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| 1 | Control of Rice Embryo Development, Shoot Apical Meristem Maintenance, and Grain Yield by a Novel Cytochrome P450显示文摘被子植物种子通常由二主要部分组成:胚胎和内乳。然而,分子的机制 underlyingembryo 和内乳发展仍然保持大部分未知,特别地在米饭,模型谷物。这里,我们报导 identificationand 米饭巨人胚胎(GE ) 基因的功能的描述。GE 的变化在种子导致了一个大胚胎,它被胚鳞房间的过多的扩大引起。embryonic 以后 growthof ge 幼苗严重地由于有缺点的射击被禁止顶端的分裂组织(SAM ) 维护。基于地图的克隆表明 thatGE 编码对 endoplasmic 蜂窝胃局部性的 CYP78A 亚科 P450 monooxygenase。GE 在 scutellar 上皮主要被表示,在胚胎和内乳之间的接口区域。Overexpressionof GE 支持了细胞增长并且提高了米饭植物生长和谷物产量,但是减少了胚胎尺寸,建议 GE 为协调米饭胚胎和内乳开发是批评的。而且,转基因的 Arabidopsis 植物 overexpressing AtCYP78A10,一个 GE 相当或相同的事物,也生产的更大的种子,在一起调整种子 development.Taken 为 P450s 的 CYP78A 亚科暗示一个保存角色,我们的结果显示 GE 在调整胚胎发展和 SAM maintenance.Key 词起关键作用: | Weibing Yang Mingjun Gao Xin Yin Jiyun Liu Yonghan Xu Longjun Zeng Qun Li Shubiao Zhang Junmin Wang Xiaoming Zhang Zuhua He | 2013 | Molecular Plant2013，6，6： | 16 |
| 2 | NUMERICAL SIMULATION OF FLOW THROUGH ORIFICE ENERGY-DISSIPATORS IN XIAOLANGDI FLOOD-DISCHAR-GE TUNNEL显示文摘The cavitation of orifi ces is one of the main problems of the Xiaolangdi flood discharge tunnels. Along with the decompression experiment, the flow field was calculated in this paper by using an axis-symmetrical k-ε turbulence model. The calculated pressur e distribution was compared with the measured data and in agreement with each ot her. The calculated results show that few of the cavitation bubbles generating a t the orifice edge can reach the wall under the calculation condition, the force applied on the orifice surface and the flow pattern before the orifice may be i mproved obviously by adding the vortex elimination ring at the upper side of the orifice. | Qu, Jingxue Xu, Weilin Yang, Yongquan Wang, Wei Diao, Mingjun | 2000 | Journal of Hydrodynamics2000，12，3： | 14 |
| 3 | Antibacterial Performance of a Cu-bearing Stainless Steel against Microorganisms in Tap Water显示文摘Tap water is one of the most commonly used water resources in our daily life. However, the increasing water contamination and the health risk caused by pathogenic bacteria, such as Staphylococcus aureus and Escherichia coli have attracted more attention. The mutualism of different pathogenic bacteria may diminish antibacterial effect of antibacterial agents. It was found that materials used for making pipe and tap played one of the most important roles in promoting bacterial growth. This paper is to report the performance of an innovative type 304 Cu-bearing stainless steel(304Cu SS) against microbes in tap water. The investigation methodologies involved were means of heterotrophic plate count, contact angle measurements, scanning electron microscopy for observing the cell and subtract surface morphology,atomic absorption spectrometry for copper ions release study, and confocal laser scanning microscopy used for examining live/dead bacteria on normal 304 stainless steel and 304 Cu SS. It was found that the surface free energy varied after being immersed in tap water with polar component and Cu ions release.The results showed 304 Cu SS could effectively kill most of the planktonic bacteria(max 95.9% antibacterial rate), and consequently inhibit bacterial biofilms formation on the surface, contributing to the reduction of pathogenic risk to the surrounding environments. | Mingjun Li Li Nan Dake Xu Guogang Ren Ke Yang | 2015 | Journal of Materials Science & Technology2015，31，3： | 10 |
