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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Human umbilical cord mesenchymal stem cells promote peripheral nerve repair via paracrine mechanisms显示文摘Human umbilical cord-derived mesenchymal stem cells(h UCMSCs) represent a promising young-state stem cell source for cell-based therapy. h UCMSC transplantation into the transected sciatic nerve promotes axonal regeneration and functional recovery. To further clarify the paracrine effects of h UCMSCs on nerve regeneration, we performed human cytokine antibody array analysis, which revealed that h UCMSCs express 14 important neurotrophic factors. Enzyme-linked immunosorbent assay and immunohistochemistry showed that brain-derived neurotrophic factor, glial-derived neurotrophic factor, hepatocyte growth factor, neurotrophin-3, basic fibroblast growth factor, type I collagen, fibronectin and laminin were highly expressed. Treatment with h UCMSC-conditioned medium enhanced Schwann cell viability and proliferation, increased nerve growth factor and brain-derived neurotrophic factor expression in Schwann cells, and enhanced neurite growth from dorsal root ganglion explants. These findings suggest that paracrine action may be a key mechanism underlying the effects of h UCMSCs in peripheral nerve repair. | Zhi-yuan Guo Xun Sun Xiao-long Xu Qing Zhao Jiang Peng Yu Wang | 2015 | Neural Regeneration Research2015，10，4： | 26 |
| 3 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 4 | Soil Organic Carbon,Carbon Fractions and Nutrients as Affected by Land Use in Semi-Arid Region of Loess Plateau of China显示文摘Cropland (CP),native grassland (NG) and two shrub land treatments which were converted from cropland in 1985:seabuckthorn (Hippophae rhamnoides L.) (ST),and branchytamarisk (Tamarix ramosissima) (BT) were investigated to evaluate effects of land use conversion on soil organic carbon (SOC) and soil nutrients in the semi-arid region of the Loess Plateau of China.Total organic carbon (TOC),light fraction organic carbon (LFOC),heavy fraction organic carbon (HFOC),total N (TN),nitrate nitrogen (NO 3-N) and nitrite nitrogen (NO 2-N),ammonium nitrogen (NH + 4-N),total P,and available P (AP) were measured.The results showed that SOC in NG,ST and BT were 12.7%,27.7% and 34.8% higher than that of the cropland,respectively.LFOC,light fraction (LF) dry matter,ratio of TOC to TN (C/N) and the ratio of TOC to AP (C/P) were higher in the shrub land or native grassland than in the cropland.Cropland had the highest TN,the sum of NO 3-N and NO 2-N,TP and AP due to the use of chemical fertilizers.TOC significantly correlated with LFOC,HFOC and C/N.LFOC significantly correlated with dry matter of the LF and C/N.TN,the sum of NO 3-N and NO 2-N and AP were significantly negatively correlated with TOC and LFOC.Therefore,land use conversion from cropland to shrub land,or maybe grassland,contributed to SOC sequestration and improved soil nutrients stabilization. | LIU Xun,LI Feng-Min,LIU Da-Qian and SUN Guo-Jun Key Laboratory of Arid and Grassland Ecology of the Ministry of Education,School of Life Sciences,Lanzhou University,Lanzhou 730000 (China) | 2010 | Pedosphere2010，20，2： | 19 |
