|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of sediment dredging on water quality and zooplankton community structure in a shallow of eutrophic lake显示文摘Effects of suction dredging on water quality and zooplankton community structure in a shallow of eutrophic lake,were evaluated.The results showed that a decreasing trend for levels of phosphorus,organic matter,total suspended solids,Chlorophyll a and Secchi transparency in the water column was found,while levels of water depth,electrical conductivity,total dissolved solids and NO 3--N concentration increased markedly post-dredging.The effects of dredging on dissolved oxygen,pH value and temperature were almost negligible.The zooplankton community structure responded rapidly to the environmental changes caused mainly by dredging.As a result,the abundance of rotifers decreased,while the density of zooplanktonic crustaceans increased markedly.The representative taxa were Brachionus angularis,B.budapestinensis,B.diversicornis,Synchaeta spp.and Neodiaptomus schmackeri.A distinct relationship between zooplankton taxa composition and their environment,unraveled by a redundancy analysis,indicating that the measured environment contributed to the variations in the zooplankton community structure to some extent.The first four synthetic environmental variables explained 51.7% of the taxonomic structure.Therefore,with the reduction of internal nutrient load and a shift in dominance by less eutrophic species,it inferred that dredging might be one of effective measures for environmental improvements of such lakes. | Shiyang Zhang Qiaohong Zhou Dong Xu Jidong Lin Shuiping Cheng Zhenbin Wu | 2010 | Journal of Environmental Sciences2010，22，2： | 41 |
| 2 | Analysis of CD8+ Treg cells in patients with ovarian cancer: a possible mechanism for immune impairment显示文摘 | Shuping Zhang | 2015 | Cellular & Molecular Immunology2015，12，5： | 17 |
| 3 | The prognostic and therapeutic implications of circulating tumor cell phenotype detection based on epithelial-mesenchymal transition markers in the first-line chemotherapy of HER2-negative metastatic breast cancer显示文摘Background:Epithelial-mesenchymal transition(EMT)is implicated in the metastatic process and presents a chal-lenge to epithelial cell adhesion molecule-based detection of circulating tumor cells(CTCs),which have been demon-strated to be a prognostic indicator in metastatic breast cancer.Although evidence has indicated that heterogeneity of CTCs based on EMT markers is associated with disease progression,no standard recommendations have been established for clinical practice.This study aimed to evaluate the prognostic significance of dynamic CTC detection based on EMT for metastatic breast cancer patients.Methods:We enrolled 108 human epidermal growth factor receptor 2-negative metastatic breast cancer patients from the prospective phase III CAMELLIA study and applied the CanPatrol CTC enrichment technique to identify CTC phenotypes(including epithelial CTCs,biphenotypic epithelial/mesenchymal CTCs,and mesenchymal CTCs)in peripheral blood samples.Receiver operating characteristic curve analyses of total CTC count and the proportion of mesenchymal CTCs for predicting the 1-year progression-free survival(PFS)rate were conducted to determine the optimal cut-off values,and Kaplan-Meier analysis and Cox proportional hazards regression analysis were performed to investigate the prognostic value of the cut-off values of both total CTC count and the proportion of mesenchymal CTCs in combination.Results:For predicting the 1-year PFS rate,the optimal cut-off value of total CTC count was 9.5(Area under the curve[AUC]=0.538,95%confidence interval[CI]=0.418-0.657),and that of the proportion of mesenchymal CTCs was 10.7%(AUC=0.581,95%CI=0.463-0.699).We used the two cut-off values in combination to forecast PFS in which the total CTC count was equaled to or exceeded 10/5 mL with the proportion of mesenchymal CTCs surpassed 10.7%.Patients who met the combined criteria had