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| 1 | Spatio-temporal changes in biomass carbon sinks in China's forests from 1977 to 2008显示文摘Forests play a leading role in regional and global carbon (C) cycles. Detailed assessment of the temporal and spatial changes in C sinks/sources of China's forests is critical to the estimation of the national C budget and can help to constitute sustainable forest management policies for climate change. In this study, we explored the spatio-temporal changes in forest biomass C stocks in China between 1977 and 2008, using six periods of the national forest inventory data. According to the definition of the forest inventory, China's forest was categorized into three groups: forest stand, economic forest, and bamboo forest. We estimated forest biomass C stocks for each inventory period by using continuous biomass expansion factor (BEF) method for forest stands, and the mean biomass density method for economic and bamboo forests. As a result, China's forests have accumulated biomass C (i.e., biomass C sink) of 1896 Tg (1Tg=1012g) during the study period, with 1710, 108 and 78 Tg C in forest stands, and economic and bamboo forests, respectively. Annual forest biomass C sink was 70.2 Tg Ca-1 , offsetting 7.8% of the contemporary fossil CO2 emissions in the country. The results also showed that planted forests have functioned as a persistent C sink, sequestrating 818 Tg C and accounting for 47.8% of total C sink in forest stands, and that the old-, mid- and young-aged forests have sequestrated 930, 391 and 388 Tg C from 1977 to 2008. Our results suggest that China's forests have a big potential as biomass C sink in the future because of its large area of planted forests with young-aged growth and low C density. | GUO ZhaoDi HU HuiFeng LI Pin LI NuYun FANG JingYun | 2013 | Science China(Life Sciences)2013，56，7： | 44 |
| 2 | Bile duct injuries associated with laparoscopic and open cholecystectomy: Sixteen-year experience显示文摘AIM: To summarize the experience in diagnosis, management and prevention of iatrogenic bile duct injury (IBDI). METHODS: A total of 210 patients with bile duct injury occurred during cholecystectomy admitted to Hunan Provincial People’s Hospital from March 1990 to March 2006 were included in this study for retrospective analysis. RESULTS: There were 59.5% (103/173) of patients with IBDI resulting from the wrong identification of the anatomy of the Calot’s triangle during cholecystectomy. The diagnosis of IBDI was made on the basis of clinical features, diagnostic abdominocentesis and imaging findings. Abdominal B ultrasonography (BUS) was the most popular way for IBDI with a diagnostic rate of 84.6% (126/149). Magnetic resonance cholangiography (MRC) could reveal the site of injury, the length of injured bile duct and variation of bile duct tree with a diagnostic rate 100% (45/45). According to the site of injury, IBDI could be divided into six types. The most common type (type 3) occurred in 76.7% (161/210) of the patients and was treated with partial resection of the common hepatic duct and common bile duct. One hundred and seventy-six patients were followed up. The mean follow-up time was 3.7 (range 0.25-10) years. Good results were achieved in 87.5% (154/176) of the patients. CONCLUSION: The key to prevention of IBDI is to follow the 'identifying-cutting-identifying' principle during cholecystectomy. Re-operation time and surgical procedure are decided according to the type of IBDI. | Jin-Shu Wu Chuang Peng Xian-Hai Mao Pin Lv | 2007 | World Journal of Gastroenterology2007，13，16： | 32 |
