|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | New insights of epithelial-mesenchymal transition in cancer metastasis显示文摘上皮间充质的转变(EMT ) 在胚胎的形态发生,心发展,长期的退化纤维变性,和癌症转移期间是关键步。几个不同特点被 EMT 传送了,包括房间活动性,侵略海角,到 apoptosis 的抵抗,和干细胞的一些性质。许多信号小径贡献了 EMT 的正式就职,例如转变生长 factor-β , Wnt,刺猬,槽口,和原子 factor-κB。在最后几年,增加证据证明了 EMT 在肿瘤前进和转移起一个必要作用。理解 EMT 的分子的机制让一个伟人在解开完成变形串联并且可以为变形疾病导致新奇干预。 | Yadi Wu Binhua P. Zhou | 2008 | Acta Biochimica et Biophysica Sinica2008，40，7： | 57 |
| 2 | 炎症--加速癌症转移的驱动力显示文摘肿瘤微环境在癌变中发挥重要作用,这一点已经得到越来越多的共识。炎症组分存在并有助于肿瘤增殖、血管生成、转移以及对激素和化疗的抵抗。本文聚焦炎症在肿瘤转移中的作用。我们关注促炎因子特别是细胞因子在肿瘤转移中的作用。了解炎症促进肿瘤转移的机制将为癌症治疗带来创新性的突破。 | Yadi WU Binhua P.ZHOU 丁燕(翻译) 南娟(翻译) 刘谦(校对) | 2009 | 中国肺癌杂志2009，12，11： | 26 |
| 3 | The chromosome-level reference genome assembly for Panax notoginseng and insights into ginsenoside biosynthesis显示文摘Panax notoginseng,a perennial herb of the genus Panax in the family Araliaceae,has played an important role in clinical treatment in China for thousands of years because of its extensive pharmacological effects.Here,we report a high-quality reference genome of P.notoginseng,with a genome size up to 2.66 Gb and a contig N50 of 1.12 Mb,produced with third-generation PacBio sequencing technology.This is the first chromosome-level genome assembly for the genus Panax.Through genome evolution analysis,we explored phylogenetic and whole-genome duplication events and examined their impact on saponin biosynthesis.We performed a detailed transcriptional analysis of P.notoginseng and explored genelevel mechanisms that regulate the formation of characteristic tubercles.Next,we studied the biosynthesis and regulation of saponins at temporal and spatial levels.We combined multi-omics data to identify genes that encode key enzymes in the P.notoginseng terpenoid biosynthetic pathway.Finally,we identified five glycosyltransferase genes whose products catalyzed the formation of different ginsenosides in P.notoginseng.The genetic information obtained in this study provides a resource for further exploration of the growth characteristics,cultivation,breeding,and saponin biosynthesis of P.notoginseng. | Zhouqian Jiang Lichan Tu Weifei Yang Yifeng Zhang Tianyuan Hu Baowei Ma Yun Lu Xiuming Cui Jie Gao Xiaoyi Wu Yuru Tong Jiawei Zhou Yadi Song Yuan Liu Nan Liu Luqi Huang Wei Gao | 2021 | Plant Communications2021，2，1： | 11 |
| 4 | Sex disparity of lung cancer risk in non-smokers:a multicenter population-based prospective study based on China National Lung Cancer Screening Program显示文摘Background: Non-smokers account for a large proportion of lung cancer patients, especially in Asia, but the attention paid to them is limited compared with smokers. In non-smokers, males display a risk for lung cancer incidence distinct from the females-even after excluding the influence of smoking;but the knowledge regarding the factors causing the difference is sparse. Based on a large multicenter prospective cancer screening cohort in China, we aimed to elucidate the interpretable sex differences caused by known factors and provide clues for primary and secondary prevention.Methods: Risk factors including demographic characteristics, lifestyle factors, family history of cancer, and baseline comorbidity were obtained from 796,283 Chinese non-smoking participants by the baseline risk assessment completed in 2013 to 2018. Cox regression analysis was performed to assess the sex difference in the risk of lung cancer, and the hazard ratios (HRs) that were adjusted for different known factors were calculated and compared to determine the