significantly shorter median PFS than did those who did not meet the criteria(6.2 vs.9.9 months,P=0.010).A nomogram was constructed based on the criteria and significant clinicopatho-logical characteristics with a C-index of 0.613(P=0.010).Conclusions: The criteria, which combine the total CTC count and the proportion of mesenchymal CTCs, may be used to monitor therapeutic resistance and predict prognosis in patients with metastatic breast cancer. | Xiuwen Guan Fei Ma Chunxiao Li Shiyang Wu Shangying Hu Jiefen Huang Xiaoying Sun Jiayu Wang Yang Luo Ruigang Cai Ying Fan Qiao Li Shanshan Chen Pin Zhang Qing Li Binghe Xu | 2019 | Cancer Communications2019，39，1： | 15 |
| 4 | Short-term effects of drawing water for connectivity of rivers and lakes on zooplankton community structure显示文摘在期间 28 29, 2005 年 9 月,水在武汉经由桑焦·莱克和南泰齐·莱克从 Hanjiang 河和豪古安·莱克被拉到 Yangzi 河以便为生态系统恢复提供有利条件。评估作为生态系统恢复的一个工具拉水的可行性和有效性,浮游动物人口被学习 3 次(以前,立即在在绘画以后完成和一个月以后流水) 在到 2005 年 11 月 2 日的从 2005 年 9 月 27 日的七个地点。在湖的水质主要被改进,一旦绘画的水一个月在拉水以后完成了,但是增加,浮游动物种类丰富减少了。浮游动物密度和生物资源被拉水在湖减少,但是因为地形几何学变化,在桑焦·莱克的入口被增加。在拉水前,在桑焦·莱克例如的大多数种类, Brachionus sp。并且 Keratella sp。污染是容忍的。在画水象 Lecane 那样的寡营养容易的种类以后, ludwigii 和 Gastropus 猪圈 lifer 出现了。我们断定拉水能为改进水质和帮助生态系统恢复是重要的。滋养的集中的冲淡可以是在效果的一个重要角色。 | WU Zhenbin LIU Aifen ZHANG Shiyang CHENG Shuiping WU Xiaohui | 2008 | Journal of Environmental Sciences2008，20，4： | 10 |
| 5 | Development and validation of a nomogram for predicting the survival of patients with non-metastatic nasopharyngeal carcinoma after curative treatment显示文摘Background: The TNM staging system is far from perfect in predicting the survival of individual cancer patients because only the gross anatomy is considered. The survival rates of the patients who have the same TNM stage disease vary across a wide spectrum. This study aimed to develop a nomogram that incorporates other clinicopathologic factors for predicting the overall survival(OS) of non-metastatic nasopharyngeal carcinoma(NPC) patients after curative treatments.Methods: We retrospectively collected the clinical data of 1520 NPC patients who were diagnosed histologically between November 2000 and September 2003. The clinical data of a separate cohort of 464 patients who received intensity-modulated radiation therapy(IMRT) between 2001 and 2010 were also retrieved to examine the extensibility of the model. Cox regression analysis was used to identify the prognostic factors for building the nomogram. The predictive accuracy and discriminative ability were measured using the concordance index(c-index).Results: We identiied and incorporated 12 independent clinical factors into the nomogram. The calibration curves showed that the prediction of OS was in good agreement with the actual observation in the internal validation set and IMRT cohort. The c-index of the nomogram was statistically higher than that of the 7th edition TNM staging system for predicting the survival in both the primary cohort(0.69 vs. 0.62) and the IMRT cohort(0.67 vs. 0.63).Conclusion: We developed and validated a novel nomogram that outperformed the TNM staging system in predicting the OS of non-metastatic NPC patients who underwent curative therapy. | Wenhua Liang Guanzhu Shen Yaxiong Zhang Gang Chen Xuan Wu Yang Li Anchuan Li Shiyang Kang Xi Yuan Xue Hou Peiyu Huang Yan Huang Hongyun Zhao Ying Tian Chong Zhao Li Zhang | 2016 | Chinese Journal of Cancer2016，35，12： | 6 |
| 6 | High Thermoelectric Performance of Cu-Doped PbSe-PbS System Enabled by High-Throughput Experimental Screening显示文摘Recent advances in high-throughput(HTP)computational power and machine learning have led to great achievements in exploration of new thermoelectric materials.However,experimental discovery and optimization of thermoelectric materials have long relied on the traditional Edisonian trial and error approach.Herein,we demonstrate that ultrahigh thermoelectric performance in a Cu-doped PbSe-PbS system can be realized by HTP experimental screening and precise property modulation.Combining the HTP experimental