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| 1 | Herbal decoctosome is a novel form of medicine显示文摘Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs(sRNAs) were reported as a new class of functional components in decoctions. However, the mechanisms by which sRNAs survive heat treatment of the decoction and enter cells are unclear.Previous studies showed that plant-derived exosome-like nanoparticles(ELNs), which we call botanosomes, could deliver therapeutic reagents in vivo. Here, we report that heat-stable decoctosomes(ELNs) from decoctions have more therapeutic effects than the decoctions in vitro and demonstrate therapeutic efficacy in vivo. Furthermore, sRNAs, such as HJT-sRNA-m7 and PGY-sRNA-6, in the decoctosome exhibit potent anti-fibrosis and anti-inflammatory effects, respectively. Decoctosome is comprised of lipids, chemical compounds, proteins, and s RNAs. A medical decoctosome mimic is called bencaosome. A single lipid sphinganine(d22:0) identified in the decoctosome was mixed and heated with the synthesized sRNAs to form the simplest bencaosome. This simple bencaosome structure was identified by critical micelle concentration(cmc) assay that sRNAs coassembled with sphinganine(d22:0) to form the lipid layers of vesicles. The heating process facilitates co-assembly of sRNAs and sphinganine(d22:0) until a steady state is reached. The artificially produced sphinganine-HJT-sRNA-m7 and sphinganinePGY-sRNA-6 bencaosomes could ameliorate bleomycin-induced lung fibrosis and poly(I:C)-induced lung inflammation, respectively, following oral administration in mice. Our study not only demonstrates that the herbal decoctosome may represent a combinatory remedy in precision medicine but also provides an effective oral delivery route for nucleic acid therapy. | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao DANDan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 26 |
| 2 | Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy显示文摘病理学的心脏的肥大是心失败的不可避免的 forerunner。不管心脏的肥大的病原学, cardiomyocyte mitochondrial 改变总是在这上下文被观察。mitochondrial 先锋蛋白质的进口调节在 pathophysiological 下面维持 mitochondrial 功能的外部膜(汤姆) 建筑群管理的 mitochondrial 的 translocases;然而,它在病理学的心脏的肥大的发展的角色仍然保持不清楚。这里,我们证明 Tom70 是在从人和试验性的动物的病理学的 hypertrophic 心的 downregulated。在 Tom70 表示的减小在 vivo 并且在 vitro 生产了不同病理学的 cardiomyocyte 肥大。指向 Tom70 的眼的 atrophy-1 的有缺点的 mitochondrial 进口触发了细胞内部的氧化应力,它导致了病理学的细胞的回答。重要地,如果有到多样的 pro-hypertrophic 的完整的抵抗的 cardiomyocytes 侮辱,增加了 Tom70 层次。一起,这些结果表明 Tom70 充当安排 hypertrophic 压力和 mitochondrial 回答决定病理学的心脏的肥大的一个分子的开关。 | Jun Li Man Qi Changming Li Dan Shi Dasheng Zhang Duanyang Xie Tianyou Yuan Jing Feng Yi Liu Dandan Liang Xinran Xu Jinjin Chen Liang Xu Hong Zhang Jiangchuan Ye Fei LV Jian Huang Luying Peng Yi-Han Chen | 2014 | Cell Research2014，24，8： | 9 |
| 3 | A meta-analysis of Chinese herbal medicines for vascular dementia显示文摘OBJECTIVE: To investigate the efficacy and safety of Chinese herbal medicines in the treatment of patients with vascular dementia. DATA RETRIEVAL: We retrieved publications from Cochrane Library (2004 to July 2011), PubMed (1966 to July 2011), the Chinese Science and Technique Journals Database (1977 to July 2011), the China National Knowledge Infrastructure (1979 to July 2011), Google Scholar (July 2011), and the Chinese Biomedical Database (1977 to July 2011) using the'Chinese medicine OR Chinese herbal medicine' and 'vascular dementia OR mild cognition impair OR multi-infarct dementia OR small-vessel dementia OR strategic infarct dementia OR hypoperfusion dementia OR hemorrhagic dementia OR hereditary vascular dementia'. SELECTION CRITERIA: Randomized controlled trials comparing Chinese herbal medicines with placebo/western medicine in the treatment of patients with vascular dementia were included. Diagnostic standards included Diagnostic and Statistical Manual of Mental Disorders-IV, and National Institute of Neurological Disorders and Stroke and Association Internationale pour la Recherché et l'Enseignement en Neurosciences. Two participants independently conducted literature screening, quality evaluation and data extraction. The quality of each trial was assessed according to the Cochrane Reviewers' Handbook 5.0. MAIN OUTCOME MEASURES: Effective rate, Mini-Mental State Examination scores, Hasegawa Dementia Scale scores, and incidence of adverse reactions. RESULTS: We