| 5 | Intercropping with Solanum nigrum and Solanum photeinocarpum from Two Ecoclimatic Regions Promotes Growth and Reduces Cadmium Uptake of Eggplant Seedlings显示文摘Soil contamination by heavy metals is a serious environmental problem worldwide, and reduction of heavy metal accumulation in vegetables grown on contaminated land is a matter of urgency. A pot experiment was conducted to study the effects of intercropping with the Cd hyperaccumulators Solanum nigrum and Solanum photeinocarpum from two ecoclimatic regions, Ya'an and Chengdu,Sichuan Province, China, on the growth and cadmium(Cd) uptake of eggplant(Solanum melongena L.). The biomass, photosynthetic pigment contents, and activities of antioxidant enzymes of eggplant were enhanced by intercropping. The biomass of eggplant was the highest after intercropping with S. photeinocarpum from Ya'an, but did not differ significantly from that after intercropping with S. nigrum from Chengdu. The shoot Cd content of eggplant was significantly reduced by intercropping with the hyperaccumulators,which ranked as follows: S. nigrum from Chengdu > S. nigrum from Ya'an > S. photeinocarpum from Chengdu > S. photeinocarpum from Ya'an, with the decreases being 19.60%, 14.36%, 9.66%, and 6.42%, respectively, as compared with the control. The lowest shoot Cd content and translocation factor of eggplant were attained after intercropping with S. nigrum from Chengdu. Therefore, it was feasible to intercrop eggplant with S. nigrum and S. photeinocarpum on Cd-contaminated soil. | TANG Yi HE Juan YU Xuena XIE Yongdong LIN Lijin SUN Guochao LI Huanxiu LIAO Mingan LIANG Dong XIA Hui WANG Xun ZHANG Jing LIU Zejing TU Lihua LIU Li | 2017 | Pedosphere2017，27，3： | 17 |
| 6 | Calycosin-7-O-β-D-glucopyranoside stimulates osteoblast differentiation through regulating the BMP/WNT signaling pathways显示文摘The iso fl avone calycosin-7-O-β-D-glucopyranoside(CG) is a principal constituent of Astragalus membranaceus(AR) and has been reported to inhibit osteoclast development in vitro and bone loss in vivo. The aim of this study was to investigate the osteogenic effects of CG and its underlying mechanism in ST2 cells. The results show that exposure of cells to CG in osteogenic differentiation medium increases ALP activity, osteocalcin(Ocal) m RNA expression and the osteoblastic mineralization process. Mechanistically, CG treatment increased the expression of bone morphogenetic protein 2(BMP-2), p-Smad 1/5/8, β-catenin and Runx2, all of which are regulators of the BMP- or wingless-type MMTV integration site family(WNT)/β-catenin-signaling pathways. Moreover, the osteogenic effects of CG were inhibited by Noggin and DKK-1 which are classical inhibitors of the BMP and WNT/β-catenin-signaling pathways, respectively. Taken together, the results indicate that CG promotes the osteoblastic differentiation of ST2 cells through regulating the BMP/WNT signaling pathways. On this basis, CG may be a useful lead compound for improving the treatment of bone-decreasing diseases and enhancing bone regeneration. | Jing Jian Lijuan Sun Xun Cheng Xiaofang Hu Jichao Liang Yong Chen | 2015 | Acta Pharmaceutica Sinica B2015，5，5： | 16 |
| 7 | Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4显示文摘补充 32 的反应基因(RGC-32 ) 是涉及房间的增长,区别和迁居的一个房间周期管理者并且也在 angiogenesis 被含有。这里,我们证明在巨噬细胞的那 RGC-32 表情被 IL-4 导致并且由 LPS 减少了,显示在 RGC-32 表示和 M2 极化之间的一个连接。我们证明 RGC-32 的增加的表示或者激活的巨噬细胞,这蛋白质在压制支持 inflammatory cytokine IL-6 的生产并且支持反煽动性的调停人 TGF-β 的生产是特征的;。与一致在 vitro,数据, RGC-32 高级的联系肿瘤的巨噬细胞(TAM ) 快车,和这个表达式被导出肿瘤的腹水的液体以一种 M-CSF- 或 IL-4-dependent 方式导致。一起,这些结果为 M2 巨噬细胞极化作为一个标记建立 RGC-32 并且显示这蛋白质是为癌症免疫疗法的一个潜在的目标,指向联系肿瘤的巨噬细胞。 | Peng Zhao Daiqing Gao Qingjie Wang Bingfeng Song Qianqian Shao Jintang Sun Chunyan Ji Xingang Li Peng Li Xun Qu | 2015 | Cellular & Molecular Immunology2015，12，6： | 12 |
