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| 1 | Less common etiologies of exocrine pancreatic insufficiency显示文摘Exocrine pancreatic insufficiency(EPI), an important cause of maldigestion and malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine pancreatic function. Besides cystic fibrosis and chronic pancreatitis, the most common etiologies of EPI, other causes of EPI include unresectable pancreatic cancer, metabolic diseases(diabetes); impaired hormonal stimulation of exocrine pancreatic secretion by cholecystokinin(CCK); celiac or inflammatory bowel disease(IBD) due to loss of intestinal brush border proteins; and gastrointestinal surgery(asynchrony between motor and secretory functions, impaired enteropancreatic feedback, and inadequate mixing of pancreatic secretions with food). This paper reviews such conditions that have less straightforward associations with EPI and examines the role of pancreatic enzyme replacement therapy(PERT). Relevant literature was identified by database searches. Most patients with inoperable pancreatic cancer develop EPI(66%-92%). EPI occurs in patients with type 1(26%-57%) or type 2 diabetes(20%-36%) and is typically mild to moderate; by definition, all patients with type 3 c(pancreatogenic) diabetes have EPI. EPI occurs in untreated celiac disease(4%-80%), but typically resolves on a gluten-free diet. EPI manifests in patients with IBD(14%-74%) and up to 100% of gastrointestinal surgery patients(47%-100%; dependent on surgical site). With the paucity of published studies on PERT use for these conditions, recommendations for or against PERT use remain ambiguous. The authors conclude that there is an urgent need to conduct robust clinical studies to understand the validity and nature of associations between EPI and medical conditions beyond those with proven mechanisms, and examine the potential role for PERT. | Vikesh K Singh Mark E Haupt David E Geller Jerry A Hall Pedro M Quintana Diez | 2017 | World Journal of Gastroenterology2017，23，39： | 5 |
| 2 | Early Systemic Inflammatory Response Syndrome Is Associated With Severe Acute Pancreatitis显示文摘 | Vikesh K. Singh Bechien U. Wu Thomas L. Bollen Kathryn Repas Rie Maurer Koenraad J. Mortele Peter A. Banks | 2009 | Clinical Gastroenterology and Hepatology2009，，11： | 3 |
| 3 | Familial chylomicronemia syndrome related chronic pancreatitis: a single-center study显示文摘BACKGROUND: Hypertriglyceridemia induces acute recurrent pancreatitis, but its role in the etiology of chronic pancreatitis(CP) is controversial. This study aimed to evaluate the clinical laboratory and radiological findings of 7 patients with CP due to type 1 hyperlipidemia compared to CP patients with other or undefined etiological factors.METHODS: We retrospectively analyzed the clinical, laboratory and radiological findings of 7 CP patients with type 1 hyper lipidemia compared to CP patients without hypertriglyceridemia These 7 patients had multiple episodes of acute pancreatitis and had features of CP on abdominal CT, endoscopic retrograde cholangiopancreatography and/or endoscopic ultrasonography.RESULTS: All CP patients were classified into two groups: a group with type 1 hyperlipidemia (n=7) and a group with other etiologies (n=58). The mean triglyceride level was 2323±894mg/dL in the first group. Age at the diagnosis of CP in the first group was significantly younger than that in the second group(16.5±5.9 vs 48.3±13.5, P<0.001). The number of episodes of acute pancreatitis in the first group was significantly higher than that in the second group (15.0±6.8 vs 4.0±4.6, P=0.011)The number of splenic vein thrombosis in the first group was significantly higher than that in the second group (4/7 vs 9/58P=0.025). Logistic regression analysis found that younger age was an independent predictor of CP due to hypertriglyceridemia(r=0.418, P=0.000).CONCLUSIONS: Type 1 hyperlipidemia appears to be an etiological factor even for a minority of patients with CP. It manifests at a younger age, and the course of the disease might be severe. | Gurhan Sisman Yusuf Erzin Ibrahim Hatemi Erkan Caglar Salih Boga Vikesh Singh Hakan Senturk | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，2： | 2 |
