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| 1 | Bile duct injuries associated with laparoscopic and open cholecystectomy: Sixteen-year experience显示文摘AIM: To summarize the experience in diagnosis, management and prevention of iatrogenic bile duct injury (IBDI). METHODS: A total of 210 patients with bile duct injury occurred during cholecystectomy admitted to Hunan Provincial People’s Hospital from March 1990 to March 2006 were included in this study for retrospective analysis. RESULTS: There were 59.5% (103/173) of patients with IBDI resulting from the wrong identification of the anatomy of the Calot’s triangle during cholecystectomy. The diagnosis of IBDI was made on the basis of clinical features, diagnostic abdominocentesis and imaging findings. Abdominal B ultrasonography (BUS) was the most popular way for IBDI with a diagnostic rate of 84.6% (126/149). Magnetic resonance cholangiography (MRC) could reveal the site of injury, the length of injured bile duct and variation of bile duct tree with a diagnostic rate 100% (45/45). According to the site of injury, IBDI could be divided into six types. The most common type (type 3) occurred in 76.7% (161/210) of the patients and was treated with partial resection of the common hepatic duct and common bile duct. One hundred and seventy-six patients were followed up. The mean follow-up time was 3.7 (range 0.25-10) years. Good results were achieved in 87.5% (154/176) of the patients. CONCLUSION: The key to prevention of IBDI is to follow the 'identifying-cutting-identifying' principle during cholecystectomy. Re-operation time and surgical procedure are decided according to the type of IBDI. | Jin-Shu Wu Chuang Peng Xian-Hai Mao Pin Lv | 2007 | World Journal of Gastroenterology2007，13，16： | 32 |
| 2 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 3 | Prediction of shield tunneling-induced ground settlement using machine learning techniques显示文摘Predicting the tunneling-induced maximum ground surface settlement is a complex problem since the settlement depends on plenty of intrinsic and extrinsic factors.This study investigates the efficiency and feasibility of six machine learning(ML)algorithms,namely,back-propagation neural network,wavelet neural network,general regression neural network(GRNN),extreme learning machine,support vector machine and random forest(RF),to predict tunneling?induced settlement.Field data sets including geological conditions,shield operational parameters,and tunnel geometry collected from four sections of tunnel with a total of 3.93 km are used to build models.Three indicators,mean absolute error,root mean absolute error,and coefficient of determination the(7?2)are used to demonstrate the performance of each computational model.The results indicated that ML algorithms have great potential to predict tunneling-induced settlement,compared with the traditional multivariate linear regression method.GRNN and RF algorithms show the best performance among six ML algorithms,which accurately recognize the evolution of tunneling-induced settlement.The correlation between the input variables and settlement is also investigated by Pearson correlation coefficient. | Renpeng CHEN Pin ZHANG Huaina WU Zhiteng WANG Zhiquan ZHONG | 2019 | Frontiers of Structural and Civil Engineering2019，13，6： | 20 |
| 4 | The prognostic and therapeutic implications of circulating tumor cell phenotype detection based on epithelial-mesenchymal transition markers in the first-line chemotherapy of HER2-negative metastatic breast cancer显示文摘Background:Epithelial-mesenchymal transition(EMT)is implicated in the metastatic process and presents a chal-lenge to epithelial cell adhesion molecule-based detection of circulating tumor cells(CTCs),which have been demon-strated to be a prognostic indicator in metastatic breast cancer.Although evidence has indicated that heterogeneity of CTCs based on EMT markers is associated with disease progression,no standard recommendations have been established for clinical practice.This study aimed to evaluate the prognostic significance of dynamic CTC detection based on EMT for metastatic breast cancer patients.Methods:We