| 3 | HIF-1α induces VE-cadherin expression and modulates vasculogenic mimicry in esophageal carcinoma cells显示文摘AIM:To investigate whether hypoxia inducible factor(HIF)-1αmodulates vasculogenic mimicry(VM)by upregulating VE-cadherin expression in esophageal squamous cell carcinoma(ESCC).METHODS:Esophageal squamous cancer cell lines Eca109 and TE13 were transfected with plasmids harboring small interfering RNAs targeting HIF-1αor VEcadherin.The proliferation and invasion of esophageal carcinoma cells were detected by MTT and Transwell migration assays.The formation of tubular networks of cells was analyzed by 3D culture in vitro.BALB/c nude mice were used to observe xenograft tumor formation.The relationship between the expression of HIF-1αand VE-cadherin,ephrin A2(Eph A2)and laminin5γ2(LN5γ2)was measured by Western blot and real-time polymerase chain reaction.RESULTS:Knockdown of HIF-1αinhibited cell proliferation(32.3%±6.1%for Eca109 cells and 38.6%±6.8%for TE13 cells,P<0.05).Both Eca109 and TE13cells formed typical tubular networks.The number of tubular networks markedly decreased when HIF-1αor VE-cadherin was knocked down.Expression of VEcadherin,Eph A2 and LN5γ2 was dramatically inhibited,but the expression of matrix metalloproteinase 2 had no obvious change in HIF-1α-silenced cells.Knockdown of VE-cadherin significantly decreased expression of both Eph A2 and LN5γ2(P<0.05),while HIF-1αexpression was unchanged.The time for xenograft tumor formation was 6±1.2 d for Eca109 cells and Eca109cells transfected with HIF-1αNeo control short hairpin RNA(sh RNA)vector,and 8.4±2.1 d for Eca109 cells transfected with an sh RNA against HIF-1α.Knockdown of HIF-1αinhibited vasculogenic mimicry(VM)and tumorigenicity in vivo.CONCLUSION:HIF-1αmay modulate VM in ESCC by regulating VE-cadherin expression,which affects VM formation through Eph A2 and LN5γ2. | Na-Na Tang Hong Zhu Hong-Jie Zhang Wei-Feng Zhang Hai-Lin Jin Lu Wang Pin Wang Gui-Jun He Bo Hao Rui-Hua Shi | 2014 | World Journal of Gastroenterology2014，20，47： | 25 |
| 4 | Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution显示文摘Shenmai 注射(SMI ) 是中国保护专利的注射,它主要用红人参和根值 Ophiopogonis 做的并且广泛地使用了由增加 Qi 和有营养的殷治疗冠的心疾病和肿瘤。在这研究,我们检验了 SMI 是否能在 vivo 并且在 vitro 在 colorectal 癌症在 adriamycin (ADR ) 和 paclitaxel (PTX ) 的 cytoxicity 上生产直接合作的效果,并且探索了内在的 pharmacokinetic 机制。有 LoVo 结肠癌异种皮移植的 BALB/c 裸体老鼠 intraperitoneally 与 ADR 被注射(2 mg 踘? 郱?? 耰? 耰? | Wen-yue LIU Jing-wei ZHANG Xue-quanYAO Chao JIANG Ji-chao HE Pin NI Jia-li LIU Qian-ying CHEN Qing-ran LI Xiao-jie ZANG Lan YAO Ya-zhong LIU Mu-lan WANG Pei-qiang SHEN Guang-ji WANG Fang ZHOU | 2017 | Acta Pharmacologica Sinica2017，38，2： | 24 |
| 5 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 6 | 中美家庭教育比较显示文摘家庭教育的成功与否关系着一个人的一生,现在社会的发展需要高素质的人才,而良好的家庭教育是培养高素质人才很关键的起点。由于中美两国社会制度,文化背景,教育目的等方面的不同,也给家庭教育孩子的观念带来不同。世界各国在培养新世纪人才的教育工程中,都很重视家庭教育这一环节。虽然家庭教育在我国已经引起了社会各界,特别是教育界的极大关注,但是时至今日,我国不少家庭的教育仍存在着误区。本文首先从介绍家庭教育的定义入手,然后指出中国家庭教育存在的主要问题,接着对中美两国家庭教育的相关方面(主要是家教内容,家教目的和家教方法)进行比较,这里所说的家庭教育的目的就是通过家庭教育要把受教育者培养成什么样的人,教育的内容和方法都得根据目的去选择。根据这些因素的比较,分析形成两国家庭教育差异的原因。最后根据对比中美两国的家庭教育,取其精华去其糟粕,提出几点适合中国的家庭教育方法。 | lizza Pin 黄磊 | 2008 | 中华文化论坛2008，，S1： | 21 |
| 7 | Prediction of shield tunneling-induced ground settlement using machine learning techniques显示文摘Predicting the tunneling-induced maximum ground surface settlement is a complex problem since the settlement depends on plenty of intrinsic and extrinsic factors.This study investigates the efficiency and feasibility of six machine learning(ML)algorithms,namely,back-propagation neural network,wavelet neural network,general regression neural network(GRNN),extreme learning machine,support vector machine and random forest(RF),to predict tunneling?induced settlement.Field data sets including geological conditions,shield operational parameters,and tunnel geometry collected from four sections of tunnel with a total of 3.93 km are used to build models.Three indicators,mean absolute error,root mean absolute error,and coefficient of determination the(7?2)are used to demonstrate the performance