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| 1 | Viral effector protein manipulates host hormone signaling to attract insect vectors显示文摘 | Dewei Wu Tiancong Qi Wan-Xiang Li Haixia Tian Hua Gao Jiaojiao Wang Jin Ge Ruifeng Yao Chunmei Ren Xian-Bing Wang Yule Liu Le Kang Shou-Wei Ding Daoxin Xie | 2017 | Cell Research2017，27，3： | 20 |
| 2 | Modeling gross primary production of a temperate grassland ecosystem in Inner Mongolia, China, using MODIS imagery and climate data显示文摘Carbon fluxes in temperate grassland ecosystems are characterized by large inter-annual variations due to fluctuations in precipitation and land water availability. Since an eddy flux tower has been in operation in the Xilin Gol grassland, which belongs to typical temperate grassland in North China, in this study, observed eddy covariance flux data were used to critically evaluate the biophysical per- formance of different remote sensing vegetation indices in relation to carbon fluxes. Furthermore, vegetation photosynthesis model (VPM) was introduced to estimate gross primary production (GPP) of the grassland ecosystem for assessing its dependability. As defined by the input variables of VPM, Moderate Resolution Imaging Spectroradimeter (MODIS) and standard data product MOD09A1 were downloaded for calculating enhanced vegetation index (EVI) and land surface water index (LSWI). Measured air temperature (Ta) and photosynthetically active radiation (PAR) data were also included for model simulating. Field CO2 flux data, during the period from May, 2003 to September, 2005, were used to estimate the 'observed' GPP (GPPobs) for validation. The seasonal dynamics of GPP predicted from VPM (GPPVPM) was compared quite well (R2=0.903, N=111, p<0.0001) with the observed GPP. The ag- gregate GPPVPM for the study period was 641.5 g C·m?2, representing a ~6% over-estimation, compared with GPPobs. Additionally, GPP predicted from other two typical production efficiency model (PEM) represents either higher overestimation or lower underestimation to GPPobs. Results of this study demonstrate that VPM has potential for estimating site-level or regional grassland GPP, and might be an effective tool for scaling-up carbon fluxes. | WU WeiXing WANG ShaoQiang XIAO XiangMing YU GuiRui FU YuLing HAO YanBin | 2008 | Science China Earth Sciences2008，51，10： | 13 |
| 3 | Protective effect of Angelica sinensis on cerebral neurons from rat embryos under hypoxia显示文摘BACKGROUND: The enhanced expression of c-Fos protein in nerve cells after hypoxia is the marker for converting extracellular hypoxia information to intracellular changes at hypoxia, and it is suspected that the increase of c-Fos protein can lead to the synthesis and excretion of related neurotrophic factor and nerve growth factor. However, it is still unclear what functional changes of nerve cells are induced by the increase of c-Fos protein at hypoxia, and whether it is good for the survival of damaged neurons. OBJECTIVE: To observe the expression of c-Fos in the cerebral neurons from embryos of rats with hypoxia in uterus, and investigate the pathway for the protective effect of Angelica sinensis injection on the cerebral neurons from rat embryos under hypoxia. DESIGN: A completely randomized controlled study. SETTING: Department of Histology and Embryology, Luzhou Medical College. MATERIALS: Twelve female Wistar rats in oestrum and 1 male adult Wistar rat with body mass of 220 to 250 g were selected. Rabbit-anti-rat neuro-specific enolase (NSE) and rabbit-anti-rat c-Fos were purchased from Wuhan Boster Biological Technology Co., Ltd.; Double-staining kit was bought from Beijing Zhongshan Golden Bridge Biotechnology Co., Ltd. Angelica sinensis injection was produced by the Department of Pharmacy, the Second Affiliated Hospital of Hubei Medical University. METHODS: The experiments were completed in the experimental animal center and the Department of Histology and Embryology of Luzhou Medical College from December 2004 to December 2005. ① Twelve adult female Wistar rats in oestrum and 1 male Wistar rat were