enrolled 108 human epidermal growth factor receptor 2-negative metastatic breast cancer patients from the prospective phase III CAMELLIA study and applied the CanPatrol CTC enrichment technique to identify CTC phenotypes(including epithelial CTCs,biphenotypic epithelial/mesenchymal CTCs,and mesenchymal CTCs)in peripheral blood samples.Receiver operating characteristic curve analyses of total CTC count and the proportion of mesenchymal CTCs for predicting the 1-year progression-free survival(PFS)rate were conducted to determine the optimal cut-off values,and Kaplan-Meier analysis and Cox proportional hazards regression analysis were performed to investigate the prognostic value of the cut-off values of both total CTC count and the proportion of mesenchymal CTCs in combination.Results:For predicting the 1-year PFS rate,the optimal cut-off value of total CTC count was 9.5(Area under the curve[AUC]=0.538,95%confidence interval[CI]=0.418-0.657),and that of the proportion of mesenchymal CTCs was 10.7%(AUC=0.581,95%CI=0.463-0.699).We used the two cut-off values in combination to forecast PFS in which the total CTC count was equaled to or exceeded 10/5 mL with the proportion of mesenchymal CTCs surpassed 10.7%.Patients who met the combined criteria had significantly shorter median PFS than did those who did not meet the criteria(6.2 vs.9.9 months,P=0.010).A nomogram was constructed based on the criteria and significant clinicopatho-logical characteristics with a C-index of 0.613(P=0.010).Conclusions: The criteria, which combine the total CTC count and the proportion of mesenchymal CTCs, may be used to monitor therapeutic resistance and predict prognosis in patients with metastatic breast cancer. | Xiuwen Guan Fei Ma Chunxiao Li Shiyang Wu Shangying Hu Jiefen Huang Xiaoying Sun Jiayu Wang Yang Luo Ruigang Cai Ying Fan Qiao Li Shanshan Chen Pin Zhang Qing Li Binghe Xu | 2019 | Cancer Communications2019，39，1： | 15 |
| 5 | Effect of endotoxin on fibronectin synthesis of rat primary cultured hepatocytes显示文摘EfectofendotoxinonfibronectinsynthesisofratprimaryculturedhepatocytesJIAJinBin,HANDeWu,XURuiLing,GAOFei,ZHAOLongFeng,ZHA... | JIA JinBin, HAN DeWu, XU RuiLing, GAO Fei, ZHAO LongFeng, ZHAO YuanChang, YAN JinPin and MA XueHuiKeywords liver cirrhosis endotoxins fibronectin/analysis liver/cytology cells, cultured lipopolysaccharide | 1998 | World Journal of Gastroenterology1998，4，4： | 14 |
| 6 | Human γδT-cell subsets and their involvement in tumor mmunity显示文摘 | Dang W u Pin Wu Fuming Qiu Qichun Wei Jian Huang | 2017 | Cellular & Molecular Immunology2017，14，3： | 11 |
| 7 | Postoperative Regulatory T-Cells and Natural Killer Cells in Stage I Nonsmall Cell Lung Cancer Underwent Video-assisted Thoracoscopic Lobectomy or Thoracotomy显示文摘 | Sai Zhang Sai-Bo Pan Qing-Hua Lyu Pin Wu Guang-Ming Qin Qi Wang Zhong-Liang He Xue-Ming He Ming Wu Gang Chen | 2015 | Chinese Medical Journal2015，，11： | 10 |
| 8 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 9 | Role of Endoplasmic Reticulum Stress in Silica-induced Apoptosis in RAW264.7 Cells*显示文摘Objective We investigated the role of endoplasmic reticulum stress(ERS) in silica-induced apoptosis in alveolar macrophages in vitro. Methods RAW264.7 cells were incubated with 200 μg/mL silica for different time periods. Cell viability was assayed by the MTT assay. Cell apoptosis was evaluated by DAPI staining, flow cytometry analysis, and Western blot analysis of caspase-3. Morphological changes in the endoplasmic reticulum were observed by transmission electron microscopy. The expression of ERS markers binding protein(BiP) and CCAAT-enhancer-binding protein homologous protein(CHOP) was examined by Western blotting and real-time PCR. As an inhibitor of ERS, 4-phenylbutyric acid(4-PBA) was used in the experiments. Results Silica exposure induced nuclear condensation and caspase-3 expression in RAW264.7 cells. The number of apoptotic cells increased after silica exposure in a time-dependent manner. Silica treatment induced expansion of the endoplasmic reticulum. In addition, the expression of BiP and CHOP increased in silica-stimulated cells. Furthermore, 4-PBA treatment inhibited silica-induced endoplasmic reticulum expansion and the expression of Bi P and CHOP. Moreover, 4-PBA treatment attenuated nuclear condensation, reduced apoptotic cells, and downregulated caspase-3 expression in silica-stimulated cells. Conclusion Silica-induced ERS is involved in the apoptosis of alveolar macrophages. | HU Yong Bin WU Xia QIN Xiao Feng WANG Lei PAN Pin Hua | 2017 | Biomedical and Environmental Sciences2017，30，8： | 6 |
