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| 1 | Neuroimaging the brain-gut axis in patients with irritable bowel syndrome显示文摘AIM:To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome(IBS).METHODS:A database search for relevant literature was conducted using Pub Med,Scopus and Embase in February 2015.Date filters were applied from the year2009 and onward,and studies were limited to those written in the English language and those performed upon human subjects.The initial search yielded 797articles,out of which 38 were pulled for full text review and 27 were included for study analysis.Investigations were reviewed to determine study design,methodology and results,and data points were placed in tabular format to facilitate analysis of study findings across disparate investigations.RESULTS:Analysis of study data resulted in the abstraction of four key themes:Neurohormonal differences,anatomic measurements of brain structure and connectivity,differences in functional responsiveness of the brain during rectal distention,and confounding/correlating patient factors.Studies in this review noted alterations of glutamate in the left hippocampus(HIPP),commonalities across IBS subjects in terms of brain oscillation patterns,cortical thickness/gray matter volume differences,and neuroanatomical regions withincreased activation in patients with IBS:Anterio cingulate cortex,mid cingulate cortex,amygdala anterior insula,posterior insula and prefrontal cortex.A striking finding among interventions was the substantia influence that patient variables(e.g.,sex,psychologica and disease related factors)had upon the identification of neuroanatomical differences in structure and con nectivity.CONCLUSION:The field of neuroimaging can provide insight into underlying physiological differences that distinguish patients with IBS from a healthy population. | Kristen R Weaver Lee Anne B Sherwin Brian Walitt Gail D'Eramo Melkus Wendy A Henderson | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，2： | 8 |
| 2 | Multiple Antibiotic Resistance and Heavy Metal Resistance Profile of Bacteria Isolated from Giant Freshwater Prawn (Macrobrachium rosenbergii) Hatchery显示文摘In this article, antibiogram and heavy metal resistance profile of bacteria isolated from giant freshwater prawn (Macrobrachium rosenbergii) hatchery in Malaysia are described. Although giant freshwater prawn was introduced into Malaysia since the 1980s, there was no database information on antibiogram and heavy metal resistance profile of bacteria from giant freshwater prawn (M. rosenbergii) hatchery in Malaysia. Therefore, this study was carried out to determine the effectiveness of antibiotic and heavy metal resistance profile to control bacterial diseases in M. rosenbergii hatchery. The results can provide valuable information for local M. rosenbergii post-larval producer. Antibiotic sensitivity test was carried out by disk-diffusion method against 15 types of antibiotics as follows: oxolinic acid (2 μg), ampicillin (10 μg), erythromycin (15 μg), furazolidone (15 μg), lincomycin (15 μg), amoxicillin (25 μg), colistin sulphate (25 μg), doxycycline (30 μg), florfenicol (30 μg), flumequine (30 μg), nalidixic acid (30 μg), tetracycline (30 μg), oleandomycin (15 μg), fosfomycin (50 μg), and spiramycin (100 μg), whereas heavy metal resistance profile of the present bacterial isolates was determined by 2-fold agar dilution technique. In this study, 5 types of bacteria were successfully isolated; they were Aeromonas spp. (n = 77), Escherichia coli (n = 73), Edwardsiella spp. (n = 62), Salmonella spp. (n = 