of each computational model.The results indicated that ML algorithms have great potential to predict tunneling-induced settlement,compared with the traditional multivariate linear regression method.GRNN and RF algorithms show the best performance among six ML algorithms,which accurately recognize the evolution of tunneling-induced settlement.The correlation between the input variables and settlement is also investigated by Pearson correlation coefficient. | Renpeng CHEN Pin ZHANG Huaina WU Zhiteng WANG Zhiquan ZHONG | 2019 | Frontiers of Structural and Civil Engineering2019，13，6： | 20 |
| 8 | Spatial pattern and decadal change of agro-meteorological disasters in the main wheat production area of China during 1991-2009显示文摘Agro-meteorological disasters(AMD) have become more frequent with climate warming. In this study, the temporal and spatial changes in the occurrence frequency of major meteorological disasters on wheat production were firstly explored by analyzing the observed records at national agro-meteorological stations(AMS) of China from 1991 to 2009. Furthermore, impact of climate change on AMD was discussed by comparing the warmer decade(2000–2009) with another decade(1991–2000). It was found that drought was the most frequent disaster during the last two decades, with a highest proportion of 79%. And the frequency of AMD increased significantly with climate change. Specifically, the main disasters occurred more frequently in the reproductive period than in the vegetative period. Besides, the spatial changes in the AMD frequency were characterized by region-specific. For example, the wheat cultivation areas located on the Loess Plateau and the middle-lower reaches of the Yellow River suffered mainly from drought. All these results were strongly linked to climate change in China. Therefore, sound adaptation options should be taken based on the latest changes of AMD under global warming to reduce agricultural damages. | ZHANG Zhao WANG Pin CHEN Yi ZHANG Shuai TAO Fulu LIU Xiaofei | 2014 | Journal of Geographical Sciences2014，24，3： | 19 |
| 9 | A review of aerial manipulation of small-scale rotorcraft unmanned robotic systems显示文摘Small-scale rotorcraft unmanned robotic systems(SRURSs) are a kind of unmanned rotorcraft with manipulating devices. This review aims to provide an overview on aerial manipulation of SRURSs nowadays and promote relative research in the future. In the past decade, aerial manipulation of SRURSs has attracted the interest of researchers globally. This paper provides a literature review of the last 10 years(2008–2017) on SRURSs, and details achievements and challenges. Firstly, the definition, current state, development, classification, and challenges of SRURSs are introduced. Then, related papers are organized into two topical categories: mechanical structure design, and modeling and control. Following this, research groups involved in SRURS research and their major achievements are summarized and classified in the form of tables. The research groups are introduced in detail from seven parts. Finally, trends and challenges are compiled and presented to serve as a resource for researchers interested in aerial manipulation of SRURSs. The problem,trends, and challenges are described from three aspects. Conclusions of the paper are presented,and the future of SRURSs is discussed to enable further research interests. | Xilun DING Pin GUO Kun XU Yushu YU | 2019 | Chinese Journal of Aeronautics2019，32，1： | 18 |
| 10 | Impact of chilling injury and global warming on rice yield in Heilongjiang Province显示文摘这研究为米饭集中于索引在 Heilongjiang 省的寒心的损害在 19602009 期间。第一,我们比较了由与传统的方法种密度的米饭加权的一个新导出的气候数据,并且发现新的是更合理的在庄稼收益上估计气候变化的影响。就在第二,寒心的索引由气象学、国家、国际的层次定义的省寒心的米饭的频率和紧张而言被估计。,结果证明气象学的标准对延期类型损害合适国际的,在阀值(GDDn ) 下面种度白天的所谓的和,描绘的最好为米饭的无菌类型的寒心的损害。当二个独立变量到达了约 92% ,包括两损害的米饭收益时间系列模型的解释能力打字(p < 0.05 ) 。最后,我们断定到米饭收益的人和天气因素的贡献率是大约87.2%和12.8%分别地,并且作为光增加的趋势因为无菌类型的寒心的损害在在最近的年里出发到流动时期期间被发现,为在未来在 Heilongjiang 省种的米饭显示高寒心的风险全球温暖。 | LIU Xiaofei ZHANG Zhao SHUAI Jiabing WANG Pin SHI Wenjiao TAO Fulu CHEN Yi | 2013 | Journal of Geographical Sciences2013，23，1： | 16 |
