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| 1 | PART BUILDING ORIENTATION OPTIMIZATION METHOD IN STEREOLITHOGRAPHY显示文摘在立体声平版印刷术(SL ) 瞄准部分质量和大楼时间问题由无理的大楼取向引起了,在 SLrapid 原型(RP ) 的一个部分大楼取向决定方法被执行。带进变丑的完整的考虑,走楼梯的效果在与部分制造取向有关的痊愈效果和大楼时间上,并且用评估功能方法,为造的取向的一个多客观的优化模型被定义。根据在在用标准三角测量语言(STL ) 的三角形的方面的向量建模的正常和 z 轴之间的角度的差别,变丑区域的表情,走楼梯的区域,在痊愈上,区域被建立。根据在 SL 过程的特征,部分大楼时间被划分成四节,也就是说孵化扫描时间,扫描时间的轮廓,支持大楼时间和等待时间的层。每造的时间节的表情被给。就这个优化模型的特征而言,基因算法(GA ) 被用来导出优化客观、相关软件被开发,优化结果通过实验被测试。这个方法有效地装的应用程序表演解决造取向的无理的部分引起的质量和效率麻烦,一个自动决定取向的程序通过测试被开发并且验证。 | HONG Jun WANG Wei TANG Yiping | 2006 | Chinese Journal of Mechanical Engineering2006，19，1： | 7 |
| 2 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 3 | Effect of pyrophosphate on the light scatter in KDP crystal显示文摘Pyrophosphate doped potassium dihydrogen phosphate (KDP) crystal was grown from aqueous solution by the temperature lowering method. Light scatter in KDP crystal was detected with the ultramicroscopic method. The light scatter in KDP crystal was aggravated when pyro-phosphate was doped into the growth solution, which was distributed ununiformly in prism and pyramidal sectors of KDP crystal. Different effects of pyrophosphate on prism and pyramidal sectors of KDP crystal can explain this case. The transmission in this crystal was measured, showing that pyrophosphate affects the transmission evidently. | Xun Sun Xinguang Xu Youjun Fu Shenglai Wang Hong Zeng Yiping Li Zhangshou Gao | 2001 | Chinese Science Bulletin2001，46，5： | 3 |
| 4 | Statistical Analysis of Regularity of Pesticide Residues in Vegetables Produced in Inner Mongoli显示文摘[Objective]The paper was to study regularity of pesticide residues in vegetables produced in Inner Mongolia.[Method]Mathematical statistic analysis was carried out on 6 800 samples of veggies,fruits,leguminous vegetables,nuts and seeds produced in Inner Mongolia.[Result]The dominated vegetables in Inner Mongolia were green leafy vegetables,solanaceous vegetables and melon vegetables,and their yields accounted for 70%of the total vegetables production.Since 2003,with the rapid increase of detected vegetable numbers,the status of vegetable quality safety had entered into a new stage of sustainable steady after a rapid decline or periodic fluctuation,and the differences in safety levels were obvious,of which the range of exceeding standard rate of pesticide residues in solanaceous vegetables,melon vegetables and leguminous vegetables(about 55%of the total vegetables)was under 2%,with average values of 1.1%,1.6%and 3.1%,respectively.They belonged to stable type.The exceeding standard rate of pesticide residues in green leafy vegetables and Chinese cabbage group(about 30%of total vegetables)presented a decreasing trend year by year,wondering in the range of 7%-10%.They belonged to main risk type.The time period of exceeding standard of pesticide residues in root vegetables and cole vegetables was under predictable,and its exceeding standard rate in some years was over 5%(amplitude variation is over 15percentage points).They belonged to random risk type.The kinds of pesticides,which exceeding standard rate in vegetables were relatively intensive,presented variance in different vegetable species.70%of the pesticides belonged to intermittent over-limits and the probability was below 5%.About 20%tradition pesticides often exceeded standard and their probabilities were over 30%.The exceeding standard of organophosphorus and carbamates pesticides in vegetables presented a decreasing tend,while the risk of some new pesticides containing nitrogen element and high effective pyrethroids showed an increasing tendency.[Conclusion]The paper provided decision making services for agricultural management departments. | Fujin ZHANG Dekun HOU Jiang HE Tianyun GAO Hong LUO Songyan LANG Xinxin ZHANG Yiping YAO | 2013 | Agricultural Science & Technology2013，14，10： | 2 |