| 8 | Mixed micelles loaded with sil.ybin-polyene phosphatidylcholine complex improve drug solubility显示文摘 | Rui-ling DUAN Xun SUN Jie LIU Tao GONG Zhi-rong ZHANG | 2011 | Acta Pharmacologica Sinica2011，32，1： | 12 |
| 9 | An experimental and thermodynamic equilibrium investigation of the Pb,Zn,Cr,Cu,Mn and Ni partitioning during sewage sludge incineration显示文摘The effects of different chlorides and operational conditions on the distribution and speciation of six heavy metals(Pb, Zn, Cr, Cu, Mn and Ni) during sludge incineration were investigated using a simulated laboratory tubular-furnace reactor. A thermodynamic equilibrium investigation using the Fact Sage software was performed to compare the experimental results. The results indicate that the volatility of the target metals was enhanced as the chlorine concentration increased. Inorganic-Cl influenced the volatilization of heavy metals in the order of Pb > Zn > Cr > Cu > Mn > Ni. However, the effects of organic-Cl on the volatility of Mn, Pb and Cu were greater than the effects on Zn, Cr and Ni.With increasing combustion temperature, the presence of organic-Cl(PVC) and inorganic-Cl(NaCl) improved the transfer of Pb and Zn from bottom ash to fly ash or fuse gas. However,the presence of chloride had no obvious influence on Mn, Cu and Ni. Increased retention time could increase the volatilization rate of heavy metals; however, this effect was insignificant. During the incineration process, Pb readily formed Pb SiO4 and remained in the bottom ash. Different Pb compounds, primarily the volatile PbCl2, were found in the gas phase after the addition of NaCl; the dominant Pb compounds in the gas phase after the addition of PVC were PbCl2, Pb(ClO4)2and Pb Cl2O4. | Jingyong Liu Jiewen Fu Xun'an Ning Shuiyu Sun Yujie Wang Wuming Xie Shaosong Huang Sheng Zhong | 2015 | Journal of Environmental Sciences2015，27，9： | 11 |
| 10 | Stromal cell derived factor-1 enhances bone marrow mononuclear cell migration in mice with acute liver failure显示文摘AIM:To evaluate the number of bone marrow mononuclear cells(BMMC) that are migrated to the liver following transplantation of murine BMMC into mice with acute liver injury.METHODS:BMMC were isolated from the bone marrow of mice in a lymphocyte separation medium and then labeled with PKH26.The labeled cells were subsequently infused into the caudal veins of BALB/c mice with hepatic injury induced by carbon tetrachloride and 2-acetylaminofluorene.Mice in experimental group were treated with stromal cell-derived factor-1(SDF-1) which was injected intraperitoneally after trans-plantation of BMMC.Mice in control group were injected intraperitoneally with 0.1 mL of saline(0.9% NaCl) after transplantation of BMMC.After 2 wk,migration of the cells in experimental group was studied by fluorescence microscopy.The expression of proliferating cell nuclear antigen and albumin was quantified with manual methods in both groups.The serum transaminase levels at different time points were compared between the two groups.RESULTS:The labeled 'cells' were found in the portalregion and central veins of hepatic lobules.The PKH26-labeled cells appeared at an average frequency of 108 ± 8/high power field in the experiment group and 65 ± 8/high power field in the control group(P < 0.05).The total number of positive cells was 29 ± 7/high power