| 11 | Effect of six kinds of scale inhibitors on calcium carbonate precipitation in high salinity wastewater at high temperatures显示文摘Precipitation of calcium carbonate(Ca CO3) scale on heat transfer surfaces is a serious and expensive problem widely occurring in numerous industrial processes. In this study, we compared the scale inhibition effect of six kinds of commercial scale inhibitors and screened out the best one(scale inhibitor SQ-1211) to investigate its scale inhibition performance in highly saline conditions at high temperature through static scale inhibition tests. The influences of scale inhibitor dosage, temperature, heating time and p H on the inhibition efficiency of the optimal scale inhibitor were investigated. The morphologies and crystal structures of the precipitates were characterized by Scanning Electron Microscopy and X-ray Diffraction analysis. Results showed that the scale inhibition efficiency of the optimal scale inhibitor decreased with the increase of the reaction temperature. When the concentration of Ca2+was 1600 mg/L, the scale inhibition rate could reach 90.7% at 80°C at p H 8. The optimal scale inhibitor could effectively retard scaling at high temperature. In the presence of the optimal scale inhibitor, the main crystal structure of Ca CO3 changed from calcite to aragonite. | Xiaochen Li Baoyu Gao Qinyan Yue Defang Ma Hongyan Rong Pin Zhao Pengyou Teng | 2015 | Journal of Environmental Sciences2015，27，3： | 15 |
| 12 | The prognostic and therapeutic implications of circulating tumor cell phenotype detection based on epithelial-mesenchymal transition markers in the first-line chemotherapy of HER2-negative metastatic breast cancer显示文摘Background:Epithelial-mesenchymal transition(EMT)is implicated in the metastatic process and presents a chal-lenge to epithelial cell adhesion molecule-based detection of circulating tumor cells(CTCs),which have been demon-strated to be a prognostic indicator in metastatic breast cancer.Although evidence has indicated that heterogeneity of CTCs based on EMT markers is associated with disease progression,no standard recommendations have been established for clinical practice.This study aimed to evaluate the prognostic significance of dynamic CTC detection based on EMT for metastatic breast cancer patients.Methods:We enrolled 108 human epidermal growth factor receptor 2-negative metastatic breast cancer patients from the prospective phase III CAMELLIA study and applied the CanPatrol CTC enrichment technique to identify CTC phenotypes(including epithelial CTCs,biphenotypic epithelial/mesenchymal CTCs,and mesenchymal CTCs)in peripheral blood samples.Receiver operating characteristic curve analyses of total CTC count and the proportion of mesenchymal CTCs for predicting the 1-year progression-free survival(PFS)rate were conducted to determine the optimal cut-off values,and Kaplan-Meier analysis and Cox proportional hazards regression analysis were performed to investigate the prognostic value of the cut-off values of both total CTC count and the proportion of mesenchymal CTCs in combination.Results:For predicting the 1-year PFS rate,the optimal cut-off value of total CTC count was 9.5(Area under the curve[AUC]=0.538,95%confidence interval[CI]=0.418-0.657),and that of the proportion of mesenchymal CTCs was 10.7%(AUC=0.581,95%CI=0.463-0.699).We used the two cut-off values in combination to forecast PFS in which the total CTC count was equaled to or exceeded 10/5 mL with the proportion of mesenchymal CTCs surpassed 10.7%.Patients