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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | SARS-Coronavirus-2 Nsp13 Possesses NTPase and RNA Helicase Activities That Can Be Inhibited by Bismuth Salts显示文摘The ongoing outbreak of Coronavirus Disease 2019(COVID-19)has become a global public health emergency.SARScoronavirus-2(SARS-CoV-2),the causative pathogen of COVID-19,is a positive-sense single-stranded RNA virus belonging to the family Coronaviridae.For RNA viruses,virus-encoded RNA helicases have long been recognized to play pivotal roles during viral life cycles by facilitating the correct folding and replication of viral RNAs.Here,our studies show that SARS-CoV-2-encoded nonstructural protein 13(nsp13)possesses the nucleoside triphosphate hydrolase(NTPase)and RNA helicase activities that can hydrolyze all types of NTPs and unwind RNA helices dependently of the presence of NTP,and further characterize the biochemical characteristics of these two enzymatic activities associated with SARS-CoV-2 nsp13.Moreover,we found that some bismuth salts could effectively inhibit both the NTPase and RNA helicase activities of SARS-CoV-2 nsp13 in a dose-dependent manner.Thus,our findings demonstrate the NTPase and helicase activities of SARS-CoV-2 nsp13,which may play an important role in SARS-CoV-2 replication and serve as a target for antivirals. | Ting Shu Muhan Huang Di Wu Yujie Ren Xueyi Zhang Yang Han Jingfang Mu Ruibing Wang Yang Qiu Ding-Yu Zhang Xi Zhou | 2020 | Virologica Sinica2020，35，3： | 11 |
| 3 | The geochemical characteristics,geochronology and tectonic significance of the Carboniferous volcanic rocks of the Santanghu area in northeastern Xinjiang,China显示文摘The Santanghu area is located on the northeastern margin of the Junggar Basin,northern Xinjiang,Northwest China.The Carboniferous volcanic rocks in this area are widely distributed in Kaokesaiergaishan,Santanghu,Daheishan and Naomaohu districts,which are located to the north of the Kalameili Fault.These rocks,sourced from a cognate magma,consist of basic,intermediate,and acidic lavas,and pyroclastic rock.The basic volcanic rocks are enriched with large-ion lithophile elements(LILE),but are relatively depleted in high field strength elements(HFSE),and have an obvious negative Nb-Ta-Ti anomaly.They were most probably derived from a depleted mantle source,and during their ascent,these magmas were not contaminated by the crustal material as they underwent magma crystallization differentiation.Based on the Carboniferous volcanic assemblage and geochemical data,it is apparent that the early Carboniferous volcanism occurred in a subduction-related tectonic setting.New LA-ICP-MS zircon U-Pb analyses constrain the age of the andesite within the volcanic rocks as the early Carboniferous(328.9-331.3 Ma).Combined with the regional geological record,comprehensive analysis of the isotope geochronological data indicates that the subduction of the Junggar Ocean predates the early Carboniferous,and that the Santanghu island arc magmatism was induced by the subduction of the Junggar Ocean in the Carboniferous. | LI Wei LIU YiQun DONG YunPeng ZHOU XiaoHu LIU XiaoMing LI Hong FAN TingTing ZHOU DingWu XU XueYi CHEN JunLu | 2013 | Science China Earth Sciences2013，56，8： | 8 |
