in the growing seasons(May–October)from 2006 to 2008.Important Findings Across the 3 years,soil respiration in the grass patch was greater than those in the forb and mixed patches,which could have been ascribed to the higher soil moisture(SM)in the grass patch.Mowing had no impact on soil respiration due to unaltered SM and plant growth.Soil respiration was stimulated by 6.53%under N addition,and the enhancement was statistically significant in 2006 but not in 2007 or 2008 because of the limited water availability in the later 2 years.There were no interactive effects between mowing and N addition on soil respiration.Soil respiration showed positive dependence upon SM,ANPP and BNPP across plots.The results suggest that soil water availability and plant growth could be the primary factors in controlling the temporal and spatial variations in soil respiration and its response to different treatments.Our observations indicate that grassland managements(i.e.mowing for hay once a year)may have little influence on soil respiration of the oldfield grassland in northern China. | Yi Han Zhe Zhang Changhui Wang Fenghe Jiang Jianyang Xia | 2012 | Journal of Plant Ecology2012，5，2： | 14 |
| 12 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 13 | Effect of Magnetic Field on Tribological Properties of Lubricating Oils with and without Tricresyl Phosphate显示文摘Tribological properties of neat 150 SN mineral base oil and the oils doped with different contents of tricresyl phosphate(TCP) under magnetic field or non-magnetic field were evaluated on a four-ball tribotester, on which an external magnetic field was applied. Furthermore, the morphology and the tribochemical characteristics of the worn surfaces were examined with a scanning electron microscope(SEM) and an X-ray photoelectron spectrograph(XPS). The tribological test results showed that the magnetic field improved anti-wear properties but impaired the friction-reducing properties of neat base oil and the TCP-doped oils. The worn surfaces tested in magnetic field were characterized by a slighter wear than those tested in normal condition, especially for the surfaces lubricated with the TCP-doped oils. Furthermore, the results of XPS analysis indicated that tribochemical films on the surfaces tested with TCP-doped oils were mainly composed of ferriccontaining compounds such as Fe_2O_3, Fe_3O_4 and FePO_4. Under the influence of a magnetic field, the atomic concentrations of oxygen and phosphorous in the frictional sub-surfaces were higher than those without magnetic impact. Thus it can be inferred that the improved anti-wear properties and impaired friction-reducing capabilities of lubricating oils with TCP under a magnetic field were related to the diffusion of phosphorus and oxygen into the substrate induced by magnetism. | Jiang Zeqi Fang Jianhua Chen Boshui Zheng Zhe Li Hao Xu Lai | 2016 | China Petroleum Processing & Petrochemical Technology2016，18，3： | 12 |
| 14 | MiR-122-5p suppresses the proliferation, migration, and invasion of gastric cancer cells by targeting LYN显示文摘Gastric cancer(GC)is one of malignant tumors with high mortality and morbidity in the world.MicroRNA-122(miR-122)acts as a tumor suppressor in a variety of cancers and has been found to be dominant in gastric adenocarcinoma.However,the specific biological function of miR-122-5p in GC is not completely clear.In this study,we found that miR-122-5p was low-expressed in GC tissues and cell lines by using qRT-PCR.Overexpression of miR-122-5p inhibited the proliferation,migration,and invasion of GC cells by using CCK-8 and transwell assays.On the contrary,downregulation of miR-122-5p promoted the proliferation,migration,and invasion of GC cells.In addition,we found that the expression of LYN,an Src family tyrosine kinase,was inversely correlated with miR-122-5p expression in GC tissues by using western blot analysis,immunohistochemistry,and qRT-PCR assays.Meanwhile,luciferase