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| 1 | Long-term effect of stent placement in 115 patients with Budd-Chiari syndrome显示文摘AIM: To report the long-term effect of stent placement in 115 patients with Budd-Chiari syndrome (BCS).METHODS: One hundred and fifteen patients with BCS were treated by percutaneous stent placement. One hundred and two patients had IVC stent placement, 30 patients had HV stent placement, 17 of them underwent both IVC stent and HV stent. All the procedures were performed with guidance of ultrasound.RESULTS: The successful rates in placing IVC stent and HV stent were 94 % (96/102) and 87 % (26/30), respectively.Ninety-seven patients with 112 stents (90 IVC stents, 22 HV stents) were followed up. 96.7 %(87/90) IVC stents and 90.9 %(20/22) HV stents remained patent during follow up periods (mean 49 months, 45 months, respectively). Five of 112 stents in the 97 patients developed occlusion. Absence of anticoagulants after the procedure and types of obstruction (segmental and occlusive) before the procedure were related to a higher incidence of stent occlusion.CONCLUSION: Patients with BCS caused by short length obstruction can be treated by IVC stent placement, HV stent placement or both IVC and HV stent placement depending on the sites of obstruction. The long-term effect is satisfactory.Anticoagulants are strongly recommended after the procedure especially for BCS patients caused by segmental occlusion. | Chun-QingZhang Li-NaFu LinXu Guo-QuanZhang TaoJia Ji-YongLiu Cheng-YongQin Ju-RenZhu | 2003 | World Journal of Gastroenterology2003，9，11： | 37 |
| 2 | Generation of cytotoxic T cell against HBcAg using retrovirally transduced dendritic cells显示文摘AIM: Cytotoxic T lymphocytes (CTLs) play an important role in resolving HBV infection. In the present study, we attempted to evaluate the efficiency of bone marrow-derived dendritic cells (DCs) transduced with recombinant retroviral vector bearing hepatitis B virus (HBV) core gene and the capability of generating CTLs against HBcAg by genetically modified DCs in vivo.METHODS: A retroviral vector containing HBV core gene was constructed. Replicating DC progenitor of C57BL/6 mice was transduced by retroviral vector and continually cultured in the presence of recombinant mouse granulocytemacrophage colony-stimulating factor (rmGM-CSF) and interleukin-4(IL-4) for 6 days. LPS was added and cultured for additional two days. The efficiency of gene transfer was determined by PCR, Western blot and FACS. Transduced DCs immunized C57BL/6 mice subcutaneously 2 times at an oneweek interval. Intracellular IFN-γ and IL-4 of immunized mice lymphocytes were analyzed. Generation of CTLs in lymphooytes stimulated with mitomycin C-treated EL4-C cell which stably expresses HBcAg was determined by LDH release assays.RESULTS: Recombinant retroviral expression vector (pLCSN) was positively detected by PCR as well as enzyme digestion with EcoRI and BamH I. Retroviruses were generated by pLCSN transfection packing cell and the virus titer was 3x10s CFU/ml. Indirect immunofluorescence and FACS showed that HBV core gene was expressed in murine fibroblasts. Transduced bone marrow cells had capability of differentiating into DCsc in vitro in the presence of rmGMCSF and rmIL-4. The result of PCR showed that HBV core gene was integrated into the genome of transduced DCs.Western blot analysis showed that HBV core gene was expressed in DCs. The transduction rate was 28 % determined by FACS. Retroviral transduction had no influence on DCs expressions of CD80 and MHC class Ⅱ. HBcAg specific CTLs and Th1 type immune responses could be generated in the mice by using transduced DCs as antigen presenting cells (APCs).CONCLUSION: Retroviral transduction of myeloid DCs progenitors expresses efficiently HBcAg, and genetically modified DCs evoke a higher CTLs response than HBcAg in vivo. | Chuan-LinDing KunYao Tian-TaiZhang FengZhou LinXu Jiang-YingXu | 2003 | World Journal of Gastroenterology2003，9，7： | 18 |
