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| 1 | HIF-1α induces VE-cadherin expression and modulates vasculogenic mimicry in esophageal carcinoma cells显示文摘AIM:To investigate whether hypoxia inducible factor(HIF)-1αmodulates vasculogenic mimicry(VM)by upregulating VE-cadherin expression in esophageal squamous cell carcinoma(ESCC).METHODS:Esophageal squamous cancer cell lines Eca109 and TE13 were transfected with plasmids harboring small interfering RNAs targeting HIF-1αor VEcadherin.The proliferation and invasion of esophageal carcinoma cells were detected by MTT and Transwell migration assays.The formation of tubular networks of cells was analyzed by 3D culture in vitro.BALB/c nude mice were used to observe xenograft tumor formation.The relationship between the expression of HIF-1αand VE-cadherin,ephrin A2(Eph A2)and laminin5γ2(LN5γ2)was measured by Western blot and real-time polymerase chain reaction.RESULTS:Knockdown of HIF-1αinhibited cell proliferation(32.3%±6.1%for Eca109 cells and 38.6%±6.8%for TE13 cells,P<0.05).Both Eca109 and TE13cells formed typical tubular networks.The number of tubular networks markedly decreased when HIF-1αor VE-cadherin was knocked down.Expression of VEcadherin,Eph A2 and LN5γ2 was dramatically inhibited,but the expression of matrix metalloproteinase 2 had no obvious change in HIF-1α-silenced cells.Knockdown of VE-cadherin significantly decreased expression of both Eph A2 and LN5γ2(P<0.05),while HIF-1αexpression was unchanged.The time for xenograft tumor formation was 6±1.2 d for Eca109 cells and Eca109cells transfected with HIF-1αNeo control short hairpin RNA(sh RNA)vector,and 8.4±2.1 d for Eca109 cells transfected with an sh RNA against HIF-1α.Knockdown of HIF-1αinhibited vasculogenic mimicry(VM)and tumorigenicity in vivo.CONCLUSION:HIF-1αmay modulate VM in ESCC by regulating VE-cadherin expression,which affects VM formation through Eph A2 and LN5γ2. | Na-Na Tang Hong Zhu Hong-Jie Zhang Wei-Feng Zhang Hai-Lin Jin Lu Wang Pin Wang Gui-Jun He Bo Hao Rui-Hua Shi | 2014 | World Journal of Gastroenterology2014，20，47： | 25 |
| 2 | Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution显示文摘Shenmai 注射(SMI ) 是中国保护专利的注射,它主要用红人参和根值 Ophiopogonis 做的并且广泛地使用了由增加 Qi 和有营养的殷治疗冠的心疾病和肿瘤。在这研究,我们检验了 SMI 是否能在 vivo 并且在 vitro 在 colorectal 癌症在 adriamycin (ADR ) 和 paclitaxel (PTX ) 的 cytoxicity 上生产直接合作的效果,并且探索了内在的 pharmacokinetic 机制。有 LoVo 结肠癌异种皮移植的 BALB/c 裸体老鼠 intraperitoneally 与 ADR 被注射(2 mg 踘? 郱?? 耰? 耰? | Wen-yue LIU Jing-wei ZHANG Xue-quanYAO Chao JIANG Ji-chao HE Pin NI Jia-li LIU Qian-ying CHEN Qing-ran LI Xiao-jie ZANG Lan YAO Ya-zhong LIU Mu-lan WANG Pei-qiang SHEN Guang-ji WANG Fang ZHOU | 2017 | Acta Pharmacologica Sinica2017，38，2： | 24 |
| 3 | Assessing the Effectiveness of a Cervical Cancer Screening Program in a Hospital-based Study显示文摘This study compared HPV testing and liquid-based cytology(LCT)as performance indicators for cervical cancer screening in a hospital-based study.A total of 61,193 outpatients were screened initially by LCT.Samples with screening results showing atypical squamous cells of undetermined significance(ASC-US)or worse were referred for colposcopy,and some | YANG Yi LANG Jing He WANG You Fang CHENG Xue Mei CAI Yu Pin LI Hui ZHU Bao Li ZHANG Rui Fen | 2015 | Biomedical and Environmental Sciences2015，28，1： | 10 |
| 4 | Postoperative Regulatory T-Cells and Natural Killer Cells in Stage I Nonsmall Cell Lung Cancer Underwent Video-assisted Thoracoscopic Lobectomy or Thoracotomy显示文摘 | Sai Zhang Sai-Bo Pan Qing-Hua Lyu Pin Wu Guang-Ming Qin Qi Wang Zhong-Liang He Xue-Ming He Ming Wu Gang Chen | 2015 | Chinese Medical Journal2015，，11： | 10 |