assay results indicated that LYN is a direct target of miR-122-5p in GC cells.Moreover,silencing LYN expression by its siRNA inhibited the proliferation,migration,and invasion of GC cells.Importantly,overexpression of LYN restored miR-122-5p-mediated inhibition of the proliferation,migration,and invasion of GC cells.Taken together,our results indicated miR-122-5p inhibited the proliferation,migration,and invasion by targeting LYN in GC. | Lei Meng Zhangming Chen Zhe Jiang Ting Huang Jie Hu Panquan Luo Hongli Zhang Mengqi Huang Lei Huang Yu Chen Ming Lu A-man Xu Songcheng Ying | 2020 | Acta Biochimica et Biophysica Sinica2020，52，1： | 12 |
| 15 | Rare earth elements and carbon isotope geochemistry of the Doushantuo Formation in South China:Implication for middle Ediacaran shallow marine redox conditions显示文摘The middle Ediacaran Shuram excursion, the largest negative δ 13 C carb excursion in Earth history, has been interpreted as indirect evidence for episodic oxidation and remineralization of deep ocean DOC (dissolved organic carbon). It has been hypothesized that such oxidation event may have occurred when anoxic DOC-laden deep water was brought to shallow shelves during oceanic upwelling, which is expected to cause localized anoxia in shallow environments. To test this prediction, we systematically analyzed rare earth elements (REE) and δ 13 C carb of the upper Doushantuo Formation carbonates in the Yangtze Gorges area of South China, which were deposited in an inner shelf environment and record a large negative δ 13 C carb excursion correlated to the Shuram event. The REE data show a significant positive shift in Ce/Ce* values, synchronous with a pronounced negative δ 13 C carb shift. This positive Ce/Ce* shift is interpreted to represent an oceanic anoxia event in shallow shelf environments, which may have been caused by the upwelling or impingement of oxygen-depleted and 12 C-enriched deep water onto shelves. This anoxia event coincides with a sharp decline in the abundance and diversity of Ediacaran acanthomorphic acritarchs, raising the possibility that these two geobiological events may be causally related. | ZHOU ChuanMing JIANG ShaoYong XIAO ShuHai CHEN Zhe YUAN XunLai | 2012 | Chinese Science Bulletin2012，57，16： | 11 |
| 16 | Improvement of Magnetic Field on Tribological Properties of Lubricating Oils with Zinc Butyloctyldithiophosphate显示文摘Tribological properties of 150 SN mineral oil and the oils doped with different contents of zinc butyloctyldithiophosphate(T202) under magnetic field or non-magnetic field were evaluated on a four-ball tribotester by applying an external magnetic field around the friction region. Moreover, the morphology and the tribochemical characteristics of worn surfaces were examined by a scanning electron microscope(SEM) and an X-ray photoelectron spectrometer(XPS). Then the lubrication mechanisms were discussed. The tribological test results indicated that the wear scar diameters(WSDs) of steel balls lubricated by the T202-containing lubricating oils and the friction coefficients of the corresponding oil under magnetic field were smaller than those without magnetic affection. The worn surface lubricated with the T202-formulated oils in a magnetic field was smoother than that obtained under the normal condition. Furthermore, the results of XPS analysis indicated that tribochemical films on the surfaces lubricated with T202-doped oils were mainly composed of compounds such as FeSO_4, FeS and ZnS. The atomic concentrations of oxygen, sulfur, iron, zinc and phosphorus species identified in T202 under magnetic field were higher than those without magnetic impact. It can be inferred that the improved anti-wear and friction-reducing ability of T202-doped oils was attributed to the promoted tribochemical reactions and the modification of the worn surfaces induced by magnetic field. | Jiang Zeqi Fang Jianhua Chen Boshui Wu Jiang Wang Jiu Zheng Zhe | 2016 | China Petroleum Processing & Petrochemical Technology2016，18，4： | 11 |