who met the combined criteria had significantly shorter median PFS than did those who did not meet the criteria(6.2 vs.9.9 months,P=0.010).A nomogram was constructed based on the criteria and significant clinicopatho-logical characteristics with a C-index of 0.613(P=0.010).Conclusions: The criteria, which combine the total CTC count and the proportion of mesenchymal CTCs, may be used to monitor therapeutic resistance and predict prognosis in patients with metastatic breast cancer. | Xiuwen Guan Fei Ma Chunxiao Li Shiyang Wu Shangying Hu Jiefen Huang Xiaoying Sun Jiayu Wang Yang Luo Ruigang Cai Ying Fan Qiao Li Shanshan Chen Pin Zhang Qing Li Binghe Xu | 2019 | Cancer Communications2019，39，1： | 15 |
| 13 | Effect of endotoxin on fibronectin synthesis of rat primary cultured hepatocytes显示文摘EfectofendotoxinonfibronectinsynthesisofratprimaryculturedhepatocytesJIAJinBin,HANDeWu,XURuiLing,GAOFei,ZHAOLongFeng,ZHA... | JIA JinBin, HAN DeWu, XU RuiLing, GAO Fei, ZHAO LongFeng, ZHAO YuanChang, YAN JinPin and MA XueHuiKeywords liver cirrhosis endotoxins fibronectin/analysis liver/cytology cells, cultured lipopolysaccharide | 1998 | World Journal of Gastroenterology1998，4，4： | 14 |
| 14 | Existence of Qiongnan suture zone on the north margin of South China Sea显示文摘This paper aims to explore whether paleo-suture zone exists in the pre-Cenozoic basement of South China Sea (SCS). By taking advantage of integrated geophysical surveying data, including multi-channel reflection seismicity, oceanic bottom seismicity, gravity and magnetic data as well as paleomagnetism and drilling information, a comprehensive analysis on sedimentary stratigraphy, seismic stratigraphy, magmatic and metamorphic petrology, geochemistry, gravity study, magnetics, paleogeomagnetics as well as geotectonics was carried out, and the results clearly indicate that a pre-Cenozoic suture zone, i.e. “Qiongnan (south Hainan Island) suture zone”, does exist on the north margin of SCS. This suture zone starts in the west from the Jiusuo-Lingshui fault zone in the south of Hainan Island, extends eastward across the continental slope to the north of SCS, and links with Shoufeng fault in Taiwan. It is inferred that the Qiongnan suture zone was sutured approximately in Indosinian (Triassic) Epoch and is actually the vestige of “Qiongnan ocean basin”, the extension of the main paleo-Tethys ocean basin in SCS. The formation of Qiongnan suture zone marked the collision-accretion of the Qiongnan Block toward the Qiongzhong Block. The Qiongnan suture zone is linked to the west with the southward extension of the principal suture zone of the Paleo-Tethys at Bitu-Changning-Menglian-Bentong-Raub, across the southern segment of the Red River-East Vietnam-Wanna strike-slip fault zone, and connected to the east with the suture zone emplaced into the south margin of the Oki-Hida Pre-Jurassic terranes in southwest Japan, across the northerni2 e segment of the Manila trench fault zone in the northeast side of Taiwan Island. The discovery of this suture zone is believed to be potentially significant toward study of the pre-Cenozoic geotectonic pattern of SCS, the temporal and spatial distribution of the east paleo-Tethys structural domain in SCS and the relationship of recombination and superimposition between the east paleo-Tethys structural domain and the west Pacific structural domain, in addition to the oil/gas geological potentials in the pre-Cenozoic marine vestige-superimposed basin in the study area. | LIU Hailing YAN Pin LIU Yingchun DENG Hui | 2006 | Chinese Science Bulletin2006，51，B12： | 12 |