| 5 | Numerical Simulation on Fluid Flow in Hot Metal Pretreatment显示文摘Basing on the commercial CFD metho d ,several models are adopted to simulate water model. The numerical simulation results are in good agreement with the experimental data of water model under the same experimental conditions. Then the numerical simulation method is presented to investigate the flow field, the vortex on gas-liquid surface and the uniform mixing time in hot metal ladles. This research shows: the vortex depth increases with increasing of immersion depth and rotation speed; Overflow appears in N=120rpm and h=3.2m; the turbulent kinetic energy increases with increasing immersion depth and rotation speed; uniform mixing time decreases with the decreasing of immersion depth and the rotation speed of stirring ; the optimal uniform mixing time is 23.5s on the conditions of N=100rpm and h=3.2m within the allowable range. | SHAO Pin, ZHANG Ting-an, LIU Yan, ZHAO Hong-liang, HE Ji-cheng (Laboratory of Ecological Untilization of Multi-Metal Intergrown Ores of Education Ministry, Shenyang 110004, Liaoning, China) | 2011 | Journal of Iron and Steel Research(International)2011，18，S2： | 8 |
| 6 | Determination of resveratrol in red wine by solid phase extraction-flow injection chemiluminescence method显示文摘一个敏感流动注射化合光方法基于 resveratrol 能极大地在硫酸媒介提高在 KMnO4 和 HCHO 之间的化合光反应的事实在红酒为 resveratrol 的察觉被开发了。Analytes 在稳固的吸着剂(C18 稳固阶段的萃取柱柱体) 上被预先集中。在最佳条件下面,建议方法在 1.32 × 的范围上允许 resveratrol 的测量 10 (? 8 )到 1.32 × 10 (? 5 )有 3.30 × 的检测极限的 mol/L 10 (? 9 ) mol/L ,并且为 1.32 × 的相对标准偏差 10 (? 5 ) mol/L resveratrol ( n = 11 )是3.8%。这个方法成功地被申请了在红酒的 resveratrol 的决心。而且,可能的反应机理也被讨论。 | Juan Juan Ren Hai Yan Liu Yu Hong Hao Pin Gang He Yu Zhi Fang | 2007 | Chinese Chemical Letters2007，18，8： | 7 |
| 7 | Existence of Solutions of Boundary Value Problem Differential a Nonlinear Three-Point for Third-Order Ordinary Equations显示文摘In this paper,existence of solutions of third-order differential equation ■with nonlinear three-point boundary condition ■is obtained by embedding Leray-Schauder degree theory in upper and lower solutions method,where a,b,c ∈ R,a < b < c;f :[a,c]×R3 → R,g :R3 → R,h :R2 → R and I :R3 → R are continuous functions.The existence result is obtained by defining the suitable upper and lower solutions and introducing an appropriate auxiliary boundary value problem.As an application,an example with an explicit solution is given to demonstrate the validity of the results in this paper. | SHEN Jian He ZHOU Zhe Yan YU Zan Pin | 2009 | Journal of Mathematical Research and Exposition2009，29，1： | 6 |
| 8 | Expression of circulating microRNA-20a and let-7a in esophageal squamous cell carcinoma显示文摘AIM: To investigate the expressions of micro RNA-20a(mi R-20a) and let-7a in esophageal squamous cell carcinoma(ESCC) and their diagnostic value. METHODS: Seventy patients with ESCC and 40 healthy subjects were enrolled to investigate the expression of mi R-20 a and let-7a using quantitative real-time PCR. The expression of mi R-20 a and let-7a was compared between ESCC patients and healthy subjects. The plasma levels of mi R-20 a and let-7a in relation to patient clinicopathologic parameters, the receiver operating characteristic(ROC) curve, and the sensitivity and specificity of mi R-20 a and let-7a in ESCC diagnosis were analyzed.RESULTS: Plasma levels of mi R-20 a were significantly higher in ESCC patients than in healthy