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| 1 | From blood to breath: New horizons for esophageal cancer biomarkers显示文摘Esophageal cancer is a lethal cancer encompassing adenocarcinoma and squamous cell carcinoma subtypes. The global incidence of esophageal cancer is increasing world-wide, associated with the increased prevalence of associated risk factors. The asymptomatic nature of disease often leads to late diagnosis and five-year survival rates of less than 15%. Current diagnostic tools are restricted to invasive and costly endoscopy and biopsy for histopathology. Minimally and non-invasive biomarkers of esophageal cancer are needed to facilitate earlier detection and better clinical management of patients. This paper summarises recent insights into the development and clinical validation of esophageal cancer biomarkers, focussing on circulating markers in the blood, and the emerging area of breath and odorant biomarkers. | Roger Yazbeck Simone E Jaenisch David I Watson | 2016 | World Journal of Gastroenterology2016，22，46： | 6 |
| 2 | 一种风力发电机自动故障诊断及预测方法显示文摘为了获得故障信号精确的时域和频域信息,提出了一种Morlet小波变换补偿方法,首先计算出故障信号的时间和频率信息,然后根据Morlet小波系数中心频率峰值对计算的故障信号的幅值进行补偿,得出故障信号的准确幅值.采用Simulink模型证明该方法的可行性,并将该方法应用到测试风力发电机和实际大型风力发电机的电功率信号分析中.结果表明:该方法可以自动获得故障信号按时序排列的振幅趋势图,显示了部件发生故障后的剩余使用寿命期限;风力发电机特别是海上风力发电机的维护维修计划可根据此时间信息进行制定,降低风电运维成本. | 向健平 姜楠楠 Simon Jonathan Watson | 2017 | 动力工程学报2017，37，10： | 3 |
| 3 | Higher infliximab and adalimumab trough levels are associated with fistula healing in patients with fistulising perianal Crohn’s disease显示文摘BACKGROUND Tumor necrosis factor-alpha inhibitors,including infliximab and adalimumab,are effective medical treatments for perianal fistulising Crohn’s disease(CD),but not all patients achieve fistula healing.AIM To determine the correlation between perianal fistula healing and closure with infliximab and adalimumab trough levels.METHODS In this multicentre retrospective study conducted across four tertiary inflammatory bowel disease centres in Australia,we identified CD patients with perianal fistulae on maintenance infliximab or adalimumab who had a trough level within twelve weeks of clinical assessment.Data collected included demographics,serum infliximab and adalimumab trough levels(mg/L)within 12 wk before or after their most recent clinical assessment and concomitant medical or surgical therapy.The primary outcome was fistula healing,defined as cessation in fistula drainage.The secondary outcome was fistula closure,defined as healing and closure of all external fistula openings.Differences between patients who did or did not achieve fistula healing were compared using the chi-square test,t test or Mann-Whitney U test.RESULTS One hundred and fourteen patients(66 infliximab,48 adalimumab)were included.Forty-eight(72.7%)patients on maintenance infliximab achieved fistula healing and 18(27.3%)achieved fistula closure.Thirty-seven(77%)patients on maintenance adalimumab achieved fistula healing and 17(35.4%)achieved fistula closure.Patients who achieved fistula healing had significantly higher infliximab and adalimumab trough levels than patients who did not[infliximab:6.4(3.8-9.5)vs 3.0(0.3-6.2)mg/L,P=0.003;adalimumab:9.2(6.5-12.0)vs 5.4(2.5-8.3)mg/L,P=0.004].For patients on infliximab,fistula healing was associated with lower rates of detectable anti-infliximab antibodies and younger age.For patients on adalimumab,fistula healing was associated with higher rates of combination therapy with an immunomodulator.Serum trough levels for patients with and without fistula closure were not significantly different for infliximab[6.9(4.3-10.2)vs 5.5(2.5-8.3)mg/L,P=0.105]or adalimumab[10.0(6.6-12.0)vs 7.8(4.2-10.0)mg/L,P=0.083].CONCLUSION Higher maintenance infliximab and adalimumab trough levels are associated with perianal fistula healing in CD. | Bonita Gu Kavya Venkatesh Astrid-Jane Williams Watson Ng Crispin Corte Ali Gholamrezaei Simon Ghaly Wei Xuan Sudarshan Paramsothy Susan Connor | 2022 | World Journal of Gastroenterology2022，28，23： | 2 |