| 4 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 5 | Effect of direct current pulse stimulating acupoints of JiaJi (T10-L3) and Ciliao (BL 32) with Han's Acupoint Nerve Stimulator on labour pain in women: a randomized controlled clinical study显示文摘OBJECTIVE: To assess the clinical effect and safety of direct current(DC) pulse produced by Han's Acupoint Nerve Stimulator in reduction(HANS) of labor pain.METHODS: Totally 120 participants were enrolled in this clinical trial, and were randomly divided into4 groups including: HANS group, patient controlled intravenous analgesia(PCIA) group, patient-controlled epidural analgesia(PCEA) group and control group. The HANS group was treated by stimulating the acupoints of Jia Ji(T10-L3) and Ciliao(BL 32)with DC pulse of 100 Hz and 15-30 m A produced by a portable battery-powered Han's Acupoint Nerve Stimulator for 30 min. The PCIA group was intravenously infused Ondansetron(8 mg) for 5 min,then tramadol injection(1.5 mg/kg) was slowly dripped by using Baxter APⅡ electronic pump with50 m L tramadol(0.70%) + ondansetron(8 mg),background infusion 2 m L/h, PCA dose of 2 m L,lockout interval of 10 min. In PCEA group, women received intrathecal injection ropivacaine(3 mg) in L2-3, and epidural catheter was connected to Baxter APⅡ electronic pump, with 100 m L Ropivacaine(0.1%) and Sufentanil(50 ug), background infusion5 m L, Patient controlled analgesia(PCA) dose of 5m L, lockout interval of 10 min. The control group was not received analgesia. The visual analogue scale(VAS), stage and manner of labor, Apgar score of newborn, neonatal weights, oxytocin dosage,postpartum hemorrhage and side effects were monitored in all groups.RESULTS: The vital signs were all stable in the four analgesic groups. After analgesia, there was statistical difference in VAS score between HANS group and control group, between PCEA group and the control group, between PCIA group and control group. The analgesic effect in the PCEA group was significantly better than that of other two groups.The second stage of labor in the PCEA group was longer than the other three groups, showing significant difference between them. The Apgar score of newborn 1min after birth in the PCIA group was slightly lower than that of the other two groups,showing significant difference between them. The neonatal weights between four groups were not significantly different. The rate of cesarean sectionin the control group was significantly higher than that of the labor analgesia group, there was statistically difference in four groups. The number of PCIA group that used oxytocin was lower than that of other three groups. There was no significant difference in postpartum hemorrhage between four groups. The side effects of the PCEA group were itching, uroschesis and neonatal asphyxia and PCIA group were nausea and vomiting and neonatal asphyxia. However, fewer side effects were observed in the HANS group.CONCLUSION: The DC pulse produced by HANS may be a non-pharmacological alternative to labor pain with fewer side effects. | Liu Ye Xu Mingjun Che Xiangming He Junqin Guo Dandan Zhao Guosheng Zhang Guogang Zhang Shuo Kang Kai Zhang Chunlei Wang Yinan Li Shan Zhang Qinglin Xu Li Zhang Ming Han Bin Jing Yumiao Zhang Ning | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 4 |