controls, and plasma levels of let-7 were lower in ESCC patients than in healthy controls(both P < 0.05). The area under the ROC curve of mi R-20 a was 0.767(95%CI: 0.677-0.857; P < 0.001), when the cut-off value was set at 4.77, the sensitivity and specificity were 64.3% and 75.0%, respectively. The area under the ROC curve of let-7a was 0.829(95%CI: 0.754-0.904; P < 0.001), when the cut-off value was set at 6.22, the sensitivity and specificity were 74.3% and 85.0%, respectively. Thus, the sensitivity and specificity of let-7a were higher than those of mi R-20 a. The median relative plasma expression of let-7a in clinical stage Ⅲ/Ⅳ(0.24) was lower than that in stage Ⅰ/Ⅱ(0.42), while the expression of mi R-20 a according to stage was not statistically different. The expressions of mi R-20 a and let-7a were not related to gender, age, tumor diameter, tumor grade, or pathologic stage.CONCLUSION: Plasma mi R-20 a and let-7a levels are significantly altered in patients with ESCC and can be used as potential biomarkers in the diagnosis of ESCC. | Fu-Cheng He Wei-Wei Meng Yun-Hui Qu Ming-Xia Zhou Jing He Pin Lv Liang Ming | 2015 | World Journal of Gastroenterology2015，21，15： | 6 |
| 9 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 10 | Ethylenediurea(EDU) pretreatment alleviated the adverse effects of elevated O3 on Populus alba 'Berolinensis' in an urban area显示文摘Ethylenediurea(EDU)has been used as a chemical protectant against ozone(O3).However,its protective effect and physiological mechanisms are still uncertain.The present study aimed to investigate the changes of foliar visible injury,physiological characteristics and emission rates of volatile organic compounds(VOCs)in one-year-old Populus alba'Berolinensis'saplings pretreated with EDU and exposed to elevated O3(EO,120μg/m3).The results showed that foliar visible injury symptoms under EO were significantly alleviated in plants with EDU application(p<0.05).Under EO,net photosynthetic rate,the maximum photochemical efficiency of PSII and the photochemical efficiency of PSII of plants pretreated with 300 and600 mg/L EDU were similar to unexposed controls and significantly higher compared to EOstressed plants without EDU pretreatment,respectively.Malondialdehyde content was highest in EO without EDU and decreased significantly by 14.9%and 21.3%with 300 and600 mg/L EDU pretreatment,respectively.EDU pretreatment alone increased superoxide dismutase activity by 10-fold in unexposed plants with further increases of 88.4%and 37.5%in EO plants pretreated with 300 and 600 mg/L EDU pretreatment,respectively(p<0.05).Abscisic acid content declined under EO relative to unexposed controls with the effect partially reversed by EDU pretreatments.Similarly,VOCs emission rate declined under EO relative to unexposed plants with a recovery of emission rate observed with 300 and 600 mg/L EDU pretreatment.These findings provided significant evidence that EDU exerted a beneficial effect and protection on the tested plants against O3 stress. | Sheng Xu Xingyuan He Kent Burkey Wei Chen Pin Li Yan Li Bo Li Yijing Wang | 2019 | Journal of Environmental Sciences2019，31，10： | 4 |
