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| 1 | Graphene-Coated Optical Fiber SPR Biosensor for BRCA1 and BRCA2 Breast Cancer Biomarker Detection:a Numerical Design-Based Analysis显示文摘This paper provides a simple hybrid design and numerical analysis of the graphene-coated fiber-optic surface plasmon resonance(SPR)biosensor for breast cancer gene-1 early onset(BRCA1)and breast cancer gene-2 early onset(BRCA2)genetic breast cancer detection.Two specific mutations named 916delTT and 6174delT in the BRCA1 and BRCA2 are selected for numerical detection of breast cancer.This sensor is based on the technique of the attenuated total reflection(ATR)method to detect deoxyribonucleic acid(DNA)hybridization along with individual point mutations in BRCA1 and BRCA2 genes.We have numerically shown that momentous changes present in the SPR angle(minimum:135%more)and surface resonance frequency(SRF)(minimum:136%more)for probe DNA with various concentrations of target DNA corresponding to a mutation of the BRCA1 and BRCA2 genes.The variation of the SPR angle and SRF for mismatched DNA strands is quite negligible,whereas that for complementary DNA strands is considerable,which is essential for proper detection of genetic biomarkers(916delTT and 6174delT)for early breast cancer.At last,the effect of electric field distribution in inserting graphene layer is analyzed incorporating the finite difference time domain(FDTD)technique by using Lumerical FDTD solution commercial software.To the best of our knowledge,this is the first demonstration of such a highly efficient biosensor for detecting BRCA1 and BRCA2 breast cancer.Therefore,the proposed biosensor opens a new window toward the detection of breast cancers. | Md.Biplob HOSSAIN Md.Muztahidul ISLAM Lway Faisal ABDULRAZAK Md.Masud RANA Tarik Bin Abdul AKIB Mehedi HASSAN | 2020 | Photonic Sensors2020，10，1： | 4 |
| 2 | Design and Simulation of a Highly Sensitive SPR Optical Fiber Sensor显示文摘An idea of the surface plasmon resonance(SPR)has been utilized for the design of highly sensitive sensors based on the wagon-wheel fiber technology.Such sensors are sensitive to changes in the refractive index of sample analyte.In this study,a three-strut wagon-wheel structure,coated with the gold layer of nano-sized thickness,has been proposed as the SPR sensor.Finite element method is employed to simulate and tune the proposed SPR's design,which leads to a highly sensitive and multichannel plasmonic sensor with the ability for a dual reading on a single analyte or simultaneous identification of two analytes.In this design,suitable thickness values for the gold layer and core struts are determined.Sensitivities of the detector due to the first resonance peak, second resonance peak,and the difference in resonance peaks are calculated to be 1120nm/RIU, 1540nm/RIU,and 420nm/RIU,respectively,when analytes are placed in all three channels of the fiber.Sensitivity of the detector with respect to the second resonant peak for analyte in Channels 2 and 3 is also found to be 1252nm/RIU when Channel 1 is filled with the reference.The sensitivity and resolution of the sensor increase as the refractive index of the analyte increases by almost a linear proportion.If the sensor is utilized to detect the difference in two peaks,it would substantially reduce the noise,and the best result is expected.The thicknesses of the struts and the gold layer are proper parameters to be tuned in designing the detector. | Motahare Sadat HOSEINIAN Mohammad Agha BOLORIZADEH | 2019 | Photonic Sensors2019，9，1： | 1 |
| 3 | Recent Progress in Fiber Optofluidic Lasing and Sensing显示文摘Fiber optofluidic laser(FOFL)integrates optical fiber microcavity and microfluidic channel and provides many unique advantages for sensing applications.FOFLs not only inherit the advantages of lasers such as high sensitivity,high signal-to-noise ratio,and narrow linewidth,but also hold the unique features of optical fiber,including ease of integration,high repeatability,and low cost.With the development of new fiber structures and fabrication technologies,FOFLs become an important branch of optical fiber sensors,especially for application in biochemical detection.In this paper,the recent progress on FOFL is reviewed.We focuse mainly on the optical fiber resonators,gain medium,and the emerging sen sing applicatio ns.The prospects for FOFL are also discussed.We believe that the FOFL sensor provides a promising technology for biomedical analysis and environmental monitoring. | Xi YANG Chaoyang GONG Yiling LIU Yunjiang RAO Mateusz SMIETANA Yuan GONG | 2021 | Photonic Sensors2021，11，2： | 1 |
| 4 | Temperature characteristics of near infrared SPR sen sors with Kretschmann configuration显示文摘The temperature characteristics of near infrared surface plasmon resonance(SPR) sensors with Kretschmann configuration are studied theoretically and experimentally. The experimental results match with the numerical simulations in the temperature range from 10 °C to 40 °C. With the increase of temperature, the resonance angle for gas increases slightly, but that for aqueous solution decreases obviously. No matter the dielectric layer is gas or aqueous solution, the resonance peaks are both broadened. | 田应鸿 郜洪云 吴紫薇 黎敏 | 2015 | Optoelectronics Letters2015，11，3： | 0 |
| 5 | Polydopamine-Assisted Fabrication of Stable Silver Nanoparticles on Optical Fiber for Enhanced Plasmonic Sensing显示文摘We present a facile and effective method for fabrication of the localized surface plasmon resonance(LSPR)optical fiber sensor assisted by two polydopamine(PDA)layers with enhanced plasmonic sensing performance.The first PDA layer was self-polymerized onto the bare optical fiber to provide the catechol groups for the reduction from Ag^(+)to Ag^(o) through chelating and redox activity.As the reduction of Ag^(+)proceeds,Ag nanoparticles(NPs)were grown in-situ on the PDA layer with uniform distribution.The second PDA layer was applied to prevent Ag NPs from oxidating and achieve an improvement of LSPR signal.The PDA/Ag/PDA-based optical fiber sensor has an enhanced LSPR sensitivity of 961 nm/RIU and excellent oxidation resistance.The stable PDA/Ag/PDA-based LSPR sensor with high optical performance is very promising for future application in optical sensing field. | Yiwen TANG Hui YUAN Jiangping CHEN Qiguo XING Rongxin SU Wei QI Zhimin HE | 2020 | Photonic Sensors2020，10，2： | 0 |
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