75), and Vibrio spp. (n = 43). The result showed that furazolidone was the most effective antibiotic to control the bacteria isolated in this study, approximately 89.7% of the bacterial isolates were sensitive to this antibiotic. Multiple antibiotic resistance (MAR) index indicated that the hatchery water source and M. rosenbergii post-larval and sediment tanks were at high-risk exposure to the tested antibiotic. Furthermore, all the tested heavy metals (Cd2+, Cr6+, Hg2+, and Cu2+) failed to inhibit the growth of the bacterial isolates. Therefore, it indicated that the water source of the hatchery is contaminated with both antibiotic residues and heavy metal. | S W Lee M Najiah W Wendy A Zahrol M Nadirah | 2009 | Agricultural Sciences in China2009，8，6： | 7 |
| 3 | “梦想”普通话标准化评估在听障儿童语言测试中的应用显示文摘目的本文讨论了用口语交流的听障儿童语言发展效果评估的最新实证。方法研究强调,语言评估须足够具体,才能捕捉到细微的词汇及语法缺陷。'普通话听力理解和表达能力标准化评估'(Diagnostic Receptive and Expressive Assessment of Mandarin,DREAM,译为'梦想')抓住儿童普通话习得的核心特征,是基于中国大陆地区的普通话儿童来建立常模的综合性的语言测试,可以测量中国大陆儿童在各个年龄阶段的语言技能。声音和图片通过平板电脑呈现,答案以触屏的方式进行记录,减少了人为差异,使操作更加标准化。结果本文报告了DREAM的题目设计、信度和效度研究等内容。试验研究显示,该测试可提供听障儿童语言发展的详细信息。测试可提供诊断儿童具体语言发育缺陷的报告,用来指导康复计划的制定,使更加个性化的康复干预成为可能。结论 DREAM是转化科学的成功范例——把科研结果从语言习得的循证研究转移到临床评估和干预康复的应用领域。以循证医学为基础的综合性普通话语言测试将推动中国听障儿童干预和康复的效果评估研究。 | 刘雪曼 de Villiers,Jill 宁春岩 Rolfhus,Eric Hutchings,Teresa Lee,Wendy 江帆 章依文 | 2015 | 中华耳科学杂志2015，13，4： | 7 |
| 4 | 家庭方言环境对儿童语言发育的影响显示文摘目的探究家庭方言环境对儿童语言发育的影响,为探讨儿童语言障碍原因提供理论依据。方法收集2015年11月-2019年9月于上海儿童医学中心发育行为儿科就诊并完成语言能力测试的儿童资料。共688名儿童,年龄范围35.1~95.7个月;根据家庭方言环境分为普通话组(n=151),方言组(n=537)。采用χ~2检验和Mann-Whitney U检验分析两组儿童的语言能力差异。结果普通话组和方言组儿童的年龄、性别构成以及语言障碍比例,差异无统计学意义(P>0.05);语言正常和障碍儿童在整体语言、听力理解、语言表达、语义、句法5个维度上均不受方言环境影响(P>0.05)。结论家庭方言环境不是儿童语言发育的危险因素,语言暴露的质量与数量对儿童早期发展更为重要。 | 林媛媛 章依文 刘雪曼 Lee Wendy | 2020 | 中国儿童保健杂志2020，28，8： | 7 |
| 5 | Antibiotic Resistance and Heavy Metals Tolerance in Gram-Negative Bacteria from Diseased American Bullfrog (Rana catesbeiana) Cultured in Malaysia显示文摘A total of 140 bacterial isolates have been successfully isolated from various organs of diseased American bullfrog (Rana catesbeiana) cultured in Malaysia. The most frequently isolated bacteria was Edwardsiella spp. (46 isolates) followed by Aeromonas spp. (33 isolates), Flavobacterium spp. (31 isolates), and Vibrio spp. (30 isolates). Majority of the bacterial isolates were found sensitive to furazolidone (85.0%), chloramphenicol (85.0%), oxolinic acid (90.0%), florfenicol (95.0%), and flumequine (97.5%). On the other hand, most of the bacterial isolates were resistant to oleandomycin (77.5%) and lincomycin (87.5%). Nitrofurantoin and flumequine can be inhibited the growth of all of Vibrio spp. whereas all isolates of Edwardsiella spp. were found sensitive to florfenicol and flumequine. Multiple antibiotic resistance (MAR) index were in range of 0.30-0.40, indicating that bacterial isolates from cultured bullfrogs may have received high risk exposure to the tested antibiotics. In addition, 90-100% of the isolates were resistant to copper, cadmium, and chromium. These results provided insight information on tolerance level of bacterial isolates from cultured bullfrogs to 21 antibiotics as well as heavy metals. | M Najiah S W Lee W Wendy L W Tee M Nadirah S H Faizah | 2009 | Agricultural Sciences in China2009，8，10： | 4 |