| 11 | Physical Mechanism and Performance Factors of Metal Oxide Based Resistive Switching Memory:A Review显示文摘This review summarizes the mechanism and performance of metal oxide based resistive switching memory The origin of resistive switching(RS) behavior can be roughly classified into the conducting filament type and the interface type. Here,we adopt the filament type to study the metal oxide based resistive switching memory,which considers the migration of metallic cations and oxygen vacancies,as well as discuss two main mechanisms including the electrochemical metallization effect(ECM) and valence change memory effect(VCM). At the light of the influence of the electrode materials and switching layers on the RS characteristics,an overview has also been given on the performance parameters including the uniformity endurance,the retention,and the multi-layer storage. Especially,we mentioned ITO(indium tin oxide electrode and discussed the novel RS characteristics related with ITO. Finally,the challenges resistive random access memory(RRAM) device is facing,as well as the future development trend,are expressed. | Cong Ye Jiaji Wu Gang He Jieqiong Zhang Tengfei Deng Pin He Hao Wang | 2016 | Journal of Materials Science & Technology2016，32，1： | 3 |
| 12 | Simultaneous determination of flavonoids and anthraquinones in chrysanthemum by capillary electrophoresis with amperometry detection显示文摘有 amperometry 察觉方法(CE 广告) 的高效的毛状的电气泳动在菊为 flavonoids 和 anthraquinones (emodin, kaempferol, apigenin, luteolin 和 rhein ) 的分析被开发了。在最佳条件下面,这五 analytes 是用运用缓冲区的 boratephosphate 在 17 min 以内分开的基线(1.5 整楲杮挠牯敲慬楴湯猠数瑣潲 ' 盏?刨卌千)?? 懀吗?? | Yin Yan Zhang Zi Cheng Li Jin Kun Zhu Zhi Yong Yang Qing Jiang Wang Pin Gang He Yu Zhi Fang | 2010 | Chinese Chemical Letters2010，21，10： | 3 |
| 13 | Simultaneous determination of active ingredients in blueberry wine by CE-AD显示文摘基于结合的毛状的电气泳动,安培计的察觉(CE 广告) 第一次为 kaempferol, ferulic 酸,香子兰的酸,咖啡的酸,法国的酸和在蓝莓酒酸的 protocatechuic 的分离和决心被开发了的一个方法。为了得到分离,工作电极潜力的效果, pH 价值和运用缓冲区,分离电压和注射的集中的最佳条件,在 CE 广告上预定被调查。在最佳条件下面, analytes 能在 pH 在 Na2B4O7KH2PO4 缓冲区被分开 7.8 在 18 min 以内。300 m 直径碳磁盘电极在 +0.95 V 有好当前的回答(对 SCE ) 为所有 analytes。回答与在有察觉限制的三个数量级上的集中是线性的(S/N = 3 ) 在 108 g/mL,为 analytes 和恢复的大小在 95.8106.7% 的范围。方法能成功地与令人满意的结果被用于真实样品的分析因此由水果酒制片人的质量控制部门为使用推荐了。 | Zi Cheng Li Lang Zhu Chi Jin Kun Zhu Yin Yan Zhang Qing Jiang Wang Pin Gang He Yu Zhi Fang | 2011 | Chinese Chemical Letters2011，22，10： | 2 |
| 14 | Differentially Expressed microRNAs as Potential Markers for Vital Reaction of Burned Skin显示文摘The identification of antemortem burns and postmortem burns is essential in forensic practice.In this study,microRNA(miRNA)microarray analysis was conducted to identify differentially expressed miRNAs in the skin of an experimental burn model.Microarray analysis revealed 24 differentially expressed miRNAs in antemortem burned mice skin,with 19 miRNAs significantly upregulated and 5 downregulated.Based on the intersection predicted using three databases(Targetscan,microRNA.org,and PITA),293 potential miRNA targets were identified.These dysregulated miRNAs and their predicted targets were further analyzed using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases.Several functional categories and signaling pathways were enriched,including the“fc epsilon ri signaling pathway,”“endometrial cancer,”and“mTOR signaling pathway.”Expression patterns of 10 differentially expressed miRNAs were verified by reverse transcription‑quantitative polymerase chain reaction in mice skins.The results agreed with the results of microarray analysis.These findings suggest that differentially expressed miRNAs revealed by microarray are potential markers for forensic molecular diagnosis of antemortem burns. | Hao‑Pin Lyu Ming Cheng Jin‑Cen Liu Ming‑Yuan Ye Di Xu Jie‑Tao He Xiao‑Li Xie Qi Wang | 2018 | Journal of Forensic Science and Medicine2018，4，3： | 2 |