| 3 | Deformation characteristics and genesis of the Waziyu metamorphic core complex in western Liaoning of China显示文摘The Waziyu metamorphic core complex is situated at the eastern end of the Yanshan tectonic belt.The NNE-striking detachment ductile shear zone in the core complex lies between the Archean metamorphic basement and Fuxin-Yixian rift basin,dips NW gently,and shows corrugation folds.Exposure structures,microstructures,and quartz C-axis fabrics all indicate top-to-the WNW sense of shear,i.e.,ca.285°,for the shear zone.Estimates of the deformation temperatures(ca.550-250°C) demonstrate its mid-crustal origination and progressive deformation from deep to shallow levels.The northern segment of the shear zone shows relatively weak exhumation with exposures of low-temperature mylonites whereas its middle and southern segments have more intense uplifting with exposures of high-temperature mylonites.Biotite and muscovite 40 Ar/39 Ar ages,U-Pb dating results of zircon from dikes and plutons as well as formation ages of the supra-detachment basin all suggest the formation time of 135-100 Ma for the core complex.The formation was also associated with syntectonic emplacement of the Early Cretaceous Shishan pluton.The western margin of the core complex was truncated by the Sunjiawan-Shaohuyingzi brittle normal fault when it uplifted to shallow crust levels,and finally exhumed to near-surface levels.The core complex was developed by the rolling-hinge model under WNW-ESE extension during the Early Cretaceous peak destruction of the North China Craton.Ductile flow did not appear in the lower plate,therefore not supporting the low-crust gravitational collapse. | ZHANG BiLong ZHU Guang CHEN Yin PIAO XueFeng JU LinXue WANG HaoQian | 2012 | Science China Earth Sciences2012，55，11： | 4 |
| 4 | Photosensitizer Nanoparticles Boost Photodynamic Therapy for Pancreatic Cancer Treatment显示文摘Patients with pancreatic cancer(PCa)have a poor prognosis apart from the few suitable for surgery.Photodynamic therapy(PDT)is a minimally invasive treatment modality whose efficacy and safety in treating unresectable localized PCa have been corroborated in clinic.Yet,it suffers from certain limitations during clinical exploitation,including insufficient photosensitizers(PSs)delivery,tumor-oxygenation dependency,and treatment escape of aggressive tumors.To overcome these obstacles,an increasing number of researchers are currently on a quest to develop photosensitizer nanoparticles(NPs)by the use of a variety of nanocarrier systems to improve cellular uptake and biodistribution of photosensitizers.Encapsulation of PSs with NPs endows them significantly higher accumulation within PCa tumors due to the increased solubility and stability in blood circulation.A number of approaches have been explored to produce NPs co-delivering multi-agents affording PDT-based synergistic therapies for improved response rates and durability of response after treatment.This review provides an overview of available data regarding the design,methodology,and oncological outcome of the innovative NPs-based PDT of PCa. | Huanyu Yang Renfa Liu Yunxue Xu Linxue Qian Zhifei Dai | 2021 | Nano-Micro Letters2021，13，2： | 3 |
| 5 | Identification of ten serum microRNAs from a genome‐wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis显示文摘 | XiChen ZhibinHu WenjingWang YiBa LijiaMa ChunniZhang ChengWang ZhijiRen YangZhao SijiaWu RuiZhuang YixinZhang HengHu ChazhenLiu LinXu JunWang HongbingShen JunfengZhang KeZen Chen‐YuZhang | 2012 | Int J Cancer2012，，7： | 3 |
