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| 1 | Real-time transient stability assessment in power system based on improved SVM显示文摘Due to the strict requirements of extremely high accuracy and fast computational speed, real-time transient stability assessment(TSA) has always been a tough problem in power system analysis.Fortunately, the development of artificial intelligence and big data technologies provide the new prospective methods to this issue, and there have been some successful trials on using intelligent method, such as support vector machine(SVM) method.However, the traditional SVM method cannot avoid false classification, and the interpretability of the results needs to be strengthened and clear.This paper proposes a new strategy to solve the shortcomings of traditional SVM,which can improve the interpretability of results, and avoid the problem of false alarms and missed alarms.In this strategy, two improved SVMs, which are called aggressive support vector machine(ASVM) and conservative support vector machine(CSVM), are proposed to improve the accuracy of the classification.And two improved SVMs can ensure the stability or instability of the power system in most cases.For the small amount of cases with undetermined stability, a new concept of grey region(GR) is built to measure the uncertainty of the results, and GR can assessment the instable probability of the power system.Cases studies on IEEE 39-bus system and realistic provincial power grid illustrate the effectiveness and practicability of the proposed strategy. | Wei HU Zongxiang LU Shuang WU Weiling ZHANG Yu DONG Rui YU Baisi LIU | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，1： | 14 |
| 2 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 3 | Significance of the lymph nodes in the 7th station in rational dissection for metastasis of distal gastric cancer with different T categories显示文摘Objective: To determine the clinicopathological characteristics, and evaluate the appropriate extent of lymph node dissection in distal gastric cancer patients with comparable T category.Methods: A retrospective study was conducted on 570 distal gastric cancer patients, who underwent gastric resection with D2 nodal dissection, which was performed by the same surgical team from January 1997 to January 2011. We compared the differences in lymph node metastasis rates and metastatic lymph node ratios between different T categories. Additionally, we investigated the impact of lymph node metastasis in the 7th station on survival rate of distal gastric cancer patients with the same TNM staging.Results: Among the 570 patients, the overall lymph node metastasis rate of advanced distal gastric cancer was 78.1%, and the metastatic lymph node ratio was 27%. The lymph node metastasis rate in the 7th station was similar to that of perigastric lymph nodes. There was no statistical significance in patients with the same TNM stage(stage II and III), irrespective of the metastatic status in the 7th station.Conclusions: Our results suggest that to a certain extent, it is reasonable to include lymph nodes in the 7th station in the D1 lymph node dissection. | Wu Song Yulong He Shaochuan Wang Weiling He Jianbo Xu | 2014 | Chinese Journal of Cancer Research2014，26，4： | 3 |
| 4 | Polymer coated nanodiamonds as gemcitabine prodrug with enzymatic sensitivity for pancreatic cancer treatment显示文摘The fabrication of Gemcitabine(GEM) prodrug was reported to be an effective method to enhance its pancreatic cancer treatment efficiency. Here, a kind of nanocarbon-based materials, nanodiamond(ND), was selected as the nanocarrier of GEM, owing to its outstanding surface properties and non-cytotoxicity. The polyelectrolytes,polyethyleneimine and polyacrylic acid, were used to self-assemble outside ND surface through electrostatic forces, followed by attachment of polyethylene glycol to address better biocompatibility. GEM was conjugated with an enzyme-sensitive peptide gly-phe-leu-gly to build up the controlled release platform. From characterization results of dynamic laser