| 10 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 11 | Studies on bio-antioxidants——Ⅱ.An ESR study on the antioxidant efficiency of ascorbyl palmitate in micelles显示文摘The kinetics for the reaction of ascorbyl palmitate and 4-hydroxy-TEMPO,4-methoxy-TEMPO or 4-hexanoyloxy-TEMPO in CTAB and SDS micelles was studied by ESR spectroscopy.It was found that the behavior of ascorbyl palmitate is remarkably different from ascorbic acid in theirantioxidant activity in micelles.The predominant factors governing the activity in micelles involvethe lipophilicity of the antioxidant and the oxidant,the charge type of the substrates and the concentra-tion of the surfactant.As high as 2×10~4 fold rate variation was observed by changing the lipophilicityof the antioxidant and the microenvironment of the reaction medium. | LIU,Zhong-Li HAN,Zheng-Xu CHENG,Pin WU,Lung-Min LIU,You-Cheng National Laboratory on Applied Organic Chemistry and Department of Chemistry,Lanzhou University,Lanzhou,730000 | 1991 | Chinese Journal of Chemistry1991，9，2： | 4 |
| 12 | Establishment and clinical application value of an automatic diagnosis platform for rectal cancer T-staging based on a deep neural network显示文摘Background:Colorectal cancer is harmful to the patient’s life.The treatment of patients is determined by accurate preoperative staging.Magnetic resonance imaging(MRI)played an important role in the preoperative examination of patients with rectal cancer,and artificial intelligence(AI)in the learning of images made significant achievements in recent years.Introducing AI into MRI recognition,a stable platform for image recognition and judgment can be established in a short period.This study aimed to establish an automatic diagnostic platform for predicting preoperative T staging of rectal cancer through a deep neural network.Methods:A total of 183 rectal cancer patients’data were collected retrospectively as research objects.Faster region-based convolutional neural networks(Faster R-CNN)were used to build the platform.And the platform was evaluated according to the receiver operating characteristic(ROC)curve.Results:An automatic diagnosis platform for T staging of rectal cancer was established through the study of MRI.The areas under the ROC curve(AUC)were 0.99 in the horizontal plane,0.97 in the sagittal plane,and 0.98 in the coronal plane.In the horizontal plane,the AUC of T1 stage was 1,AUC of T2 stage was 1,AUC of T3 stage was 1,AUC of T4 stage was 1.In the coronal plane,AUC of T1 stage was 0.96,AUC of T2 stage was 0.97,AUC of T3 stage was 0.97,AUC of T4 stage was 0.97.In the sagittal plane,AUC of T1 stage was 0.95,AUC of T2 stage was 0.99,AUC of T3 stage was 0.96,and AUC of T4 stage was 1.00.Conclusion:Faster R-CNN AI might be an effective and objective method to build the platform for predicting rectal cancer T-staging.Trial registration:chictr.org.cn:ChiCTR1900023575;http://gffzz62a03ee25e6f4a77h0kxpkvu6co6b65nn.ffgz.tsg.suse.edu.cn/showproj.aspx?proj=39665. | Qing-Yao Wu Shang-Long Liu Pin Sun Ying Li Guang-Wei Liu Shi-Song Liu Ji-Lin Hu Tian-Ye Niu Yun Lu | 2021 | Chinese Medical Journal2021，，7： | 4 |
| 13 | Homologous fault monitoring technology of redundant INS in airborne avionics systems显示文摘Redundant technology plays an important role in improving the reliability and fault-tolerance of the airborne avionics systems.A Markov state transition model is introduced to the reliability analysis of the redundant inertial navigation system (RINS) in airborne navigation systems.An information processing mechanism based on difference filtering is put forward to strengthen the consistency between the outputs of the equal-precision inertia navigation system (INS).On this basis,the homologous fault monitoring algorithm is designed to realize the homologous fault monitoring of RINS.The simulation is carried out based on the above algorithms,and the results verify the effectiveness of the proposed fault monitoring algorithm based on difference filtering.Research results have good reference value for the configuration and design of RINS in airborne integrated avionics systems. | Xiuzhi Wu Jizhou Lai Min Liu Pin Lv | 2013 | Journal of Systems Engineering and Electronics2013，24，6： | 4 |