housed in one rearing cage. The appearance of vaginal embolus at 8:00 in the next morning was recorded as 0 day of pregnancy and the rats were recorded for 15 days, and they were divided randomly into three groups, control group (n =4), hypoxia group (n =4) and Angelica group (n =4). The pregnant rats in the hypoxia group were firstly injected with saline (8 mL/kg), then put into 2 L wide-mouthed bottle containing 100 g sodalime, and then the lid of the bottle was closed tightly to induce hypotonic hypoxia for 1 hour followed by 1-hour re-oxygenation. The pregnant rats were killed under anesthesia, and then fetuses were taken out by rapid cesarean. Part of the brain tissues were exposed and then fixed in formaldehyde (40 g/L). The pregnant rats in the Angelica group were treated the same as those in the hypoxia group except that saline was replaced by 250 g/L Angelica sinensis injection which was injected via caudal vein (8 mL/kg). The rats in the control group were injected with saline (8 mL/kg) slowly via caudal vein, but not put into the wide-mouthed bottle for hypoxia, and then the brain tissues were removed and fixed as those in the hypoxia group after 1 hour. ② Twenty embryos from rats were chosen randomly in each group and then routinely embedded in paraffin. Paraffin sections of 4 μm thick were prepared through the anterior fontanelle of head of the fetal rats. The sections were immunohistologically stained with c-Fos/NSE. ③ The one-way analysis of variance (ANOVA) was used to compare the differences of measurement data among the groups, and the q test was applied in the two-two comparison. MAIN OUTCOME MEASURES: The numbers of c-Fos and c-Fos/NSE positive neurons in cerebrum from rat embryos were observed. RESULTS: ① Numbers of NSE positive neurons in cerebrum of rat embryos in the control group, hypoxia group and Angelica group were (84.3±9.0), (90.2±12.5) and (86.7±9.7) cells/high power field (P > 0.05). ② The number of c-Fos/NSE positive neurons was more in the hypoxia group than in the control group and Angelica group [(38.4±5.28), (11.35±2.67), (20.65±4.07) cells/high power field, q =29.17, 19.14, P < 0.05]. CONCLUSION: Hypoxia can stimulate the expression of c-Fos in cerebral neurons from rat embryos. Angelica sinensis injection could reducing the damage of hypoxia to neurons and play a neuroprotective roleby decreasing the expression of c-Fos protein in hypoxic neurons. | Yuling Wu Hongxian Zhao Hong Yu | 2007 | Neural Regeneration Research2007，2，1： | 7 |
| 4 | EBV-Induced Human CD8^+ NKT Cells Synergise CD4^+ NKT Cells Suppressing EBV-Associated Tumours upon Induction of Thl-Bias显示文摘 | Wei Xiao Li Li Rui Zhou Ruijing Xiao Yujuan Wang Xiang Ji Mengjun Wu Lan Wang Wei Huang Xiaoling Zheng Xinti Tan Lang Chen Tao Xiong Jie Xiong Youxin Jin Jinquan Tan Yuling He | 2009 | Cellular & Molecular Immunology2009，6，5： | 5 |
| 5 | Decrease in the Ki67 index during neoadjuvant chemotherapy predicts favorable relapse-free survival in patients with locally advanced breast cancer显示文摘Objective: The purpose of this study was to explore the optimal cutoffs of the three parameters of Ki67 during NAC for predicting patient prognosis and investigate whether the optimal cutoffs of the Ki67 values were associated with relapse-free survival(RFS) or breast cancer-specific survival(BCSS).Methods: A total of 92 patients with locally advanced breast cancer(LABC), who had residual disease after NAC were retrospectively investigated.The optimal cutoff values of the Ki67 parameters were assessed by the online algorithm Cutoff Finder.Kaplan-Meier analysis, the log-rank test and Cox regression analysis were carried out to analyze survival.Results: The optimal cutoff values for the postsurgical Ki67 level and the decrease in the Ki67 level during NAC were defined as 25% and 12.5%, respectively.According to the univariate survival analysis, a higher Ki67 level in residual disease was associated with poor RFS(P = 0.004) and BCSS(P = 0.014).In addition, a Ki67 expression decrease > 12.5% during NAC was related to favorable RFS(P = 0.007), but was not related to BCSS(P = 0.452).Cox regression analysis showed that the Ki67 expression decrease(> 12.5% vs.