field in the experimental group and 13 ± 2/high power field in the control group.The albumin expres-sion level was also higher in the experimental group than in the control group(29 ± 7 vs 13 ± 2,P < 0.05).The total number of crossing points was 156 ± 5/high power field in the experimental group and 53 ± 5/high power field in the control group(P < 0.05).The serum alanine aminotransferase levels in experimental and control groups were measured at different time points(120 ± 40 vs 118.50 ± 1.75,P > 0.05;80.60 ± 6.50 vs 101.08 ± 5.67,P < 0.05;50.74 ± 5.38 vs 80.47 ± 4.62,P < 0.05;30.54 ± 2.70 vs 60.72 ± 4.37,P < 0.05;30.77 ± 5.36 vs 40.47 ± 6.50,P < 0.05).At the same time,the serum aspartate aminotransferase levels were measured in experimental and control groups at different time points(122.55 ± 1.46 vs 120.70 ± 4.22,P > 0.05;54.26 ± 6.50 vs 98.70 ± 8.20,P < 0.05;39.47 ± 5.39 vs 78.34 ± 4.50,P < 0.05;28.94 ± 2.70 vs 56.44 ± 4.28,P < 0.05;30.77 ± 5.45 vs 42.50 ± 6.28,P < 0.05).CONCLUSION:SDF-1 can promote the migration of BMMC to the liver of mice with acute liver failure. | Shi-Zhu Jin Xiang-Wei Meng Ming-Zi Han Xun Sun Li-Ying Sun Bing-Rong Liu | 2009 | World Journal of Gastroenterology2009，15，21： | 10 |
| 11 | In-hospital delay to primary angioplasty for patients with ST-elevated myocardial infarction between cardiac specialized hospitals and non-specialized hospitals in Beijing, China显示文摘背景证据显示在有圣举起心肌的梗塞(STEMI ) 的病人的那早灌注治疗减少复杂并发症。这研究被承担在中国北京为病人把在里面医院延期与在专业化医院和非专业化的医院之间的 STEMI 作比较到主要经皮的冠的干预(PPCI ) 。二专业化医院和能够执行 PPCI 的十五所非专业化的医院的方法被选择参予这研究。308 个病人的一个总数,在 12 以内,在 2005 年 11 月 1 日和 2006 年 12 月 31 日之间的症状和经历的 PPCI 的发作的小时被注册。数据被中部的在里面医院延期是的医药 records.Results 的结构化的会见和评论收集(interquartile 范围 105 ~ 180 ) 98 纪录,并且 16.9% 病人在 90 分钟以内被对待。全部的在里面医院延期和 ECG-to-treatment 决策时间比在心脏的专业化医院里在非专业化的医院里是更长的(147 分钟对 120 分钟, P < 0.001;55 分钟对 45 分钟, P=0.035 ) 。在控制惊讶的因素以后,非专业化的医院独立地与在的增加的风险被联系上面在那里的在里面医院 delays.Conclusions 中部是在在医院和为有在北京的 STEMI 的病人的 PPCI 的管理的到达之间的实质的在里面医院延期。因为 ECG-to-treatment 决策的一更短的时间,进入心脏的专业化医院的病人比那些有更短的在里面医院延期到非专业化的医院。 | XUN Yi-wen YANG Jin-gang SONG Li SUN Yi-hong LU Chang-lin YANG Yue-jin HU Da-yi | 2010 | Chinese Medical Journal2010，，7： | 10 |
| 12 | Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma显示文摘Due to the critical correlation between inflammation and carcinogenesis, a therapeutic candidate with anti-inflammatory activity may find application in cancer therapy. Here, we report the therapeutic efficacy of celastrol as a promising candidate compound for treatment of pancreatic carcinoma via na?ve neutrophil membrane-coated poly(ethylene glycol) methyl ether-block-poly(lactic-co-glycolic acid)(PEG-PLGA) nanoparticles. Neutrophil membranecoated nanoparticles(NNPs) are well demonstrated to overcome the blood pancreas barrier to achieve pancreas-specific drug delivery in vivo. Using tumor-bearing mice xenograft model, NNPs showed selective accumulations at the tumor site following systemic administration as compared to nanoparticles without neutrophil membrane coating. In both orthotopic and ectopic tumor models,celastrol-loaded NNPs demonstrated greatly enhanced tumor inhibition which significantly prolonged the survival of tumor bearing mice and minimizing liver metastases. Overall, these results suggest that celastrol-loaded NNPs represent a viable and effective treatment option for pancreatic carcinoma. | Xi Cao Ying Hu Shi Luo Yuejing Wang Tao Gong Xun Sun Yao Fun Zhirong Zhang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 9 |
