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| 1 | Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats显示文摘AIM:To investigate the effects of long term pretreatment with low-,medium-and high-dose aspirin(acetylsalicylic acid,ASA) on a model of acute pancreatitis(AP) induced in rats.METHODS:Forty male Wistar rats were used.Three experimental groups,each consisting of eight animals,received low-(5 mg/kg per day),medium-(150 mg/kg per day) and high-dose(350 mg/kg per day) ASA in supplemented pellet chow for 100 d.Eight animals,serving as the AP-control group,and another eight,serving as reference value(RV) group,were fed with standard pellet chow for the same period.After pretreatment,AP was induced in the experimental animals by intraperitoneal administration of cerulein(2 × 50 μg/kg),while the RV group received saline in the same way.Twelve hours after the second injection,the animals were sacrificed.Pancreatic tissue and plasma samples were collected.One part of the collected pancreatic tissues was used for histopathological evaluation,and the remaining portion was homogenized.Cytokine levels [tumor necrosis factor,interleukin(IL)1β,IL-6],hemogram parameters,biochemical parameters(amylase and lipase),nuclear factor-κB,aspirin triggered lipoxins and parameters related to the antioxidant system(malondialdehyde,nitric oxide,hemeoxygenase-1,catalase and superoxide dismutase) were measured.RESULTS:Cerulein administration induced mild pancreatitis,characterized by interstitial edema(total histopathological score of 5.88 ± 0.44vs 0.25 ± 0.16,P < 0.001).Subsequent pancreatic tissue damage resulted in an increase in amylase(2829.71 ± 772.48 vs 984.57 ± 49.22 U/L,P = 0.001) and lipase(110.14 ± 75.84 U/L vs 4.71 ± 0.78 U/L,P < 0.001) in plasma,and leucocytes(6.89 ± 0.48 vs 4.36 ± 0.23,P = 0.001) in peripheral blood.Cytokines,IL-1β(18.81 ± 2.55 pg/μg vs 6.65 ± 0.24 pg/μg,P = 0.002) and IL-6(14.62 ± 1.98 pg/μg vs 9.09 ± 1.36 pg/μg,P = 0.04) in pancreatic tissue also increased.Aspirin pretreatment reduced the increase in the aforementioned parameters to a certain degree and partially improved the histopathological alterations caused by cerulein.No evidence of side effects related to chronic ASA administration(e.g.,inflammation or bleeding) was observed in the gastrointestinal tract in macroscopic and histopathological examination.CONCLUSION:Long term ASA pretreatment could prevent and/or ameliorate certain hematological,serological and histological alterations caused by ceruleininduced AP. | Ibrahim Akyazi Evren Eraslan Ahmet Gülubuk Elif Ergül Ekiz Zeynep L rakli Damla Haktanir Deniz Aktaran Bala Mete zkurt Erdal Matur Mukaddes zcan | 2013 | World Journal of Gastroenterology2013，19，19： | 5 |
| 2 | 半胱氨酸在碳钢与硫酸界面的缓蚀行为(英文)显示文摘Interfacial behavior of cysteine (Cys) between mild steel and sulfuric acid solution as a corrosion inhibitor has been studied with electrochemical AC (alternating current) and DC (direct current) techniques at (25.0±0.1) ℃. The AC impedance results were evaluated using equivalent circuits in which a constant phase element (CPE) has been replaced with double layer capacitance (Cdl) to represent the frequency distribution of experimental data. Changes in impedance parameters (charge transfer resistance and double layer capacitance) indicated that cysteine molecules acted by accumulating at the metal/solution interface. The fractional coverage of the metal surface (θ) was determined using AC impedance results and it was found that the adsorption of cysteine on the mild steel surface followed a Langmuir isotherm model with a standard free energy of adsorption (△G0 ads) of -35.1 kJ·mol-1. To clarify the type of interaction between mild steel surface and cysteine molecules with a molecular orbital approach, electronic properties, such as, the highest occupied molecular orbital (HOMO) energy, the lowest unoccupied molecular orbital (LUMO) energy, and the frontier molecular orbital coefficients have been calculated. Energy gaps for the interaction of mild steel surface and cysteine molecules (ELUMO Fe-EHOMO Cys and ELUMO Cys-EHOMO Fe) were used to determine whether cysteine molecules acted as electron donors or electron acceptors when they interacted with the mild steel surface. The local reactivity was evaluated through the condensed Fukui indices. Theoretical calculations were carried out using the density functional theory (DFT) at B3LYP level with the 6-311++G(d,p) basis set for all atoms by Gaussian 03W program. | ZCAN Muzaffer KARADA■ Faruk DEHRI lyas | 2008 | 物理化学学报2008，24，8： | 5 |