| 6 | New language outcome measures for Mandarin speaking children with hearing loss显示文摘Objective:The paper discusses recent evidence on the assessment of language outcomes in children with hearing loss acquiring oral language.Methods:Research emphasizes that language tests must be specific enough to capture subtle deficits in vocabulary and grammar learning at different developmental ages.The Diagnostic Receptive and Expressive Assessment of Mandarin(DREAM) was carefully designed to be a comprehensive standardized Mandarin assessment normed in China's Mainland.Objective:The paper discusses recent evidence on the assessment of language outcomes in children with hearing loss acquiring oral language.Methods:Research emphasizes that language tests must be specific enough to capture subtle deficits in vocabulary and grammar learning at different developmental ages.The Diagnostic Receptive and Expressive Assessment of Mandarin(DREAM)was carefully designed to be a comprehensive standardized Mandarin assessment normed in China's Mainland.Results:This paper summarizes the evidence-based item design process and validity and reliability results of DREAM.A pilot study reported here shows that DREAM provided detailed information about hearing impaired children's language abilities and can be used to aid intervention planning to maximize progress.Conclusion:DREAM represents an example of translational science,transferring methods from empirical studies of language acquisition in research environments into applied domains such as assessment and intervention.Research on outcomes in China will advance significantly with the availability of evidence-based comprehensive language tests that measure a sufficient age range of skills,are normed on Mandarin speaking children in China's Mainland,and are designed to capture features central to Mandarin language acquisition. | Xueman Liu Jill de Villiers Wendy Lee Chunyan Ning Eric Rolfhus Teresa Hutchings Fan Jiang Yiwen Zhang | 2016 | Journal of Otology2016，11，1： | 4 |
| 7 | 执行功能在语言障碍和多动/注意缺陷行为关系中的调节作用显示文摘目的分析执行功能是否能够在儿童语言障碍与多动/注意缺陷行为问题的相互关系中起到显著的调节作用,为儿童语言障碍和多动/注意缺陷障碍共病的诊治提供依据。方法收集2014年9-11月上海儿童医学中心确诊的语言障碍儿童19例(男∶女为12∶7),平均年龄(57.5±11.8)个月,选同期门诊健康体检的语言正常儿童41例(男∶女为29∶12),平均年龄(63.0±15.9)个月,采用年龄和性别1∶2配对病例对照研究,回顾性收集两组儿童的语言、执行功能、长处与困难问卷SDQ、非语言智力等资料。分析两组儿童神经认知功能的差异和多动/注意缺陷行为的差异。使用Bootstrapping分析短时记忆与抑制功能是否在语言障碍影响多动/注意缺陷行为发生的关系中存在显著的中介作用。结果语言障碍组儿童短时记忆与抑制控制均显著低于非语言障碍组儿童(t=3.72、3.30,P<0.01,效应值为0.96、0.82),SDQ多动/注意缺陷得分均显著高于正常组儿童(t=-2.24,P=0.029,效应值0.65)。短时记忆和抑制控制未产生显著的共同中介效应。探讨独立中介效应时,短时记忆与抑制功能均产生显著的中介作用,非语言智力不能影响这一过程。结论语言障碍儿童短时记忆与抑制控制均能够独立作为中介因素,影响语言障碍儿童产生多动/注意缺陷行为。但短时记忆与抑制控制不能够共同调节这一效应。 | 马希瑞 章依文 林媛媛 刘雪曼 Lee Wendy | 2019 | 中国儿童保健杂志2019，0，8： | 2 |
| 8 | An Interaction of Race and Ethnicity With Socioeconomic Status in Rectal Cancer Outcomes显示文摘 | Joseph Kim Avo Artinyan Brian Mailey Stefanie Christopher Wendy Lee Shaun McKenzie Steven L. Chen Smita Bhatia Alessio Pigazzi Julio Garcia-Aguilar | 2011 | Annals of Surgery2011，，4： | 2 |
| 9 | Vasopressin: a new target for the treatment of heart failure显示文摘 | Craig R Lee Michael L Watkins J.Herbert Patterson Wendy Gattis Christopher M O'Connor Mihai Gheorghiade Kirkwood F Adams | 2003 | American Heart Journal2003，，1： | 1 |
| 10 | Aspartic proteinase inhibitors from tomato and potato are more potent against yeast proteinase A than cathepsin D显示文摘 | Simon A Cater Wendy E Lees Jeffrey Hill | 2002 | Biochimica et Biophysica Acta2002，1596，： | 1 |
| 11 | Characterizing Alzheimer’s disease using a hypometabolic convergence index显示文摘 | Kewei Chen Napatkamon Ayutyanont Jessica B.S. Langbaum Adam S. Fleisher Cole Reschke Wendy Lee Xiaofen Liu Dan Bandy Gene E. Alexander Paul M. Thompson Leslie Shaw John Q. Trojanowski Clifford R. Jack Susan M. Landau Norman L. Foster Danielle J. Harvey Mi | 2011 | Neuroimage2011，，1： | 1 |