| 17 | A new DSmT combination rule in open frame of discernment and its application显示文摘A new combination rule based on Dezert-Smarandache theory (DSmT) is proposed to deal with the conflict evidence resulting from the non-exhaustivity of the discernment frame. A two-dimensional measure factor in Dempster-Shafer theory (DST) is extended to DSmT to judge the conflict degree between evidence. The original DSmT combination rule or new DSmT combination rule can be selected for fusion according to this degree. Finally, some examples in simultaneous fault diagnosis of motor rotor are given to illustrate the effectiveness of the proposed combination rule. | WEN ChengLin XU XiaoBin JIANG HaiNa ZHOU Zhe | 2012 | Science China(Information Sciences)2012，55，3： | 10 |
| 18 | Whole-Genome Resequencing of a Worldwide Collection of Rapeseed Accessions Reveals the Genetic Basis of Ecotype Divergence显示文摘Rapeseed (Brassica napus),an important oilseed crop,has adapted to diverse climate zones and latitudes by forming three main ecotype groups,namely winter,semiwinter,and spring types. However,genetic variations underlying the divergence of these ecotypes are largely unknown. Here,we report the global pattern of genetic polymorphisms in rapeseed determined by resequencing a worldwide collection of 991 germplasm accessions.A total of 5.56 and 5.53 million singlenucleotide polymorphisms (SNPs)as Well as 1.86 and 1.92 million InDels were identified by mapping reads to the reference genomes of 'Darmor-bzh'and 'Tapidor,'respectively.We generated a map of allelic drift paths that shows splits and mixtures of the main populations,and revealed an asymmetric evolution of the two subgenomes of B.napus by calculating the genetic diversity and linkage disequilibrium parameters.Selective-sweep analysis revealed genetic changes in genes orthologous to those regulating various aspects of plant development and response to stresses.A genome-wide association study identified SNPs in the promoter regions of FLOWERING LOCUS T and FLOWERING LOCUS C orthologs that corresponded to the different rapeseed ecotype groups. Our study provides important insights into the genomic footprints of rapeseed evolution and flowering-time divergence among three ecotype groups,and will facilitate screening of molecular markers for accelerating rapeseed breeding. | Dezhi Wu Zhe Liang Tao Yan Ying Xu Lijie Xuan Juan Tang Gang Zhou Ulrike Lohwasser Shuijin Hua Haoyi Wang Xiaoyang Chen Qian Wang Le Zhu Antony Maodzeka Nazim Hussain Zhilan Li Xuming Li Imran Haider Shamsi Ghulam Jilani Linde Wu Hongkun Zheng Guoping Zhang Boulos Chalhoub Lisha Shen Hao Yu Lixi Jiang | 2019 | Molecular Plant2019，12，1： | 10 |
| 19 | Less cytotoxicity to combination therapy of 5-fluorouracil and cisplatin than 5-fluorouracil alone in human colon cancer cell lines显示文摘AIM: Our previous studies showed increased sensitivityto 5-FU in colon cancer cell lines with microsatelliteinstability, and considered that mutations of TGFβ-RⅡ,IGF Ⅱ R, RIZ gene might enhance the potentials of cellgrowth and proliferation, which increased the sensitivityto 5-FU. Here we compared the distribution of cell cycleand P53 status between two human colon cancer cell lineswith different sensitivity to 5-FU. Because mechanisticdifferences exist between 5-FU andCD DP, we alsoanalyzed the efficacy of CDDP and combination therapyon two human colon cancer cell linesMETHODS: We compared the sensitivity to CDDP of thesetwo cell lines by MTT assay. Distribution of cell cycle undertreatment of 5-FU, CDDP alone or both was analyzed byFlow Cytometry, and expression of P53 was detected byimmunocytochemical staining.RESULTS: SW480 cells were more sensitive to CDDP thanLoVo cells at the concentrations above 16 μmol/I (Ratio ofabsorption is 0.64 and 0.79 at 16 μmol/I, respectively;P<0.01). Efficacy of combination therapy was converselylower than that of single-therapy of 5-FU (Ratio of absorptionin LoVo+5-FU, SW480+5-FU, LoVo+5-FU+CDDP andSW480+5-FU+CDDP is 0.53, 0.54, 0.72, 0.78, respectively;P<0.01). LoVo cells were negative whereas SW480 cellspositive in P53 expression. 