scattering, zeta potential and transmission electron microscope, the significant improvement of ND stability in physiological condition was proved. Non-cytotoxicity of this functionalized ND carriers and cytotoxicity of the prodrug against Bx PC-3 pancreatic cancer cells were indicated by methylthiazolyl tetrazolium(MTT) assay. In vivo experiments also revealed its superior anticancer effect compared with free GEM treatment. Therefore, the combination of polymer coated NDs with high surface capability and enzymeresponsive intracellular GEM release make it possible to realize higher treatment efficiency on pancreatic tumor therapy. | Wanying Ye Haijie Han Huan Li Qiao Jin Yuzhou Wu Sabyasachi Chakrabortty Tanja Weil Jian Ji | 2020 | Progress in Natural Science:Materials International2020，30，5： | 3 |
| 5 | Diagnosis and treatment of infantile malignant solid tumors in Beijing,China:A multicenter 10-year retrospective study显示文摘Importance:Cancer is the main cause of death by disease in children.Children experience the highest incidence of cancer in the first year of life.However,there is no comprehensive registration system for children with tumors in China.Objective:To summarize the diagnosis and treatment of infant cancer and analyze the status of standardized diagnosis and management among several treatment centers in Beijing,China,thereby providing evidence to guide further clinical research.Methods:From January 1,2010 to December 31,2019,patients with newly diagnosed infantile malignant solid tumors were admitted to six large tertiary pediatric solid tumor diagnosis and treatment centers in Beijing.The epidemiology,clinical features,and therapeutic effects of tumors in these patients were analyzed retrospectively.All patients were followed up until March 31,2020.Results:In total,938 patients were enrolled in this study.There were 530 boys(56.5%)and 408 girls(43.5%);the median age was 6.0 months(range,0-12.0 months).The three most common tumors were retinoblastoma in 366 patients(39.0%),neuroblastoma in 266 patients(28.4%),hepatoblastoma in 133 patients(14.2%),and central nervous system tumors in 52 patients(5.5%).The estimated 5-year overall survival rate was 81.3%±1.8%,and the 5-year event-free survival rate was 71.8%±2.9%.The 5-year overall survival rates of non-rhabdomyosarcoma soft tissue sarcoma,neuroblastoma,and retinoblastoma were 100%,88%±2.2%,and 86.9%±2.1%,respectively.The 5-year event-free survival rates were 81.1%±2.7%for neuroblastoma,81.6%±9.8%for non-rhabdomyosarcoma soft tissue sarcoma,and 72.7%±14.1%for extracranial malignant germ cell tumors.Interpretation:The three most common infantile malignant solid tumors were retinoblastoma,neuroblastoma,and hepatoblastoma.Multidisciplinary combined diagnosis and treatment is needed for infantile tumors. | Mei Jin Zhi Tian Yao Xie Zhaoxia Zhang Miao Li YaxiongYu Weiling Zhang Junyang Zhao Huanmin Wang Qi Zeng Long Li Ming Ge Ning Sun Xiaolun Zhang Jian Gong Wanshui Wu Rong Liu Weihong Zhao Dongsheng Huang Xiaoli Ma | 2020 | Pediatric Investigation2020，4，3： | 3 |
| 6 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 7 | Proximal gastric cancer: lymph node metastatic patterns according to different T stages dictate surgical approach显示文摘 | Song Wu Liu Yuyi Ye Jinning Peng Jianjun He Weiling Chen Jianhui Chen Chuangqi He Yulong | 2014 | Chinese Medical Journal2014，，23： | 2 |
| 8 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 9 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 10 | Detection efficien- cy of cooperative spectrum sensing in cognitive radio network显示文摘 | Chen X Bie Zhisong Wu Weiling | 2008 | The Journal of China Universities of Posts and Telecommunications September2008，15，3： | 1 |
| 11 | A Writable Polypeptide–DNA Hydrogel with Rationally Designed Multi‐modification Sites显示文摘 | Chuang Li Ping Chen Yu Shao Xu Zhou Yuzhou Wu Zhongqiang Yang Zhibo Li Tanja Weil Dongsheng Liu | 2015 | Small2015，，9： | 1 |