≤ 12.5%) and histological grade(grade 3 vs.grade 1-2) were the independent factors associated with RFS(P =0.020 and P = 0.023, respectively), with HR values of 0.353(95% CI: 0.147-0.850) and 3.422(95% CI: 1.188-9.858), respectively.Conclusions: The Ki67 decrease was one of the independent factors associated with RFS in LABC patients with residual disease after receiving NAC. | Chunfa Chen Yuling Zhang Ziyi Huang Jundong Wu Wenhe Huang Guojun Zhang | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 6 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 7 | Overexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression显示文摘 | Xiaofei Wang Haiping Tang Yuling Chen Binghuan Chi Shiyu Wang Yang Lv Di WU Renshan Ge Haiteng Deng | 2016 | Protein & Cell2016，7，4： | 3 |
| 8 | Review of Text Classification Methods on Deep Learning显示文摘Text classification has always been an increasingly crucial topic in natural language processing.Traditional text classification methods based on machine learning have many disadvantages such as dimension explosion,data sparsity,limited generalization ability and so on.Based on deep learning text classification,this paper presents an extensive study on the text classification models including Convolutional Neural Network-Based(CNN-Based),Recurrent Neural Network-Based(RNN-based),Attention Mechanisms-Based and so on.Many studies have proved that text classification methods based on deep learning outperform the traditional methods when processing large-scale and complex datasets.The main reasons are text classification methods based on deep learning can avoid cumbersome feature extraction process and have higher prediction accuracy for a large set of unstructured data.In this paper,we also summarize the shortcomings of traditional text classification methods and introduce the text classification process based on deep learning including text preprocessing,distributed representation of text,text classification model construction based on deep learning and performance evaluation. | Hongping Wu Yuling Liu Jingwen Wang | 2020 | Computers, Materials & Continua2020，，6： | 3 |
| 9 | Insulin-like growth factor 1 receptor signaling regulates embryonic epicardial cell proliferation through focal adhesion kinase pathway显示文摘 | Yuling Yan Qin Qin Ling Wu Xiaodong Jing Songbai Deng Qiang She | 2018 | Acta Biochimica et Biophysica Sinica2018，50，10： | 3 |
| 10 | SELDI-TOF-MS in chronic obstructive pulmonary disease显示文摘Chronic obstructive pulmonary disease(COPD) has a profound impact on daily life,yet remains underdiagnosed and undertreated.This study aims to discover potential protein biomarkers for diagnosis and classification of COPD.Fifty-seven COPD patients and 40 controls were divided into a training set(30 COPD patients,20 healthy controls) and a test set(27 COPD patients,20 healthy controls).Serum proteomic profiles were measured using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry(SELDI-TOF-MS).A classification tree was established using Biomarker Pattern Software(BPS).Next we screened distinct proteins present in patients with acute exacerbations of COPD(AECOPD),stable COPD and healthy controls,in order to establish diagnostic models for classification of COPD.Twenty peaks showed statistically significant differences between COPD patients and healthy controls(P < 0.05).Two proteomic peaks(3167 and 5477 m/z) were chosen by BPS to establish a classification tree in the training set.The sensitivity and specificity of this classification tree were 92.59% and 90.00% respectively in the testing set.Furthermore,differently expressed proteins were detected among the patients with AECOPD,stable COPD,and healthy controls.Two protein profiles(3167 and 4645 m/z) could distinguish between stable COPD patients and healthy controls.Three protein profiles(3167,2963 and 2973 m/z) could distinguish between AECOPD patients and healthy controls.Three protein profiles(5476,14039 and 2831 m/z) could distinguish between stable COPD patients and AECOPD patients.SELDI-TOFMS Proteinchip technology is a quick,easy and practical,high throughput analytic method.It shows the diagnostic models established by distinguished proteomic peaks can discriminate COPD patients from healthy control and can identify different stages of COPD.It will provide a highly accurate approach for diagnosis and clinical staging of COPD. | ZHANG Xia ZHANG Jie LI Qi WU XiaoYi WANG Ting WANG YuLing | 2013 | Chinese Science Bulletin2013，58，6： | 2 |