proportion of excess risk and to explain the existing risk factors.Results: With a median follow-up of 4.80 years, 3351 subjects who were diagnosed with lung cancer were selected in the analysis. The lung cancer risk of males was significantly higher than that of females;the HRs in all male non-smokers were 1.29 (95% confidence interval [CI]: 1.20-1.38) after adjusting for the age and 1.38 (95% CI: 1.28-1.50) after adjusting for all factors, which suggested that known factors could not explain the sex difference in the risk of lung cancer in non-smokers. Known factors were 7% (|1.29-1.38|/1.29) more harmful in women than in men. For adenocarcinoma, women showed excess risk higher than men, contrary to squamous cell carcinoma;after adjusting for all factors, 47% ([1.30-1.16]/[1.30-1]) and 4% ([7.02-6.75]/[7.02-1])) of the excess risk was explainable in adenocarcinoma and squamous cell carcinoma. The main causes of gender differences in lung cancer risk were lifestyle factors, baseline comorbidity, and family history.Conclusions: Significant gender differences in the risk of lung cancer were discovered in China non-smokers. Existing risk factors did not explain the excess lung cancer risk of all non-smoking men, and the internal causes for the excess risk still need to be explored;most known risk factors were more harmful to non-smoking women;further exploring the causes of the sex difference would help to improve the prevention and screening programs and protect the non-smoking males from lung cancers. | Zheng Wu Fengwei Tan Zhuoyu Yang Fei Wang Wei Cao Chao Qin Xuesi Dong Yadi Zheng Zilin Luo Liang Zhao Yiwen Yu Yongjie Xu Jiansong Ren Jufang Shi Hongda Chen Jiang Li Wei Tang Sipeng Shen Ning Wu Wanqing Chen Ni Li Jie He | 2022 | Chinese Medical Journal2022，，11： | 3 |
| 5 | Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates显示文摘Emerging SARS-CoV-2 variants and the gradually decreasing neutralizing antibodies over time post vaccination have led to an increase in incidents of breakthrough infection across the world.To investigate the potential protective effect of the recombinant protein subunit COVID-19 vaccine targeting receptor-binding domain(RBD)(PS-RBD)and whole inactivated virus particle vaccine(IV)against the variant strains,in this study,rhesus macaques were immunized with PS-RBD or IV vaccine,followed by a Beta variant(B.1.351)challenge.Although neutralizing activity against the Beta variant was reduced compared with that against the prototype,the decreased viral load in both upper and lower respiratory tracts,milder pathological changes,and downregulated inflammatory cytokine levels in lung tissues after challenge demonstrated that PS-RBD and IV still provided effective protection against the Beta variant in the macaque model.Furthermore,PS-RBD-induced macaque sera possessed general binding and neutralizing activity to Alpha,Beta,Delta,and Omicron variants in our study,though the neutralizing antibody(NAb)titers declined by varying degrees,demonstrating potential protection of PS-RBD against current circulating variants of concern(VOCs).Interestingly,although the IV vaccine-induced extremely low neutralizing antibody titers against the Beta variant,it still showed reduction for viral load and significantly alleviated pathological change.Other correlates of vaccine-induced protection(CoP)like antibody-dependent cellular cytotoxicity(ADCC)and immune memory were both confirmed to be existing in IV vaccinated group and possibly be involved in the protective mechanism. | Qian He Qunying