identified 1 143 articles discussing the effects of Chinese medicine on vascular dementia. Thirty-one of these were included in the analysis. These studies involved a total of 2 868 participants (1 605 patients took Chinese medicine decoctions (treatment group); 1 263 patients took western medicine or placebo). The results of our meta-analysis revealed that Chinese herbal remedies in the treatment group were more efficacious than the control intervention (relative risk (RR)=1.27; 95% confidence interval (CI): 1.18-1.38, P<0.01). Mini-Mental State Examination scores were higher in patients taking Chinese herbal medicines than in those in the control group (weighted mean difference (WMD)=2.83; 95%CI: 2.55-3.12, P<0.01). Patients in the treatment group showed better disease amelioration than those in the control group (Hasegawa Dementia Scale scores; WMD=2.41, 95%CI: 1.48-3.34, P<0.01). There were also considerably fewer adverse reactions among those in the treatment group compared with those in the control group (RR=0.20, 95%CI: 0.08-0.47, P<0.01). CONCLUSION: Chinese herbal medicine appears to be safer and more effective than control measures in the treatment of vascular dementia. However, the included trials were generally low in quality. More well-designed, high-quality trials are needed to provide better evidence for the assessment of the efficacy and safety of Chinese medicines for vascular dementia. | Xiude Qin Yu Liu Yanqing Wu Shuo Wang Dandan Wang Jinqiang Zhu Qiaofeng Ye Wei Mou Liyuan Kang | 2013 | Neural Regeneration Research2013，8，18： | 7 |
| 4 | Resveratrol induces AMPK and mTOR signaling inhibition-mediated autophagy and apoptosis in multiple myeloma cells显示文摘Resveratrol,a natural compound extracted from the skins of grapes,berries,or other fruits,has been shown to have anti-tumor effects against multiple myeloma(MM)via promoting apoptosis and inhibiting cell viability.In addition to apoptosis,autophagy also plays a significant role in anti-tumor effects.However,whether autophagy is involved in anti-MM activity of resveratrol remains unclear.In this study,human MM cell lines U266,RPMI-8226,and NCI-H929 were treated with resveratrol.Cell Counting Kit-8 assay and colony formation assay were used to measure cell viability.Western blot analysis was used to detect apoptosis-and autophagy-associated proteins.3-Methyladenine(3-MA)was applied to inhibit autophagy.Results showed that resveratrol inhibited cell viability and colony formation via promoting apoptosis and autophagy in MM cell lines U266,RPMI-8226,and NCI-H929.Resveratrol promoted apoptosis-related proteins,Caspase-3 activating poly-ADP-ribose polymerase and Caspase-3 cleavage,and decreased the protein level of Survivin in a dose-dependent manner.Additionally,resveratrol upregulated the levels of LC3 and Beclin1 in a dose-dependent way,indicating that autophagy might be implicated in anti-MM effect of resveratrol.Furthermore,3-MA relieved the cytotoxicity of resveratrol by blocking the autophagic flux.Resveratrol increased the phosphorylation of adenosine monophosphate(AMP)-activated protein kinase and decreased the phosphorylation of mammalian target of rapamycin(mTOR)and its downstream substrates p70S6K and 4EBP1 in a dose-dependent manner,leading to autophagy.Therefore,our results suggest that resveratrol exerts anti-MM effects through apoptosis and autophagy,which can be used as a new therapeutic strategy for MM in clinic. | Ruye Ma Dandan Yu Yu Peng Hongfei Yi Yingcong Wang Taofang Cheng Bingqing Shi Guang Yang Weiming Lai Xiaosong Wu Ye Lu Jumei Shi | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 7 |
| 5 | Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS显示文摘The activity and stability of the adapter protein MAVS (also known as VISA, Cardif and IPS-1), which critically mediates cellular antiviral responses, are extensively regulated by ubiquitination. However, the process whereby MAVS is deubiquitinated is unclear. Here, we report that the ovarian tumor family deubiquitinase 4 (OTUD4) targets MAVS for deubiquitination. Viral infection leads to the IRF3/7-dependent upregulation of OTUD4 which interacts with MAVS to remove K48-linked polyubiquitin chains, thereby maintaining MAVS stability and promoting innate antiviral signaling. Knockout or knockdown of OTUD4 impairs RNA virus-triggered activation of IRF3 