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| 1 | Targeted lapatinib anti-HER2/ErbB2 therapy resistance in breast cancer:opportunities to overcome a difficult problem显示文摘Approximately 20%of invasive breast cancers have upregulation/gene amplification of the oncogene human epidermal growth factor receptor-2(HER2/ErbB2).Of these,some also express steroid receptors(the so-called Luminal B subtype),whereas others do not(the HER2 subtype).HER2 abnormal breast cancers are associated with a worse prognosis,chemotherapy resistance,and sensitivity to selected anti-HER2 targeted therapeutics.Transcriptional data from over 3000 invasive breast cancers suggest that this approach is overly simplistic;rather,the upregulation of HER2 expression resulting from gene amplification is a driver event that causes major transcriptional changes involving numerous genes and pathways in breast cancer cells.Most notably,this includes a shift from estrogenic dependence to regulatory controls driven by other nuclear receptors,particularly the androgen receptor.We discuss members of the HER receptor tyrosine kinase family,heterodimer formation,and downstream signaling,with a focus on HER2 associated pathology in breast carcinogenesis.The development and application of anti-HER2 drugs,including selected clinical trials,are discussed.In light of the many excellent reviews in the clinical literature,our emphasis is on recently developed and successful strategies to overcome targeted therapy resistance.These include combining anti-HER2 agents with programmed cell death-1 ligand or cyclin-dependent kinase 4/6 inhibitors,targeting crosstalk between HER2 and other nuclear receptors,lipid/cholesterol synthesis to inhibit receptor tyrosine kinase activation,and metformin,a broadly inhibitory drug.We seek to facilitate a better understanding of new approaches to overcome anti-HER2 drug resistance and encourage exploration of two other therapeutic interventions that may be clinically useful for HER+invasive breast cancer patients. | Reema Wahdan-Alaswad Bolin Liu Ann D.Thor | 2020 | Cancer Drug Resistance2020，3，2： | 3 |
| 2 | Acute Fatty liver of pregnancy显示文摘 | Dey M Reema K | 2012 | N Am J Med Sci2012，4，： | 1 |
| 3 | Anthology of anther/pollen-specific promoters and transcription factors显示文摘 | Reema Khurana Sanjay Kapcor Akhilesh K | 2012 | Criti- cal Reviews in Plant Sciences2012，31，5： | 1 |
| 4 | Deep Learning and SVM-Based Approach for Indian Licence Plate Character Recognition显示文摘Every developing country relies on transportation,and there has been an exponential expansion in the development of various sorts of vehicles with various configurations,which is a major component strengthening the automobile sector.India is a developing country with increasing road traffic,which has resulted in challenges such as increased road accidents and traffic oversight issues.In the lack of a parametric technique for accurate vehicle recognition,which is a major worry in terms of reliability,high traffic density also leads to mayhem at checkpoints and toll plazas.A system that combines an intelligent domain approach with more sustainability indices is a better way to handle traffic density and transparency issues.The Automatic Licence Plate Recognition(ALPR)system is one of the components of the intelligent transportation system for traffic monitoring.This study is based on a comprehensive and detailed literature evaluation in the field of ALPR.The major goal of this study is to create an automatic pattern recognition system with various combinations and higher accuracy in order to increase the reliability and accuracy of identifying digits and alphabets on a car plate.The research is founded on the idea that image processing opens up a diverse environment with allied fields when employing distinct soft techniques for recognition.The properties of characters are employed to recognise the Indian licence plate in this study.For licence plate recognition,more than 200 images were analysed with various parameters and soft computing techniques were applied.In comparison to neural networks,a hybrid technique using a Convolution Neural Network(CNN)and a Support Vector Machine(SVM)classifier has a 98.45%efficiency. | Nitin Sharma Mohd Anul Haq Pawan Kumar Dahiya B.R.Marwah Reema Lalit Nitin Mittal Ismail Keshta | 2023 | Computers, Materials & Continua2023，，1： | 1 |