| 15 | Adsorptive removal of antibiotics from water using magneticion exchange resin显示文摘The occurrence of antibiotics in the environment has recently raised serious concern regarding their potential threat to aquatic ecosystem and human health. In this study, the magnetic ion exchange(MIEX) resin was applied for removing three commonly-used antibiotics, sulfamethoxazole(SMX), tetracycline(TCN) and amoxicillin(AMX) from water.The results of batch experiments show that the maximum adsorption capacities on the MIEX resin for SMX, TCN and AMX were 789.32, 443.18 and 155.15 μg/m L at 25°C,respectively, which were 2–7 times that for the powdered activated carbon. The adsorption kinetics of antibiotics on the MIEX resin could be simulated by the pseudo-second-order model(R^2= 0.99), and the adsorption isotherm data were well described by the Langmuir model(R^2= 0.97). Solution p H exhibited a remarkable impact on the adsorption process and the absorbed concentrations of the tested antibiotics were obtained around the neutral p H.The MIEX resin could be easily regenerated by 2 mol/L Na Cl solution and maintained high adsorption removal for the tested antibiotics after regeneration. Anion exchange mechanism mainly controlled the adsorption of antibiotic and the formation of hydrogen binding between the antibiotic and resin can also result in the increase of adsorption capacity. The high adsorption capacity, fast adsorption rate and prominent reusability make the MIEX resin a potential adsorbent in the application for removing antibiotics from water. | Tianyue Wang Xun Pan Weiwei Ben Jianbing Wang Pin Hou Zhimin Qiang | 2017 | Journal of Environmental Sciences2017，29，2： | 12 |
| 16 | Human γδT-cell subsets and their involvement in tumor mmunity显示文摘 | Dang W u Pin Wu Fuming Qiu Qichun Wei Jian Huang | 2017 | Cellular & Molecular Immunology2017，14，3： | 11 |
| 17 | Variations of root and heterotrophic respiration along environmental gradients in China’s forests显示文摘Aims Root and heterotrophic respiration may respond differently to environmental variability,but little evidence is available from largescale observations.Here we aimed to examine variations of root and heterotrophic respiration across broad geographic,climatic,soil and biotic gradients.Methods We conducted a synthesis of 59 field measurements on root and heterotrophic respiration across China’s forests.Important Findings Root and heterotrophic respiration varied differently with forest types,of which evergreen broadleaf forest was significantly different from those in other forest types on heterotrophic respiration but without statistically significant differences on root respiration.The results also indicated that root and heterotrophic respiration exhibited similar trends along gradients of precipitation,soil organic carbon and satellite-indicated vegetation growth.However,they exhibited different relationships with temperature:root respiration exhibited bimodal patterns along the temperature gradient,while heterotrophic respiration increased monotonically with temperature.Moreover,they showed different relationships with MOD17 GPP,with increasing trend observed for root respiration whereas insignificant change for heterotrophic respiration.In addition,root and heterotrophic respiration exhibited different changes along the age sequence,with insignificant change for root respiration and decreasing trend for heterotrophic respiration.Overall,these results suggest that root and heterotrophic respiration may respond differently to environmental variability.Our findings could advance our understanding on the different environmental controls of root and heterotrophic respiration and also improve our ability to predict soil CO_(2) flux under a changing environment. | Pin Li Yuanhe Yang Jingyun Fang | 2013 | Journal of Plant Ecology2013，6，5： | 11 |
