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| 1 | Ehealth:Low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome显示文摘AIM:To investigate the effects of a low fermentable,oligosaccharides,disaccharides,monosaccharides and polyols diet(LFD)and the probiotic Lactobacillus rhamnosus GG(LGG)in irritable bowel syndrome(IBS).METHODS:Randomised,unblinded controlled trial on the effect of 6-wk treatment with LFD,LGG or a normal Danish/Western diet(ND)in patients with IBS fulfilling Rome III diagnostic criteria,recruited betweenNovember 2009 and April 2013.Patients were required to complete on a weekly basis the IBS severity score system(IBS-SSS)and IBS quality of life(IBS-QOL)questionnaires in a specially developed IBS web selfmonitoring application.We investigated whether LFD or LGG could reduce IBS-SSS and improve QOL in IBS patients.RESULTS:One hundred twenty-three(median age 37years,range:18-74 years),90(73%)females were randomised:42 to LFD,41 to LGG and 40 to ND.A significant reduction in mean±SD of IBS-SSS from baseline to week 6 between LFD vs LGG vs ND was revealed:133±122 vs 68±107,133±122 vs 34±95,P<0.01.Adjusted changes of IBS-SSS for baseline covariates showed statistically significant reduction of IBS-SSS in LFD group compared to ND(IBS-SSS score75;95%CI:24-126,P<0.01),but not in LGG compared to ND(IBS-SSS score 32;95%CI:18-80,P=0.20).IBS-QOL was not altered significantly in any of the three groups:mean±SD in LFD 8±18 vs LGG 7±17,LFD 8±18 vs ND 0.1±15,P=0.13.CONCLUSION:LFD is efficacious for patients with IBS. | Natalia Pedersen Nynne Nyboe Andersen Zsuzsanna Végh Lisbeth Jensen Dorit Vedel Ankersen Maria Felding Mette Hestetun Simonsen Johan Burisch Pia Munkholm | 2014 | World Journal of Gastroenterology2014，20，43： | 16 |
| 2 | Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease显示文摘AIM To investigate the effect of a low-FODMAP diet on irritable bowel syndrome(IBS)-like symptoms in patients with inflammatory bowel disease(IBD).METHODS This was a randomised controlled open-label trial of patients with IBD in remission or with mild-to-moderate disease and coexisting IBS-like symptoms(Rome III) randomly assigned to a Low-FODMAP diet(LFD) or a normal diet(ND) for 6 wk between June 2012 andDecember 2013. Patients completed the IBS symptom severity system(IBS-SSS) and short IBD quality of life questionnaire(SIBDQ) at weeks 0 and 6. The primary end-point was response rates(at least 50-point reduction) in IBS-SSS at week 6 between groups; secondary end-point was the impact on quality of life. RESULTS Eighty-nine patients, 67(75%) women, median age 40, range 20-70 years were randomised: 44 to LFD group and 45 to ND, from which 78 patients completed the study period and were included in the final analysis(37 LFD and 41 ND). There was a significantly larger proportion of responders in the LFD group(n = 30, 81%) than in the ND group(n = 19, 46%);(OR = 5.30; 95%CI: 1.81-15.55, P < 0.01). At week 6, the LFD group showed a significantly lower median IBSSSS(median 115; inter-quartile range [IQR] 33-169) than ND group(median 170, IQR 91-288), P = 0.02. Furthermore, the LFD group had a significantly greater increase in SIBDQ(median 60, IQR 51-65) than the ND group(median 50, IQR 39-60), P < 0.01.CONCLUSION In a prospective study, a low-FODMAP diet reduced IBS-like symptoms and increased quality of life in patients with IBD in remission. | Natalia Pedersen Dorit Vedel Ankersen Maria Felding Henrik Wachmann Zsuzsanna Végh Line Molzen Johan Burisch Jens Rikardt Andersen Pia Munkholm | 2017 | World Journal of Gastroenterology2017，23，18： | 15 |
| 3 | Follow-up of patients with functional bowel symptoms treated with a low FODMAP diet显示文摘AIM: To investigate patient-reported outcomes from, and adherence to, a low FODMAP diet among patients suffering from irritable bowel syndrome and inflammatory bowel disease.METHODS: Consecutive patients with irritable bowel syndrome(IBS) or inflammatory bowel disease(IBD) and co-existing IBS fulfilling the ROME Ⅲ criteria, who previously attended an outpatient clinic for low FODMAP diet(LFD) dietary management and assessment by a gastroenterologist, were invited to participate in a retrospective questionnaire analysis. The questionnaires were sent and returned by regular mail and gathered information on recall of dietarytreatment, efficacy, symptoms, adherence, satisfaction, change in disease course and stool type, and quality of life. Before study enrolment all patients had to sign an informed written consent.RESULTS: One hundred and eighty patients were included, 