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| 1 | 针刺太冲穴得气及疼痛激发相对抗的脑功能网络效应fMRI研究显示文摘目的:采用磁共振脑功能成像技术,比较针刺太冲穴得气及针刺疼痛时所激发的脑功能网络效应异同。方法:47例初次接受针刺的志愿者参加手针右侧太冲穴fMRI实验。针刺时脑fMRI扫描10min,共2次捻针,各2min,间隔3min。其中17例接受体表触觉刺激作为针刺对照,分为3组:①针刺得气组;②针刺得气合并尖锐性疼痛组(简称针刺疼痛组);③触觉对照组。采用Fisher’s精确检验和t检验分析感觉频率及强度;用AFNI处理fMRI数据,得到激活、负激活脑区;用种子相关分析法,以前扣带回膝部为种子点,分析其与全脑的功能网络联系图谱,并比较得气与疼痛组之间的差异。结果:针刺2组的酸痛、酸感、压感、麻感、钝痛等得气感觉的频率和强度均明显强于触觉刺激组;针刺2组间除尖锐性疼痛及酸痛外,各种感觉差异无统计学意义。针刺得气及疼痛2组均激活了体感及丘脑岛叶皮层,重要的是,针刺得气时在大脑边缘叶-旁边缘叶-新皮层系统(LPNN)产生了较强而广泛的负激活区,加强了负激活区之间的脑功能网络联系。此网络包括杏仁核、海马、旁海马、颞极、前额叶腹内侧回、前扣带回膝及下部、前楔叶内侧回和后扣带回(BA31,23_腹侧核,29,30),另外,小脑蚓部、导水管周围灰质及脑干网状结构也见负激活现象。然而,在针刺疼痛时,这些脑区负激活程度减低且区域缩小,大部分脑区fMRI信号逆转为激活信号,被疼痛激活的脑区之间功能网络明显增强。这些脑区参与了疼痛、镇痛(如感觉、情感、认知、自主性、内源性镇痛)功能调制环路。结合既往研究表明,负激活与脑血氧消耗及血流量下降呈正相关。本结果支持针刺通过调制LPNN和疼痛中枢网络的活动,产生其镇痛、抗焦虑和其他调节效应的假说。结论:针刺得气及针刺得气伴随疼痛产生了相对抗的脑功能网络效应。针刺得气对LPNN及疼痛脑中枢网络(Pain matrix)的负激活效应,可能与针刺镇痛脑中枢机制相关。LPNN和静息态默认网络(Default mode)之间的相似性,提示针刺需通过这一内在脑功能网络系统发挥其广泛的调制作用。 | 方继良 Hui KS Kathleen Liu Jing Nixon Erika 周科华 王小玲 朱兵 | 2012 | 中国中西医结合影像学杂志2012，10，1： | 52 |
| 2 | Brighton合作组关于Guillain-Barré综合征的诊断定义和资料收集规范显示文摘Guillain—Barre综合征(GBS)和Miller Fisher综合征(MFS)的诊断标准随着临床研究的深入在不断演变。2011年1月,《疫苗》杂志发表了国际疫苗安全性监测Brighton合作组关于GBS/MFS的诊断定义和研究资料收集规范。 | Sejvar JJ Kohl KS Gidudu J 李海峰 刘涛 | 2011 | 中国神经免疫学和神经病学杂志2011，18，5： | 28 |
| 3 | Outcome of gall bladder polypoidal lesions detected by transabdominal ultrasound scanning: A nine year experience显示文摘AIM: To determine the outcome of polypoidal lesions within the gall bladder (PLG) diagnosed by trans-abdominal scanning.METHODS: A nine-year (1993-2002) retrospective casenote review of all patients who underwent ultrasound scanning after referral to a single Upper GI Surgeon at a District General Hospital was conducted. Patients who were diagnosed with a PLG were included in our study. A database was constructed and patient details, investigations including ultrasound scan (USS) findings, treatment and histology and final diagnosis were recorded. RESULTS: Twenty-three (out of 651) patients were diagnosed pre-operatively by USS to have a polyp-likegall bladder lesion (PLG). Post cholecystectomy histological examination revealed 12 gallstones, 7 cholesterol polyps, 3 adenocarcinomas within polyps and 1 normal gall bladder. The specificity of USS in the diagnosis of PLG was 92.3%. All the true polyps were malignant. Overall USS had 66.66% sensitivity and 100% specificity in the pre-operative suspicion of malignancy. Using size greater than 10 mm as measured on USS as a cut-off, we find 100% sensitivity and 86.95% specificity with a positive predictive value of 50% in the diagnosis of malignancy in PLG.CONCLUSION: A large number of PLG are in fact calculi within diseased gall bladder. In cases of gall bladder polyps more then 10 mm in size on USS further imaging (crosssectional and/or EUS) is indicated prior to surgery. This will help in the optimal management of patients and avoid histological surprises. | D Chattopadhyay R Lochan S Balupuri BR Gopinath KS Wynne | 2005 | World Journal of Gastroenterology2005，11，14： | 23 |
| 4 | Unusual life-threatening Rosai-Dorfman disease of the trachea. role of NF-kappa B显示文摘 | Zhou, LF Chen, LA Zhu, QA Wang, C Xu, H Cui, XF Jiang, LF He, Ski Huang, M Yin, KS | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 21 |