| 12 | VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance显示文摘Radiotherapy remains the mainstay for treatment of various types of human cancer;however,the clinical efficacy is often limited by radioresistance,in which the underlying mechanism is largely unknown.Here,using esophageal squamous cell carcinoma(ESCC)as a model,we demonstrate that guanine nucleotide exchange factor 2(VAV2),which is overexpressed in most human cancers,plays an important role in primary and secondary radioresistance.We have discovered for the first time that VAV2 is required for the Ku70/Ku80 complex formation and participates in non-homologous end joining repair of DNA damages caused by ionizing radiation. | Weiling Liu Chuanwang Miao Shaosen Zhang Yachen Liu Xiangjie Niu Yiyi Xi Wenjia Guo Jiahui Chu Ai Lin Hongjin Liu Xinyu Yang Xinjie Chen Ce Zhong Yuling Ma Yuqian Wang Shihao Zhu Shuning Liu Wen Tan Dongxin Lin Chen Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 13 | Correlation Between Right Ventricular Tei Index by Tissue Doppler Imaging and Pulsed Doppler Imaging in Fetuses显示文摘 | Yuqing Duan Kenji Harada Weiling Wu Haruka Ishii Goro Takada | 2008 | Pediatric Cardiology2008，，4： | 1 |
| 14 | Differentiation of dried sea cucumber products from different geographical areas by surface desorption atmospheric pressure chemical ionization mass spectrometry显示文摘 | Wu Zhongchen Chen Huanwen Wang Weiling | 2009 | J Agric Food Chem2009，57，20： | 1 |
| 15 | Design of the Image-guided Biopsy Marking System for Gastroscopy显示文摘 | Sun Deyu Hu Weiling Wu Wei | 2012 | Journal of Medical Systems2012，36，5： | 1 |
| 16 | Mining maximal hyperclique pattern: a hybrid search strategy 显示文摘 | Huang Yaochun Xiong Hui Wu Weiling | 2007 | Information Sciences2007，177，3： | 1 |
| 17 | Aptamer Identification of Brain Tumor–Initiating Cells显示文摘 | Youngmi Kim Qiulian Wu Petra Hamerlik Masahiro Hitomi Andrew E. Sloan Gene H. Barnett Robert J. Weil Patrick Leahy Anita B. Hjelmeland Jeremy N. Rich | 2013 | Cancer Research2013，，15： | 1 |
| 18 | Antibiotics in global rivers显示文摘Antibiotics have received extensive attention due to their sophisticated effects on human health and ecosystems.However,there is an extreme scarcity of information on composition,content,geographic distribution,and risk of riverine antibiotics at a large spatial scale.Based on a systematic review of over 600 pieces of literature(1999-2021),we established a global dataset containing more than 90,000 records covering 169 antibiotics and their metabolites in surface water and sediment across 76 countries.The occurrence of prioritized antibiotics largely depended on socioeconomic developmental levels,and the current“hotspots”of polluted rivers were found mostly in less developed countries or emerging economies(e.g.,some in Africa,South America,and Asia).By developing the screening protocol for risk-based prioritization of antibiotics,we advanced a rank list of antibiotics for guiding formulation of region-specific strategies,which highlighted the importance of whole life cycle management of antibiotics in health maintenance of the world’s rivers. | Si Li Yi Liu Yang Wu Jingrun Hu Yiqing Zhang Qian Sun Weiling Sun Jiagen Geng Xiaoying Liu Dantong Jia Xiuqi You Dianqing Qi Moran Tang Yitao Lyu Fanguang Kong Leilei Cai Yufan Ai Yichu Wang Jinren Ni | 2022 | National Science Open2022，1，2： | 1 |
| 19 | Differentiation of dried sea cucumber products from different geographical areas by surface desorption atmospheric pressure chemical ionization mass spectrometry显示文摘 | WU Zhongchen CHEN Huanwen WANG Weiling | 2009 | Journal of Agricultural and Food Chemistry2009，57，20： | 1 |
| 20 | Depositional Responding to Tectonic Evolution of East China Sea Shelf Basin显示文摘DepositionalRespondingtoTectonicEvolutionofEastChinaSeaShelfBasin*LuYongchaoWuFadongXieXinongChenPingFacultyofEarthResources,... | Lu Yongchao Wu Fadong Xie Xinong Chen PingFaculty of Earth Resources, China University of Geosciences, Wuhan 430074 Zhou Ping Li Peilian Xu WeilingShanghai Institute of Offshore Petroleum Exploration and Development, MGMR, Shanghai 200120 | 1997 | Journal of Earth Science1997，16，1： | 1 |
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