| 15 | Social insights on the implementation of One Health in zoonosis prevention and control: a scoping review显示文摘Background:The One Health (OH) concept has been promoted widely around the globe. OH framework is expected to be applied as an integrated approach to support addressing zoonotic diseases as a significant global health issue and to improve the efficiency and effectiveness of zoonosis prevention and control. This review is intended to overview the social impact of the implementation of OH on zoonosis prevention and control.Methods:A scoping review of studies in the past 10 years was performed to overview the integration feature of OH in zoonosis prevention and control and the social impacts of OH. PubMed and Web of Science were searched for studies published in English between January 2011 and June 2021. The included studies were selected based on predefined criteria.Results:Thirty-two studies were included in this review, and most of them adopted qualitative and semi-qualitative methods. More than 50% of the studies focused on zoonosis prevention and control. Most studies were conducted in low- and middle-income countries in Africa and Asia. Applying OH approach in diseases control integrates policymakers, stakeholders, and academics from various backgrounds. The impact of OH on economic is estimated that it may alleviate the burden of diseases and poverty in the long term, even though more financial support might be needed at the initial stage of OH implementation. OH implementation considers social and ecological factors related to zoonosis transmission and provides comprehensive strategies to assess and address related risks in different communities according to regions and customs.Conclusions:Based on reviewed literature, although there seems to be a lack of guidelines for assessing and visualizing the outcomes of OH implementation, which may limit the large-scale adoption of it, evidence on the contributions of implementing OH concepts on zoonosis prevention and control indicates long-term benefits to society, including a better integration of politics, stakeholders and academics to improve their cooperation, a potential to address economic issues caused by zoonosis, and a comprehensive consideration on social determinants of health during zoonosis prevention and control. | Junyi He Zhaoyu Guo Pin Yang Chunli Cao Jing Xu Xiaonong Zhou Shizhu Li | 2022 | Infectious Diseases of Poverty2022，11，3： | 1 |
| 16 | Renal medullary car- cinoma and ABL gene amplification显示文摘 | Simpson L: He X Pins M | 2005 | J Urol2005，173，6： | 1 |
| 17 | Study on phase dia gram of fatty acids mixtures to determine eutectic temperatures and the corresponding mixing proportions显示文摘 | Zhao Pin Yue Qinyan He Hongtao | 2014 | Applied Energy2014，115，4： | 1 |
| 18 | Effect of Tungsten Addition on Properties of Ni-Based Alloy Sheet Prepared by EB-PVD显示文摘 | Song Guang Pin He Xiao Dong Sun Yue Li Ming Wei | 2007 | Key Engineering Materials2007，，353： | 1 |
| 19 | Contribution of MDR1 gene polymorphisms on IBD predisposition and response to glucocorticoids in IBD in a C hinese population显示文摘 | Qing Fan Yang Bai Li Chen Qing Sen Zhang Zhen Hua Zhu Bin Hu Yao He Xiang Gao Yi Ming Wang Pin Jin Hu Min Hu Chen Zhi Rong Zeng | 2015 | Journal of Digestive Diseases2015，，1： | 1 |
| 20 | Study on the radiated acoustic field of the curved vibrating plate 显示文摘 | ZHENG Ke HE Xiping ZHANG Pin | 2008 | Journal of Shaanxi Normal University (NATURAL SCIENCE EDITION)2008，36，3： | 1 |
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