| 4 | Geology and geochemistry of the Bingdaban ophiolitic mélange in the boundary fault zone on the northern Central Tianshan Belt,and its tectonic implications显示文摘The properties and tectonic significance of the fault bound zone on the northern margin of the Central Tianshan belt are key issues to understand the tectonic framework and evolutionary history of the Tianshan Orogenic Belt. Based on the geological and geochemical studies in the Tianshan orogenic belt, it is suggested that the ophiolitic slices found in the Bingdaban area represent the remaining oceanic crust of the Early Paleozoic ocean between the Hazakstan and Zhungaer blocks. Mainly com-posed of basalts, gabbros and diabases, the ophiolites were overthrust onto the boundary fault be-tween the Northern Tianshan and Central Tianshan belts. The major element geochemistry is charac-terized by high TiO2 (1.50%-2.25%) and MgO (6.64%-9.35%), low K2O (0.06%-0.41%) and P2O5 (0.1%-0.2%), and Na2O>K2O as well. Low ΣREE and depletion in LREE indicate that the original magma was derived from a depleted mantle source. Compared with a primitive mantle, the geochemistry of the basalts from the Bingdaban area is featureded by depletion in Th, U, Nb, La, Ce and Pr, and unfrac-tionated in HFS elements. The ratios of Zr/Nb, Nb/La, Hf/Ta, Th/Yb and Hf/Th are similar to those of the typical N-MORB. It can be interpreted that the basalts in the Bingdaban area were derived from a de-pleted mantle source, and formed in a matured mid-oceanic ridge setting during the matured evolu-tionary stage of the Northern Tianshan ocean. In comparison with the basalts, the diabases from the Bingdaban area show higher contents of Al2O3, ∑REE and HFS elements as well as unfractionated incompatible elements except Cs, Rb and Ba, and about 10 times the values of the primitive mantle. Thus, the diabases are thought to be derived from a primitive mantle and similar to the typical E-MORB. The diabases also have slight Nb depletion accompanying no apparent Th enrichment compared with N-MORB. From studies of the regional geology and all above evidence, it can be suggested that the diabases from the Bingdaban area were formed in the mid-oceanic ridge of the Northern Tianshan ocean during the initial spreading stage. | DONG YunPeng ZHANG GuoWei ZHOU DingWu LUO JinHai ZHANG ChengLi XIA LinQi XU XueYi LI XiangMin | 2007 | Science China Earth Sciences2007，50，1： | 5 |
| 5 | Computing depth averaged flow using bounda fitted coordinates and staggered grid显示文摘 | Hong Yiping Zhou Xueyi Chen Yongcan | 2000 | Tsinghua Science and Technology2000，5，2： | 1 |
| 6 | Impact of ablation ratio on 5-year postoperative posterior corneal stability after refractive surgery:SMILE and FS-LASIK显示文摘Background:To investigate the impact of the ablation ratio on 5-year postoperative posterior corneal stability in myopic eyes after small incision lenticule extraction(SMILE)and femtosecond laser-assisted in situ keratomileusis(FS-LASIK)surgery.Methods:A prospective,nonrandomized,cohort study:80 eyes of 43 patients underwent SMILE surgery and 63 eyes of 32 patients underwent FS-LASIK surgery at the EYE&ENT Hospital,Fudan University.Ablation ratio was defined as lenticule thickness(SMILE cases)or ablation depth(FS-LASIK cases)divided by central corneal thickness(CCT).Posterior corneal elevation changes were recorded as posterior central elevation(PCE),posterior corneal surface at thinnest point(PTE)and posterior corneal mean elevation(PME).Patients were followed up at 6-month and 5-year interval to investigate the impact of the ablation ratio on posterior corneal elevation after SMILE and FSLASIK surgery.Results:PCE dropped at the 6-month follow-up for both SMILE(decreased by−1.11±2.93μm,P<0.05)and FSLASIK groups(decreased by−0.46±3.72μm,P<0.05).PTE also dropped in SMILE(reduced by−2.04±3.02μm,P<0.05)and FS-LASIK group(reduced by−1.28±4.21μm,P<0.05)at the 6-month follow-up.Stable PCE(elevation change:SMILE−0.28±4.03μm;FS-LASIK 0.79±4.13μm,P>0.05)and PTE(elevation change:SMILE−0.08±4.28μm;FS-LASIK 1.42±3.85μm,P>0.05)for both