| 11 | Coat protein promoter from cotton leaf curl virus is not a tissue-specifically expressed promoter显示文摘Geminivirus is a kind of single-stranded DNA virus. Experimental results from tomato golden mosaic virus (TGMV) showed that expression pattern of coat protein gene (cp) promoter was phloem specifically expressed. In this note, the studies on cp promoter of cotton leaf curl virus (CLCuV) which is found and identified recently suggest that the promoter is not phloem specifically expressed. The expressing activity of gus gene driven by the promoter exists not only in phloem but also in mesophyll tissues and root tip meristem. Transient expression suggests that cp promoter transactivated by AC2 shows expressing activity in mesophyll and vascular tissue of leaf vein. | XIE Yingqiu ZHU Zhen LIU Yule WU Qian XU Honglin | 2000 | Chinese Science Bulletin2000，45，20： | 2 |
| 12 | High-loading single cobalt atoms on ultrathin MOF nanosheets for efficient photocatalytic CO_(2) reduction显示文摘Based on suitable scaffolds,constructing high-loading single-atom catalysts is a promising strategy to achieve highly efficient catalysis.Herein,using ultrathin metal-organic framework(MOF)nanosheets(2.4±0.5 nm)as the support,single-atom catalysts with high cobalt loading(6.0 wt%)were constructed(denoted as Co-MNSs)by a simple bottom-up synthetic strategy.The catalytic system of Co-MNSs exhibited an outstanding photocatalytic CO_(2)-to-CO evolution rate of 7,041μmol g^(-1)h^(-1)and a selectivity of 86%in aqueous media under visible-light irradiation,which has reached the top level of the reported MOF-based photocatalysts.The control experiments and theoretical calculation revealed that the Co-N_(4)moiety in the MOF nanosheets acted as the active site for the photocatalytic CO_(2)-to-CO conversion.The boosted photocatalytic performance could be ascribed to the high aspect-ratio of layered Co-MNSs providing abundant accessible active sites on their surfaces,which reduced the energy barrier,improved the charge separation efficiency,and also facilitated the adsorption of CO_(2)to form the reactive radicals of*COOH.Our study provides an appealing strategy for constructing high-loading single-atom catalysts and demonstrates the significance of 2D ultrathin MOF nanosheets as the support in boosting CO_(2)photoreduction efficiency. | Quan Zuo Rui Cui Lei Wang Yuling Wang Chunyang Yu Liang Wu Yiyong Mai Yongfeng Zhou | 2023 | Science China Chemistry2023，66，2： | 2 |
| 13 | Flabellariopteris, a new aquatic fern leaf from the Late Triassic of western Liaoning, China显示文摘An aquatic fern leaf,Flabellariopteris mii Sun gen.et sp.nov.from the Late Triassic of Western Liaoning,China,is described and proposed as the type species of the new morphortaxon of the Marsileaceae.The fossil leaves are preserved as impression.No fertile and rhizomatic materials are found.The leaves attached at a common point on the top of the petiole are composed of two leaflets joined basally in an opposite arrangement.The petiole is slender.The leaflet is fan-shaped or semi-circular,and commonly divided into four wedge-shaped lobes.Terminal margin of lobes is usually incised,incisions shallow or deep,with bluntly rounded or notched apex.The veins are conspicuously dichotomous,but anastomoses and marginal vein are absent.The unique morphological features,including twoparted thin leaflets,size,shape,veins and slender petiole,indicate that the present specimen represents an aquatic fern,which is the oldest fossil record and the first megafossil evidence assignable to Marsileaceae from the Triassic floras. | Chunlin Sun Tao Li Yuling Na Wenhao Wu Yunfeng Li Lixia Wang Lijun Zhang | 2014 | Chinese Science Bulletin2014，59，20： | 2 |