technique with transport model analysis,an optimal Se/S ratio showing high thermoelectric performance has been efficiently screened out.Subsequently,based on the screened Se/S ratio,the doping content of Cu has been subtly adjusted to reach the optimum carrier concentration.As a result,an outstanding peak zT~1:6 is achieved at 873 K for a 1.8 at%Cu-doped PbSe_(0.6)S_(0.4) sample,which is the superior value among the n-type Te-free lead chalcogenides.We anticipate that current work will stimulate large-scale unitization of the HTP experimental technique in the thermoelectric field,which can greatly accelerate the research and development of new high-performance thermoelectric materials. | Li You Zhili Li Quanying Ma Shiyang He Qidong Zhang Feng Wang Guoqiang Wu Qingyi Li Pengfei Luo Jiye Zhang Jun Luo | 2020 | Research2020，，1： | 4 |
| 7 | IntegrinαEβ7^(+)T cells direct intestinal stem cell fate decisions via adhesion signaling显示文摘Intestinal stem cell(ISC)differentiation is regulated precisely by a niche in the crypt,where lymphocytes may interact with stem and transient amplifying(TA)cells.However,whether and how lymphocyte–stem/TA cell contact affects ISC differentiation is largely unknown.Here,we uncover a novel role of T cell–stem/TA cell contact in ISC fate decisions.We show that intestinal lymphocyte depletion results in skewed ISC differentiation in mice,which can be rescued by T cell transfer.Mechanistically,integrinαEβ7 expressed on T cells binds to E-cadherin on ISCs and TA cells,triggering E-cadherin endocytosis and the consequent Wnt and Notch signaling alterations.BlockingαEβ7−E-cadherin adhesion suppresses Wnt signaling and promotes Notch signaling in ISCs and TA cells,leading to defective ISC differentiation.Thus,αEβ7^(+)T cells regulate ISC differentiation at single-cell level through cell–cell contact-mediatedαEβ7−E-cadherin adhesion signaling,highlighting a critical role of the T cell–stem/TA cell contact in maintaining intestinal homeostasis. | Shiyang Chen Yajuan Zheng Xiaojuan Ran Hui Du Hua Feng Lei Yang Yating Wen Changdong Lin Shihui Wang Mengwen Huang Zhanjun Yan Dianqing Wu Hongyan Wang Gaoxiang Ge An Zeng Yi Arial Zeng Jianfeng Chen | 2021 | Cell Research2021，31，12： | 3 |
| 8 | Investigation on Reduction of Pressure Fluctuation for a Double-Suction Centrifugal Pump显示文摘Double-suction centrifugal pumps have been applied extensively in many areas,and the significance of pressure fluctuations inside these pumps with large power is becoming increasingly important.In this study,a double-suction centrifugal pump with a high-demand for vibration and noise was redesigned by increasing the flow uniformity at the impeller discharge,implemented by combinations of more than two parameters.First,increasing the number of the impeller blades was intended to enhance the bounding effect that the blades imposed on the fluid.Subsequently,increasing the radial gap between the impeller and volute was applied to reduce the rotor-stator interaction.Finally,the staggered arrangement was optimized to weaken the efficacy of the interference superposition.Based on numerical simulation,the steady and unsteady characteristics of the pump models were calculated.From the fluctuation analysis in the frequency domain,the dimensionless pressure fluctuation amplitude at the blade passing frequency and its harmonics,located on the monitoring points in the redesigned pumps(both with larger radial gap),are reduced a lot.Further,in the volute of the model with new impellers staggered at 12°,the average value for the dimensionless pressure fluctuation amplitude decreases to 6%of that in prototype pump.The dimensionless rootmean-square pressure contour on the mid-span of the impeller tends to be more uniform in the redesigned models(both with larger radial gap);similarly,the pressure contour on the mid-section of the volute presents good uniformity in these models,which in turn demonstrating a reduction in the pressure fluctuation intensity.The results reveal the mechanism of pressure fluctuation reduction in a double-suction centrifugal pump,and the results of this study could provide a reference for pressure fluctuation reduction and vibration performance reinforcement of doublesuction centrifugal pumps and other pumps. | Qianqian Li Shiyang Li Peng Wu Bin Huang Dazhuan Wu | 2021 | Chinese Journal of Mechanical Engineering2021，34，1： | 2 |