| 18 | New index to predict esophageal variceal bleeding in cirrhotic patients显示文摘AIM:To develop a safe,simple,noninvasive and affordable system to predict esophageal variceal bleeding(EVB)in decompensated cirrhosis patients.METHODS:Four hundred and eighty-six patients with decompensated cirrhosis(238 males and 248 females),with a mean age of 63.1±11.2 years,were admitted to Changshu Affiliated Hospital of Suzhou University between May 2008 and March 2011.Patients enrolled in this study underwent ultrasound-Doppler(US-Doppler)to assess left gastric vein(LGV)blood flow velocity(LGVV)and blood flow direction(LGVBFD),and were evaluated by the Model For End-Stage Liver Disease(MELD)scoring system.All patients received followup evaluations every three months.The resulting data were entered into a database after each time point collection.RESULTS:Four hundred and sixteen patients com-pleted follow-up evaluations for an average of 31.6mo(range:12 to 47 mo).Fifty-one(12.3%)patients experienced EVB.The change in the MELD score over three months(ΔMELD),LGVV and LGVBFD were independently associated with EVB occurrence.MELDUS-Doppler Index(MUI),a new index,was developed and calculated using the following logistic regression equation:MUI=Logit(P)=1.667(ΔMELD)+2.096(LGVV)-3.245(LGVBFD)-1.697.The area under the receiver operating characteristic curve for prediction of EVB occurrence was significantly higher for the MUI[0.858(95%CI:0.774-0.920)]than forΔMELD[0.734(95%CI:0.636-0.817);P<0.05],LGVV[0.679(95%CI:0.578-0.769);P<0.05]or LGVBFD[0.726(95%CI:0.627-0.810);P<0.05]alone.When the MUI was set at 46,the index had high diagnostic accuracy(85.8%),with high specificity(80%)and sensitivity(87.27%).CONCLUSION:The MUI,a noninvasive and affordable index,can predict EVB occurrence in decompensated cirrhotic patients and serve as an alternative when conventional endoscopic screening is declined. | Xiao-Dan Xu Jian-Jun Dai Jian-Qing Qian Xun Pin Wei-Jun Wang | 2014 | World Journal of Gastroenterology2014，20，22： | 11 |
| 19 | Effect of Arctium lappa L.in the dextran sulfate sodium colitis mouse model显示文摘AIM:To analyze the possible protective role of Arctium lappa L.(AL)in a murine model of ulcerative colitis(UC).METHODS:BALB/c mice were administered 100 mg/kg AL powder orally each day.After 7 d,colitis was induced by administration of dextran sulfate sodium(DSS)(5% W/V)in drinking water for a further 8 consecutive days.Diarrhea and bloody stools as well as colonic histology were observed.The level of interleukin-6(IL-6)and tu-mor necrosis factor-α(TNF-α)in colonic sections were detected by immunohistochemistry.RESULTS:There were significant differences in mean body weight values and disease activity indices between controls and AL-treated animals.Moreover,the histological findings showed that AL treatment can prevent mucosal edema,submucosal erosions,ulceration,inflammatory cell infiltration and colon damage.In addition,immunohistochemistry analysis showed that the levels of the inflammatory cytokines,IL-6 and TNF-α were also decreased in AL-treated groups.CONCLUSION:We suggest that AL can prevent intestinal damage and decrease inflammatory cytokines in mice with DSS-induced colitis.Thus,AL could prove to be a useful food for UC. | Tzou-Chi Huang Shinn-Shyong Tsai Li-Fang Liu Yu Lin Liu Hung-Jen Liu Kuo Pin Chuang | 2010 | World Journal of Gastroenterology2010，16，33： | 10 |
| 20 | 影响慢性阻塞性肺病急性加重患者生活质量的危险因素显示文摘目的测定和评价慢性阻塞性肺病(COPD)急性加重患者的生活质量和潜在危险因素的发生率及其影响。方法研究两家大型医院因COPD急性加重入院的196个中重度COPD患者。在患者出院时和出院后1月稳定状态,测量肺功能指标、精神状态及用圣乔治呼吸问卷测定生活质量,并收集了患者的临床性状、社会性状和照料因素。结果196例患者中,吸烟、抑郁及嗜用镇痛剂、安眠药相当普遍,而完成肺康复、接种流感病毒疫苗和肺炎球菌疫苗以及看护支持却很少。生活质量的症状域均值为55.9,活动域均值为65,影响域均值为32.9,总体均值为46.5。多变量分析显示慢性黏液高分泌症、男性、抑郁、前1年多次入院和治疗依顺性差与症状域值低下独立显著相关;前1年多次入院、抑郁、严重气促和72岁以上老年与活动域值低下独立显著相关;抑郁、前1年多次入院、严重气促、病程长和重度吸烟与影响域值低下独立显著相关;抑郁、前1年多次入院、严重气促和病程长与总体数值低下独立显著相关(P<0.05)。结论COPD急性加重患者的生活质量低下与COPD严重程度、患者精神抑郁状态及照料这些可改善因素有关。 | 曹振英 Tan Wan Cheng Ng Tze Pin | 2005 | 上海第二医科大学学报2005，25，7： | 10 |
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