| 6 | Urban-rural disparities in mild cognitive impairment and its functional subtypes among community- dwelling older residents in central China显示文摘background Substantial variations in the prevalence of mild cognitive impairment(MCI)and its subtypes have been reported,although mostly in geographically defined developed countries and regions.Less is known about MCI and its subtypes in rural areas of less developed central China.Aims The study aimed to compare the prevalence of MCI and its subtypes in residents aged 65 years or older in urban and rural areas of Hubei Province,China.Methods Participants aged 65 years or older were recruited between 2018 and 2019.Inperson structured interviews and clinical and neuropsychological assessments were performed at city health community centres and township hospitals.results Among 2644 participants without dementia,735 had MCI,resulting in a prevalence of 27.8%for total MCI,20.9%for amnestic MCI(aMCI)and 6.9%for non-amnestic MCI(naMCI).The prevalence of MCI in urban and rural areas was 20.2%and 44.1%,respectively.After adjusting for demographic factors,the prevalence of total MCI,aMCI and naMCI differed significantly between rural and urban areas(adjusted odds ratio(OR)2.10,1.44 and 3.76,respectively).Subgroup analysis revealed an association between rural socioeconomic and lifestyle disadvantage and MCI and its subtypes.Conclusions Our findings suggest that the prevalence of MCI among urban residents in central China is consistent with that in other metropolis areas,such as Shanghai,but the prevalence in rural areas is twice that in urban areas.Prospective studies and dementia prevention in China should focus on rural areas. | Dan Liu Lin Li Lina An Guirong Cheng Cong Chen Mingjun Zou Bo Zhang Xuguang Gan Lang Xu Yangming Ou Qingming Wu Ru Wang Yan Zeng | 2021 | General Psychiatry2021，34，5： | 3 |
| 7 | Overpotential-dependent shape evolution of gold nanocrystals grown in a deep eutectic solvent显示文摘这份报纸报导在胆碱氯化物脲(ChCl 脲) 的金 nanocrystals (Au NC ) 的过电位依赖者形状进化基于深最容易溶解的溶剂(DES ) 。生长过电位在调节 Au NC 的形状起一个关键作用,这被发现。Au NC 的形状进化连续地从凹面菱形的 dodecahedra (RD ) 到凹面立方体,八足类动物, cuboctahedral 盒子,并且最后,到空 octahedra (哦) 被小心地从 -0.50 在范围控制生长过电位到 -0.95 V 完成(对磅伪参考电极) 。另外,脲的存在在 Au NC 的形状进化是重要的。同样准备的 Au NC 的表面结构被扫描电子显微镜学(SEM ) 包括地描绘,传播电子显微镜学(TEM ) 和电气化学的研究。为 D 葡萄糖 electrooxidation 的同样准备的 Au NC 的 electrocatalytic 活动易感知地依赖于他们的形态学,这被表明。说明的结果使脱氢的葡萄糖在凹面 RD 和凹面上吸附了立方的 Au NC,这优先地在低电极潜力被转变到 gluconolactone。随后的 gluconolactone 氧化在八足类动物上有利地发生了与 { 111 } 截断的手臂并且空在高电极潜力的 OH。这研究开创一条新途径由把 DES 与电气化学的技术相结合开发 Au NC 的 surface-structurecontrolled 生长。另外,它为调节 NC 的 electrocatalytic 性质是重要的。 | Lu Wei Bangan Lu Mingjun Sun Na Tian Zhiyou Zhou Binbin Xu Xinsheng Zhao Shigang Sun | 2016 | Nano Research2016，9，11： | 2 |
| 8 | DYRK1A suppression restrains Mcl-1 expression and sensitizes NSCLC cells to Bd-2 inhibitors显示文摘Objective:Mcl-1 overexpression confers acquired resistance to Bcl-2 inhibitors in non-small cell lung cancer(NSCLC),but no direct Mcl-1 inhibitor is currently available for clinical use.Thus,novel therapeutic strategies are urgently needed to target Mcl-1 and sensitize the anti-NSCLC activity of Bcl-2 inhibitors.Methods:Cell proliferation was measured using sulforhodamine B and colony formation assays,and apoptosis was detected with Annexin V-FITC staining.Gene expression was manipulated using siRNAs and plasmids.Real-time PCR and Western blot were used to measure mRNA and protein levels.Immunoprecipitation and immunofluorescence were used to analyze co-localization o f dual specificity tyrosine-phosphorylation-regulated kinase 1A(DYRK1A)and Mcl-1.Results:Suppression of DYRK1A resulted in reduced Mcl-1 expression in NSCLC cells,whereas overexpression of DYRK1A significantly increased Mcl-1 expression.Suppression of DYRK1A did not alter Mcl-1 mRNA levels,but did result in an accelerated degradation o f Mcl-1 protein in NSCLC cells.Furthermore,DYRK1A mediated proteasome-dependent degradation o f Mcl-1 in NSCLC cells,and DYRK1A co-localized with Mcl-1 in NSCLC cells and was co-expressed with Mcl-1 in tumor samples from lung cancer patients,suggesting that Mcl-1 may be a novel DYRK1A substrate.We showed that combined therapy with harmine and Bcl-2 antagonists significantly inhibited cell proliferation and induced apoptosis in NSCLC cell lines as well as primary NSCLC cells.Conclusions:Mcl-1 is a novel DYRK1A substrate,and the role of DYRK1A in promoting Mcl-1 stability makes it an attractive target for decreasing Bcl-2 inhibitor resistance. | Yangling Li Dongmei Zhou Shuang Xu Mingjun Rao Zuoyan Zhang Linwen Wu Chong Zhang Nengming Lin | 2020 | Cancer Biology & Medicine2020，17，2： | 2 |
