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| 1 | Sulforaphane Protects Astrocytes Against Oxidative Stress and Delayed Death Caused by Oxygen and Glucose Deprivation显示文摘氧化应激是缺血再灌注后星形胶质细胞损伤和死亡的重要分子机制之一,可能成为有效的干预靶点。下述治疗策略可减轻缺血再灌注条件下产生的多种反应性氮氧化合物损伤。这种方法可通过使用化学试剂或适当条件促进转录活化因子NRF2从细胞浆转入细胞核,并与抗氧化基因反应位点结合,来诱导缺血再灌注后损伤细胞的Ⅱ期基因反应。本研究将验证如下假说:NRF2基因表达通路激活剂sulforaphane能对体外无氧无糖环境处理的培养皮质星形胶质细胞起神经保护作用。将皮质星形胶质细胞暴露于无氧无糖环境(OGD)4 h,于干预前48 h或干预后给予5μMsulforaphane(NRF2基因表达通路激活剂)培养48 h,两种培育条件下细胞死亡均明显减少。免疫细胞化学结果表明干预前给予sulforaphane处理,细胞中DNA/RNA氧化标志物8-hydroxy-2-deox-yguanosine的表达在恢复给氧4 h后降低,两种培育条件下胞浆内及胞核内NRF2的免疫反应均增强且NQO1(NRF2转录活化基因产物)的表达和酶活性均增强。本研究提示sulforaphane可通过激活NRF2抗氧化基因表达通路,减少体外缺氧再灌注后星形胶质细胞的死亡。 | CAMELIA A.DANILOV KRISH CHANDRASEKARAN JENNIFER RACZ LUCIAN SOANE CAROL ZIELKE AND GARY FISKUM | 2009 | 神经损伤与功能重建2009，4，2： | 12 |
| 2 | Endoscopic Tri-Modal Imaging Is More Effective Than Standard Endoscopy in Identifying Early-Stage Neoplasia in Barrett’s Esophagus显示文摘 | Wouter L. Curvers Lorenza Alvarez Herrero Michael B. Wallace Louis–Michel Wong Kee Song Krish Ragunath Herbert C. Wolfsen Ganapathy A. Prasad Kenneth K. Wang Venkataraman Subramanian Bas L.A.M. Weusten Fiebo J. Ten Kate Jacques J.G.H.M. Bergman | 2010 | Gastroenterology2010，，4： | 6 |
| 3 | Biochar-based bioenergy and its environmental impact in Northwestern Ontario Canada: A review显示文摘Biochar is normally produced as a by-product of bioenergy. However, if biochar is produced as a co-product with bioenergy from sustainably managed forests and used for soil amendment, it could provide a carbon neutral or even carbon negative solution for current environmental degradation problems. In this paper, we present a comprehensive review of biochar production as a co-product of bioenergy and its implications. We focus on biochar production with reference to biomass availability and sustainability and on biochar utilization for its soil amendment and greenhouse gas emissions reduction properties. Past studies confirm that northwestern Ontario has a sustainable and sufficient supply of biomass feedstock that can be used to produce bioenergy, with biochar as a co-product that can replace fossil fuel consumption, increase soil productivity and sequester carbon in the long run. For the next step, we recommend that comprehensive life cycle assessment of biochar-based bioenergy production, from raw material collection to biochar application, with an extensive economic assessment is necessary for making this technology commercially viable in northwestern Ontario. | Krish Homagain Chander Shahi Nancy Luckai Mahadev Sharma | 2014 | Journal of Forestry Research2014，25，4： | 5 |
| 4 | Evaluation of accuracy of linear regression models in predicting urban stormwater discharge characteristics显示文摘Stormwater runoff has been identified as a source of pollution for the environment, especially for receiving waters. In order to quantify and manage the impacts of stormwater runoff on the environment, predictive models and mathematical models have been developed. Predictive tools such as regression models have been widely used to predict stormwater discharge characteristics. Storm event characteristics, such as antecedent dry days(ADD), have been related to response variables,such as pollutant loads and concentrations. However it has been a controversial issue among many studies to consider ADD as an important variable in predicting stormwater discharge characteristics.In this study, we examined the accuracy of general linear regression models in predicting discharge characteristics of roadway runoff. A total of 17 storm events were monitored in two highway segments, located in Gwangju, Korea. Data from the monitoring were used to calibrate United States Environmental Protection Agency's Storm Water Management Model(SWMM). The calibrated SWMM was