| 5 | 臂间血压差异与冠状动脉粥样硬化的相关性显示文摘臂间血压差异(interm-arm blood pressure difference,IABPD)是较易获得的无创参数,从20世纪早期开始,临床医生已开始研究其用途[1]。右臂血压通常高于左臂血压,因为与右侧锁骨下动脉相比,左侧锁骨下动脉来源于主动脉,形成一个锐角,导致紊流,降低血流和血压,造成IABPD。英国国家卫生与临床研究所推出的新高血压临床指南建议,IABPD〈10mm Hg(1mm Hg=0.133kPa)可考虑为正常。 | Park SJ Son JW Park SM Choi HH Hong KS | 2017 | 中华高血压杂志2017，25，8： | 18 |
| 6 | 胶质瘤的基因治疗(英文)显示文摘Glioblastoma multiforme(GBM) is a highly invasive brain tumour that is unvaryingly fatal in humans despite even aggressive therapeutic approaches such as surgical resection followed by chemotherapy and radiotherapy.Unconventional treatment options such as gene therapy provide an intriguing option for curbing glioma related deaths.To date,gene therapy has yielded encouraging results in preclinical animal models as well as promising safety profiles in phase I clinical trials,but has failed to demonstrate significant therapeutic efficacy in phase III clinical trials.The most widely studied antiglioma gene therapy strategies are suicide gene therapy,genetic immunotherapy and oncolytic virotherapy,and we have attributed the challenging transition of these modalities into the clinic to four major roadblocks:(1) anatomical features of the central nervous system,(2) the host immune system,(3) heterogeneity and invasiveness of GBM and(4) limitations in current GBM animal models.In this review,we discuss possible ways to jump these hurdles and develop new gene therapies that may be used alone or in synergy with other modalities to provide a powerful treatment option for patients with GBM. | Tobias A Ahmed A Moon KS Lesniak MS. | 2013 | 中华神经外科疾病研究杂志2013，12，4： | 16 |
| 7 | Prognostic significance of annexin VII expression in glioblastomas multiforme in humans显示文摘OBJECT:Glioblastoma multiforme(GBM)is the most common and lethal primary brain tumor in adults.It isnearly uniformly fatal,with a median survival time of approximately l year,despite modem treatment modalities.Nevertheless,a range of survival times exists around this median.Efforts to understand why some patients livelonger or shorter than the average may provide insight into the biology of these neoplasms.The annexin VII(ANX7)gene is located on the human chromosome 10q21,a site long hypothesized to harbor tumor | Hung KS Howng SL | 2003 | 中国神经肿瘤杂志2003，1，4： | 14 |
| 8 | Lancet:世界心脏联盟全球心血管疾病预防展望显示文摘动脉粥样硬化性心血管疾病是世界头号致死致残因素,不成比例地影响着中低收入国家(LMIC)的居民。二十世纪六七十年代,心血管疾病被视为高收入国家的常见病,此后通过采取更好的预防措施(如改变生活方式、控制风险因素等),并广泛应用简单有效的紧急事件处理和二级预防措施,心血管疾病的年龄标准化死亡率得以减半。然而,即便在发达国家,所采取的这些行之有效的策略仍远远不够,如果在大多数高收入国家中推广,未来二十年心血管疾病的发生率将进一步降低。 | Yusuf S Wood D Ralston J Reddy KS | 2015 | 疾病监测2015，30，5： | 14 |
| 9 | 手针针刺合谷穴得气和疼痛相反的脑边缘叶效应fMRI研究1例显示文摘受试者,男,36岁,身体健康,参加手针针刺右侧合谷穴fMRI试验。
试验1:首先在右侧合谷穴体表实施触觉刺激作为针刺对照实验,采用标准5.88mm塑料细纤维(von Frey纤维,美国Stoeling公司生产),均匀柔和手动刺激穴位,频率60次/min,fMRI扫描和刺激间隔模式与针刺组相同。刺激后无明显疼痛及酸麻胀重感觉。试验2:针刺右侧合谷穴,完成扫描后,告知针刺只感觉到尖锐性疼痛,但能忍受,无酸麻胀重感觉。 | 方继良 Hui KS Kathleen Liu Jing Nixon Erika 周科华 王小玲 | 2012 | 中国中西医结合影像学杂志2012，10，2： | 12 |
| 10 | PREPARATION AND PROPERTIES OF RARE EARTH HYDROXIDES AND OXIDES ULTRAFINE POWDERS IN ALCOHOL显示文摘PREPARATIONANDPROPERTIESOFRAREEARTHHYDROXIDESANDOXIDESULTRAFINEPOWDERSINALCOHOL￥XiangTingDONG;ZongRuiLIU;KuiShengYANG;JingHeL... | Dong, XT Liu, ZR Yang, KS Liu, JH Hong, GY Yu, DC | 1995 | Chinese Chemical Letters1995，6，11： | 11 |