and NF-κB, expression of their downstream target genes, and potentiates VSV replication in vitro and in vivo. Consistently, Cre-ER Otud4fl/fl or Lyz2-Cre Otud4fl/fl mice produce decreased levels of type I interferons and proinflammatory cytokines and exhibit increased sensitivity to VSV infection compared to their control littermates. In addition, reconstitution of MAVS into OTUD4-deficient cells restores virus-induced expression of downstream genes and cellular antiviral responses. Together, our findings uncover an essential role of OTUD4 in virus-triggered signaling and contribute to the understanding of deubiquitination-mediated regulation of innate antiviral responses. | Tianzi Liuyu Keying Yu Liya Ye Zhidong Zhang Man Zhang Yujie Ren Zeng Cai Qiyun Zhu Dandan Lin Bo Zhong | 2019 | Cell Research2019，29，1： | 7 |
| 6 | Spatial-temporal Characteristics and Factors Influencing Commuting Activities of Middle-class Residents in Guangzhou City, China显示文摘The middle class in metropolitan Chinese cities has become an important social group. With the rapid development of urbanization and constant advancement of suburbanization, the middle class has increasingly come to influence city traffic. Research into middle-class commuting activities thus has practical significance for improving traffic congestion and reducing the commuting burden in metropolitan cities. Based on a dataset formed by 816 completed surveys, this paper analyzes the commuting mode, time and distance of middle-class residents in Guangzhou City using the descriptive statistical method. The results indicate that private cars are the main commuting mode, followed by public transport. Meanwhile, middle-class residents mainly undertake medium-short time and medium-short distance commuting. The study subsequently uses multilevel logistic regression and multiple linear regression models to analyze the factors that influence commuting mode choice, time and distance. The gender, age, number of family cars, housing source and jobs-housing balance are the most important factors influencing commuting mode choice; housing, population density, jobs-housing balance and commuting mode significantly affect commuting time; and transport accessibility, jobs-housing balance and commuting mode are the notable factors affecting commuting distance. Finally, this paper analyzes what is affecting the commuting activities of middle-class residents and determines the differences in commuting activity characteristics and influence factors between middle-class and ordinary residents. Policy suggestions to improve urban planning and urban management are also proposed. | DAI Dandan ZHOU Chunshan YE Changdong | 2016 | Chinese Geographical Science2016，26，3： | 7 |
| 7 | Elevating H3K27me3 level sensitizes colorectal cancer to oxaliplatin显示文摘Histone methylation is a context-dependent modification that regulates gene expression,and the trimethylation of histone H3 lysine 27(H3K27me3)usually induces gene silencing.Overcoming colorectal cancer(CRC)chemoresistance is currently a huge challenge,but the relationship between H3K27me3 modification and chemoresistance remains largely unclear.Here,we found that H3K27me3 levels positively correlated with the metastasis-free survival of CRC patients and a low H3K27me3 level predicted a poor outcome upon chemotherapeutic drug treatment.Oxaliplatin stimulation significantly induced the expression of H3K27 lysine demethylase 6A/6B(KDM6A/6B),thus decreasing the level of H3K27me3 in CRC cells.Elevation of H3K27me3 level through KDM6A/6B depletion or GSK-J4(a KDM6A/6B inhibitor)treatment significantly enhanced oxaliplatin-induced apoptosis.Conversely,when inhibiting the expression of H3K27me3 by EPZ-6438,an inhibitor of the histone methyltransferase EZH2,the proportion of apoptotic cells remarkably decreased.In addition,the combination of GSK-J4 and oxaliplatin significantly inhibited tumor growth in an oxaliplatin-resistant patient-derived xenograft model.Importantly,we revealed that oxaliplatin treatment dramatically induced NOTCH2 expression,which was caused by downregulation of H3K27me3 level on the NOTCH2 transcription initiation site.Thus,the activated NOTCH signaling promoted the expression of stemness-related genes,which resulted in oxaliplatin resistance.Furthermore,oxaliplatin-induced NOTCH signaling could be interrupted by GSK-J4 treatment.Collectively,our findings suggest that elevating H3K27me3 level can improve drug sensitivity in CRC patients. | Qi Wang Xi Chen Yuhang Jiang Sanhong Liu Hanshao Liu Xiaohua Sun Haohao Zhang Zhi Liu Yu Tao Cuifeng Li Yiming Hu Dandan Liu Deji Ye Yongzhong Liu Mingliang Wang Xiaoren Zhang | 2020 | Journal of Molecular Cell Biology2020，12，2： | 6 |