simulated for 55 storm events, and the results of total suspended solid(TSS) discharge loads and event mean concentrations(EMC) were extracted. From these data, linear regression models were developed. R2 and p-values of the regression of ADD for both TSS loads and EMCs were investigated. Results showed that pollutant loads were better predicted than pollutant EMC in the multiple regression models. Regression may not provide the true effect of site-specific characteristics,due to uncertainty in the data. | Krish J.Madarang Joo-Hyon Kang | 2014 | Journal of Environmental Sciences2014，26，6： | 3 |
| 5 | White light endoscopy,narrow band imaging and chromoendoscopy with magnification in diagnosing colorectal neoplasia显示文摘AIM:To evaluate the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of 3 different techniques:high resolution white light endoscopy(WLE),Narrow Band Imaging(NBI) and Chromoendoscopy(CHR),all with magnification in differentiating adenocarcinomas,adenomatous and hyperplastic colorectal polyps.METHODS:Each polyp was sequentially assessed first by WLE,followed by NBI and finally by CHR.Digital images of each polyp with each modality were taken and stored.Biopsies or polypectomies were then performed followed by blinded histopathological analysis.Each image was blindly graded based on the Kudo's pit pattern(KPP).In the assessment with NBI,the mesh brown capillary network pattern(MBCN) of each polyp was also described.The Sn,Sp,PPV and NPV of differentiating hyperplastic(Type Ⅰ & Ⅱ-KPP,Type Ⅰ-MBCN) adenomatous(Types Ⅲ,Ⅳ-KPP,Type Ⅱ-MBCN) and carcinomatous polyps(Type Ⅴ-KPP,Type Ⅲ-MCBN) was then compared with reference to the final histopathological diagnosis.RESULTS:A total of 50 colorectal polyps(5 adenocarcinomas,38 adenomas,7 hyperplastic) were assessed.CHR and NBI [KPP,MBCN or the combined classification(KPP & MBCN)] were superior to WLE in the prediction of polyp histology(P < 0.001,P=0.002,P=0.001 and P < 0.001,respectively).NBI,using the MBCN pattern or the combined classification showed higher numerical accuracies compared to CHR,but this was not statistically significant(P=0.625,0.250).CONCLUSION:This feasibility study demonstrated that this combined classification with NBI could potentially be useful in routine clinical practice,allowing the endoscopist to predict histology with higher accuracies using a less cumbersome and technically less challenging method. | Rajvinder Singh Victoria Owen Anthony Shonde Philip Kaye Christopher Hawkey Krish Ragunath | 2009 | World Journal of Gastrointestinal Endoscopy2009，1，1： | 3 |
| 6 | Diagnosis of autoimmune gastritis by high resolution magnification endoscopy显示文摘胃的萎缩的内视镜的可视化通常不与常规内视镜检查法是可行的。放大内视镜检查法是有用的分析潜水艇没有织物的上皮的微脉管的建筑学以及粘膜表面微观结构活体检视。用这种技术,我们能描述正常胃的微脉管系统模式,我们也在自体免疫的萎缩性胃炎的二种情况中识别了典型模式。 | George K Anagnostopoulos Krish Ragunath Anthony Shonde Christopher J Hawkey | 2006 | World Journal of Gastroenterology2006，12，28： | 3 |
| 7 | SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress显示文摘 | Hyun-Seok Kim Krish Patel Kristi Muldoon-Jacobs Kheem S. Bisht Nukhet Aykin-Burns J. Daniel Pennington Riet van der Meer Phuongmai Nguyen Jason Savage Kjerstin M. Owens Athanassios Vassilopoulos Ozkan Ozden Seong-Hoon Park Keshav K. Singh Sarki A. Abdulka | 2010 | Cancer Cell2010，，1： | 3 |