| 14 | Physical Mechanism and Performance Factors of Metal Oxide Based Resistive Switching Memory:A Review显示文摘This review summarizes the mechanism and performance of metal oxide based resistive switching memory The origin of resistive switching(RS) behavior can be roughly classified into the conducting filament type and the interface type. Here,we adopt the filament type to study the metal oxide based resistive switching memory,which considers the migration of metallic cations and oxygen vacancies,as well as discuss two main mechanisms including the electrochemical metallization effect(ECM) and valence change memory effect(VCM). At the light of the influence of the electrode materials and switching layers on the RS characteristics,an overview has also been given on the performance parameters including the uniformity endurance,the retention,and the multi-layer storage. Especially,we mentioned ITO(indium tin oxide electrode and discussed the novel RS characteristics related with ITO. Finally,the challenges resistive random access memory(RRAM) device is facing,as well as the future development trend,are expressed. | Cong Ye Jiaji Wu Gang He Jieqiong Zhang Tengfei Deng Pin He Hao Wang | 2016 | Journal of Materials Science & Technology2016，32，1： | 3 |
| 15 | Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders in mice显示文摘Both immunosuppressants and antibiotics (ABX) are indispensable for transplant patients. However, the former increases the risk of new-onset diabetes, whereas the latter impacts intestinal microbiota (IM). It is still unclear whether and how the interaction between immunosuppressants and ABX alters the IM and thus leads to glucose metabolism disorders. This study examined the alterations of glucose and lipid metabolism and IM in mice exposed to tacrolimus (TAC) with or without ABX. We found that ABX further aggravated TAC-induced glucose tolerance and increased insulin secretion. Combined treatment resulted in exacerbated lipid accumulation in the liver. TAC-altered microbial community was further amplified by ABX administration, as characterized by reductions in phylum Firmicutes, family Lachnospiraceae, and genus Copyococcus. Analyses based on the metagenomic profiles revealed that ABX augmented the effect of TAC on microbial metabolic function mostly related to lipid metabolism. The altered components of gut microbiome and predicted microbial functional profiles showed significant correlation with hepatic lipid accumulation and glucose disorders. In conclusion, ABX aggravated the effect of TAC on the microbiome and its metabolic capacities, which might contribute to hepatic lipid accumulation and glucose disorders. These findings suggest that the ABX-altered microbiome can amplify the diabetogenic effect of TAC and could be a novel therapeutic target for patients. | Yuqiu Han Xiangyang Jiang Qi Ling Li Wu Pin Wu Ruiqi Tang Xiaowei Xu Meifang Yang Lijiang Zhang Weiwei Zhu Baohong Wang Lanjuan Li | 2019 | Frontiers of Medicine2019，13，4： | 3 |
| 16 | Cenozoic Calcareous Nannofossil Biostratigraphy of Sediments from Lingfeng Well in East China Sea显示文摘A biostratigraphic study of calcareous nannofossils of sediments from Lingfeng No.1 well in the East China Sea was carried out to provide more detailed nannofossil data and a stratigraphic correlation among offshore wells located in the East China Sea.14 Paleocene to Pleistocene calcareous nannofossil zones were recognized based on a detailed examination. According to these nannofossil data, the Paleocene/Eocene and Pliocene/Pleistocene boundaries, as well as the Miocene base were determined.Oligocene NP23 and Miocene NN1 zones are firstly recognized by this study. The existence of Miocene NN1 at this well suggests that the Miocene transgression began in the Early Miocene in this area. The records of NP23 indicate that the marine Oligocene sediments exist in the series of Lingfeng wells, but probably as very thin layers. | Su Xin Wu Fadong Center of Marine Geosciences, China University of Geosciences, Beijing 100083, China Zhou Pin Liu Jinshui Shanghai Offshore Petroleum Planning and Designing Institute, Shanghai 200093, China | 2000 | Journal of Earth Science2000，19，3： | 2 |