| 14 | Study of peach freshness predictive method based on electronic nose显示文摘 | Hui Guohua Wu Yuling Ye Dandan Ding Wenwen Zhu Linshan Wang Lvye | 2012 | Food Control2012，，1： | 2 |
| 15 | Study of peach freshness predictive method based on electronic nose 显示文摘 | Hui Guohua Wu Yuling Ye Dandan | 2012 | Food Control2012，28，1： | 1 |
| 16 | Study of peach freshness predictive method based on electronic nose显示文摘 | Hui Guohua Wu Yuling Ye Dandan | 2012 | Food Control2012，28，1： | 1 |
| 17 | Fluorescence detection of Escherichia coli on mannose modified ZnTe quantum dots显示文摘Rapid detection and identification of Escherichia coli(E.coli)is essential to prevent its quickly spread.In this study,a novel fluorescence probe based on ZnTe quantum dots(QDs)modified by mannose(MAN)had been prepared for the determination of E.coli.The results showed that the obtained QDs showed excellent selectivity toward E.coli,and presented a good linearity in range of 1.0×10~5~1.0×10~8 CFU/mL.The optimum fluorescence intensity for detecting E.coli was found to be at pH 7.0 with a temperature of25℃and incubation time of 20 min.Under these optimum conditions,the detection limit of E.coli was4.6×10~4 CFU/mL.The quenching was discussed to be a static quenching procedure,which was proved by the quenching efficiency of QDs decreased with the temperature increasing. | Dudu Wu Dongming Wang Xiaomei Ye Kangrui Yuan Yuling Xie Baohong Li Chaobo Huang Tairong Kuang Zhiqiang Yu Zhi Chen | 2020 | Chinese Chemical Letters2020，31，6： | 1 |
| 18 | Chalcocite(bio)hydrometallurgy-current state,mechanism,and future directions:A review显示文摘There has been a strong interest in technologies suited for mining and processing of low-grade ores because of the rapid depletion of mineral resources in the world.In most cases,the extraction of copper from such raw materials is achieved by applying the leaching procedures.However,its low extraction efficiency and the long extraction period limit its large-scale commercial applications in copper recovery,even though bioleaching has been widely employed commercially for heap and dump bioleaching of secondary copper sulfide ores.Overcoming the technical challenges requires a better understanding of leaching kinetics and on-site microbial activities.Herein,this paper reviews the current status of main commercial biomining operations around the world,identifies factors that affect chalcocite dissolution both in chemical leaching and bioleaching,summarizes the related kinetic research,and concludes with a discussion of two on-site chalcocite heap leaching practices.Further,the challenges and innovations for the future development of chalcocite hydrometallurgy are presented in the end. | Shichao Yu Rui Liao Baojun Yang Chaojun Fang Zhentang Wang Yuling Liu Baiqiang Wu Jun Wang Guanzhou Qiu | 2022 | Chinese Journal of Chemical Engineering2022，35，1： | 1 |
| 19 | Incorporation of Lysine-Containing Copolymer with Polyurethane Affording Biomaterial with Specific Adsorption of Plasminogen显示文摘新奇 biomaterial 通过包含离氨酸的共聚物的物理加入基于聚氨酯(PU ) 被准备改进它的 hemocompatibility 和 plasminogen 的表面识别。包含离氨酸的共聚物经由 2-ethylhexyl methacrylate ( EHMA )的 copolymerization 被综合, oligo (乙烯乙二醇)甲基醚 methacrylate ( OEGMA )和 6-tert-butoxycarbonyl amino-2-( 2-methyl-acryloylamino ) -hexanoic 酸tert丁基酉旨( Lys (P)麻省),在共聚物在离氨酸残余上由 COOH 和 -NH2 组的 deprotection 列在后面。共聚物的作文能被改变单体调整喂比率。三个部件贡献分别地与 PU,到 nonspecific 蛋白质吸附的抵抗和 plasminogen 的特定的绑定改进相容性。向 plasminogen 的有约束力的能力在共聚物与离氨酸内容增加了。这条途径与改进 hemocompatibility 和特定的 biomolecules 的表面识别为新奇 biomaterials 的产生说明一个简单方法。 | Haichao Xu Yafei Luan Zhaoqiang Wu Xinming Li Yuling Yuan Xiaoli Liu Lin Yuan Dan Li Hong Chen | 2014 | Chinese Journal of Chemistry2014，32，1： | 1 |
| 20 | Study of peach freshness predictive method based on electronic nose 显示文摘 | Hui Guohua Wu Yuling Ye Dandan | 2012 | Food Control2012，，166167： | 1 |
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