| 8 | Epidemiology of urticaria in China:a population-based study显示文摘Background:Urticaria is a common skin disease characterized by episodes of wheals,and it has a negative effect on patients’quality of life.Large-scale population-based epidemiological studies of urticaria are scarce in China.The aim of this survey was to determine the prevalence,clinical forms,and risk factors of urticaria in the Chinese population.Methods:This survey was conducted in 35 cities from 31 provinces,autonomous regions,and municipalities of China.Two to three communities in each city were selected in this investigation.Participants completed questionnaires and received dermatological examinations.We analyzed the prevalence,clinical forms,and risk factors of urticaria.Results:In total,44,875 questionnaires were distributed and 41,041 valid questionnaires were collected(17,563 male and 23,478 female participants).The lifetime prevalence of urticaria was 7.30%,with 8.26%in female and 6.34%in male individuals(P<0.05).The point prevalence of urticaria was 0.75%,with 0.79%in female and 0.71%in male individuals(P<0.05).Concomitant angioedema was found in 6.16%of patients.Adults had a higher prevalence of urticaria than adolescents and children.Living in urban areas,exposure to pollutants,an anxious or depressed psychological status,a personal and family history of allergy,thyroid diseases,and Helicobacter pylori infection were associated with a higher prevalence of urticaria.Smoking was correlated with a reduced risk of urticaria.Conclusion:This study demonstrated that the lifetime prevalence of urticaria was 7.30%and the point prevalence was 0.75%in the Chinese population;women had a higher prevalence of urticaria than men.Various factors were correlated with urticaria. | Jiaqing Li Dandan Mao Shuoshuo Liu Ping Liu Jing Tian Chenhong Xue Xiaojing Liu Ruiqun Qi Bingxue Bai Jianjun Nie Siqi Ye Yu Wang Yuye Li Qing Sun Juan Tao Shuping Guo Hong Fang Jianqin Wang Qiri Mu Quanzhong Liu Yan Ding Jianzhong Zhang | 2022 | Chinese Medical Journal2022，，11： | 6 |
| 9 | The beneficial effects of intermittent fasting:an update on mechanism,and the role of circadian rhythm and gut microbiota显示文摘Importance:There is accumulating evidence that intermittent fasting(IF)is connected to improved health condition and longevity time-restricted feeding(TRF)is the most recognized and extensively studied model of IF.Objective:To investigate the underlying mechanism of pleiotropic benefits of IF and hint the most advantageous feeding pattern for humans.Evidence review:We searched MEDLINE,EMBASE,Cochrane Library and Google Scholar by 2020 April for publications on IF or TRF and their mechanisms.Studies include animal models and human cohorts.Findings:One important mechanism is that IF allows certain period of fasting time,in which our bodies activate pathways of repair and rejuvenation.Moreover,the advantages of IF,especially TRF over total caloric restriction(CR)provided bases for various animal and human studies which suggested that the feeding-fasting rhythm stimulates the fluctuation of our gut microbiota and a series of subsequent molecular alterations,which in turn restored a healthier circadian clock that resembled our inherent clock formed throughout millions of years of homo sapiens history.Conclusions and Relevance for Reviews:Complete understanding of the mechanism leading to the beneficial effects of IF paves the way for tailored dietary regimen to combat a wide range of diseases and ill health conditions. | Dandan Hu Zhibo Xie Yuqian Ye Suhad Bahijri Minshan Chen | 2020 | Hepatobiliary Surgery and Nutrition2020，9，5： | 5 |