131(73%) IBS and 49(27%) IBD patients. Median age was 43 years(range: 18-85) and 147(82%) were females. Median follow-up time was 16 mo(range: 2-80). Eighty-six percent reported either partial(54%) or full(32%) efficacy with greatest improvement of bloating(82%) and abdominal pain(71%). The proportion of patients with full efficacy tended to be greater in the IBD group than in the IBS group(42% vs 29%, P = 0.08). There was a significant reduction in patients with a chronic continuous disease course in both the IBS group(25%, P < 0.001) and IBD group(23%, P = 0.002) along with a significant increase in patients with a mild indolent disease course of 37%(P < 0.001) and 23%(P = 0.002), respectively. The proportion of patients having normal stools increased with 41% in the IBS group(P < 0.001) and 66% in the IBD group(P < 0.001). One-third of patients adhered to the diet and high adherence was associated with longer duration of dietary course(P < 0.001). Satisfaction with dietary management was seen in 83(70%) IBS patients and 24(55%) IBD patients. Eightyfour percent of patients lived on a modified LFD, where some foods rich in FODMAPs were reintroduced, and 16% followed the LFD by the book without deviations. Wheat, dairy products, and onions were the foods most often not reintroduced by patients.CONCLUSION: These data suggest that a diet low in FODMAPs is an efficacious treatment solution in the management of functional bowel symptoms for IBS and IBD patients. | Louise Maagaard Dorit V Ankersen Zsuzsanna Végh Johan Burisch Lisbeth Jensen Natalia Pedersen Pia Munkholm | 2016 | World Journal of Gastroenterology2016，22，15： | 8 |
| 4 | Ehealth monitoring in irritable bowel syndrome patients treated with low fermentable oligo-, di-, mono-saccharides and polyols diet显示文摘In the present study we report on changes in irritable bowel syndrome-severity scoring system(IBS-SSS)and irritable bowel syndrome-quality of life(IBS-QoL)in 19 IBS patients,aged 18 to 74 years(F/M:14/5),during 12 wk registering their symptoms on the webapplication(www.ibs.constant-care.dk).During a control period of the first 6-wk patients were asked to register their IBS-SSS and IBS-QoL on the web-application weekly without receiving any intervention.Thereafter,low fermentable oligo-,di-,mono-saccharides and polyols(FODMAP)diet(LFD)was introduced for the next6 wk while continuing the registration.Though a small sample size a significant improvement in disease activity(IBS-SSS)was observed during both the control period,median:278(range:122-377),P=0.02,and subsequently during the LFD period,median:151(range:29-334),P<0.01.The IBS-QoL solely changed significantly during the LFD period,median:67(37-120),P<0.01.The significant reduction in disease activity during the control period shows a positive effect of the web-application on IBS symptoms when presented as a'traffic light'.However adding the diet reduced IBSSSS to<150,inactive to mild symptoms.In the future results from larger scale trials are awaited. | Natalia Pedersen Zsuzsanna Vegh Johan Burisch Lisbeth Jensen Dorit Vedel Ankersen Maria Felding Nynne Nyboe Andersen Pia Munkholm | 2014 | World Journal of Gastroenterology2014，20，21： | 7 |
| 5 | Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up显示文摘 | Shira Zelber-Sagi Roni Lotan Amir Shlomai Muriel Webb Gil Harrari Assaf Buch Dorit Nitzan Kaluski Zamir Halpern Ran Oren | 2012 | Journal of Hepatology2012，，5： | 4 |
| 6 | Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): A population based study显示文摘 | Shira Zelber-Sagi Dorit Nitzan-Kaluski Rebecca Goldsmith Muriel Webb Laurie Blendis Zamir Halpern Ran Oren | 2007 | Journal of Hepatology2007，，5： | 3 |
| 7 | Platelets:A possible glance into brain biological processes in schizophrenia显示文摘Schizophrenia is a severe mental disorder, characterized by behavioral, emotional and cognitive disturbances,which commonly follows a chronic course. Diagnostic accuracy, management plans, treatment evaluation and prognosis are dependent on relatively subjective assessments. Despite extensive research and improvement in imaging technology, as well as modern genetic and molecular methodologies, the biological basis of this disease is still unclear. Therefore, there is a need for objective and valid biological markers. Platelets have often been used as a model in neurobiological research. The accessibility of platelets and their similarities with neurons turns them into an attractive candidate to search for biological markers for diagnosis and for unraveling pathophysiological processes relevant