| 13 | Renal-targeting triptolide-glucosamine conjugate exhibits lower toxicity and superior efficacy in attenuation of ischemia/reperfusion renal injury in rats显示文摘我们以前报导了新奇 triptolide (TP )-glucosamine 结合(TPG ) 那明确地在肾积累了并且保护了肾的功能免受尖锐 ischemia/reperfusion (I/R ) 的伤害在老鼠的损害。在这研究,我们进一步检验了位于 TPG.Methods 的 renoprotective 行动下面的分子的机制:TPG 肾指向被测量 TP 或 TPG 的房间举起在一根人的近似肾的管状的上皮的房间线(HK-2 ) 调查。房间周期分发和 HK-2 房间的 apoptosis 率上的 TP 或 TPG 的效果被估计,并且 caspase-3 和 caspase-9 的活动也被测量。SD 老鼠被暂时夹钳两根肾的小花梗受到双边的肾的局部缺血。老鼠是管理 TP (4.17 μ mol· kg −1·d−1, iv ) 或 TPG (4.17 μ mol· kg −1·d−1, iv ) 为在肾的外科前的 3 d。肾从外科在恢复的 24 h 以后被收获。在肾的氧化应力, proinflammatory cytokines,趋化性的 cytokines 和细胞内部的粘附分子的层次是 examined.Results:在 HK-2 房间的 TPG 的举起比在测试的集中的 TP 的高是 2-3 时间。而且,指向近似小管的 TPG 通过和 megalin 受体的相互作用被调停。TP (40-160 nmol/L ) concentration-dependently 在 HK-2 房间增加了 G 2/M 拘捕, apoptosis 和 caspase-3/caspase-9 活动,而 TPG 的一样的集中没看那些特征什么时候与控制相比组织。在 I/R-treated 老鼠, TPG 管理引起了 proinflammatory cytokines 的更柔韧的下面规定(TNF-α, IL-6, IL-1, TGF-β) 并且在肾的趋化性的 cytokines (MCP-1 ) 与 TP 管理相比,建议增长的抑制和淋巴细胞的累积。并且 TPG 管理也在肾引起了更突出的抑制氧化应力和细胞内部的粘附分子的 on the levels,与 TP administration.Conclusion 相比:肾指向的 TPG 比 TP 更有效、不太有毒,在 I/R-induced 老鼠的改善肾的损害,它可以为尖锐的肾损害的处理提供一条新大街。 | Yu FU Qing LIN Tao GONG Xun SUN Zhi-rong ZHANG | 2016 | Acta Pharmacologica Sinica2016，37，11： | 9 |
| 14 | MdATG18a overexpression improves basal thermotolerance in transgenic apple by decreasing damage to chloroplasts显示文摘High temperature is an abiotic stress factor that threatens plant growth and development.Autophagy in response to heat stress involves the selective removal of heat-induced protein complexes.Previously,we showed that a crucial autophagy protein from apple,MdATG18a,has a positive effect on drought tolerance.In the present study,we treated transgenic apple(Malus domestica)plants overexpressing MdATG18a with high temperature and found that autophagy protected them from heat stress.Overexpression of MdATG18a in apple enhanced antioxidase activity and contributed to the production of increased beneficial antioxidants under heat stress.Transgenic apple plants exhibited higher photosynthetic capacity,as shown by the rate of CO_(2) assimilation,the maximum photochemical efficiency of photosystem II(PSII),the effective quantum yield,and the electron transport rates in photosystems I and II(PSI and PSII,respectively).We also detected elevated autophagic activity and reduced damage to chloroplasts in transgenic plants compared to WT plants.In addition,the transcriptional activities of several HSP genes were increased in transgenic apple plants.In summary,we propose that autophagy plays a critical role in basal thermotolerance in apple,primarily through a combination of enhanced antioxidant activity and reduced chloroplast damage. | Liuqing Huo Xun Sun Zijian Guo Xin Jia Runmin Che Yiming Sun Yanfei Zhu Ping Wang Xiaoqing Gong Fengwang Ma | 2020 | Horticulture Research2020，7，1： | 9 |