| 9 | Synthesis of novel superhard materials under ultrahigh pressure显示文摘Superhard materials are solids whose Vickers hardness is beyond 40 GPa. They have wide applications in industry such as cutting and polishing tools, wear-resistant coatings. Most preparations of superhard materials are conducted under extreme pressure and temperature conditions, not only for scientific investigations, but also for the practical applications. In this paper, we would introduce the recent progress on the design and preparations of novel superhard materials, mainly on nanopolycrystalline diamond, B–C–N superhard solid solutions, and cubic-Si3N4/diamond nanocomposites prepared under ultrahigh pressure and high temperature(HPHT), using multi-anvil apparatus based on the hinged-type cubic press. Bulk materials of all these superhard phases have been successfully synthesized and are systematically tested. We emphasize that ultra-HPHT method plays an important role in the scientific research and industrial production of superhard materials. It provides the driving forces for the light elements forming novel superhard phases as well as the way for sintering high-density nanosuperhard materials. | Chao Xu Duanwei He Haikuo Wang Wendan Wang Mingjun Tang Pei Wang | 2014 | Chinese Science Bulletin2014，59，36： | 2 |
| 10 | Privacy Preserving Hop-distance Computation in Wireless Sensor Networks显示文摘 | XIAO Mingjun HUANG Liusheng XU Hongli WANG Yang PEI Zegen | 2010 | Chinese Journal of Electronics2010，19，1： | 2 |
| 11 | A Multifunctional Sampling Chamber for Laser-Induced Breakdown Spectroscopy for On-Site Elemental Analysis显示文摘 | Wang Shuai Xu Mingjun Lin Qingyu | 2015 | Instrumentation Science and Technology2015，43，4： | 1 |
| 12 | Bipolar spin-filtering, rectifying and giant magnetoresistance effects in zigzag silicene nanoribbons with asymmetric edge hydrogenation显示文摘 | Dan Zhang Mengqiu Long Xiaojiao Zhang Can Cao Hui Xu Mingjun Li Kowksum Chan | 2014 | Chemical Physics Letters2014，，： | 1 |
| 13 | A nuclear localized protein ZCCHC9 is expressed in cerebral cortex and suppresses the MAPK signal pathway显示文摘The CCHC-type zinc finger motif has numerous biological activities (such as DNA binding and RNA binding) and can also mediate protein-protein interaction. This article gives a primary report about the human ZCCHC9 gene. Protein ZCCHC9 contains four CCHC motifs and is highly conserved in humans, mice, and rats. The whole cDNA sequence of the ZCCHC9 gene has been amplified by PCR and a number of plasmids have been constructed for further study. The results show that ZCCHC9 is localized in the nucleus, and especially concentrated in the nucleolus. It is highly expressed in the brain and testicles of the mouse. This has been confirmed by real-time reverse transcription polymerase chain reaction (RT-PCR). In situ hybridization of the mouse brain indicates that ZCCHC9 is mainly expressed in the cerebral cortex. Reporter gene assay shows that ZCCHC9 suppresses the transcription activities of NF-kappa B and SRE, and may play roles in the Mitogen-Activated Protein Kinase (MAPK) signaling transduction pathway. | Aidong Zhou Jianlin Zhou Liping Yang Mingjun Liu Hong Li Su Xu Mei Han Jian Zhang | 2008 | Journal of Genetics and Genomics2008，35，8： | 1 |