| 8 | Life cycle environmental impact assessment of biochar-based bioenergy production and utilization in Northwestern Ontario,Canada显示文摘Biochar-based bioenergy production and subsequent land application of biochar can reduce greenhouse gas emissions by fixing atmospheric carbon into the soil for a long period of time. A thorough life cycle assessment of biochar-based bioenergy production and biochar land application in Northwestern Ontario is conducted using Sima Pro Ver. 8.1. The results of energy consumption and potential environmental impact of biochar-based bioenergy production system are compared with those of conventional coal-based system. Results show that biochar land application consumes 4847.61 MJ per tonne dry feedstock more energy than conventional system, but reduces the GHG emissions by 68.19 kg CO2e per tonne of dry feedstock in its life cycle. Biochar land application improves ecosystem quality by 18 %, reduces climate change by15 %, and resource use by 13 % but may adversely impact on human health by increasing disability adjusted life years by 1.7 % if biomass availability is low to medium.Replacing fossil fuel with woody biomass has a positive impact on the environment, as one tonne of dry biomass feedstock when converted to biochar reduces up to 38 kg CO2e with biochar land application despite using more energy. These results will help understand a comprehensive picture of the new interventions in forestry businesses,which are promoting biochar-based bioenergy production. | Krish Homagain Chander Shahi Nancy Luckai Mahadev Sharma | 2015 | Journal of Forestry Research2015，26，4： | 2 |
| 9 | Diversity and ex- ploration of bioactive marine actinomyeetes in the Bay of Bengal of the Puducherry coast of India显示文摘 | Krish Suthindhiran Krishnan Kannabiran | 2010 | Indian Microbi ol2010，50，1： | 1 |
| 10 | Parti- tioned presentation of multicomponent bundle prices: evalua- tion, choice and underlying processing effects显示文摘 | Chakravarti D Krish R Paul P et A1 | 2002 | Journal of Consumer Psychology2002，12，3： | 1 |
| 11 | Early salt stress effects on the differential expression of vacuolar H -ATPase genes in roots and leaves of mesembryanthemum erystallinum 显示文摘 | LOW R ROCKED B KRISH M | 1996 | Plant Physiol1996，110，1： | 1 |
| 12 | The Autoignition of Hydro-Carbon Fuels at High Temperatures and Pressures-Fitting of a Mathematical Model 显示文摘 | Halstead M P Krish L J Quinn C P | 1977 | Combust and Flame1977，30，1： | 1 |
| 13 | Utility of B-type natriuretic peptide in the diagonosis of congestive heart failure in an uregent-care setting显示文摘 | Dao Q Krish naswamy P Kazanegra R | 2001 | J Am Coll Cardiol2001，37，2： | 1 |
| 14 | Comparison of Vascular Smooth Muscle Cell Apoptosis and Fibrous Cap Morphology in Symptomatic and Asymptomatic Carotid Artery Disease显示文摘 | Ashwini S. Dhume Krish Soundararajan William J. Hunter Devendra K. Agrawal | 2003 | Annals of Vascular Surgery2003，，1： | 1 |
| 15 | High Polyacrylamide Application Rates Do Not Affect Eubacterial Structural Diversity显示文摘 | James A. Entry DeEtta Mills Krish Jayachandran R. E. Sojka | 2013 | Water, Air, & Soil Pollution2013，，1： | 1 |
| 16 | Enzymatic synthesis of isoamyl acetate using immobilized lipase from Rhizomucor miehei 显示文摘 | Krish S H Divakar S Prapulla S G | 2001 | J Biotechnol2001，87，3： | 1 |
| 17 | SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress显示文摘 | Hyun-Seok Kim Krish Patel Kristi Muldoon-Jacobs Kheem S. Bisht Nukhet Aykin-Burns J. Daniel Pennington Riet van der Meer Phuongmai Nguyen Jason Savage Kjerstin M. Owens Athanassios Vassilopoulos Ozkan Ozden Seong-Hoon Park Keshav K. Singh Sarki A. Abdulka | 2010 | Cancer Cell2010，，1： | 1 |
| 18 | Acetic acid chromoendoscopy for the diagnosis of early neoplasia and specialized intestinal metaplasia in Barrett’s esophagus: a meta-analysis显示文摘 | Marina Coletta Sarmed S. Sami Arun Nachiappan Mirella Fraquelli Giovanni Casazza Krish Ragunath | 2015 | Gastrointestinal Endoscopy2015，，： | 1 |
| 19 | A two-phase algorithm for solving the single allocation p-hub center problem 显示文摘 | KRISH M MEYER M ERNST T | 2009 | Com- puters and Operations Research2009，，36： | 1 |
| 20 | Efficient algorithm for the uncapacitated single allocation p-hub median problem 显示文摘 | ERNST A T KRISH M | 1996 | Location Science1996，7，3： | 1 |
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