| 15 | Accelerating leaching of copper ore with surfactant and the analysis of reaction kinetics显示文摘To solve the problem of low permeability and lower extraction rates of high-mud ores, a surfactant was added as a penetrant to the pregnant leaching solution during column leaching tests. On the basis of the theories of physical chemistry and seepage flow mechanics, the mechanism by which seepage is enhanced under the effects of the surfactant was analyzed. The results show that the action modes of the surfactant were divided into four aspects: changing the wettability of the ore, reducing the viscosity of the leaching solution, adsorbing onto the surface of ore, and enhancing the permeability effect. The findings of column leaching tests demonstrated that permeability was substantially improved by the surfactant. In the later period of leaching, the permeability coefficient was two times higher than that of the control group. Meanwhile, the ore extraction rate increased by approximately 10%. During the leaching process, the surface tension of the solution did not substantially change, and that of the solution with surfactant increased slightly. The kinetics analysis of ore column leaching illustrated that the leaching processes were controlled by both internal diffusion(principal factor) and chemical reaction. | Chun-ming Ai Ping-ping Sun Ai-xiang Wu Xun Chen Chao Liu | 2019 | International Journal of Minerals,Metallurgy and Materials2019，26，3： | 9 |
| 16 | Overexpression of MdATG18a in apple improves resistance to Diplocarpon mali infection by enhancing antioxidant activity and salicylic acid levels显示文摘Marssonina apple blotch,caused by Diplocarpon mali,is one of the most serious diseases of apple.Autophagy plays a key role in pathogen resistance.We previously showed that MdATG18a has a positive influence on drought tolerance.Herein,we describe how overexpression(OE)of MdATG18a enhances resistance to D.mali infection,probably because less H2O2 but more salicylic acid(SA)is accumulated in the leaves of OE apple plants.Expression of chitinase,β-1,3-glucanase,and SA-related marker genes was induced more strongly by D.mali in OE lines.Transcript levels of other important MdATG genes were also drastically increased by D.mali in OE plants,which indicated increased autophagy activities.Taken together,these results demonstrate that OE of MdATG18a enhances resistance to infection by D.mali and plays positive roles in H2O2-scavenging and SA accumulations.Our findings provide important information for designing strategies which could induce autophagy to minimize the impact of this disease on apple production. | Xun Sun Liuqing Huo Xin Jia Runmin Che Xiaoqing Gong Ping Wang Fengwang Ma | 2018 | Horticulture Research2018，5，1： | 8 |
| 17 | Spatial Restructuring of Industries Under Economic Globalization: Enterprises’ Choice and Governments’ Response | LI Xun, Professor, Department of Urban and Regional Planning, Geography and Planning School, Sun Yat-sen University Deputy Director, Planning and Design Institute of Sun Yat-sen University Center for Studies of Hong Kong, Macao and Pearl River Delta, Sun Yat-sen University, Guangzhou, P. R. China. FU Wenying, Department of Urban and Regional Planning, Geography and Planning School, Sun Yat-sen University, Guangzhou, P. R. China. LIU Hongfeng, Department of Urban and Regional Planning, Geography and Planning School, Sun Yat-sen University, Guangzhou, P. R. China. | 2009 | China City Planning Review2009，18，2： | 8 |