5-FU induced G1-phase arrestin both cell lines, but LoVo cells peaked 24 hours earlierthan SW480 cells, and 48 hours earlier for an apparenthypodiploid DNA. However, CDDP showed the contrary,inducing S-phase arrest, and SW480 cells peaking 36 hoursearlier. Both cell lines showed hypodipliod nuclei 48 hoursafter CDDP treatment. Percentage of cells in G1-phase andS-phase dominated alternatively under combination therapyin both cell lines.CONCLUSION: These results suggest that colon cancercells with microsatellite instability are more sensitive to 5-FU, whereas more resistant to CDDP. Combination therapyof 5-FU and CDDP shows fewer efficacies than 5-FU single-therapy, although it can render a cell cycle arrest. P53 may beinvolved in the shift of G1-phase to S-phase, but inessentially. | Xiu-Xu Chen Mao-De Lai Qiong Huang Department of Pathology,School of Medicine,Zhe Jiang University,Hang Zhou,310031,Zhejiang Province,China Yong-Liang Zhang Department of Basic Medicine,School of Medicine,Zhe Jiang University,Hang Zhou,310031,Zhejiang Province,China | 2002 | World Journal of Gastroenterology2002，8，5： | 10 |
| 20 | Study of HIV-1 Drug Resistance in Patients Receiving Free Antiretroviral Therapy in China显示文摘To investigate the prevalence of drug-resistance mutations,resistance to antiretroviral drugs,and the subsequent virological response to therapy in treatment-naive and antiretroviral-treated patients infected with HIV/AIDS in Henan,China,a total of 431 plasma samples were collected in Queshan county between 2003 and 2004,from patients undergoing the antiretroviral regimen Zidovudine + Didanosine + Nevirapine(Azt+Ddi+Nvp).Personal information was collected by face to face interview.Viral load and genotypic drug resistance were tested.Drug resistance mutation data were obtained by analyzing patient-derived sequences through the HIVdb Program(http://gffzz38c50ed9119344cfhfc0nwk5cbpk96vxw.ffgz.tsg.suse.edu.cn).Overall,38.5% of treatment-naive patients had undetectable plasma viral load(VL),the rate significantly increased to 61.9% in 0 to 6 months treatment patients(mean 3 months)(P<0.005)but again significantly decrease to 38.6% in 6 to 12 months treatment patients(mean 9 months)(P<0.001)and 40.0% in patients receiving more than 12 months treatment(mean 16 months)(P<0.005).The prevalence of drug resistance in patients who had a detectable VL and available sequences were 7.0%,48.6%,70.8%,72.3% in treatment-na?ve,0 to 6 months treatment,6 to 12 months treatment,and treatment for greater than 12 months patients,respectively.No mutation associated with resistance to Protease inhibitor(PI)was detected in this study.Nucleoside RT inhibitor(NRTI)mutations always emerged after non-nucleoside RT inhibitor(NNRTI)mutations,and were only found in patients treated for more than 6 months,with a frequency less than 5%,with the exception of mutation T215Y(12.8%,6/47)which occurred in patients treated for more than 12 months.NNRTI mutations emerged quickly after therapy begun,and increased significantly in patients treated for more than 6 months(P<0.005),and the most frequent mutations were K103N,V106A,Y181C,G190A.There had been optimal viral suppression in patients undergoing treatment for less than 6 months in Queshan,Henan.The drug resistance strains were highly prevalent in antiretroviral-treated patients,and increased with the continuation of therapy,with many patients encountering virological failure after 6 months therapy. | Xin-ping LIP Hui XING Zhe WANG Xue-feng SI Lian-en WANG Hua CHENG Wei-guo CUI Shu-lin JIANG Ling-jie LIAO Hai-wei ZHOU Jiang-hong HUANG Hong PENG Peng-fei MA Yi-ming SHAO | 2007 | 中国病毒学2007，22，3： | 9 |
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