groups were recorded at the 5-year follow-up compared to the 6-month visit.Ablation ratio was strongly correlated with 5-year postoperative PCE(β=2.68±1.05,P<0.01)and PTE(β=2.35±1.17,P<0.05).Cut-off value for 5-year postoperative raised PCE and PTE was 27.3 and 27.1%,respectively.Conclusions:Ablation ratio was strongly correlated with postoperative posterior corneal elevation in a 5-year follow-up in both SMILE and FS-LASIK groups.PCE and PTE underwent slight backward displacement 6-month postoperatively and remain stable at the 5-year follow-up.Threshold of the ablation ratio for resisting forward displacement of posterior corneal surface was 27.3 and 27.1%for SMILE and FS-LASIK groups,respectively. | Meiyan Li Danjuan Yang Yu Zhao Weiming Yang Jianmin Shang Xueyi Zhou Peijun Yao Dong Yang Xue Lin Xingtao Zhou | 2020 | Eye and Vision2020，7，1： | 1 |
| 7 | Computing Depth-Averaged Flow Using Boundary-Fitted Coordinates and Staggered Grid显示文摘 | Hong Yiping Zhou Xueyi Chen Yongcan | 2000 | Tsinghua Science and Technology2000，5，2： | 1 |
| 8 | Efficacy and Safety of Dexamethasone Ointment on Recurrent Aphthous Ulceration显示文摘 | Chuanxia Liu Zengtong Zhou Guanjian Liu Qintao Wang Jiangang Chen Ling Wang Yongmei Zhou Guangying Dong Xueyi Xu Yuechun Wang Yiqing Guo Mei Lin Lan Wu Gefei Du Changlei Wei Xin Zeng Xiaoyi Wang Junzheng Wu Bingqi Li Gang Zhou Hongmei Zhou | 2012 | The American Journal of Medicine2012，，3： | 1 |
| 9 | Design Method for Throttle Holes Area of Tele- scopic Shock Absorber for Small Electric Vehicles 显示文摘 | Zhou Changcheng Zheng Zhiyun Zhang Xueyi | 2009 | Journal of Asian Electric Vehicles2009，7，1： | 1 |
| 10 | Design Method for Throttle Holes Area of Telescopic Shock Absorber for Small Electric Vehicles 显示文摘 | Zhou Changcheng Zheng Zhiyun Zhang Xueyi | 2009 | Journal of Asian Electric Vehicles2009，7，1： | 1 |
| 11 | Predominant expression of β-chain variable region genes of T-cell receptor in TILs from human renal cell carcinoma显示文摘THE repertoire of T-cell antigen receptor(TcR)can be effectively analysed by an approachwith quantitative polymerase chain reaction(qPCR),which allows to characterize the ex-panding T-cell clones by the patterns of restricted usage of TcR V and J region genes. | LI Xueyi, WANG Ying, ZHENG Zhongcheng, ZHANG Dongqing, FUSaili, LING Jianyu and ZHOU Guangyan (CHOU Kuangyen)1. Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025, China 2. Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai 200031, China 3. Shanghai Ruijin Hospital, Shanghai 200025, China | 1997 | Chinese Science Bulletin1997，42，8： | 0 |
| 12 | On-chip photonic spatial-temporal descrambler显示文摘As an indispensable part to compensate for the signal crosstalk in fiber communication systems,conventional digital multi-input multi-output(MIMO)signal processor is facing the challenges of high com-putational complexity,high power consumption and relatively low processing speed.The optical MIMOenables the best use of light and has been proposed to remedy this limitation.However,the currently existing optical MIMO methods are all restricted to the spatial di-mension,while the temporal dimension is neglected.Here,an on-chip spatial-temporal descrambler with four channels were devised and its MIMO functions were experimentally verified simultaneously in both spatial and temporal dimensions.The spatial crosstalk of single-channel descrambler and four-channel descrambler is respectively less than-21 dB and-18 dB,and the time delay is simultaneously com-pensated successfully.Moreover,a more universal model extended to mode-dependent loss and gain(MDL)compensation was further de-veloped,which is capable of being cascaded for the real optical trans-mission system.The first attempt at photonic spatial-temporal de-scrambler enriched the varieties of optical MIMO,and the proposed scheme provided a new opportunity for all-optical MIMO signal pro-cessing. | Wenkai Zhang Xueyi Jiang Wentao Gu Junwei Cheng Hailong Zhou Jianji Dong Dongmei Huang Xinliang Zhang | 2023 | Chip2023，2，2： | 0 |