| 18 | A Novel Surgery Classification for Endoscopic Approaches to Middle Ear Cholesteatoma显示文摘This study aimed to develop a novel surgery classification for an endoscopic approach to middle ear cholesteatoma.We retrospectively analyzed the surgical approaches and outcomes of patients with middle ear cholesteatoma.Middle ear cholesteatoma surgeries were divided into four types and two special types as follows:type I,attic retraction pocket,which only requires tympanostomy tube placement or retraction pocket resection and cartilage reconstruction;typeⅡ,cholesteatoma which is limited to the attic or in which endoscopy can confirm complete removal of mastoid cholesteatoma lesions,including type Ⅱa,requiring only use of a curette,and type Ⅱ b,requiring use of an electric drill or chisel;type Ⅲ,cholesteatoma not limited to the attic,in which endoscopy cannot confirm complete removal of mastoid cholesteatoma lesions,requiring the combined use of endoscope and microscope to perform endoscopic tympanoplasty and'Canal Wall Up'mastoidectomy;type Ⅳ,extensive involvement of mastoid cavity cholesteatoma lesions and/or cases with a potential risk of complications,removal of which can only be performed under a microscope for'Canal Wall Down'mastoidectomy.In addition,there were two special types:'difficult external auditory canal'and congenital cholesteatoma in children.In our system,type I and type U middle ear cholesteatoma surgery was completely performed under an endoscope alone.However,estimating the extent of the lesions,determining the choice of mastoid opening and reestablishing ventilation are the key points for an endoscopic approach to middle ear cholesteatoma.The classification of endoscopic middle ear cholesteatoma surgery may benefit the selection of surgical indications. | Yu SUN En-hao WANG Jin-tao YU Gang ZHONG Li-xin ZHU-Yi WANG Niu XUN Hong YU Wen ZHOU Zhen XIE Kun ZHANG Guo-run FAN Yi ZHONG Hong-jun XIAO Wei-jia KONG | 2020 | Current Medical Science2020，40，1： | 8 |
| 19 | Extracellular matrix from human umbilical cordderived mesenchymal stem cells as a scaffold for peripheral nerve regeneration显示文摘The extracellular matrix,which includes collagens,laminin,or fibronectin,plays an important role in peripheral nerve regeneration.Recently,a Schwann cell-derived extracellular matrix with classical biomaterial was used to mimic the neural niche.However,extensive clinical use of Schwann cells remains limited because of the limited origin,loss of an autologous nerve,and extended in vitro culture times.In the present study,human umbilical cord-derived mesenchymal stem cells(h UCMSCs),which are easily accessible and more proliferative than Schwann cells,were used to prepare an extracellular matrix.We identified the morphology and function of h UCMSCs and investigated their effect on peripheral nerve regeneration.Compared with a non-coated dish tissue culture,the h UCMSC-derived extracellular matrix enhanced Schwann cell proliferation,upregulated gene and protein expression levels of brain-derived neurotrophic factor,glial cell-derived neurotrophic factor,and vascular endothelial growth factor in Schwann cells,and enhanced neurite outgrowth from dorsal root ganglion neurons.These findings suggest that the h UCMSC-derived extracellular matrix promotes peripheral nerve repair and can be used as a basis for the rational design of engineered neural niches. | Bo Xiao Feng Rao Zhi-yuan Guo Xun Sun Yi-guo Wang Shu-yun Liu Ai-yuan Wang Quan-yi Guo Hao-ye Meng Qing Zhao Jiang Peng Yu Wang Shi-bi Lu | 2016 | Neural Regeneration Research2016，11，7： | 8 |
| 20 | Human trophoblast cells induced MDSCs from peripheral blood CD14+ myelomonocytic cells via elevated levels of CCL2显示文摘 | Yun Zhang Daiwei Qu Jintang Sun Lei Zhao Qingjie Wang Qianqian Shao Beihua Kong Xun Qu | 2016 | Cellular & Molecular Immunology2016，13，5： | 7 |
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