| 6 | Correlation Between Phase Stability and Tensile Properties of the Ni-Based Superalloy MAR-M247显示文摘Phase stability and its effect on tensile properties of MAR-M247 alloy have been investigated during thermal exposure at 800–900°C for up to 10,000 h.Detailed investigations reveal that the larger secondaryγ′phase has no obvious growth,but the smaller tertiaryγ′phase obviously coarsens and the coalescence occurs during thermal exposure at 850°C and below.γ′coarsening behavior is consistent with the description of Ostwald ripening theory beforeγ′coalescence.Hf-rich blocky MC carbide shows excellent thermal stability,but Ta-rich script-type MC carbide gradually degenerates via reaction,MC+γ→M_(23)C_(6)+γ′and finally formsγ film around MC and M_(23)C_(6) carbides.With increasing thermal exposure time,the tensile strength decreases.The ductility first increases and then decreases during exposure at 800°C,but it decreases continuously at 900°C.In addition,the ductility keeps almost constant when the exposure time is longer than 5000 h. | Linxu Li Xiufang Gong Changshuai Wang Yunsheng Wu Hongyao Yu Haijun Su Lanzhang Zhou | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，6： | 2 |
| 7 | Connexin 43 Reverses Malignant Phenotypes of Glioma Stem Cells by Modulating E‐Cadherin显示文摘 | Shi‐CangYu Hua‐LiangXiao Xue‐FengJiang Qing‐LiangWang YanLi Xiao‐JunYang Yi‐FangPing Jiang JieDuan Jian‐YongJiang Xian‐ZongYe Sen‐LinXu Yang‐HongXin Xiao‐HongYao Jian‐HongChen Wei‐HuaChu WeiSun BingWang Ji MingWang XiaZhang Xiu‐WuBian | 2012 | STEM CELLS2012，，2： | 1 |
| 8 | Genome-wide association analysis reveals genetic loci and candidate genes associated with intramuscular fat in Duroc pigs显示文摘Intramuscular fat(IMF) is a major meat-quality trait in pigs. The content of IMF is directly associated with the taste and flavor of pork. As a complex trait, there could be multiple genes affecting IMF content in pork. Genomewide association study is a powerful tool to detect genomic regions associated with phenotypic variations. The objectives of the present study were to identify or refine the positions of genomic regions affecting IMF, and to characterize candidate genes and pathways that may influence this trait. Of note, we identified a significant region in longissium dorsi muscle in a Duroc pig population for IMF content with Porcine SNP60 v2 Bead Chip. This region spans 1.24 Mb on chromosome 8 and had been identified as a quantitative trait locus for IMF in Pietrain, Large White, Landrace, and Leicoma pigs. In this region, eight SNPs were significantly associated with IMF content. Three genes proximal to these significant SNPs were considered candidate genes, including ZDHHC16, LOC102162218 and PCDH7. Our results confirm several previous findings and highlight several genes that may contribute to IMF variation in Duroc pigs. | Xingwang WANG Rongrong DING Jianping QUAN Linxue YANG Ming YANG Enqin ZHENG Dewu LIU Gengyuan CAI Zhenfang WU Jie YANG | 2017 | Frontiers of Agricultural Science and Engineering2017，4，3： | 1 |
| 9 | A molecular epidemiological study targeting the glycoprotein gene ofrabiesvirus isolates from China显示文摘 | Sheng-LiMeng Jia-XinYan Ge -LinXu | 2007 | Virus Research2007，124，： | 1 |
| 10 | A study on new polymerization technology of styrene 显示文摘 | Si Linxu Zheng Anna Yang Haibo | 2002 | Journal of Applied Polymer Science2002，85，10： | 1 |
| 11 | Identification of ten serum microRNAs from a genome‐wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis显示文摘 | XiChen ZhibinHu WenjingWang YiBa LijiaMa ChunniZhang ChengWang ZhijiRen YangZhao SijiaWu RuiZhuang YixinZhang HengHu ChazhenLiu LinXu JunWang HongbingShen JunfengZhang KeZen Chen‐YuZhang | 2012 | Int J Cancer2012，，7： | 1 |
| 12 | Effect of long-term exercise training on regional myocardial perfusion changes in patients with coronary artery disease显示文摘 | Linxue L Nohara R Makita S | 1999 | Japanese Circulation Journal1999，63，2： | 1 |
| 13 | Interlocked and Interdigitated Architectures from Self‐Assembly of Long Flexible Ligands and Cadmium Salts显示文摘 | Xin‐LongWang ChaoQin En‐BoWang LinXu Zhong‐MinSu Chang‐WenHu | 2004 | Angewandte Chemie International Edition2004，，38： | 1 |