| 4 | Optimum Lymphadenectomy for Esophageal Cancer显示文摘 | Nabil P. Rizk Hemant Ishwaran Thomas W. Rice Long-Qi Chen Paul H. Schipper Kenneth A. Kesler Simon Law Toni E. M. R. Lerut Carolyn E. Reed Jarmo A. Salo Walter J. Scott Wayne L. Hofstetter Thomas J. Watson Mark S. Allen Valerie W. Rusch Eugene H. Blacksto | 2010 | Annals of Surgery2010，，1： | 2 |
| 5 | Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging 显示文摘 | Phadwal K Watson AS Simon AK | 2013 | Cell Mol Life Sci2013，70，1： | 1 |
| 6 | Levels of Neonatal Thyroid Hormone in Preterm Infants and Neurodevelopmental Outcome at 5? Years: Millennium Cohort Study显示文摘 | Caroline Delahunty Shona Falconer Robert Hume Lesley Jackson Paula Midgley Marie Mirfield Simon Ogston Oliver Perra Judith Simpson Jennifer Watson Peter Willatts Fiona Williams | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，11： | 1 |
| 7 | Reliability analysis for wind turbines with incomplete failure data collected from after the date of initial installation显示文摘 | Haitao Guo Simon Watson Peter Tavner | 2009 | Reliability Engineering and System Safety2009，94，： | 1 |
| 8 | Treatment of allergic rhinitis with intranasal corticosteroids in patients with mild asthma: effect on lower airwar responsiveness显示文摘 | Watson WTA Becker AB Simons FER | 1993 | J Allergy Clin Immunol1993，91，3： | 1 |
| 9 | Prevalence of physical activity among New Zealand youth and its association with community enviornments显示文摘 | Jennifer Utter Simon Denny Peter Watson | 2004 | Journal of Adolescent Health2004，，2： | 1 |
| 10 | Lack of auto- phagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation 显示文摘 | MORTENSEN M WATSON AS SIMON AK | 2011 | Autophagy2011，7，9： | 1 |
| 11 | Intestinal permeability tests in coeliac disease显示文摘 | Simon D Johnson Mike Smye Rg Peter Watson | 2001 | Clin Lab2001，47，34： | 1 |
| 12 | Dynamic modelling of a UK North Sea saline for- mation for CO2 sequestration显示文摘 | Francesca E Watson Simon A Mathias Susie E Daniels | 2014 | Petroleum Geoscience2014，20，： | 1 |
| 13 | A review: Challenges and opportunities for artificial intelligence and robotics in the offshore wind sector显示文摘The UK has set plans to increase offshore wind capacity from 22GW to 154GW by 2030. With such tremendous growth, the sector is now looking to Robotics and Artificial Intelligence (RAI) in order to tackle lifecycle service barriers as to support sustainable and profitable offshore wind energy production. Today, RAI applications are predominately being used to support short term objectives in operation and maintenance. However, moving forward, RAI has the potential to play a critical role throughout the full lifecycle of offshore wind infrastructure, from surveying, planning, design, logistics, operational support, training and decommissioning. This paper presents one of the first systematic reviews of RAI for the offshore renewable energy sector. The state-of-the-art in RAI is analyzed with respect to offshore energy requirements, from both industry and academia, in terms of current and future requirements. Our review also includes a detailed evaluation of investment, regulation and skills development required to support the adoption of RAI. The key trends identified through a detailed analysis of patent and academic publication databases provide insights to barriers such as certification of autonomous platforms for safety compliance and reliability, the need for digital architectures for scalability in autonomous fleets, adaptive mission planning for resilient resident operations and optimization of human machine interaction for trusted partnerships between people and autonomous assistants. Our study concludes with identification of technological priorities and outlines their integration into a new ‘symbiotic digital architecture’ to deliver the future of offshore wind farm lifecycle management. | Daniel Mitchell Jamie Blanche Sam Harper Theodore Lim Ranjeetkumar Gupta Osama Zaki Wenshuo Tang Valentin Robu Simon Watson David Flynn | 2022 | Energy and AI2022，8，2： | 1 |
