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| 1 | Flavonoid profiling of a traditional Chinese medicine formula of Huangqin Tang using high performance liquid chromatography显示文摘The quality control processes for herbal medicines have been problematic. Flavonoids are the major active components of Huangqin Tang(HQT, a traditional Chinese medicine formula). In this study, we used a combinative method approach consisting of chromatographic fingerprinting(high performance liquid chromatography; HPLC), quantitative methods and a pharmacodynamic evaluation model to analyze the flavonoids of HQT obtained from different sources. Ten batches of HQT were analyzed by the HPLC fingerprinting method and 26 common peaks were detected, of which 23 peaks corresponded with the chemical profile of HQT. In addition, 11 major compounds were identified by LC–MS analysis(liquid chromatography–tandem mass spectrometer; LC–MS^n) and quantified by the HPLC quantitative method approach. The studied10 batches of HQT were found to be homogeneous in their composition with a similarity between 0.990 and1.000. The distribution of the 11 identified compounds was found to be very similar among the batches. Only slight pharmacodynamic differences were detected between the different batches, confirming the homogeneity of HQT. The results of this study prove that the combination of chromatographic fingerprinting and quantitative analysis can be readily used for comprehensive quality control of herbal medicines. | Tao Li Shuaixing Zhuang Yiwei Wang Yanli Wang Weihao Wang Huihui Zhang Li Chen Dunfang Wang Zhongming Zhou Weipeng Yang | 2016 | Acta Pharmaceutica Sinica B2016，6，2： | 19 |
| 2 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 3 | Adverse factors increase preeclampsia-like changes in pregnant mice with abnormal lipid metabolism显示文摘 | Ding Xiaoyan Yang Zi Han Yiwei Yu Huan | 2014 | Chinese Medical Journal2014，，15： | 18 |
| 4 | Dihydroartemisinin regulates the immune system by promotion of CD8^+T lymphocytes and suppression of B cell responses显示文摘Artemisia annua is an anti-fever herbal medicine first described in traditional Chinese medicine 1,000 years ago.Artemisinin,the extract of A.annua,and its derivatives(dihydroartemisinin(DHA),artemether,and artesunate)have been used for the treatment of malaria with substantial efficacy.Recently,DHA has also been tested for the treatment of lupus erythematosus,indicating that it may function to balance the immune response in immunocompromised individuals.In the present study,the regulatory effect of artemisinin on the murine immune system was systematically investigated in mice infected with two different protozoan parasites(Toxoplasma gondii and Plasmodium berghei).Our results revealed that the mouse spleen index significantly increased(spleen enlargement)in the healthy mice after DHA administration primarily due to the generation of an extra number of lymphocytes and CD8^+T lymphocytes in both the spleen and circulation.DHA could increase the proportion of T helper cells and CD8^+T cells,as well as decrease the number of splenic and circulatory B cells.Further,DHA could reduce the production of proinflammatory cytokines.Our study revealed that apart from their anti-parasitic activity,artemisinin and its derivatives can also actively modulate the immune system to directly benefit the host. | Ting Zhang Yiwei Zhang Ning Jiang Xu Zhao Xiaoyu Sang Na Yang Ying Feng Ran Chen Qijun Chen | 2020 | Science China(Life Sciences)2020，63，5： | 12 |