| 17 | γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer显示文摘 | Pin Wu Dang Wu Chao Ni Jun Ye Wuzhen Chen Guoming Hu Zhen Wang Changrong Wang Zhigang Zhang Wenjie Xia Zhigang Chen Ke Wang Tao Zhang Jinghong Xu Yuehua Han Ting Zhang Xianguo Wu Jianwei Wang Weihua Gong Shu Zheng Fuming Qiu Jun Yan Jian Huang | 2014 | Immunity2014，，5： | 2 |
| 18 | Association of hypomethylation of LINE-1 repetitive element in blood leukocyte DNA with an increased risk of hepatocellular carcinoma显示文摘Global DNA hypomethylation has been associated with increased risk for cancers of the colorectum,bladder,breast,head and neck,and testicular germ cells.The aim of this study was to examine whether global hypomethylation in blood leukocyte DNA is associated with the risk of hepatocellular carcinoma (HCC).A total of 315 HCC cases and 356 age-,sex-and HBsAg status-matched controls were included.Global methylation in blood leukocyte DNA was estimated by analyzing long interspersed element-1 (LINE-1) repeats using bisulfite-polymerase chain reaction (PCR) and pyrosequencing.We observed that the median methylation level in HCC cases (percentage of 5-methylcytosine (5mC)=77.7%) was significantly lower than that in controls (79.5% 5mC) (P=0.004,Wilcoxon rank-sum test).The odds ratios (ORs) of HCC for individuals in the third,second,and first (lowest) quartiles of LINE-1 methylation were 1.1 (95% confidence interval (CI) 0.7-1.8),1.4 (95% CI 0.8-2.2),and 2.6 (95% CI 1.7-4.1) (P for trend <0.001),respectively,compared to individuals in the fourth (highest) quartile.A 1.9-fold (95% CI 1.4-2.6) increased risk of HCC was observed among individuals with LINE-1 methylation below the median compared to individuals with higher (>median) LINE-1 methylation.Our results demonstrate for the first time that individuals with global hypomethylation measured in LINE-1 repeats in blood leukocyte DNA have an increased risk for HCC.Our data provide the evidence that global hypomethylation detected in the easily obtainable DNA source of blood leukocytes may help identify individuals at risk of HCC. | Jian-zhong DI Xiao-dong HAN Wen-ye GU Yu WANG Qi ZHENG Pin ZHANG Hui-min WU Zhong-zheng ZHU | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，10： | 2 |
| 19 | Current Status and Prospect of Stent Placement for May-Thurner Syndrome显示文摘Stent implantation has been proven to be safe and has become the first-line intervention for May-Thumer syndrome(MTS),with satisfactory mid-term patency rates and clinical outcomes.Recent research has demonstrated that catheter-directed thrombolysis is the preferred strategy when MTS is combined with deep vein thrombosis after self-expanding stent placement.However,the stent used for the venous system was developed based on the experience obtained in the treatment of arterial disease.Consequently,relatively common corresponding complications may come along later,which include stent displacement,deformation,and obstruction.Different measures such as adopting a stent with a larger diameter,improving stent flexibility,and increasing stent strength have been employed in order to prevent these complications.The ideal venous stent is presently being evaluated and will be introduced in detail in this review. | Qin LIU Fang LIU Ping LÜ Hong-xiao WU Pin YE Yun YOU Zhong YAO | 2021 | Current Medical Science2021，41，6： | 2 |
| 20 | Ionic Electroactive Polymers Used in Bionic Robots: A Review显示文摘 | Longfei Chang Yanfa Liu Qian Yang Linfeng Yu Jiaqin Liu Zicai Zhu Pin Lu Yucheng Wu Ying Hu | 2018 | Journal of Bionic Engineering2018，15，5： | 2 |
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