| 11 | Polymethylmethacrylate bone cements and additives: A review of the literature显示文摘Polymethylmethacrylate(PMMA) bone cement technology has progressed from industrial Plexiglass administration in the 1950 s to the recent advent of nanoparticle additives. Additives have been trialed to address problems with modern bone cements such as the loosening of prosthesis, high post-operative infection rates, and inflammatory reduction in interface integrity. This review aims to assess current additives used in PMMA bone cements and offer an insight regarding future directions for this biomaterial. Low index(< 15%) vitamin E and low index(< 5 g) antibiotic impregnated additives significantly address infection and inflammatory problems, with only modest reductions in mechanical strength. Chitosan(15% w/w PMMA) and silver(1% w/w PMMA) nanoparticles have strong antibacterial activity with no significant reduction in mechanical strength. Future work on PMMA bone cements should focus on trialing combinations of these additives as this may enhance favourable properties. | Manit Arora Edward KS Chan Sunil Gupta Ashish D Diwan | 2013 | World Journal of Orthopedics2013，4，2： | 10 |
| 12 | Role of autophagy in liver physiology and pathophysiology显示文摘Autophagy is a highly conserved intracellular degradation pathway by which bulk cytoplasm and superfluous or damaged organelles are enveloped by double membrane structures termed autophagosomes. The autophago-somes then fuse with lysosomes for degradation of their contents, and the resulting amino acids can then recycle back to the cytosol. Autophagy is normally activated in response to nutrient deprivation and other stressors and occurs in all eukaryotes. In addition to maintaining energy and nutrient balance in the liver, it is now clear that autophagy plays a role in liver protein aggregates related diseases, hepatocyte cell death, steatohepatitis, hepatitis virus infection and hepatocellular carcinoma. In this review, I discuss the recent findings of autophagy with a focus on its role in liver pathophysiology. | Wen-Xing Ding, Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, MS 1018, 3901 Rainbow Blvd, Kansas City, Kansas, KS 66160, United States | 2010 | World Journal of Biological Chemistry2010，1，1： | 9 |
| 13 | AUTOMATED REASONING IN DIFFERENTIAL GEOMETRY AND MECHANICS USING THE CHARACTERISTIC METHOD Ⅳ. Bertrand Curves显示文摘This paper reports the study of properties of the curve pairs of the Bertrandtypes using our automated reasoning program based on Wu’s method of mechanical the-orem proving for differential geometry. A complete list of results about Bertrand curvesin metric and affine spaces is derived mechanically. The list includes most of the knownresults of various Bertrand curves. We also derive some new results about Bertrand curves. | CHOU Shangching GAO Xiaoshan Department of Computer Science,the Wichita State University,Wichita,KS 67260,UsA Institute of Systems Science, Academia Sinica, Beijing 100080, China | 1993 | Systems Science and Mathematical Sciences1993，6，2： | 8 |