| 5 | MicroRNAs and lung caner:Biology and applications in diagnosis and prognosis显示文摘 | Reema M Santosh K and Sai Y | 2010 | Journal of Carcinogenesis2010，9，8： | 1 |
| 6 | The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels显示文摘 | Griffin Courtney T Curtis Carol D Davis Reema B | 2011 | Proc Natl Acad Sci USA2011，108，6： | 1 |
| 7 | Nutritional evaluation of supplementary foods prepared from germinated cereals and legumes显示文摘 | Reema Hira C K Balwinder Sadana | 2004 | Journal of Food Science and Technology2004，41，6： | 1 |
| 8 | Curcumin Content of Turmeric and Curry Powders显示文摘 | Reema F. Tayyem Dennis D. Heath Wael K. Al-Delaimy Cheryl L. Rock | 2006 | Nutrition and Cancer2006，，2： | 1 |
| 9 | Laser peripheral iridotomy across the spectrum of primary angle closure显示文摘 | Surinder Singh Pandav Sushmita Kaushik Rajeev Jain Reema Bansal Amod Gupta | 2007 | Canadian Journal of Ophthalmology/Journal canadien d’ophtalmologie2007，，2： | 1 |
| 10 | Health-related quality of life, work productivity and health care resource use associated with constipation predominant irritable bowel syndrome显示文摘 | Marco DiBonaventura Shawn X. Sun Susan C. Bolge Jan-Samuel Wagner Reema Mody | 2011 | Current Medical Research & Opinion2011，，11： | 1 |
| 11 | An epidemiological overview of diabetes across the world显示文摘 | Meetoo D Mcgovem P Reema S | 2007 | Br J Nurs2007，16，16： | 1 |
| 12 | Developing profiles of postmenopausal women being prescribes estrogen therapy to prevent osteoporosis显示文摘 | Mayur M A Reema M | 2002 | J Community Health2002，27，5： | 1 |
| 13 | New Quantization Technique in Semi-fragile Digital Watermarking for Image Authentication显示文摘 | Sushil K Prasad Susmi Routray Reema Khurana | 2009 | Communications in Computer and Information Science2009，31，9： | 1 |
| 14 | Hydrogen production through oxidative steam reforming of ethanol over Ni-based catalysts derived from La 1? x Ce x NiO 3 perovskite-type oxides显示文摘 | Sania M. de Lima Adriana M. da Silva Lídia O.O. da Costa José M. Assaf Lisiane V. Mattos Reema Sarkari A. Venugopal Fábio B. Noronha | 2012 | Applied Catalysis B Environmental2012，，： | 1 |
| 15 | The revised Atlanta classification for acute pancreatitis: updates in imaging terminology and guidelines显示文摘 | Atif Zaheer Vikesh K. Singh Reema O. Qureshi Elliot K. Fishman | 2013 | Abdominal Imaging2013，，1： | 1 |
| 16 | Prevalence and risk of developing comorbid conditions in patients with chronic constipation显示文摘 | Reema Mody Annie Gué rin Beverly Fok Karen L. Lasch Zhou Zhou Eric Q. Wu Wen Zhou Nicholas J. Talley | 2014 | Current Medical Research & Opinion2014，，12： | 1 |
| 17 | Green tea extract: Possible mechanism and antibacterial activity on skin pathogens显示文摘 | Anjali Sharma Sonal Gupta Indira P. Sarethy Shweta Dang Reema Gabrani | 2012 | Food Chemistry2012，，2： | 1 |
| 18 | Killing two birds with one RKIP显示文摘 | Reema Goel Joseph J Baldassare | 2004 | Trenods in Endocrinol Metab2004，15，3： | 1 |
| 19 | Targeting the EGFReceptor for Ovarian Cancer Therapy显示文摘 | Reema Zeineldin Carolyn Y Muller M | 2009 | Oncol2009，，28： | 1 |
| 20 | Patient and Physician Satisfaction with Proton Pump Inhibitors (PPIs): Are There Opportunities for Improvement?显示文摘 | William D. Chey Reema R. Mody Esin Izat | 2010 | Digestive Diseases and Sciences2010，，12： | 1 |
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