| 9 | Transcriptomic Response to Yersinia pestis:RIG-I Like Receptor Signaling Response Is Detrimental to the Host against Plague显示文摘Bacterial pathogens have evolved various mechanisms to modulate host immune responses for successful infection.In this study,RNAsequencing technology was used to analyze the responses of human monocytes THP1 to Yersinia pestis infection.Over 6000 genes were differentially expressed over the 12 h infection.Kinetic responses of pathogen recognition receptor signaling pathways,apoptosis,antigen processing,and presentation pathway and coagulation system were analyzed in detail.Among them,RIG-I-like receptor(RLR) signaling pathway,which was established for antiviral defense,was significantly affected.Mice lacking MAVS,the adaptor of the RLR signahng pathway,were less sensitive to infection and exhibited lower IFN-P production,higher Thl-type cytokines IFN-y and IL-12 production,and lower Th2-type cytokines EL-4 and IL-13 production in the serum compared with wild-type mice.Moreover,infection of pathogenic bacteria other than Y.pestis also altered the expression of the RLR pathway,suggesting that the response of RLR pathway to bacterial infection is a universal mechanism. | Zongmin Du Huiying Yang Yafang Tan Guang Tian Qingwen Zhang Yujun Cui Yanfeng Yan Xiaohong Wu Zuyun Chen Shiyang Cao Yujing Bi Yanping Han Xiaoyi Wang Yajun Song Ruifu Yan | 2014 | Journal of Genetics and Genomics2014，41，7： | 2 |
| 10 | Coupling magnetic particles with flocculants to enhance demulsification and separation of waste cutting emulsion for engineering applications显示文摘Magnetic particles were coupled with a flocculant to enhance the demulsification and separation of waste cutting emulsions.The optimal magnetic particle size and critical magnetic field conditions were investigated to achieve large-scale engineering application of magnetic demulsification separation for waste cutting emulsion treatment.The micro-scale magnetic particles were found to show comparable effects to nano-scale magnetic particles on enhancing the demulsification and separation of cutting emulsions,which are beneficial for broadening the selectivity of low-cost magnetic particles.The critical magnetic separation region was determined to be an area 40 mm from the magnetic field source.Compared to the flocculant demulsification,the magnetic demulsification separation exhibited a significant advantage in accelerating flocs-water separation by decreasing the separation time of flocs from 180-240 min to less than 15 min,compressing the flocs by reducing the floc volume ratio from 60%-90%to lower than 20%,and showing excellent adaptability to the variable properties of waste cutting emulsions.Coupled with the design of the magnetic disk separator,continuous demulsification separation of the waste cutting emulsion was achieved at 1.0 t/hr for at least 10 hr to obtain clear effluent with 81%chemical oxygen demand removal and 89%turbidity reduction.This study demonstrates the feasibility of applying magnetic demulsification separation to large-scale continuous treatment of waste emulsion.Moreover,it addresses the flocs-water separation problems that occur in practical flocculant demulsification engineering applications. | Yongjiao Xiong Baoqiang Wu Xiangfeng Huang Chenlu Li Bin Lu Jia Liu Lijun Lu Shiyang Li Kaiming Peng | 2021 | Journal of Environmental Sciences2021，33，7： | 2 |
| 11 | Groundwater vulnerability assessment and feasibility mapping under reclaimed water irrigation by a modified DRASTIC model 显示文摘 | Wu Wenyong Yin Shiyang Liu Honglu | 2014 | Water Resources Management2014，28，： | 1 |