| 5 | Computing depth averaged flow using bounda fitted coordinates and staggered grid显示文摘 | Hong Yiping Zhou Xueyi Chen Yongcan | 2000 | Tsinghua Science and Technology2000，5，2： | 1 |
| 6 | Multidisciplinary approach for the management of term pregnancy complicated by Eisenmenger syndrome显示文摘Pregnancy in patients with Eisenmenger syndrome(ES)is associated with high maternal mortality rates of 30%‒50%,or even up to 65%in the case of a cesarean section(Yuan,2016).Here,we report a case of term pregnancy complicated with ES and severe pulmonary artery hypertension(PAH),which was managed by a multidisciplinary team(MDT)and resulted in an uncomplicated delivery via elective cesarean section.The goal of this study is to emphasize the importance of multidisciplinary approach in the management of pregnancy with ES,which can profoundly improve maternal and infant outcomes. | Shibin HONG Xin KANG Ka ULIO Yiping LE Chuan WANG Jianhua LIN Ning ZHANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，1： | 1 |
| 7 | Investigation of viscosity effect on droplet formation in T-shaped microchannels by numerical and analytical methods显示文摘 | Long Sang Hong Yiping Wang Fujun | 2009 | Microfluidics and Nanofluidics2009，6，5： | 1 |
| 8 | Flotation separation of diaspore from kaolinite, pyrophyllite and illite using three cationic collectors显示文摘 | Hong Zhong Guangyi Liu Liuyin Xia Yiping Lu Yuehua Hu Shenggui Zhao Xinyang Yu | 2008 | Minerals Engineering2008，，： | 1 |
| 9 | A novel approach for preferential flotation recovery of molybdenite from a porphyry copper-molybdenum ore 显示文摘 | Guangyi Liu Yiping Lu Hong Zhong | 2012 | Minerals engineering2012，，10： | 1 |
| 10 | Simultaneous determination of (fluoro) quinolones antibacterials resi- dues in bovine milk using ultra performance liquid chro- matography-tandem mass spectrometry 显示文摘 | ZHANG Hong REN Yiping BAO Xiaoli | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，49，2： | 1 |
| 11 | Simultaneous de-rminadon of (fluoro) quinolones antibactcriais residues in bovine milk using ultra performance liquid chromatography-tandem mass spectrometry显示文摘 | ZHANG Hong PEN Yiping BAO Xiaoli | 2009 | Jour- nal of Pharmaceutical and Biomedical Analysis2009，49，2： | 1 |
| 12 | Computing Depth-Averaged Flow Using Boundary-Fitted Coordinates and Staggered Grid显示文摘 | Hong Yiping Zhou Xueyi Chen Yongcan | 2000 | Tsinghua Science and Technology2000，5，2： | 1 |
| 13 | Effects of the bias-controlled grid on performances of the corona poling system for electro-optic polymers显示文摘 | Hong Jianxun Chen Jianping Wang Yiping | | 0，，： | 1 |
| 14 | A novel ap- proach for preferential flotation recovery of molybdenite from a porphyry copper-molybdenum ore 显示文摘 | Liu Guangyi Lu Yiping Zhong Hong | 2012 | Minerals Engineering2012，36，： | 1 |
| 15 | Numerical modeling of a Newtonian and a Bingham fluid in a Rayleigh step bearing 显示文摘 | HONG Yiping CHEN Darong WANG Jiadao | 2003 | Transactions of ASME Journal of Tribology2003，125，： | 1 |
| 16 | Improved mean shift segmentation approach for natural images 显示文摘 | Yiping Hong Jianqiang Yi Dongbin Zhao | 2007 | Ap- plied Mathematics aml Computation2007，185，： | 1 |
| 17 | Improved mean shift segmentation approach for natural images显示文摘 | Hong Yiping Yi Jianqiang Zhao Dongbin | 2007 | Applied Mathematics and Computation2007，185，2： | 1 |
| 18 | Effects of impurities on growth habit of KDP crystal显示文摘The effects of metaphosphate, boric acid and quaternary ammonium cations with different concentration on the growth habit of KDP crystal are reported. The results are analyzed and discussed, which show that the effects of different impurities on the growth habit of KDP are not the same. It is due to the different adsorption mechanism of the impurities. | Sun Xun Fu Youjun Gao Zhangshou Wang Shenglai Zeng Hong Li Yiping | 2001 | Chinese Science Bulletin2001，46，13： | 0 |