| 10 | Effect of direct current pulse stimulating acupoints of JiaJi (T10-L3) and Ciliao (BL 32) with Han's Acupoint Nerve Stimulator on labour pain in women: a randomized controlled clinical study显示文摘OBJECTIVE: To assess the clinical effect and safety of direct current(DC) pulse produced by Han's Acupoint Nerve Stimulator in reduction(HANS) of labor pain.METHODS: Totally 120 participants were enrolled in this clinical trial, and were randomly divided into4 groups including: HANS group, patient controlled intravenous analgesia(PCIA) group, patient-controlled epidural analgesia(PCEA) group and control group. The HANS group was treated by stimulating the acupoints of Jia Ji(T10-L3) and Ciliao(BL 32)with DC pulse of 100 Hz and 15-30 m A produced by a portable battery-powered Han's Acupoint Nerve Stimulator for 30 min. The PCIA group was intravenously infused Ondansetron(8 mg) for 5 min,then tramadol injection(1.5 mg/kg) was slowly dripped by using Baxter APⅡ electronic pump with50 m L tramadol(0.70%) + ondansetron(8 mg),background infusion 2 m L/h, PCA dose of 2 m L,lockout interval of 10 min. In PCEA group, women received intrathecal injection ropivacaine(3 mg) in L2-3, and epidural catheter was connected to Baxter APⅡ electronic pump, with 100 m L Ropivacaine(0.1%) and Sufentanil(50 ug), background infusion5 m L, Patient controlled analgesia(PCA) dose of 5m L, lockout interval of 10 min. The control group was not received analgesia. The visual analogue scale(VAS), stage and manner of labor, Apgar score of newborn, neonatal weights, oxytocin dosage,postpartum hemorrhage and side effects were monitored in all groups.RESULTS: The vital signs were all stable in the four analgesic groups. After analgesia, there was statistical difference in VAS score between HANS group and control group, between PCEA group and the control group, between PCIA group and control group. The analgesic effect in the PCEA group was significantly better than that of other two groups.The second stage of labor in the PCEA group was longer than the other three groups, showing significant difference between them. The Apgar score of newborn 1min after birth in the PCIA group was slightly lower than that of the other two groups,showing significant difference between them. The neonatal weights between four groups were not significantly different. The rate of cesarean sectionin the control group was significantly higher than that of the labor analgesia group, there was statistically difference in four groups. The number of PCIA group that used oxytocin was lower than that of other three groups. There was no significant difference in postpartum hemorrhage between four groups. The side effects of the PCEA group were itching, uroschesis and neonatal asphyxia and PCIA group were nausea and vomiting and neonatal asphyxia. However, fewer side effects were observed in the HANS group.CONCLUSION: The DC pulse produced by HANS may be a non-pharmacological alternative to labor pain with fewer side effects. | Liu Ye Xu Mingjun Che Xiangming He Junqin Guo Dandan Zhao Guosheng Zhang Guogang Zhang Shuo Kang Kai Zhang Chunlei Wang Yinan Li Shan Zhang Qinglin Xu Li Zhang Ming Han Bin Jing Yumiao Zhang Ning | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 4 |
| 11 | The State-of-the-Art Review on Applications of Intrusive Sensing,Image Processing Techniques,and Machine Learning Methods in Pavement Monitoring and Analysis显示文摘In modern transportation,pavement is one of the most important civil infrastructures for the movement of vehicles and pedestrians.Pavement service quality and service life are of great importance for civil engineers as they directly affect the regular service for the users.Therefore,monitoring the health status of pavement before irreversible damage occurs is essential for timely maintenance,which in turn ensures public transportation safety.Many pavement damages can be detected and analyzed by monitoring the structure dynamic responses and evaluating road surface conditions.Advanced technologies can be employed for the collection and analysis of such data,including various intrusive sensing techniques,image processing techniques,and machine learning methods.This review summarizes the state-ofthe-art of these three technologies in pavement engineering in recent years and suggests possible developments for future pavement monitoring and analysis based on these approaches. | Yue Hou Qiuhan Li Chen Zhang Guoyang Lu Zhoujing Ye Yihan Chen Linbing Wang Dandan Cao | 2021 | Engineering2021，7，6： | 3 |