| 5 | In vitro inhibitory and pro-apoptotic effect of Stellera Chamaejasme LExtract on human lung cancer cell line NCI-H157显示文摘OBJECTIVE:To investigate the inhibitory and pro-apoptotic effect of Stellera Chamaejasme L extract(ESC) in vitro.METHODS:ESC was first extracted with ethanol,and then washed using a polyamide column with 60% ethanol.ESC was then decompressively recycled and vacuum dried at room temperature to obtain active fractions.Subsequently,the cytotoxic and apoptotic effects of ESC on NCI-H157 human lung cancer cells were determined.RESULTS:The results showed that ESC was rich in isomers of Chamaejasminor,neochamaejasmine and Sikokianin.ESC had significant cytotoxicity against NCI-H157 cells,with an IC 50 of approximately 18.50 μg.mL-1.ESC caused significant increase in total apoptotic rate,the activity of caspase 3 and 8,and Fas protein expression(P<0.05).CONCLUSION:The inhibitory effect of ESC on NCI-H157 tumor cells might partly be attributed to its apoptotic induction through activation of the Fas death receptor pathway. | Xiaoni Liu Yujie Li Qing Yang Ying Chen Xiaogang Weng Yiwei Wang Ning Li Xiaoxin Zhu | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 8 |
| 6 | Abnormal expression of bHLH3 disrupts a flavonoid homeostasis network,causing differences in pigment composition among mulberry fruits显示文摘Mulberry fruits with high concentrations of anthocyanins are favored by consumers because of their good taste,bright color,and high nutritional value.However,neither the regulatory mechanism controlling flavonoid biosynthesis in mulberry nor the molecular basis of different mulberry fruit colors is fully understood.Here,we report that a flavonoid homeostasis network comprising activation and feedback regulation mechanisms determines mulberry fruit color.In vitro and in vivo assays showed that MYBA-bHLH3-TTG1 regulates the biosynthesis of anthocyanins,while TT2L1 and TT2L2 work with bHLH3 or GL3 and form a MYB-bHLH-WD40(MBW)complex with TTG1 to regulate proanthocyanidin(PA)synthesis.Functional and expression analyses showed that bHLH3 is a key regulator of the regulatory network controlling mulberry fruit coloration and that MYB4 is activated by MBW complexes and participates in negative feedback control of the regulatory network to balance the accumulation of anthocyanins and proanthocyanidins.Our research demonstrates that the interaction between bHLH3 and MYB4 in the homeostasis regulatory network ensures that the fruits accumulate desirable flavonoids and that this network is stable in pigmentrich mulberry fruits.However,the abnormal expression of bHLH3 disrupts the balance of the network and redirects flavonoid metabolic flux in pale-colored fruits,resulting in differences in the levels and proportions of anthocyanins,flavones,and flavonols among differently colored mulberry fruits(red,yellow,and white).The results of our study reveal the molecular basis of the diversity of mulberry fruit colors. | Han Li Zhen Yang Qiwei Zeng Shibo Wang Yiwei Luo Yan Huang Youchao Xin Ningjia He | 2020 | Horticulture Research2020，7，1： | 8 |
| 7 | Influence of tunnel length on the pressure wave generated by high-speed trains passing each other显示文摘The prediction of the pressure wave amplitude produced when two trains pass each other in the tunnel is important to the train design for airtightness and tunnel conditions in China.In this paper,the key factors of this problem were firstly stud-ied based on theoretical analysis.The equation of the worst tunnel length for the global maximum and minimum pressure values was derived.Then,the influence of tunnel length on global minimum pressure and the critical region in which the global minimum pressure varies rapidly were investigated.Finally,a numerical method based on two-dimensional Na-vier-Stokes equations was established.Typical conditions of two trains passing-by in tunnels of different lengths were simulated.The theoretical and computational results agree with each other closely. | WANG YiWei YANG GuoWei HUANG ChengGuang WANG Wei | 2012 | Science China(Technological Sciences)2012，55，1： | 7 |
| 8 | Aerodynamic simulation of high-speed trains based on the Lattice Boltzmann Method (LBM)显示文摘Aerodynamic simulation of high-speed trains has been carried out by using Lattice Boltzmann Method (LBM). Non-simplified train model was used and the number of space grids reached tens of millions. All results under different working conditions reflected the actual situation. | WANG YiWei WANG Yang AN YiRan CHEN YaoSong | 2008 | Science China(Technological Sciences)2008，51，6： | 7 |