| 14 | Cytotoxici- ty and apoptosis induced by nanobacteria in human breast cancer cells 显示文摘 | ZHANG Mingjun LIU Shengnan XU Ge | 2014 | Int J Nanomedicine2014，9，1： | 1 |
| 15 | Plasma biomarkers and plaque strain predict long-term cardiovascular events in patients with acute coronary syndrome显示文摘To test whether circulating and intracoronary biomarkers and coronary plaque strain have additive values to Global Registry of Acute Coronary Events(GRACE) score for predicting long-term cardiovascular events in ACS patients. One hundred ACS patients were enrolled and the GRACE score and plasma levels and intracoronary gradients of a number of biomarkers were measured. Coronary plaque burden and morphology in non-critical stenotic plaques were determined by intravascular ultrasound(IVUS) technique, and the maximal shear strain(SSmax) and maximal area strain(ASmax) were determined by intravascular ultrasound elastography(IVUSE) technique. Patients were followed for cardiovascular events and the predictive values of clinical characteristics, plasma biomarkers and plaque parameters were compared with GRACE score, and the incremental values of these measurements to the GRACE score were assessed. GRACE score, plasma biomarkers and plaque strain were independent predictors of cardiovascular events. Combination of GRACE score, plasma biomarkers and plaque strains significantly improved the predictive value of the GRACE score alone with the receiver-operating characteristic area increased from0.457 to 0.667(P=0.014). The combination of circulating and intracoronary biomarkers, plaque strain and GRACE score provides a better predictive tool than GRACE score alone in patients with ACS. | Mingjun Xu Xiaobo Hu Lin Wang Wei Zhang Lindi Wu Jifu Li Yuguo Chen Pengfei Zhang Haijun Su Yaling Han Cheng Zhang Mei Zhang Yun Zhang | 2020 | Science China(Life Sciences)2020，63，2： | 1 |
| 16 | C50 for Propofol-Remifentanil Target-Controlled Infusion and Bispectral Index at Loss of Consciousness and Response to Painful Stimulus in Chinese Patients: A Multicenter Clinical Trial显示文摘 | Zhipeng Xu Fang Liu Yun Yue Tiehu Ye Bingxi Zhang Mingzhang Zuo Mingjun Xu Rongrong Hao Yuan Xu Ning Yang Xiangming Che | 2009 | Anesthesia & Analgesia2009，，2： | 1 |
| 17 | Association between epidermal growth factor gene rs4444903 polymorphism and risk of glioma显示文摘 | Mingjun Hu Hangyu Shi Zanfeng Xu Weiping Liu | 2013 | Tumor Biology2013，，3： | 1 |
| 18 | Characterization of refractive index distribution of polymer optical fiber显示文摘A focusing method is developed to characterize the refractive index profile of polymer optical fiber (POF). Based on the refractive index profile the theoretical bandwidth and the core index exponent a (a > 0) of POF are calculated. The results show that the value of theoretical bandwidth agrees well with the experimental data. | DAI Xinhua AI Xicheng LIU Zhimin YANG Mingjun YANG Guangying HAN Buxing XU Jian ZHANG Xianmin WU Xin | 2002 | Chinese Science Bulletin2002，47，12： | 1 |
| 19 | Feature modeling based on design catalogues for principle con- ceptual design显示文摘 | Feng Peien Xu Guorong Zhang Mingjun | 1996 | Artificial Intelligence for Engineer- ing Design Analysis and Mannfactureing1996，10，4： | 1 |
| 20 | Impact of substrate temperature on the microstructure, electrical and optical properties of sputtered nanoparticle V 2 O 5 thin films显示文摘 | Zhenfei Luo Zhiming Wu Xiangdong Xu Mingjun Du Tao Wang Yadong Jiang | 2010 | Vacuum2010，，2： | 1 |
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