Mao Xiaozhong Peng Zhanlong He Shuaiyao Lu Jialu Zhang Fan Gao Lianlian Bian Chaoqiang An Wenhai Yu Fengmei Yang Yanan Zhou Yun Yang Yanyan Li Yadi Yuan Xujia Yan Jinghuan Yang Xing Wu Weijin Huang Changgui Li Junzhi Wang Zhenglun Liang Miao Xu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 6 | N^(6)-methyladenosine Steers RNA Metabolism and Regulation in Cancer显示文摘As one of the most studied ribonucleic acid(RNA)modifications in eukaryotes,N^(6)-methyladenosine(m^(6)A)has been shown to play a predominant role in controlling gene expression and influence physiological and pathological processes such as oncogenesis and tumor progression.Writer and eraser proteins,acting opposite to deposit and remove m^(6)A epigenetic marks,respectively,shape the cellular m^(6)A landscape,while reader proteins preferentially recognize m^(6)A modifications and mediate fate decision of the methylated RNAs,including RNA synthesis,splicing,exportation,translation,and stability.Therefore,RNA metabolism in cells is greatly influenced by these three classes of m^(6)A regulators.Aberrant expression of m^(6)A regulators has been widely reported in various types of cancer,leading to cancer initiation,progression,and drug resistance.The close links between m^(6)A and cancer shed light on the potential use of m^(6)A methylation and its regulators as prognostic biomarkers and drug targets for cancer therapy.Given the notable effects of m^(6)A in reversing chemoresistance and enhancing immune therapy,it is a promising target for combined therapy.Herein,we summarize the recent discoveries on m^(6)A and its regulators,emphasizing their influences on RNA metabolism,their dysregulation and impacts in diverse malignancies,and discuss the clinical implications of m^(6)A modification in cancer. | Shenghua Dong Yutong Wu Yadi Liu Hengyou Weng Huilin Huang | 2021 | Cancer Communications2021，41，7： | 2 |
| 7 | Stablization of snail by NF- κB is required for inflammation - induced cell migra- tion and invasion显示文摘 | Yadi Wu Jiong Deng Piotr G | 2009 | Cancer cell2009，5，15： | 1 |
| 8 | COa interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer 显示文摘 | Chenfang Dong Yadi Wu Jun Yao | 2012 | The Joumal of Clinical Investigation2012，122，4： | 1 |
| 9 | Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion显示文摘 | Yadi Wu Jiong Deng Piotr G. Rychahou Suimin Qiu B. Mark Evers Binhua P. Zhou | 2009 | Cancer Cell2009，，5： | 1 |
| 10 | Snail:more than EMT显示文摘 | Yadi Wu Binhua P.Zhou | | 0，，02： | 1 |
| 11 | CD151 represses mammary gland development by maintaining the niches of progenitor cells显示文摘 | Yuanqin Yin Xinyu Deng Zeyi Liu Lauren A Baldwin Jason Lefringhouse Jiayang Zhang John T Hoff Sonia F Erfani Edmund B Rucker Kathleen O’Connor Chunming Liu Yadi Wu Binhua P Zhou Xiuwei H Yang | 2014 | Cell Cycle2014，，17： | 1 |
| 12 | Kinases meet at TSC显示文摘有块茎的硬化建筑群(TSC ) 是多重 hamartomas 的存在描绘在的正染色体的主导的 neurocutaneous 混乱几乎每个机关,尤其是在皮肤的大多数,大脑,心,肾,肝,和肺。TSC 的经典症候群是发作,智力迟钝,和皮肤的 angiofibromas。二个肿瘤压制或基因, Tsc1 和 Tsc2,为 TSC 的致病被识别了。Tscl 位于染色体 9q34 并且为蛋白质编码哈燕子(130 kDa ) 。Tsc2 位于染色体 16pl3.3 并且为蛋白质 tuber 编码为(180 kDa ) 。 | Yadi Wu Binhua P Zhou | 2007 | Cell Research2007，17，12： | 0 |
| 13 | A natural communication system on genome evolution显示文摘The central dogma of molecular biology describes the flow of genetic information from DNA via RNA to protein and duplication from ancestral to descendent DNA(Crick,1958).However,the genetic information could not be quantified and mathematically modeled.So it differs from the'information'formulated by Shannon and used in information and coding theories(Shannon,1949).Although physicists have suggested that life absorbs negative entropy(or information)from the environment(Schrodinger et al.,1944),no | Qi Wu Yadi Wang Yun Ding Shuai Ma Zongmin Wu Fuwen Wei | 2017 | Science China(Life Sciences)2017，60，4： | 0 |