| 14 | Comparison of iprat- ropium solution,fenoterol solution, and their combination administered by nebulizer and face mask to children with acute asthma显示文摘 | Watson WT Becket AB Simons FE | 1988 | J Allergy Clin Immunol1988，82，6： | 1 |
| 15 | Treatment of allergic rhinitis with intranasal corticosteroids in patients with mild asthma: effect on lower airway responsiveness 显示文摘 | Watson WTA Becker AB Simons FER | 1993 | J Allergy Clin Immunol1993，91，3： | 1 |
| 16 | Cetirizine: a pharmacokinetic and pharmacodynamic evaluation in children with seasonal allergic rhinitis 显示文摘 | Watson WTA Simons KJ Chen XY | 1989 | J-Allergy-Clin-Immunol1989，84，： | 1 |
| 17 | THE 4C APPROACH AS A WAY TO UNDERSTAND SPECIES INTERACTIONS DETERMINING INTERCROPPING PRODUCTIVITY显示文摘Modern agriculture needs to develop transition pathways toward agroecological,resilient and sustainable farming systems.One key pathway for such agroecological intensification is the diversification of cropping systems using intercropping and notably cereal-grain legume mixtures.Such mixtures or intercrops have the potential to increase and stabilize yields and improve cereal grain protein concentration in comparison to sole crops.Species mixtures are complex and the 4C approach is both a pedagogical and scientific way to represent the combination of four joint effects of Competition,Complementarity,Cooperation,and Compensation as processes or effects occurring simultaneously and dynamically between species over the whole cropping cycle.Competition is when plants have fairly similar requirements for abiotic resources in space and time,the result of all processes that occur when one species has a greater ability to use limiting resources(e.g.,nutrients,water,space,light)than others.Complementarity is when plants grown together have different requirements for abiotic resources in space,time or form.Cooperation is when the modification of the environment by one species is beneficial to the other(s).Compensation is when the failure of one species is compensated by the other(s)because they differ in their sensitivity to abiotic stress.The 4C approach allows to assess the performance of arable intercropping versus classical sole cropping through understanding the use of abiotic resources. | Eric JUSTES Laurent BEDOUSSAC Christos DORDAS Ela FRAK Gaetan LOUARN Simon BOUDSOCQ Etienne-Pascal JOURNET Anastasios LITHOURGIDIS Chrysanthi PANKOU Chaochun ZHANG Georg CARLSSON Erik Steen JENSEN Christine WATSON Long LI | 2021 | Frontiers of Agricultural Science and Engineering2021，8，3： | 1 |
| 18 | Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging显示文摘 | Phadwal K Watson AS Simon AK | 2013 | Cell Mol Life Sci2013，70，1： | 1 |
| 19 | The association of clinical outcome with right atrial and ventricular remodelling in patients with pulmonary arterial hypertension: study with real-time three-dimensional echocardiography显示文摘 | Julia Grapsa J. Simon R. Gibbs Ines Zimbarra Cabrita Geoffrey F. Watson Harry Pavlopoulos David Dawson Wendy Gin-Sing Luke S.G.E. Howard Petros Nihoyannopoulos | 2012 | European Heart Journal – Cardiovascular Imaging2012，，8： | 1 |
| 20 | Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation显示文摘 | Mortensen M Watson AS Simon AK | 2011 | Autophagy2011，7，9： | 1 |
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