| 4 | Comparison of Existing Clinical Scoring Systems to Predict Persistent Organ Failure in Patients With Acute Pancreatitis显示文摘 | Rawad Mounzer Christopher J. Langmead Bechien U. Wu Anna C. Evans Faraz Bishehsari Venkata Muddana Vikesh K. Singh Adam Slivka David C. Whitcomb Dhiraj Yadav Peter A. Banks Georgios I. Papachristou | 2012 | Gastroenterology2012，，7： | 2 |
| 5 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 2 |
| 6 | A Comparative Evaluation of EUS-Guided Biliary Drainage and Percutaneous Drainage in Patients with Distal Malignant Biliary Obstruction and Failed ERCP显示文摘 | Mouen A. Khashab Ali Kord Valeshabad Elham Afghani Vikesh K. Singh Vivek Kumbhari Ahmed Messallam Payal Saxena Mohamad El Zein Anne Marie Lennon Marcia Irene Canto Anthony N. Kalloo | 2015 | Digestive Diseases and Sciences2015，，2： | 2 |
| 7 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 1 |
| 8 | Heat Transfer Calculations for Decomposition of Structure I Methane Hydrates by Molecular Dynamics Simulation 显示文摘 | Vikesh Singh Baghel Rajnish Kumar Sudip Roy | 2013 | The Journal of Physical Chemistry C2013，117，12： | 1 |
| 9 | Incidence, severity, and mortality of post-ERCP pancreatitis: a systematic review by using randomized, controlled trials显示文摘 | Bharati Kochar Venkata S. Akshintala Elham Afghani B. Joseph Elmunzer Katherine J. Kim Anne Marie Lennon Mouen A. Khashab Anthony N. Kalloo Vikesh K. Singh | 2014 | Gastrointestinal Endoscopy2014，，： | 1 |
| 10 | Posterior approach white line advancement ptosis repair: the evolving posterior approach to ptosis surgery显示文摘 | VIKESH P SALAM A RAMAN M | 2010 | Clin Sci2010，94，： | 1 |
| 11 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 1 |
| 12 | Delayed and Unsuccessful Endoscopic Retrograde Cholangiopancreatography Are Associated With Worse Outcomes in Patients With Acute Cholangitis显示文摘 | Mouen A. Khashab Ali Tariq Usman Tariq Katherine Kim Lucia Ponor Anne Marie Lennon Marcia I. Canto Ahmet Gurakar Qilu Yu Kerry Dunbar Susan Hutfless Anthony N. Kalloo Vikesh K. Singh | 2012 | Clinical Gastroenterology and Hepatology2012，，10： | 1 |
| 13 | 5-Fr vs. 3-Fr pancreatic stents for the prevention of post-ERCP pancreatitis in high-risk patients: a systematic review and network meta-analysis显示文摘 | Elham Afghani Venkata Akshintala Mouen Khashab Joanna Law Susan Hutfless Katherine Kim Anne Lennon Anthony Kalloo Vikesh Singh | 2014 | Endoscopy2014，，： | 1 |
| 14 | Betatron contributions to the angular gain spectrum of a free-electron laser with an imperfect beam trajectory显示文摘 | G. Mishra Vikesh Gupta | 2005 | Journal of Modern Optics2005，，9： | 1 |
| 15 | 850d Human bile contains microRNA-laden exosomes that can be used for cholangiocarcinoma diagnosis显示文摘 | Ling Li David Masica Masaharu Ishida Anthony N. Kalloo Vikesh K. Singh Mouen Khashab Zhiping Li Patrick Okolo Anne Marie Lennon Payal Saxena Marcia I. Canto Joanna K. Law Michael G. Goggins Eun Ji Shin Vivek Kumbhari Susan Hutfless Esteban Mezey Stephen J | 2014 | Gastroenterology2014，，： | 1 |
| 16 | The revised Atlanta classification for acute pancreatitis: updates in imaging terminology and guidelines显示文摘 | Atif Zaheer Vikesh K. Singh Reema O. Qureshi Elliot K. Fishman | 2013 | Abdominal Imaging2013，，1： | 1 |
| 17 | An Assessment of the Severity of Interstitial Pancreatitis显示文摘 | Vikesh K. Singh Thomas L. Bollen Bechien U. Wu Kathryn Repas Rie Maurer Song Yu Koenraad J. Mortele Darwin L. Conwell Peter A. Banks | 2011 | Clinical Gastroenterology and Hepatology2011，，12： | 1 |
| 18 | Extraction of ursolic acid from Ocimum sanctum leaves : Kinetics and modeling 显示文摘 | Mangesh D Vetal Vikesh G Lade Virendra K Rathod | 2012 | Food and Bioproducts Processing2012，90，4： | 1 |
| 19 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 1 |
| 20 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 1 |
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