| 12 | A novel liquidchip platform for simultaneous detection of 70 alleles of DNA somatic mutations on EGFR, KRAS, BRAF and PIK3CA from formalin-fixed and paraffin-embedded slides containing tumor tissue显示文摘 | Guoqiang Li Xiaodi Luo Jiaying He Zeyao Zhu Gang Yu Huijuan Qin Tao Zeng Zhiming Liu Shiyang Wu Jiasen Xu Lifen Ren-Heidenreich | 2011 | Clinical Chemistry and Laboratory Medicine2011，，2： | 1 |
| 13 | CFD simulation of flow-pressure characteristics of a pressure control valve for au- tomotive fuel supply system显示文摘 | WU Dazhuan LI Shiyang WU Peng | 2015 | Energy conversion and man agement2015，10，： | 1 |
| 14 | 基于上皮–间质转化标志物的循环肿瘤细胞表型检测对HER2阴性转移性乳腺癌一线化疗的预后意义显示文摘背景与目的上皮–间质转化(epithelia-mesenchymal,EMT)参与肿瘤细胞的转移,并且对基于上皮细胞黏附分子的循环肿瘤细胞(circulating tumor cells,CTCs)检测技术提出了挑战,CTCs已被证实是转移性乳腺癌的预后指标。虽然有证据表明基于EMT标志物的CTCs异质性与疾病进展相关,但在临床应用方面尚无统一的参考标准。本研究旨在评估基于EMT的动态CTCs检测对转移性乳腺癌患者的预后意义。方法我们从CAMELLIA III期前瞻性研究中招募了108例人表皮生长因子受体2阴性转移性乳腺癌患者,并应用CanPatrol CTC富集技术检测外周血中不同亚型的CTCs(包括上皮型CTCs、混合型上皮/间质CTCs和间质型CTCs)。应用1年无进展生存(progression-free survival,PFS)率作为界值分别寻找CTC总数和间质CTCs比例的受试者工作曲线来确定最佳阈值,并采用Kaplan-Meier分析和Cox比例风险回归分析验证综合考虑CTC总数和间质型CTCs比例制定的诊断标准的预后价值。结果CTC总数的最佳阈值为9.5[曲线下面积(area under the curve,AUC)=0.538,95%置信区间(confidence interval,CI=0.418–0.657)]及间质CTCs比例为10.7%(AUC=0.581,95%CI:0.463–0.699)作为预测1年PFS率的界值。我们采用CTC总数≥10/5 mL且间质CTCs比例>10.7%的联合标准预测PFS。符合联合标准的患者的中位PFS显著短于不符合标准的患者(6.2个月vs.9.9个月,P=0.010)。根据该标准和显著的临床病理学特征绘制列线图,C指数为0.613(P=0.010)。结论CTC总数和间质CTCs比例的联合标准可用于监测转移性乳腺癌患者的治疗耐药性和预测患者预后。 | Xiuwen Guan Fei Ma Chunxiao Li Shiyang Wu Shangying Hu Jiefen Huang Xiaoying Sun Jiayu Wang Yang Luo Ruigang Cai Ying Fan Qiao Li Shanshan Chen Pin Zhang Qing Li Binghe Xu | 2019 | 癌症2019，38，9： | 1 |
| 15 | A novel mutant-enriched liquidchip technology for the qualitative detection of somatic mutations in KRAS gene from both serum and tissue samples显示文摘 | Shiyang Wu Zeyao Zhu Jiaying He Xiaodi Luo Jiasen Xu Lifen Ren-Heidenreich | 2010 | Clinical Chemistry and Laboratory Medicine2010，，： | 1 |
| 16 | Study on the Influence of Ni Modifying on Phase Transformation and Photocatalytic Activity of TiO_2显示文摘The Ni-modified TiO2 was synthesized using two methods including co-precipitation(Ni doped TiO2, Ni-TiO2) and wet impregnation(Ni loaded TiO2, Ni/TiO2). The surface and bulk crystalline phases of Ni-modified TiO2 were investigated by using X-ray diffractometry(XRD), UV Raman spectroscopy, TEM, and SEM. It is observed that Ni doping can promote the phase transition and grain size growth of TiO2. Moreover, the propagation of the rutile phase from the bulk into the surface region of TiO2 is increased when the Ni doping amount reaches up to 3%. However, in Ni/TiO2, it is found out that the surface and bulk phase transformation of TiO2 can be inhibited after impregnation of 1% of Ni on the TiO2. Compared with the co-precipitation method, Ni species may be more enriched in the surface of the Ni/TiO2 sample upon adoption of the impregnation method, and the direct contact of anatase particles of TiO2 is avoided. As a consequence, the phase transition in the surface and bulk region of TiO2 can be effectively inhibited by Ni loading. Additionally, the activity of the photocatalytic degradation of RhB on the 3Ni-TiO2-600 ℃ sample is higher than that on the 3 Ni/TiO2-600 ℃ sample. The phase junction formed between anatase and rutile in the surface region of 3Ni-TiO2-600 ℃ may the main reason for its high photocatalytic activity. | Wang Yan Zhang Jing Liu Shiyang Yan Song Wu Weicheng Xu Qian Li Can | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，3： | 1 |
| 17 | Enrichment and enumeration of circulating tumor cells by efficient depletion of leukocyte fractions显示文摘 | Shiyang Wu Zhiming Liu Suyan Liu Li Lin Weiwei Yang Jiasen Xu | 2014 | Clinical Chemistry and Laboratory Medicine2014，，： | 1 |