| 14 | 血清HBV RNA和HBsAg水平在判断亚洲慢性乙型肝炎患者是否适合停用恩替卡韦中的作用显示文摘【据Gut 2020年8月报道】题:血清HBV RNA和HBsAg水平在判断亚洲慢性乙型肝炎患者是否适合停用恩替卡韦中的作用(作者Seto WK等)来自中国香港的Seto等研究显示,在HBsAg血清清除前,慢性HBV感染的某些亚群患者可能已经停止治疗了。血清HBV RNA在决定停止治疗适宜性方面的作用中尚未得到很好的研究。 | SETO WK LIU KS MAK LY 徐晓桐 金晶兰 | 2020 | 临床肝胆病杂志2020，36，11： | 7 |
| 15 | Hepatic steatosis and fibrosis: Non-invasive assessment显示文摘Chronic liver disease is a major cause of morbidity and mortality worldwide and usually develops over many years, as a result of chronic inflammation and scarring, resulting in end-stage liver disease and its complications. The progression of disease is characterised by ongoing inflammation and consequent fibrosis, although hepatic steatosis is increasingly being recognised as an important pathological feature of disease, rather than being simply an innocent bystander. However, the current gold standard method of quantifying and staging liver disease, histological analysis by liver biopsy, has several limitations and can have associated morbidity and even mortality. Therefore, there is a clear need for safe and noninvasive assessment modalities to determine hepatic steatosis, inflammation and fibrosis. This review covers key mechanisms and the importance of fibrosis and steatosis in the progression of liver disease. We address non-invasive imaging and blood biomarker assessments that can be used as an alternative to information gained on liver biopsy. | Rustam N Karanjia Mary ME Crossey I Jane Cox Haddy KS Fye Ramou Njie Robert D Goldin Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，45： | 6 |
| 16 | Cell surface activation of progelatinase A (proMMP-2) and cell migration显示文摘Gelatinase A (MMP-2) is considered to play a critical role in cell migration and invasion. The proteinase is secreted from the cell as an inactive zymogen. In vivo it is postulated that activation of progelationase A (proMMP-2) takes place on the cell surface mediated by membrane-type matrix metalloproteinases (MT-MMPs). Recent studies have demonstrated that proMMP-2 is recruited to the cell surface by interacting with tissue inhibitor of metalloproteinases-2 (TIMP-2) bound to MT1MMP by forming a ternary complex. bee MT1-MMP closely located to the ternary complex then activates proMMP-2 on the cell surface. MT1-MMP is found in cultured invasive cancer cells at the invadopodia. The MTMMP/TIMP-2/ MMP- 2 system t bus provides localized expression of proteolysis of the extracellular matrix required for cell migration. | NAGASE HIDEAKI(Department of Biochemistry and Molecular Biology,University of Kansas Medical Center, 3901 Rainbow Blvd,Kansas City, KS 66160. E-mail: hnagase@kumc.edu) | 1998 | Cell Research1998，8，3： | 6 |
| 17 | 猪营养新概念显示文摘1母乳1.1前言2~3周龄前的仔猪几乎完全靠母乳获取营养。因此,母乳的量和质是生死攸关的,它们是仔猪断奶前生存和生长的限制性因素。能否通过营养调控来改变母乳的量和质呢?如能,它将对窝性能有何影响?1.2母猪泌乳量相对于牛,猪的泌乳量很难度量,不过,日... | Sohn,KS 郗伟斌 | 1998 | 养猪1998，，1： | 6 |
| 18 | 关节盘无移位的症状性颞下颌关节的核磁共振研究显示文摘目的:本研究的目的是应用核磁共振成像(MRI)诊断颞下颌关节紊乱病(TMD),讨论在关节盘位置正常的TMD关节中的核磁共振影像发现,并探讨这些影像发现与临床症状间的关系。方法:本研究对2000-2002年期间在芬兰欧鲁大学牙学院颌面外科就诊的78名TMD患者中,经MRI发现为关节盘位置正常的68侧关节作了影像及临床症状的对比分析。结果:在此68侧关节MRI中,发现了髁突运动异常:过度运动(61.8%)及运动受限(2.9%);发现了怀疑为翼外肌上头和/或下头的肥大、萎缩及挛缩等病理改变(58.8%)。在关节盘形态方面,未发现明显的关节盘畸形,但发现了关节盘整体变厚的病理影像表现(22.1%)。还观察到涉及关节囊上腔、下腔和/或双板区的炎性渗出(35.3%)。髁突过度运动及翼外肌病理改变与症状组有显著性关系。结论:本研究的结果提示,髁突过度运动及可能发生的翼外肌病理改变,在引起关节盘位置正常的颞下颌关节的临床TMD症状中,扮有十分重要的角色。 | 杨晓江 AM Raustia KS Oikarinen | 2002 | 口腔颌面修复学杂志2002，3，4： | 6 |