| 13 | Impact of ablation ratio on 5-year postoperative posterior corneal stability after refractive surgery:SMILE and FS-LASIK显示文摘Background:To investigate the impact of the ablation ratio on 5-year postoperative posterior corneal stability in myopic eyes after small incision lenticule extraction(SMILE)and femtosecond laser-assisted in situ keratomileusis(FS-LASIK)surgery.Methods:A prospective,nonrandomized,cohort study:80 eyes of 43 patients underwent SMILE surgery and 63 eyes of 32 patients underwent FS-LASIK surgery at the EYE&ENT Hospital,Fudan University.Ablation ratio Was defined as lenticule thickness(SMILE cases)or ablation depth(FS-LASIK cases)divided by central corneal thickness(CCT).Posterior corneal elevation changes were recorded as posterior central elevation(PCE),posterior corneal surface at thinnest point(PTE)and posterior corneal mean elevation(PME).Patients were followed up at 6-month and 5-year intervals to investigate the impact of the ablation ratio on posterior corneal elevation after SMILE and FS-LASIK surgery.Results:PCE dropped at the 6-month follow-up for both SMILE(decreased by-1.11±2.93μm,P<0.05)and FSLASIK groups(decreased by-0.46±3.72μm,P<0.05).PTE also dropped in SMILE(reduced by-2.04±3.02μm,P<0.05)and FS-LASIK group(reduced by-1.28±4.21μm,P<0.05)at the 6-month follow-up.Stable PCE(elevation change:SMILE-0.28±4.03μm;FS-LASIK 0.79±4.13μm,P>0.05)and PTE(elevation change:SMILE-0.08±4.28μm;FS-LASIK 1.42±3.85μm,P>0.05)for both groups were recorded at the 5-year follow-up compared to the 6-month visit.Ablation ratio was strongly correlated with 5-year postoperative PCE(β=2.68±1.05,P<0.01)and PTE(β=2.35±1.17,P<0.05).Cut-off value raised for 5-year postoperative PCE and PTE was 27.3%and 27.1%,respectively.Conclusions:Ablation ratio was strongly correlated with postoperative posterior corneal elevation in a 5-year follow-up in both SMILE and FS-LASIK groups.PCE and PTE underwent slight backward displacement 6 months postoperatively and remain stable at the 5-year follow-up.Threshold of the ablation ratio for resisting forward displacement of posterior corneal surface Was 27.3%and 27.1%for SMILE and FS-LASIK groups,respectively. | Meiyan Li Danjuan Yang Yu Zhao Weiming Yang Jianmin Shang Xueyi Zhou Peijun Yao Dong Yang Xue Lin Xingtao Zhou | 2023 | Eye and Vision2023，9，1： | 0 |
| 14 | Liposome-coated CaO_(2)nanoblockers for enhanced checkpoint blockade therapy by inhibiting PD-L1 de novo biosynthesis显示文摘The blocking of the immune checkpoint pathway with antibodies,especially targeting to programmed death-1/programmed death ligand-1(PD-1/PD-L1)pathway,was currently a widely used treatment strategy in clinical practice.However,the shortcomings of PD-L1 antibodies were constantly exposed with the deepening of its research and their therapeutic effect was limited by the translocation and redistribution of intracellular PD-L1.Herein,we proposed to improve immune checkpoint blockade therapy by using liposomes-coated CaO_(2)(CaO_(2)@Lipo)nanoparticles to inhibit the de novo biosynthesis of PD-L1.CaO_(2)@Lipo would produce oxygen and reduce hypoxia-inducible factor-1α(HIF-1α)level,which then downregulated the expression of PD-L1.Our in vitro and in vivo results have confirmed CaO_(2)@Lipo promoted the degradation of HIF-1αand then downregulated