to the etiology of brain disorders, including schizophrenia.The present review addresses the main changes in platelet physiology observed in schizophrenia and its response to antipsychotic medication. We summarize numerous studies demonstrating impaired metabolism,uptake and receptor kinetics of schizophrenia-relevantneurotransmitters, abnormalities in membrane derived phospholipids and polyunsaturated fatty acids, as well as dysfunctions in the mitochondria. These changes fit with the various hypotheses raised for the etiology of schizophrenia, including the dopamine-glutamate hypothesis, the autoimmune hypothesis, the polyunsaturated fatty acid hypothesis and the impaired energy metabolism hypothesis. Despite extensive research in platelets, no conclusive reliable biomarker has been identified yet. This review suggests that the clinical heterogeneity and the biological complexity of schizophrenia lead to the inevitable conclusion that biomarkers will be identified only for subgroups characterized according to the different diagnostic criteria. Moreover, any biomarker would have to be an array of interrelated factors or even a set of several such arrays. | Eyal Asor Dorit Ben-Shachar | 2012 | World Journal of Psychiatry2012，2，6： | 3 |
| 8 | Non‐alcoholic fatty liver disease independently predicts prediabetes during a 7‐year prospective follow‐up显示文摘 | Shira Zelber‐Sagi Roni Lotan Oren Shibolet Muriel Webb Assaf Buch Dorit Nitzan‐Kaluski Zamir Halpern Erwin Santo Ran Oren | 2013 | Liver Int2013，，9： | 3 |
| 9 | Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer显示文摘 | Jie Liang Masayuki Nagahashi Eugene Y. Kim Kuzhuvelil B. Harikumar Akimitsu Yamada Wei-Ching Huang Nitai C. Hait Jeremy C. Allegood Megan M. Price Dorit Avni Kazuaki Takabe Tomasz Kordula Sheldon Milstien Sarah Spiegel | 2013 | Cancer Cell2013，，： | 3 |
| 10 | Quest for the best endoscopic imaging modality for computer-assisted colonic polyp staging显示文摘BACKGROUND It was shown in previous studies that high definition endoscopy, high magnification endoscopy and image enhancement technologies, such as chromoendoscopy and digital chromoendoscopy [narrow-band imaging(NBI), iScan] facilitate the detection and classification of colonic polyps during endoscopic sessions. However, there are no comprehensive studies so far that analyze which endoscopic imaging modalities facilitate the automated classification of colonic polyps. In this work, we investigate the impact of endoscopic imaging modalities on the results of computer-assisted diagnosis systems for colonic polyp staging.AIM To assess which endoscopic imaging modalities are best suited for the computerassisted staging of colonic polyps.METHODS In our experiments, we apply twelve state-of-the-art feature extraction methods for the classification of colonic polyps to five endoscopic image databases of colonic lesions. For this purpose, we employ a specifically designed experimental setup to avoid biases in the outcomes caused by differing numbers of images per image database. The image databases were obtained using different imaging modalities. Two databases were obtained by high-definition endoscopy in combination with i-Scan technology(one with chromoendoscopy and one without chromoendoscopy). Three databases were obtained by highmagnification endoscopy(two databases using narrow band imaging and one using chromoendoscopy). The lesions are categorized into non-neoplastic and neoplastic according to the histological diagnosis.RESULTS Generally, it is feature-dependent which imaging modalities achieve high results and which do not. For the high-definition image databases, we achieved overall classification rates of up to 79.2% with chromoendoscopy and 88.9% without chromoendoscopy. In the case of the database obtained by high-magnification chromoendoscopy, the classification rates were up to 81.4%. For the combination of high-magnification endoscopy with NBI, results of up to 97.4% for one database and up to 84% for the other were achieved. Non-neoplastic lesions were classified more accurately in general than non-neoplastic lesions. It was shown that the image recording conditions highly affect the performance of automated diagnosis systems and partly contribute to a stronger effect on the staging results than the used imaging modality.CONCLUSION Chromoendoscopy has a negative impact on the results of the methods. NBI is better suited than chromoendoscopy. High-definition and high-magnification endoscopy are equally suited. | Georg Wimmer Michael Gadermayr Gernot Wolkersdorfer Roland Kwitt Toru Tamaki Jens Tischendorf Michael Hafner Shigeto Yoshida Shinji Tanaka Dorit Merhof Andreas Uhl | 2019 | World Journal of Gastroenterology2019，25，10： | 2 |