| 9 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 10 | Characteristics and genesis of the Feixianguan Formation oolitic shoal reservoir, Puguang gas field, Sichuan Basin, China显示文摘在在西南中国的东北四川盆的著名 Puguang gasfield 的更低的三叠纪的 Feixianguan 形成生产一座代表性的鲕状的水库,吗最大的采购水兵的 gasfield 到目前为止在中国是哪个(比 350 大的证明煤气的储备地在 2003 发现了??????????????楥楸湡畧湡????畐畧湡?? | Peiyuan CHEN Xiucheng TAN Huiting YANG Ming TANG Yiwei JIANG Xiuju JIN Yang YU | 2015 | Frontiers of Earth Science2015，9，1： | 7 |
| 11 | Brief Introduction to a Unique Edible Bolete---Phlebopus portentosus in Southern China显示文摘 | Chunxia Zhang Mingxia He Jing Liu Xinjing Xu Yang Cao Feng Gao Yiwei Fang Wenbing Wang Yun Wang | 2017 | Journal of Agricultural Science and Technology(B)2017，7，6： | 6 |
| 12 | A general strategy for one-step fabrication of biocompatible microcapsules with controlled active release显示文摘Fabrication of biocompatible core-shell microcapsules in a controllable and scalable manner remains an important but challenging task.Here,we develop a one-step microfluidic approach for the highthroughput production of biocompatible microcapsules,which utilizes single emulsions as templates and controls the precipitation of biocompatible polymer at the water/oil interface.The facile method enables the loading of various oils in the core and the enhancement of polymer shell strength by polyelectrolyte coating.The resulting microcapsules have the advantages of controllability,scalability,biocompatibility,high encapsulation efficiency and high loading capacity.The core-shell microcapsules are ideal delivery vehicles for programmable active release and various controlled release mechanisms are demonstrated,including burst release by vigorous shaking,pH-triggered release for targeted intestinal release and sustained release of perfume over a long period of time.The utility of our technique paves the way for practical applications of core-shell microcapsules. | Zeyong Sun Chenjing Yang Max Eggersdorfer Jiecheng Cuic Yiwei Li Mingtan Hai Dong Chen David AWeitz | 2020 | Chinese Chemical Letters2020，31，1： | 5 |
| 13 | Correlation between the different chain lengths of free fatty acid oxidation and abili .ty of trophoblastic invasion显示文摘 | Yu Huan Yang Zi Ding Xiaoyan Wang Yanling Han Yiwei | 2014 | Chinese Medical Journal2014，，19： | 5 |
| 14 | Fault tolerant quantum secret sharing against collective-amplitude-damping noise显示文摘We present a quantum secret sharing protocol against collective-amplitude-damping noise. Each logical qubit is encoded in two qubit noiseless states. So it can function over such a noisy channel. The two agents encode their messages on each logical qubit only by performing a permutation operation on two physical qubits. Although each logical qubit received by each agent only carries a bit of information, the boss Alice can read out her agents' information by discriminating two orthogonal states by performing single-qubit measurements assisted by local operation and classical communication (LOCC). | YANG YuGuang CHAI HaiPing WANG Yuan TENG YiWei WEN QiaoYan | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，9： | 4 |
| 15 | Recent advances in acid-resistant zeolite T membranes for dehydration of organics显示文摘Zeolite membranes offer outstanding potentials in separation of many molecular mixtures due to their molecular sieving selectivity and the high thermal and mechanical stability that allow them to operate at harsh conditions.Development of durable and high separation performance membranes with lower fabrication and operation cost are highly demanded for industrial applications. Zeolite T membrane possesses good acid-resistance with excellent hydrophilic properties as compared to NaA zeolite membrane and can be extended to industrial organic dehydrations under an acidic environment. In the present review the research advances in development of zeolite T membranes for the dehydration of organic mixtures in acidic conditions are summarized. Especially the low temperature synthesis, and epitaxial growth of the zeolite membrane with high performance are well addressed, besides emphasis is particularly placed on ensemble synthesis of hollow fiber zeolite T membrane module and its future prospects for industrial separations. | Yiwei Luo Waseem Raza Jianhua Yang Liangqing Li Ying Lu | 2019 | Chinese Journal of Chemical Engineering2019，27，6： | 4 |