| 19 | miR-126 mitigates the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting the ERK1/2 and Bcl-2 pathways显示文摘Human bone marrow mesenchymal stem cells(hBMMSCs)are a promising cell source for bone engineering owing to their high potential to differentiate into osteoblasts.The objective of the present study is to assess microRNA-126(miR-126)and examine its effects on the osteogenic differentiation of hBMMSCs.In this study,we investigate the role of miR-126 in the progression of osteogenic differentiation(OD)as well as the apoptosis and inflammation of hBMMSCs during OD induction.OD is induced in hBMMSCs,and matrix mineralization along with other ODassociated markers are evaluated by Alizarin Red S(AR)staining and quantitative PCR(qPCR).Gain-and loss-offunction studies are performed to demonstrate the role of miR-126 in the OD of hBMMSCs.Flow cytometry and qPCR-based cytokine expression studies are performed to investigate the effect of miR-126 on the apoptosis and inflammation of hBMMSCs.The results indicate that miR-126 expression is downregulated during the OD of hBMMSCs.Gain-and loss-of function assays reveal that miR-126 upregulation inhibits the differentiation of hBMMSCs into osteoblasts,whereas the downregulation of miR-126 promotes hBMMSC differentiation,as assessed by the determination of osteogenic genes and alkaline phosphatase activity.Furthermore,the miR-126 level is positively correlated with the production of inflammatory cytokines and apoptotic cell death.Additionally,our results suggest that miR-126 negatively regulates not only B-cell lymphoma 2(Bcl-2)expression but also the phosphorylation of extracellular signal-regulated protein kinase(ERK)1/2.Moreover,restoring ERK1/2 activity and upregulating Bcl-2 expression counteract the miR-126-mediated suppression of OD in hBMMSCs by promoting inflammation and apoptosis,respectively.Overall,our findings suggest a novel molecular mechanism relevant to the differentiation of hBMMSCs into osteoblasts,which can potentially facilitate bone formation by counteracting miR-126-mediated suppression of ERK1/2 activity and Bcl-2 expression. | Ying Zhang Yiping Dong Qiushi Wei Zhikun Zhuang Youwen Liu Qiang Yuan Wei He Zhenhao Jing Jitian Li Peifeng Li Leilei Zhang Zhinan Hong Ning Zhang Haibin Wang Wuyin Li | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
| 20 | Construction and application of gene targeting replacement vector formouse coagulation factor IX gene显示文摘Objective: To construct and apply a replacement targeting vector for mouse coagulation factor IX(mFIX) gene in embryonic stem (ES) cells. Methods: Based on the cloning and structural analysis of the genomic DNA fragment of coagulation factor IX gene from 129Sv mouse genomic DNA A phage library, PMFIXDEL plasmid was designed with positive-negative-selection (PNS) strategy, and constructed with commonmolecular cloning techniques. Structure of PMFIXDEL was identified by PCR and restriction analysis. Afterelectroporation with the linearized PMFIXDEL DNA, transfected ES cells were cultured in G418/GANC drugselection medium. The recombination efficacy of this vector was tested. Results: The main components ofPMFIXDEL were two copies of negative selection gene (HSV-tk expression cassette), a positive selectiongene (Neo expression cassette), long and short homologous fragments and plasmid backbone. The introduction of negative selection gene (HSV-tk ) into the construct resulted in 24-fold increase of selection.Conclusion: An effective replacement vector for mFIX gene targeting was constructed and applied in ES cell. | Dai Xuming’ Xue Hong Yang Hual Hu Yiping’ Fu Jiliang (Open Laboratory of Medical Molecular Genetics, Department of Basic Medicine Science, Second MilitaryMedical University, Shanghai, 200433)(Department of Biochemistry, hong Kong University of Scienc | 1998 | Journal of Medical Colleges of PLA(China)1998，13，2： | 0 |
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