| 3 | Hepatitis B-related events in autologous hematopoietic stem cell transplantation recipients显示文摘AIM: To investigate the frequency of occult hepatitis B, the clinical course of hepatitis B virus (HBV) reactivation and reverse seroconversion and associated risk factors in autologous hematopoietic stem cell transplantation (HSCT) recipients. METHODS: This study was conducted in 90 patients undergoing autologous HSCT. Occult HBV infection was investigated by HBV-DNA analysis prior to transplantation, while HBV serology and liver function tests were screened prior to and serially after transplantation. HBV-related events including reverse seroconversion and reactivation were recorded in all patients. RESULTS: None of the patients had occult HBV prior to transplantation. Six (6.7%) patients were positivefor HBV surface antigen (HBsAg) prior to transplantation and received lamivudine prophylaxis; they did not develop HBV reactivation after transplantation. Clinical HBV infection emerged in three patients after transplantation who had negative HBV-DNA prior to HSCT. Two of these three patients had HBV reactivation while one patient developed acute hepatitis B. Three patients had anti-HBc as the sole hepatitis B-related antibody prior to transplantation, two of whom developed hepatitis B reactivation while none of the patients with antibody to HBV surface antigen (anti-HBs) did so. The 14 anti-HBs-and/or anti-HBc-positive patients among the 90 HSCT recipients experienced either persistent (8 patients) or transient (6 patients) disappearance of anti-HBs and/or anti-HBc. HBsAg seroconversion and clinical hepatitis did not develop in these patients. Female gender and multiple myeloma emerged as risk factors for loss of antibody in regression analysis (P < 0.05). CONCLUSION: Anti-HBc as the sole HBV marker seems to be a risk factor for reactivation after autologous HSCT. Lamivudine prophylaxis in HbsAg-positive patients continues to be effective. | zcan eneli Zübeyde Nur zkurt Kadir Acar Seyyal Rota Sahika Zeynep Aki Zeynep Arzu Yegin Münci Yagci Seren zenirler Gülsan Türkz Sucak | 2010 | World Journal of Gastroenterology2010，16，14： | 3 |
| 4 | Intraperitoneal dedifferentiated liposarcoma:A case report显示文摘Dedifferentiated liposarcoma is a variant of liposarcoma with a more aggressive course. Mutations of the p53 gene have been found in different types of soft tissue sarcoma. It is generally accepted that p53 mutations in human malignant tumors are often related to a poor prognosis. In our case, analysis of p53 gene mutation in tumor samples was performed. p53 gene mutation was observed in dedifferentiated tumor tissue samples but not in well-differentiated tumor tissue samples. It has been reported that p53 gene mutation occurs most commonly in the retroperitoneum and rarely in other anatomic locations. Herein we report a case of dedifferentiated liposarcoma located at intraperitoneum. | Ali Karaman Mehmet Esref Kabalar nder zcan Timur Koca Dogan Nasir Binici | 2008 | World Journal of Gastroenterology2008，14，38： | 3 |
| 5 | Red cell distribution width and inflammation in patients with non-dipper hypertension显示文摘 | Firat ?zcan Osman Turak Akif Durak Ahmet ??leyen Fatih U?ar Zeynep Gini? Fatma U?ar Fatma Nurcan Ba?ar Sinan Aydo?du | 2013 | Blood Pressure2013，，2： | 3 |
| 6 | Investigation of impact of DC component on breakdown characteristics for different electric fields under composite AC&DC voltage显示文摘The valve side of the converter in the high‐voltage direct current is subjected to mixed voltages such as composite AC&DC voltage.In this study,the effects of the homo-geneity of electric field on breakdown voltage were investigated for different�DC component amplitudes of the composite voltage.The field efficiency factor was calcu-lated using mean and maximum field strengths for all of them.Variation of breakdown voltage of air was examined under the composite AC&DC voltage for different ratios�DC.As one result of the study,the breakdown occurs at the positive half‐wave of the AC voltage despite−DC voltage being applied due to positive corona discharge pulses.This breakdown point is named as the polarity change point.The breakdown voltage increases with the decrease of DC voltage component up to polarity change point in non‐uniform electric field.In less uniform electric field,the AC breakdown voltage was measured slightly higher than the DC breakdown voltage.In less uniform electric field,as the ratio of the applied AC voltage to DC voltage increases,the breakdown voltage gradually approaches the AC breakdown voltage.This result is similar to the result ob-tained for the+DC component in non‐uniform electric field experiments. | Mehmet Murat Ispirli Özcan Kalenderli Florian Seifert Michael Rock Bülent Oral | 2022 | High Voltage2022，7，2： | 2 |