| 18 | In Situ IR Spectroscopic Study on the Hydrogenation of 1,3-Butadiene on Fresh Mo_2C/γ-Al_2O_3 Catalyst显示文摘The surface species formed from the adsorption of 1,3-butadiene and 1,3-butadiene hydrogenation over the fresh Mo2C/γ-Al2O3 catalyst was studied by in situ IR spectroscopy. It is found that 1,3-butadiene adsorption on the Mo2C/γ-Al2O3 catalyst mainly forms π-adsorbed butadiene(πs and πd) and σ-bonded surface species. These species are adsorbed mainly on the surface Moδ+(0<δ<2) sites as evidenced by co-adsorption of 1,3-butadiene and CO on the fresh Mo2C/γ-Al2O3 catalyst. The IR spectrometric analysis show that hydrogenation of 1,3-butadiene over fresh Mo2C/γ-Al2O3 catalyst produces mainly butane coupled with a small portion of butene. The selectivity of butene during the hydrogenation of 1,3-butadiene over fresh Mo2C/γ-Al2O3 catalyst might be explained by the adsorption mode of adsorbed 1,3-butadiene. Additionally, the active sites of the fresh Mo2C/γ-Al2O3 catalyst may be covered by coke during the hydrogenation reaction of 1,3-butadiene. The treatment with hydrogen at 673 K cannot remove the coke deposits from the surface of the Mo2C/γ-Al2O3 catalyst. | Zhang Jing Wu Weicheng Liu Shiyang | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，4： | 0 |
| 19 | Single-cell transcriptomics of immune cells in lymph nodes reveals their composition and alterations in functional dynamics during the early stages of bubonic plague显示文摘Bubonic plague caused by Yersinia pestis is highly infectious and often fatal.Characterization of the host immune response and its subsequent suppression by Y.pestis is critical to understanding the pathogenesis of Y.pestis.Here,we utilized single-cell RNA sequencing to systematically profile the transcriptomes of immune cells in draining lymph nodes(d LNs)during the early stage of Y.pestis infection.Dendritic cells responded to Y.pestis within 2 h post-infection(hpi),followed by the activation of macrophages/monocytes(Mφs/Mons)and recruitment of polymorphonuclear neutrophils(PMNs)to d LNs at 24 hpi.Analysis of cell-to-cell communication suggests that PMNs may be recruited to lymph nodes following the secretion of CCL9 by Mφs/Mons stimulated through CCR1-CCL9 interaction.Significant functional suppression of all the three innate immune cell types occurred during the early stage of infection.In summary,we present a dynamic immune landscape,at single-cell resolution,of murine d LNs involved in the response to Y.pestis infection,which may facilitate the understanding of the plague pathogenesis of during the early stage of infection. | Yifan Zhao Tong Wang Ziyang Liu Yuehua Ke Ruoyan Li Hongyan Chen Yang You Gengshan Wu Shiyang Cao Zongmin Du Fan Bai Ruifu Yang | 2023 | Science China(Life Sciences)2023，66，1： | 0 |
| 20 | Extraction of Natural Nanostructured Hydroxyapatite from Pacific Cod(Gadus macrocephalus)Bone with a Thermostable Collagenolytic Protease and Its ex vivo Intestinal Bioavailability显示文摘Natural nano-hydroxyapatite(HA)was extracted from Pacific cod(Gadus macrocephalus)bone with a thermostable col-lagenolytic protease in the present study.Conditions for the enzymatic reaction were optimized to be 60℃and pH 7.0,and a desir-able extraction efficiency was achieved by using the crude collagenolytic protease.Dynamic light scattering,transmission electron microscopy and energy-dispersive X-ray analysis revealed that nano-HA are anionic spherical(about 110nm)particles mainly com-prised of calcium and phosphorus at an approximate ratio of 5:3.As evaluated with the mouse ex vivo intestinal segments,the extracted nano-HA displayed comparable level of intestinal bioavailability to the positive control CaCl_(2).By treating with inhibitors(NaN3,ami-loride)and low temperature(4℃),clathrin-mediated endocytosis was assumed to involve the intestinal absorption of nano-HA.Over-all,the application of thermostable collagenolytic protease is proved to be a promising alternative method for nano-HA extraction from natural resource with improved ecological and biological value. | GUO Wei LI Shiyang JING Zhehua WU Haohao | 2023 | Journal of Ocean University of China2023，22，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员