| 14 | Disparities in the global burden of tracheal,bronchus,and lung cancer from 1990 to 2019显示文摘Background:Tracheal,bronchus,and lung(TBL)cancer imposes a high disease burden globally,and its pattern varies greatly across regions and countries.This study aimed to explore the global burden and temporal trends of TBL cancer from 1990 to 2019.Methods:Data on incidence,mortality,and disability-adjusted life years(DALYs)metrics(number,crude rate,and age-standardized rates),and the attributable risk fraction of DALY of TBL cancer from 1990 to 2019 in 21 Global Burden of Disease(GBD)regions,four World Bank income regions,204 countries and territories,and the globe were obtained from the up-to-date GBD 2019 study.We applied estimated annual percentage changes(EAPCs)to the age-standardized incidence rate(ASIR),age-standardized mortality rate(ASMR),and age-standardized DALY rate(ASDR)to quantify the temporal trends of the TBL cancer burden from 1990-2019.Associations of EAPC of age-standardized rates with universal health coverage(UHC)index at the national level were evaluated with Pearson correlation analysis.Results:Globally,approximately 2,260,000 new TBL cancer cases,2,042,600 deaths,and 45,858,000 DALYs were reported in 2019.Combination of all modifiable risk factors,behavioral,environmental,and metabolic risk factors accounted for 79.1%,66.4%,33.3%,and 7.9%of global lung cancer DALYs,respectively.The overall ASIR(EAPC:-0.1[95%confidence interval[CI]:-0.2,-0.1]),ASMR(EAPC:-0.3[95%CI:-0.4,-0.3]),and ASDR(EAPC:-0.7[95%CI:-0.7,-0.6])decreased from 1990 to 2019.The highest mortality rate of TBL cancer occurred in the>85-year-old age group for both sexes among high-income countries(HICs)and upper-middle-income countries(UMCs),and in males aged 80-84 years and females aged>85 years in lower middle-income countries(LMCs).HICs experienced the largest declines in ASIR(-12.6%),ASMR(-20.3%),and ASDR(-27.8%)of TBL cancer between 1990 and 2019,while UMCs had the highest increases in ASIR(16.7%)and ASMR(8.0%)over the period.Eleven(52.4%),14(66.7%),and 15(71.4%)regions of the 21 GBD regions experienced descending trends in ASIR,ASMR,and ASDR of TBL cancer between 1990 and 2019,respectively,with the greatest mean decrease per year(EAPC:-1.7[95%CI:-2.0,-1.5]for ASIR,-1.9[95%CI:-2.2,-1.7]for ASMR,and-2.2[95%CI:-2.5,-2.0]for ASDR)being observed in eastern Europe.The ASIR,ASMR,and ASDR of TBL cancer were deemed to be in decreasing trends in 85,91,and 104 countries and territories,with the largest decrease in Bahrain(EAPC:-3.0[95%CI:-3.3,-2.7]for ASIR,-3.0[95%CI:-3.3,-2.6]for ASMR,and-3.4[95%CI:-3.8,-3.1]for ASDR).ASIR(r=0.524),ASMR(r=0.411),and ASDR(r=0.353)of TBL cancer were positively associated with UHC index at the national level in 2019.Conclusions:The TBL cancer burden shows a downward trend at the global level but varies greatly across regions and countries.A decreasing trend in the TBL cancer burden was observed in the most of the 21 GBD regions and 204 countries from 1990 to 2019.UMCs had the highest burden of TBL cancer and showed the largest increases in ASIR and ASMR. | Chenran Wang Zheng Wu Yongjie Xu Yadi Zheng Zilin Luo Wei Cao Fei Wang Xuesi Dong Chao Qin Liang Zhao Changfa Xia Fengwei Tan Wanqing Chen Ni Li Jie He | 2023 | Chinese Medical Journal Pulmonary and Critical Care Medicine2023，1，1： | 0 |