| 14 | 显示文摘 | LINXue(林雪) GUANQing-Feng(关庆丰) ZHOUChun-Jie(邹春杰) etal | 2013 | 无机化学学报2013，29，： | 1 |
| 15 | Efficientsimilarityjoinsfornearduplicatedetection显示文摘 | XIAOChuan WANGWei LINXuemin etal | 2011 | ACM TransonDatabaseSystems2011，36，3： | 1 |
| 16 | Optimistic value model of uncertain optimal control显示文摘 | SHENG Linxue ZHU YYuanguo | 2013 | International Journal of Uncertainty Fuzziness andKnowledge-Based Systems2013，21，1： | 1 |
| 17 | Edjoin:anefficientalgorithmforsimilarityjoinswitheditdistanceconstraints显示文摘 | XIAOChuan WANGWei LINXuemin | 2008 | ProceedingsoftheVLDBEndowment2008，1，1： | 1 |
| 18 | SINS Stationary Initial Alignment Based on Simplified Autocovariance Least-Squares Method 显示文摘 | LINXu Luo Z Zhou B | 2014 | Wuhan Daxue Xuebao2014，39，5： | 1 |
| 19 | A Study on the Recovery and Classification of Meteorites from the Mt. Grove Region of Antarctica显示文摘The Antarctic Continent has become the largest natural preservatory of meteorites in the world because of its unique geographical position and climatic conditions. Mt. Grove is located in the inland area of the Antarctic Continent where the conditions are favorable for the preservation of meteorites. During China's 15th, 16th and 19th Antarctic Scientific Explorations a large number of meteorites were recovered in the Mt. Grove region. Especially during the 19th Exploration in 2002/03 a total of 4448 meteorites were recovered, which at one stroke put China among countries that have recovered most numbers of meteorites. Here, we report mainly the results of microscope and electron microprobe studies of 28 meteorites recovered during the 16th Exploration. The meteorites are chemically classified based on their mean Fa contents of olivine, mean Fs contents of low-Ca pyroxene and abundances of Fe-Ni metal. We also give a brief account of the meteorite recovery during the three Explorations and of some preliminary classification results of the Antarctic meteorites. | Jian-ZhongLiu Yong-LiaoZou Chun-LaiLi LinXu Zi-YuanOuyang | 2004 | Chinese Journal of Astronomy and Astrophysics2004，4，2： | 0 |
| 20 | Observation on Flower Bud Differentiation of Crape Myrtle in Red Soil Environment显示文摘Flower bud differentiation is a key component of plant blooming biology and understanding how it works is vital for flowering regulation and plant genetic breeding,increasing the number and quality of flowering.Red soil is the most widely covered soil type in the world,and it is also the most suitable soil type for crape myrtle planting.The flower buds of crape myrtle(Lagerstroemia indica)planted in red soil were employed as experimental materials in this study,and the distinct periods of differentiation were identified using stereomicroscopy and paraffin sectioning.We optimized the steps of dehydration,transparency,embedding,sectioning and staining when employing paraffin sections.When seen under a microscope,this optimization can make the cell structure of paraffin sections obvious,the tissue structure complete,and the staining clear and natural.The flower bud differentiation process is divided into 7 periods based on anatomical observations of the external morphology and internal structure during flower bud differentiation:undifferentiated period,start of differentiation period,inflorescence differentiation period,calyx differentiation period,petal differentiation period,stamen differentiation period,and pistil differentiation period.The differentiation time is concentrated from the end of May to mid-June.Crape myrtle flower bud differentiation is a complicated process,and the specific regulatory mechanism and affecting elements need to be investigated further. | Linxue Shang Dandan Ma Sidan Hong Yu Zhao Guozhe Zhang Qingqing Ma Qun Wang Cuihua Gu | 2022 | Phyton-International Journal of Experimental Botany2022，91，12： | 0 |
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