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| 1 | Interferon therapy in hepatitis Cleading to chronic type 1 diabetes显示文摘AIM: To review the prevalence,clinical data and course of interferon-associated type 1 diabetes in chronic hepatitis C virus(HCV) infection.METHODS: Search of all interferon(INF)-related type 1diabetes mellitus(T1DM) cases published in the English literature from 1992 to December 2013 according to the key words: chronic hepatitis C infection,diabetes mellitus type 1,insulin dependent diabetes mellitus,and interferon treatment.We found 107 cases and analyzed their clinical and laboratory data and long-term followup.Due to the predominance of cases described in Japanese literature,we analyzed separately cases of Caucasian and Japanese origin.In addition we describe a representative case with HCV who developed INFrelated T1 DM.RESULTS: Our data show that INF treatment increases the risk of developing T1 DM by 10-18 fold compared with the corresponding general population and the median age of onset was 43 years(range: 24-66 years) in Caucasians and 52 years(range: 45-63 years) in Japanese.Most patients developed T1 DM during INF treatment,after a median time-period of 4.2 and 5.7 mo in Caucasian and Japanese groups,respectively.The clinical course was characterized by a fulminant course with abrupt severe hyperglycemia or ketoacidosis,a high titer of anti-islet autoantibodies and almost all patients(105/107) permanently required insulin therapy with a follow-up of up to 4 years.A substantial number of patients had evidence for other autoimmune disorders mainly thyroid diseases(25% and 31% in Caucasian and Japanese groups,respectively).CONCLUSION: INF-associated T1 DM in HCV has a fulminant course,often associated with other autoimmune diseases,and results almost inevitably in permanent insulin therapy requirement. | Taiba Zornitzki Stephen Malnick Lyudmila Lysyy Hilla Knobler | 2015 | World Journal of Gastroenterology2015，21，1： | 17 |
| 2 | Metabolic regulation by protein tyrosine phosphatases显示文摘肥胖和新陈代谢的症候群和他们的联系病态是主要公共健康问题,谁的流行将继续在可预见的未来增加。为 leptin 和胰岛素的由受体的异常发信号在新陈代谢的症候群的开发起一个枢轴的作用。这两条关键发信号小径怎么被调整的更完全的分子水平的理解为肥胖,新陈代谢的症候群,和类型 II 的完整的描述是必要的糖尿病,并且为为这些疾病开发新奇处理。酷氨酸残余上的蛋白质的 Phosphorylation 在调停起一个关键作用他们的目标房间上的 leptin 和胰岛素的效果。这里,我们讨论蛋白质酷氨酸磷酸酶,是在 vivo 的蛋白质 phosphorylation 的关键生理的管理者,由假装在他们的主要目标纸巾由 leptin 和胰岛素受体发信号的分子的方法。 | Hilla Knobler Ari Elson | 2014 | The Journal of Biomedical Research2014，28，3： | 2 |
| 3 | Congenital toxoplasmosis—prenatal aspects of Toxoplasma gondii infection显示文摘 | Efrat Rorman Chen Stein Zamir Irena Rilkis Hilla Ben-David | 2005 | Reproductive Toxicology2005，，4： | 2 |
| 4 | VEGF and IL-18 in induced sputum of lung cancer patients 显示文摘 | Nikoletta Rovina Georgios Hillas Efressini Dima ct al | 2011 | Cyto- kine2011，54，： | 1 |
| 5 | Evaluating pseudorange multipath effects at stations in the national CORS networks 显示文摘 | Stephen Hilla and Michael Cline | 1999 | GPS Solutions1999，7，4： | 1 |
| 6 | Microwave-assisted extraction of bioactive saponins from chickpea(Cicer arietinum L)显示文摘 | Zohar K Hilla G S Oded Y | 2005 | Journal of the Science of Food and Agriculture2005，85，： | 1 |
| 7 | C-reactive protein and procalcitonin as predictors of survival and septic shock in ventilator-associated pneumonia 显示文摘 | HILLAS G VASSILAKOPOULOS T PLANTZA P | 2010 | Eur Respir J2010，35，4： | 1 |
| 8 | Exhaled nitric oxide and exhaledbreath condensate pH in severe refractory asthma显示文摘 | Tseliou E’Bessa V Hillas G | 2010 | Chest2010，，： | 1 |
| 9 | Feedback between node and network dynamics can produce real-world network properties显示文摘 | Brot Hilla Muchnik Lev Goldenberg Jacob | 2012 | Physica A2012，391，24： | 1 |
| 10 | A rigorous formation damage skin factor and reservoir inflow model for a horizontal well显示文摘 | Furui K Zhu D HillA D | 2003 | SPE Production&Facilities2003，18，3： | 1 |
| 11 | Resistance to the Soybean Aphid in Soybean Germplasm显示文摘 | Curtis B Hilla Yah Lia | 2004 | Crop Science2004，44，： | 1 |
| 12 | On the definition of the strategic stability of equilibria显示文摘 | Hillas J | 1990 | Econometrica1990，58，： | 1 |
| 13 | C-reactive protein and procalcitonin aspredietors of survival and septic shock in ventilator-associated pneumonia显示文摘 | HILLAS G VASSILAKOPOULOS T PLANTZA P | 2010 | Eur Respir J2010，35，4： | 1 |
| 14 | On the relation among some definitions of strategic stability显示文摘 | HILLAS J JANSEN M POTTERS J | 2002 | Mathematics of Operations Research2002，26，： | 1 |
| 15 | C-reactive protein and procalcitonin aspredictors of survival and septic shock ineventilator-assocciated pneumonia 显示文摘 | Hillas G Vassilakopoulos T Plantza P | 2010 | Eur Respir ]2010，35，4： | 1 |
| 16 | C-reactive protein and procalcitonin as predictors of survival and septic shock in ventilator-associated pneumonia显示文摘 | Hillas G Vassilakopoulos T Plantza P | 2010 | Eur Respir J2010，35，4： | 1 |
| 17 | Degradation of the pharmaceutical Metronidazole via UV, Fenton and photo-Fenton processes显示文摘 | HILLA S YASEMIN K K KARL G L | 2006 | Chemosphere2006，63，2： | 1 |
| 18 | Downregulation of Microglial Activation by Achillolide A显示文摘 | Anat Elmann Alona Telerman Sharon Mordechay Hilla Erlank Miriam Rindner Yoel Kashman Rivka Ofir | 2015 | Planta Med2015，，： | 1 |
| 19 | Exhaled nitric oxide and exhaled breath condensate PH in severe refractoy asthma显示文摘 | Tseliou E Bessa V Hillas G | 2010 | Chest2010，138，1： | 1 |
| 20 | Bacteriophage T4 development depends on the physiology of its host Escherichia coli 显示文摘 | Hilla H | 1997 | Microbiology1997，143，： | 1 |
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