| 12 | Long-Term Use of Aspirin and the Risk of Gastrointestinal Bleeding显示文摘 | Edward S. Huang Lisa L. Strate Wendy W. Ho Salina S. Lee Andrew T. Chan | 2011 | The American Journal of Medicine2011，，5： | 1 |
| 13 | Ocular damage secondary to lights and lasers: How to avoid and treat if necessary显示文摘An armamentarium of the latest light and laser technologies are used by physicians of different disciplines to address a variety of aesthetic challenges in the periocular region and throughout the body. If improperly used, these modalities can inflict serious ocular injury on the patient, support personnel, and operator. It is paramount that providers involved in operating these technologies be knowledgeable about the physical and clinically relevant properties of the unit being used. This involves training in the proper utilization, appropriate treatment parameters, and safety measure for each. Selection of the appropriate eye protection is particularly important for both the patient and the personnel. It is also imperative for the laser operator to understand the range of potential ocular complications associated with the cosmetic use of lasers and lights, to recognize the signs and symptoms associated with ocular damage, and to provide efficient first aid measures should damage ensue. Possible ocular complications related to the cosmetic use of lasers and lights range from mild eyelid swelling and erythema to potentially blinding macular injury. Ocular injury may also be inflicted by the improper selection or placement of eye protection.A complete ophthalmologic evaluation and timely management of potential complications is mandated when there is any concern for ocular injury. | Mohamed S Sayed Marcus J Ko Audrey C Ko Wendy W Lee | 2014 | World Journal of Ophthalmology2014，4，1： | 1 |
| 14 | Computed Tomography-Pathologic Assessment of Laser-Induced Necrosis in Rat Liver显示文摘 | ZAHIR AMIN WENDY THURRELL GLENN M. SPENCER SIMON A. HARRIES WILLIAM E. GRANT STEPHEN G. BOWN WILLIAM R. LEES | 1993 | INVESTIGATIVE RADIOLOGY1993，，12： | 1 |
| 15 | Evaluation of an Integrated Orbital Tissue Expander in an Anophthalmic Feline Model显示文摘 | David T. Tse Leonard Pinchuk Stewart Davis Steven F. Falcone Wendy Lee Ana Caroline Acosta Eleut Hernandez Elizabete Lee Jean-Marie Parel | 2007 | American Journal of Ophthalmology2007，，2： | 1 |
| 16 | Turnover contagion:how coworkers'job embeddedness and job search behaviors influence quitting显示文摘 | WILL FELPS TERENCE R MITCHELL DAVID R HEKMAN THOMS W LEE BROOKS C HOLTOM WENDY S HARMAN | 2009 | Academy of Management Journal2009，，3： | 1 |
| 17 | Sustained Benefits from Ranibizumab for Macular Edema following Central Retinal Vein Occlusion: Twelve-Month Outcomes of a Phase III Study显示文摘 | Peter A. Campochiaro David M. Brown Carl C. Awh S. Young Lee Sarah Gray Namrata Saroj Wendy Yee Murahashi Roman G. Rubio | 2011 | Ophthalmology2011，，10： | 1 |
| 18 | The Semantic Web Revisited显示文摘 | Nigel Shadboh Wendy Hall Tim Berners -lee | 2006 | IEEE Intelligent Systems2006，21，3： | 1 |
| 19 | Improved common carotid elasticity and intima-media thickness measurements from computer analysis of sequential ultrasound frames显示文摘 | Robert H Selzer Wendy J Mack Paul L Lee Helen Kwong-Fu Howard N Hodis | 2001 | Atherosclerosis2001，，： | 1 |
| 20 | Milan Criteria and UCSF Criteria: A Preliminary Comparative Study of Liver Transplantation Outcomes in the United States显示文摘 | Supriya S. Patel Amanda K. Arrington Shaun McKenzie Brian Mailey Michelle Ding Wendy Lee Avo Artinyan Nicholas Nissen Steven D. Colquhoun Joseph Kim Giuliano Ramadori | 2012 | International Journal of Hepatology2012，，： | 1 |
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