| 19 | Comparison of three PCR methods for detection of Helicobacter pylori DNA and detection of cagA gene in gastric biopsy specimens显示文摘AIM: To comparatively evaluate PCR and other diagnostic methods (the rapid urease test and / or culture) in order to determine which of the three PCR methods (ureA, glmM and 26-kDa, SSA gene) was most appropriate in the diagnosis of Helicobacterpylon (Hpylo#) infection and also to evaluate the detection of a putative virulence marker of Hpylori,the cagA. gene, by PCR in biopsy specimens.METHODS: One hundred and eighty-nine biopsy specimens were collected from 63 patients (three biopsies each) undergoing upper gastroduodenal endoscopy for various dyspeptic symptoms. The PCR methods used to detect HpylonDNA directly from biopsies were the glmM, 26-kDa,ureA and then cagA was used to compare the culturet echnique and CLO for urease with the culture technique being used as the gold standard.RESULTS: Thirty-five percent of the biopsies were positive for Hpy/or/DNA using the 3 PCR methods, while 68% of these were positive for the cagA gene. Twenty-four percent of the biopsies were negative for Hpy/or/DNA in all PCR methods screened. The remaining 41% were either positive for urea gene only, g/mMonly, 26-kDa only, or urea + g/mM,urea + 26-kDa, glmM + 26-kDa. Out of the 35% positive biopsies, 41% and 82% were positive by culture and CLO respectively, while all negative biopsies were also negative by culture and cagA. Cag A+ infection was also predominantly found in H pylori DNA of the biopsies irrespective of the clinical diagnosis.CONCLUSION: This method is useful for correctly identifying infections caused by Hpy/or/and can be easily applied in our laboratory for diagnostic purposes. | SI Smith KS Oyedeji AO Arigbabu FCantet FMegraud OOOjo AOUwaifo JAOtegbayo SOOla AO Coker | 2004 | World Journal of Gastroenterology2004，10，13： | 5 |
| 20 | Transarterial chemoembolization for liver metastases from solid pseudopapillary epithelial neoplasm of pancreas: A case report显示文摘Solid pseudo-papillary epithelial neoplasm(SPEN) is a rare epithelial tumor of pancreas with a low malignant potential occurs most commonly in young females. We report a case of 40 years old woman presented withextensive liver metastasis from SPEN of pancreatic body for which she was operated four years ago. Due to the extensive nature of metastatic disease she was offered Transarterial chemoembolisation(TACE) using gemcitabine as chemotherapeutic agent. Short term follow up after a month of TACE with multiphase computed tomography showed > 90% resolution in the viable tumor with significant clinical improvement. TACE ensures targeted delivery of chemotherapeutic drugs in higher doses with least systemic toxicity and is more effective and safe than systemic chemotherapy. TACE with gemcitabine was found to be very effective in our patient with numerous liver metastasis. | TV Prasad KS Madhusudhan Deep N Srivastava Nihar R Dash Arun K Gupta | 2015 | World Journal of Radiology2015，7，3： | 5 |
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