| 7 | Effect of colouring green stage zirconia on the adhesion of veneering ceramics with different thermal expansion coefficients显示文摘This study evaluated the adhesion of zirconia core ceramics with their corresponding veneering ceramics, having different thermal expansion coefficients(TECs), when zirconia ceramics were coloured at green stage. Zirconia blocks(N5240; 6 mm37 mm37 mm) were manufactured from two materials namely, ICE Zirconia(Group 1) and Prettau Zirconia(Group 2). In their green stage, they were randomly divided into two groups. Half of the specimens were coloured with colouring liquid(shade A2). Three different veneering ceramics with different TEC(ICE Ceramic, GC Initial Zr and IPS e.max Ceram) were fired on both coloured and non-coloured zirconia cores. Specimens of high noble alloys(Esteticor Plus) veneered with ceramic(VM 13)(n516) acted as the control group. Core–veneer interface of the specimens were subjected to shear force in the Universal Testing Machine(0.5 mm?min21). Neither the zirconia core material(P50.318) nor colouring(P50.188) significantly affected the results(three-way analysis of variance, Tukey's test). But the results were significantly affected by the veneering ceramic(P50.000). Control group exhibited significantly higher mean bond strength values(45.768) MPa than all other tested groups((27.164.1)2(39.764.7) and(27.465.6)2(35.964.7) MPa with and without colouring, respectively)(P,0.001). While in zirconia–veneer test groups, predominantly mixed type of failures were observed with the veneering ceramic covering,1/3 of the substrate surface, in the metal–ceramic group, veneering ceramic was left adhered.1/3 of the metal surface. Colouring zirconia did not impair adhesion of veneering ceramic, but veneering ceramic had a significant influence on the core–veneer adhesion. Metal–ceramic adhesion was more reliable than all zirconia–veneer ceramics tested. | Guliz Aktas Erdal Sahin Pekka Vallittu Mutlu zcan Lippo Lassila | 2013 | International Journal of Oral Science2013，5，4： | 2 |
| 8 | NT-Pro-BNP levels and their response to exercise in patients with slow coronary flow显示文摘 | Yurtda?1 M ?zcan IT ?amsar A | | 0，，： | 1 |
| 9 | Adsorption of Acid Blue 193 from aqueous solutions onto Na-bentonite and DTMA-bentonite显示文摘 | (O)zcan A S Erdem B (O)zcan A | 2004 | Journal of Colloid and interface Science2004，280，1： | 1 |
| 10 | Cervical Actinomycosis causing spinal cord compression and multisegmental root failure:case report and review of the literature显示文摘 | Hakan OH (O)zcan S Figen S | 1998 | Neurosurgery1998，43，： | 1 |
| 11 | Y-TZP ceramic processing from coprecipitated powders: a comparative study with three commercial dental ceramics显示文摘 | LAZAR D R R BOTTINO M C ZCAN M | 2008 | Dental Materials2008，24，12： | 1 |
| 12 | Effect of Abdominal Obesity on Insulin Resistance and the Components of the Metabolic Syndrome: Evidence Supporting Obesity as the Central Feature显示文摘 | ?avlan Türkoglu MD Belgin Süsleyici Duman PhD Demet Günay PhD Penbe ?agatay PhD Remzi ?zcan MD A Sevim Büyükdevrim MD | 2003 | Obesity Surgery2003，，5： | 1 |
| 13 | Erythrocyte Membrane Anionic Content and Urinary Glycosaminoglycan Excretion in Type 1 Diabetes: Association with Retinopathy显示文摘 | ? zlem Yenice Haluk Kazoko&gbreve lu Eda ? zcan Meral Yü ksel G? ksenin Adigü zel Goncagü l Haklar Dilek Gogas Yavuz | 2006 | Current Eye Research2006，，11： | 1 |
| 14 | Adsorption of Acid Blue 193 from aqueous solutions onto BTMA-bentonite显示文摘 | OZCAN A S ERDEM B ZCAN A | 2005 | Colloid Surf A : Physicochem2005，266，： | 1 |
| 15 | Restoration of fertility by in-vitro spermatogenesis显示文摘 | Tesarik J Bahceci M zcan C | 1999 | Lancet1999，353，： | 1 |
| 16 | Severcan, Influence of dry and wet curing conditions on compressive strength of silica fume conerete显示文摘 | ATIS C D ZCAN F O KILIC A K | 2005 | Building and Environment2005，，40： | 1 |
| 17 | The Use of Expressive Methods for Developing Empathic Skills显示文摘 | Neslihan Keser ?zcan Hülya Bilgin Nevin Eracar | 2011 | Issues in Mental Health Nursing2011，，2： | 1 |
| 18 | Adsorption of Acid Blue 193 from aqueous solutions onto Na–bentonite and DTMA–bentonite显示文摘 | A. Safa ?zcan Bilge Erdem Adnan ?zcan | 2004 | Journal of Colloid And Interface Science2004，，1： | 1 |
| 19 | Ochratoxin A activates opposing c-MET/PI3K/Akt and MAPK/ERK 1-2 pathways in human proximal tubule HK-2 cells显示文摘 | zcan Z Gül G Yaman I | 2015 | Arch Toxicol2015，89，8： | 1 |
| 20 | Penetration of amalgam constituents into dentine显示文摘 | Johannes D. Scholtanus Mutlu ?zcan Marie-Charlotte D.N.J.M. Huysmans | 2009 | Journal of Dentistry2009，，5： | 1 |
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