| 11 | A study of projections for key point based registration of panoramic terrestrial 3D laser scan显示文摘This paper surveys state-of-the-art image features and descriptors for the task of 3D scan registration based on panoramic reflectance images.As modern terrestrial laser scanners digitize their environment in a spherical way,the sphere has to be projected to a two-dimensional image.To this end,we evaluate the equirectangular,the cylindrical,the Mercator,the rectilinear,the Pannini,the stereographic,and the z-axis projection.We show that the Mercator and the Pannini projection outperform the other projection methods. | Hamidreza HOUSHIAR Jan ELSEBERG Dorit BORRMANN Andreas NÜCHTER | 2015 | Geo-Spatial Information Science2015，18，1： | 2 |
| 12 | Individualized home-monitoring of disease activity in adult patients with inflammatory bowel disease can be recommended in clinical practice: A randomized-clinical trial显示文摘BACKGROUND The optimal way to home-monitor patients with inflammatory bowel disease(IBD)for disease progression or relapse remains to be found.AIM To determine whether an electronic health(eHealth)screening procedure for disease activity in IBD should be implemented in clinical practice,scheduled every third month(3M)or according to patient own decision,on demand(OD).METHODS Adult IBD patients were consecutively randomized to 1-year open-label eHealth interventions(3M vs OD).Both intervention arms were screening for disease activity,quality of life and fatigue and were measuring medical compliance with the constant care web-application according to the screening interventions OD or 3M.Disease activity was assessed using home measured fecal calprotectin(FC)and a disease activity score.RESULTS In total,102 patients were randomized(n=52/503M/OD)at baseline,and 88 patients completed the 1-year study(n=433M;n=45 OD).No difference in the two screening procedures could be found regarding medical compliance(P=0.58),fatigue(P=0.86),quality of life(P=0.17),mean time spent in remission(P>0.32),overall FC relapse rates(P=0.49),FC disease courses(P=0.61),FC time to a severe relapse(P=0.69)and remission(P=0.88)during 1 year.Median(interquartile range)numbers of FC home-monitoring test-kits used per patient were significantly different,3M:6.0(5.0-8.0)and OD:4.0(2.0-9.0),P=0.04.CONCLUSION The two eHealth screening procedures are equally good in capturing a relapse and bringing about remission.However,the OD group used fewer FC home testkits per patient.Individualized screening procedures can be recommended for adult IBD patients in clinical web-practice. | Dorit Vedel Ankersen Petra Weimers Dorte Marker Mette Bennedsen Sanaz Saboori Kristine Paridaens Johan Burisch Pia Munkholm | 2019 | World Journal of Gastroenterology2019，25，40： | 2 |
| 13 | An computational study of the pseudoflow and push-relabel algorithms for the maximum flow problem显示文摘 | BALA G C DORIT S H | 2009 | Operations Research2009，57，2： | 1 |
| 14 | Molecular evolution of genes controlling petal and stamen Development: duplication and divergence within the APETALA3 and PISTILLA TA MADS-box gene lineage 显示文摘 | KRAMER E M DORIT R L IRISH V F | 1998 | Genetics1998，149，： | 1 |
| 15 | The Development of Green Care in Western European Countries显示文摘 | Dorit Karla Haubenhofer Marjolein Elings Jan Hassink Rachel Elizabeth Hine | 2010 | Explore: The Journal of Science and Healing2010，，2： | 1 |
| 16 | Genetic characterization of commercial Saccharomyces cerevisiae isolates recovered from vineyard environment显示文摘 | DORIT S LEONOR P HUGO A | 2007 | Yeast2007，24，8： | 1 |
| 17 | A unified approach to approximation algorithms for bottleneck problems显示文摘 | Dorit S Hochbaum David B Shmoys | 1986 | Journal of ACM1986，33，3： | 1 |
| 18 | The genetic structure of fermentative vineyard associated Saccharomyces cerevisiae populations revealed by microsatellite analysis显示文摘 | DORIT S MARGARIDA C | 2007 | Aaron Leenw Int J G2007，91，2： | 1 |
| 19 | Rheological properties and stability of NMP based cathode slurries for lithium ion batteries显示文摘 | Wemer B Dorit N | 2014 | Ceramics Inter- national2014，40，3： | 1 |
| 20 | Molecular evolution of genes controlling petal and stamen development: duplieatian and di- vergence within the APETALA3 and PISTIL1ATA MADS-box gene lineages 显示文摘 | Kramer EM Dorit RL Irish VF | 1998 | Genet/cs1998，149，： | 1 |
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