| 12 | Erratum to:Herbal decoctosome is a novel form of medicine显示文摘Following the published article,we noticed an error duplication in Figure 5G“control”and“PGY-6”that was introduced during the revised process,with an attempt to replace it with higher-resolution images.Here we provide the original data in the first submitted manuscript(Figure 5G). | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao Dandan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2020 | Science China(Life Sciences)2020，63，9： | 2 |
| 13 | The S 1P, receptor-selective agonist CYM-5442 reduces the severity of acute GVHD byinhibiting macrophage recruitment显示文摘FTY720,为五已知的 sphingosine-1-phosphate (S1P ) 中的四个的收缩筋受体,被报导了禁止尖锐 graft-versus-host 疾病(aGVHD ) 。因为 FTY720 通过多重 S1P 受体工作,通过至少一这些受体的行动的机制可以说明它的副作用。因此,更选择的 S1P 受体调节的人被需要评估不同 S1P 受体和他们的治疗学的功效的角色。在这研究,我们调查了 S1P 1-selective 收缩筋的效果, CYM-5442,在 aGVHD 的前进上。我们显示出显著地禁止的那 CYM-5442 但是没阻止 aGVHD。CYM-5442 没影响施主 T 细胞的渗入进目标器官,当在 GVHD 器官的巨噬细胞的数字被 CYM-5442 处理显著地减少时。在 vivo 增长,试金证明巨噬细胞的增长没被 CYM-5442 压制。用人的 endothelial 房间的进一步的研究在 endothelial 房间表明了那 CYM-5442 处理 downregulated CCL2 和 CCL7 表情,因此减少单核白血球,从纸巾,巨噬细胞发源的迁居。我们的数据在 aGVHD 和它行动的可能的机制表明 S1P 1-selective 收缩筋的治疗学的功效。结果建议进一步的调查为 aGVHD 作为潜在的治疗学的政体关于 CYM-5442 被需要。 | Qiao Cheng Shoubao Ma Dandan Lin Yu Mei Huanle Gong Lei Lei Yuanyuan Chen Ye Zhao Bo Hut Yan Wu Xiao Yu Lixiang Zhao Haiyan Liu | 2015 | Cellular & Molecular Immunology2015，12，6： | 2 |
| 14 | Study of peach freshness predictive method based on electronic nose显示文摘 | Hui Guohua Wu Yuling Ye Dandan Ding Wenwen Zhu Linshan Wang Lvye | 2012 | Food Control2012，，1： | 2 |
| 15 | Electrodeposition of Ni micro/nano-structures显示文摘A quasi two-dimension electrodeposition method was used to prepare materials with arborized, tree-shaped, and membrane patterned micro/nano-structures. The morphology of the membrane patterned micro/nano-structure was characterized using scanning electron microscopy, and a mechanism for the morphology formation was suggested. The novel preparation method used in this study, which is proprietary to our research group, does not require a template and so has many advantages including controllable, low cost, large scale preparation. The electrolyte concentration and electrodeposition voltage had a significant effect on the resulting morphology. | NIU LianPing YE DanDan LI Feng ZHANG MingZhe | 2011 | Chinese Science Bulletin2011，56，32： | 1 |
| 16 | Study of peach freshness predictive method based on electronic nose 显示文摘 | Hui Guohua Wu Yuling Ye Dandan | 2012 | Food Control2012，28，1： | 1 |
| 17 | Study of peach freshness predictive method based on electronic nose显示文摘 | Hui Guohua Wu Yuling Ye Dandan | 2012 | Food Control2012，28，1： | 1 |
| 18 | The prognostic significance of polymorphisms in hMLH1/hMSH2 for colorectal cancer显示文摘 | Yibaina Wang Guangxiao Li Fulan Hu Haoran Bi Zhiwei Wu Xiaojuan Zhao Ye Li Shuying Li Dandan Li Binbin Cui Xinshu Dong Yashuang Zhao | 2014 | Medical Oncology2014，，6： | 1 |
| 19 | S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis byactivating the TGF-β signaling pathway in cancer cells显示文摘 | Dandan Tong Hui Qu Xiangning Meng Yang Jiang Duanyang Liu Shengqian Ye He Chen Yan Jin Songbin Fu Jingshu Geng | 2014 | Oncology Reports2014，，3： | 1 |
| 20 | Exogenous Spermidine Promotes Somatic Embryogenesis of Cunninghamia lanceolata by Altering the Endogenous Phytohormone Content显示文摘In order to study how exogenous hormones in C.lanceolata(gymnosperm)regulate somatic embryogenesis,we measured the endogenous phytohormones of two genotypes with different somatic embryogenesis efficiency and found that an increase in endogenous concentrations of IAA and ABA may be correlated to more efficient somatic embryogenesis.By applying exogenous spermidine,we found that exogenous hormones may affect somatic embryogenesis efficiency through affecting the endogenous phytohormone content.Based on these results,further studies can be conducted whereby the concentration of exogenous hormones or the levels of endogenous phytohormones by molecular methods are regulated to promote somatic embryogenesis.Our research may benefit the long-term economic output of the forestry industry and lays the foundation to studying the molecular mechanism that controls somatic embryogenesis efficiency. | Dandan Wang Yulin Guo Xiaofei Long Yan Pan Dingjie Yang Rui Li Ye Lu Ying Chen Jisen Shi Jinhui Chen | 2020 | Phyton-International Journal of Experimental Botany2020，89，1： | 1 |
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