the expression of PD-L1 in cancer cells for avoiding immune escape.Furthermore,to mimicking the clinical protocol of anti-PD-L1 antibodies+chemo-drugs,CaO_(2)@Lipo was combined with doxorubicin(DOX)to investigate the tumor inhibition efficiency.We found CaO_(2)@Lipo enhanced DOX-induced immunogenic cell death(ICD)effect,which then promoted the infiltration of T cells,strengthened the blocking effect,thus provided an effective means to overcome the traditional immune checkpoint blockade treatment. | Ruijun Che Dandan Han Fei Wang Huifang Liu Miao Fan Hongyu Yan Tingshan Xiao Zhaoshuo Wang Xiaohan Zhou Xueyi Wang Kaihan Zhang Caiwen Ou Jinchao Zhang Zhenhua Li | 2023 | Nano Research2023，16，5： | 0 |
| 15 | Ectopic expression of poplar gene PsnERF138 in tobacco confers salt stress tolerance and growth advantages显示文摘The AP2/ERF family is one of the largest plant-specific transcription factors and plays a vital role in plant growth and stress response.In this study,PsnERF138 was cloned from Populus alba×Populus glandulosa and transformed into tobacco using the Agrobacterium-mediated transformation method.PsnERF138 was localized in the nucleus through subcellular localization assay in tobacco.Under normal conditions,the root lengths of PsnERF138 transgenic lines were much longer than those of wild type.Under salt stress,the transgenic tobacco lines over-expressing PsnERF138 showed a significant increase in seed germination rate,plant height,and root length,compared to control plants.In addition,the transgenic tobacco lines displayed some advantages at the physiological level,such as higher superoxide dismutase(SOD)activity,peroxidase(POD)activity,proline content,and lower malondialdehyde(MDA)content,as compared to those in the control plants.Histochemical staining also showed that the transgenic tobacco lines had lower reactive oxygen species(ROS)accumulation,compared to control plants under salt stress.The combined results indicate that poplar PsnERF138 plays a contributing role in augmenting salt tolerance and conferring multiple growth advantages as being overexpressed in tobacco. | Lin Liu Zihan Cheng Wenjing Yao Xueyi Wang Fenglin Jia Boru Zhou Tingbo Jiang | 2021 | Forestry Research2021，1，1： | 0 |
| 16 | Signal-on bimodal sensing glucose based on enzyme product-etching MnO_(2)nanosheets for detachment of MoS_(2)quantum dots显示文摘The sensitive and rapid detection of blood glucose is very important for monitoring and managing diabetes.Herein,a fluorescent/magnetic bimodal sensing strategy is proposed for glucose detection using a multifunction-responsive nanocomposite(MoS_(2)QDs-MnO_(2)NS).MoS_(2)QDs act as fluorescent probes,and MnO_(2)nanosheets are used as both quenchers and recognizers in this sensing platform.In the presence of glucose-mediated enzyme product(H_(2)O_(2)),MnO_(2)nanosheet is etched,thus releasing MoS_(2)QDs and Mn^(2+)ions,which causes the significantly enhancement of fluorescent and magnetic signals.Furthermore,MoS_(2)QDs-MnO_(2)NS-based fluorescent test paper is constructed for H_(2)O_(2)sensing with the naked eyes.Under optimal conditions,the dual linear ranges of 20-300μmol/L and 40-250μmol/L toward glucose detection are obtained for the fluorescent and magnetic mode,respectively.Furthermore,this bimodal assay exhibits good reproducibility and acceptable accuracy in glucose detection of clinical samples,demonstrating great versatility and flexibility of multifunctional probes in glucose detection. | Lingzhi Chen Xueqin Huang Xueyi Zeng Guiting Fang Weijian Chen Haibo Zhou Xing Zhong Huaihong Cai | 2021 | Chinese Chemical Letters2021，32，6： | 0 |
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