| 15 | Diverse Structural Design Strategies of MXene‑Based Macrostructure for High‑Performance Electromagnetic Interference Shielding显示文摘There is an urgent demand for flexible,lightweight,mechanically robust,excellent electromagnetic interference(EMI)shielding materials.Two-dimensional(2D)transition metal carbides/nitrides(MXenes)have been potential candidates for the construction of excellent EMI shielding materials due to their great electrical electroconductibility,favorable mechanical nature such as flexibility,large aspect ratios,and simple processability in aqueous media.The applicability of MXenes for EMI shielding has been intensively explored;thus,reviewing the relevant research is beneficial for advancing the design of high-performance MXene-based EMI shields.Herein,recent progress in MXene-based macrostructure development is reviewed,including the associated EMI shielding mechanisms.In particular,various structural design strategies for MXene-based EMI shielding materials are highlighted and explored.In the end,the difficulties and views for the future growth of MXene-based EMI shields are proposed.This review aims to drive the growth of high-performance MXene-based EMI shielding macrostructures on basis of rational structural design and the future high-efficiency utilization of MXene. | Yue Liu Yadi Wang Na Wu Mingrui Han Wei Liu Jiurong Liu Zhihui Zeng | 2023 | Nano-Micro Letters2023，15，12： | 0 |
| 16 | Aldh2 deficiency plays a dual role in lung tumorigenesis and tumor progression显示文摘Alcohol consumption contributes to global mortality and cancer development.Acetaldehyde(ACE),the oxidized metabolite of alcohol,is highly reactive towards DNA,resulting in DNA adducts.ACE can be detoxified to acetate by acetaldehyde dehydrogenase type 2(ALDH2).ALDH2 deficiency can lead to ACE accumulation and DNA damage. | Hongjia Zhang Xueqian Sun Zhanming Li Tingting Liu Fang Zhang Xinyu Meng Kaimi Li Jianhua Xu Wei He Bo Jing Tong Wang Na Ni Beibei Sun Feng Yao Yadi Wu Qi Wang Jing Du Eugene Y.Chin Binhua P.Zhou Ping Jiang Lishun Wang Jiong Deng | 2024 | Genes & Diseases2024，11，3： | 0 |
| 17 | Ruthenium Oxide/Reduced Graphene Oxide Nanoribbon Composite and Its Excellent Rate Capability in Supercapacitor Application显示文摘化学氧化被用来切并且在横向的方向和轴的方向解开多围的碳 nanotubes 形成 graphene 氧化物 nanoribbon (GONR ) 。钌氧化物 / 还原剂 graphene 氧化物 nanoribbon 合成(有装载的 72.5 wt% RuO 2 的 RuO 2/rGONR) 通过水阶段的反应被综合在哪个 GONR 作为开始材料被服务,在周围的空中由温和热处理列在后面。产生 RuO 2/rGONR 合成在三电极的系统使用在 1 A·g −1 的当前的密度完成特定的电容直到 677 F·g −1 1 mol·L −1 H 2 同样多象电解质一样。结果的电极展出一个优秀的率能力(在 20 A·g −1) 的 91.8% 保留率。特别,根据 RuO 2/rGONR 电极装配的对称的 supercapacitor 交付高精力密度(甚至在为 supercapacitors 很必要的 9885 W·kg −1, 的力量密度的 16.2 Wh·kg −1) 。 | Ruijing Wang Pengfei Jia Yuying Yang Ning An Yadi Zhang Hongying Wu Zhongai Hu | 2016 | Chinese Journal of Chemistry2016，34，1： | 0 |
| 18 | Modules of the Intermediate Series over Not-finitely Graded Lie Algebras W(Г)显示文摘Let W(Г)be a class of not-finitely graded Lie algebras related to generalized Virasoro algebras with basis{L_(α,i),C|α∈Г,i∈Z_(+)},which satisfies relations[L_(α,i),L_(β,j)]=L_(α+β,i+j)+(j-i)L_(α+β,i+j+1)+δ_(α+β,0)δ_(i+j),0α^(3)-α/12 C and[C,L_(α,i)]=0.In this paper,W(Г)-modules of the intermediate series satisfying some conditions are constructed and classified.We also obtain modules of the intermediate series over the related Lie superalgebra. | Yadi Wu Xiaoqing Yue | 2021 | Algebra Colloquium2021，28，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员