| 16 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 17 | Size,morphology,and composition of lunar samples returned by Chang'E-5 mission显示文摘This study focuses on the physical and chemical properties of surficial lunar regolith(LR)samples returned from the Moon by the Chang’E-5(CE-5)mission.Insights regarding the effect of a new sampling geological site on the surficial lunar sample CE5 C0400 were illustrated using nondestructive techniques such as laser diffractometry coupled with image analysis,X-ray computed tomography,and field emission scanning electron microscopy equipped with energy dispersive spectroscopy,and Xray diffraction combined with Rietveld refinement.From the characterization analyses,the CE-5 sampling site in the northeastern Oceanus Procellarum on the Moon yields a unique collection of relatively regular-shaped and fine basalt-dominated particles.The median grain size D_(50) is(55.24±0.96)μm,falling within the relatively low end of the range of the Apollo lunar returned samples.The coefficient of uniformity C_(u)of 15.1 and the coefficient of curvature C_(c)of 1.7 could classify CE5 C0400 to be well-graded.The minerals in CE5 C0400 comprise approximately 44.5%pyroxene,30.4%plagioclase,3.6%olivine,and6.0%ilmenite.There is a relatively low content of approximately 15.5%glass phase in the CE-5 lunar sample.From the results,we deduce that the CE-5 LR structure could have mainly resulted from micrometeoroid impacts to achieve such a high level of maturity. | Hui Zhang Xian Zhang Guang Zhang Keqi Dong Xiangjin Deng Xiaosong Gao Yaodong Yang Yuan Xiao Xiao Bai Kaixin Liang Yiwei Liu Wenbin Ma Shaofan Zhao Ce Zhang Xiaojing Zhang Jian Song Wei Yao Hong Chen Weihua Wang Zhigang Zou Mengfei Yang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，2： | 4 |
| 18 | Securing Multicast Route Discovery for Mobile Ad Hoc Networks显示文摘This paper presents SMRAN, a novel securing multicast route discovery scheme for mobile ad hoc networks. The scheme relies entirely on hash chains based one-time signature mechanism, HORSEI, with very efficient signing and verifying, and we do this by improving the HORSE protocol through the introduction of interme- diate hash joints. The main purpose of SMRAN is to provide source authentication for multicast routing discovery messages in mobile ad hoc networks. SMRAN will construct multicast tree with authentica- tion constrains in ad hoc networks. The performance measure of SMRAN is evaluated using simulator NS2. The results represent that SMRAN produces less end-to-end packet latency than public key based secure routing scheme, and it is a feasible approach to securing multicast routing for mobile ad hoc networks. | YANG Mingxi LI Layuan FANG Yiwei | 2007 | Wuhan University Journal of Natural Sciences2007，12，1： | 3 |
| 19 | Phospholipid Transfer Protein Deficiency Decreases the Content of S1P in HDL via the Loss of its Transfer Capability显示文摘 | Yang Yu Shoudong Guo Yumei Feng Lei Feng Yingjie Cui Guohua Song Tian Luo Ke Zhang Yiwei Wang Xian-Cheng Jiang Shucun Qin | 2014 | Lipids2014，，2： | 2 |
| 20 | Cyclin-dependent kinase 4 is a novel target in micoRNA-195-mediated cell cycle arrest in bladder cancer cells显示文摘 | Yiwei Lin Jian Wu Hong Chen Yeqing Mao Yunfu Liu Qiqi Mao Kai Yang Xiangyi Zheng Liping Xie | 2012 | FEBS Letters2012，，4： | 2 |
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