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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Crohn's disease environmental factors in the developing world: A case-control study in a statewide catchment area in Brazil显示文摘AIM To identify environmental risk factors associated with the development of Crohn's disease(CD) in order to reassess the hygiene hypothesis.METHODS A hospital-based, case-control study was carried out with CD patients(n = 145) and controls(n = 163)representing a socioeconomically diverse statewide catchment area in Brazil. Controls were recruited from caregivers of patients seen in different outpatient clinics at the same hospital. A multi-item survey with 94 questions regarding family history of CD, perinatal and childhood circumstances, living conditions, tobacco use and familial socioeconomic status was carried out by interviewers. RESULTS On the univariate analysis, predictive variables for CD included being male, under age of 40, a high education level, urban dweller, smaller family size, exposure to enteric pathogens and user of treated water(P < 0.005). On the multivariate analysis, variables significantly associated with CD were male gender(OR = 2.09), under age 40(OR = 3.10), white(OR = 2.32), from a small family in childhood(OR = 2.34) and adulthood(OR = 3.02), absence of viral infections in childhood(OR = 2.23), exposure to enteric pathogens(OR = 2.41), having had an appendectomy(OR = 2.47) and prior or current smoker(OR = 2.83/1.12). CONCLUSION Most variables supporting the 'hygiene hypothesis' are associated with the development of CD but are not independent predictors of the diagnosis. | Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Boechat Bianca C Schorr Isabella S Leao Tiago Nunes Cyrla Zaltman | 2017 | World Journal of Gastroenterology2017，23，30： | 2 |
| 3 | Induction of CTGF by TGF-β1 in normal and radiation enteritis human smooth muscle cells: Smad/Rho balance and therapeutic perspectives显示文摘 | Valérie Haydont Denis Mathé Céline Bourgier Jalil Abdelali Jocelyne Aigueperse Jean Bourhis Marie-Catherine Vozenin-Brotons | 2005 | Radiotherapy and Oncology2005，，2： | 2 |
| 4 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 2 |
| 5 | Therapeutic efficiency of everolimus and lapatinib in xenograft model of human colorectal carcinoma with KRAS mutation显示文摘 | Céline Chu Marie‐Sophie No?l‐Hudson Valérie Boige Diane Goéré Sylvie Marion Mélanie Polrot Ludovic Bigot Patrick Gonin Robert Farinotti Laurence Bonhomme‐Faivre | 2013 | Fundamental & Clinical Pharmacology2013，，4： | 2 |
| 6 | Making Euler deconvolution applicable to small ground magnetic surveys显示文摘 | Valéria C F Barbosa Joao B C Silva Walter E Medeiros | 2000 | Journal of Applied Geophysics2000，43，1： | 1 |
| 7 | Regulation of gene expression programs during Arabidopsis seed development: roles of the ABI3 locus and of endogenous abscisic acid显示文摘 | Parcy F Val on C Raynal M | 1994 | The Plant Cell Online1994，6，11： | 1 |
| 8 | Lapaa, o- scopic treatment of varicocele 显示文摘 | S6nchezde Badajoz E Dfaz Ramirez F Val~a Thorbeck C | 1991 | Arch Esp Ul~ol1991，44，5： | 1 |
| 9 | ldiometric stability of the Multi-angle Imaging SpectroRa- diometer (MISR) following 15 years on-orbit 显示文摘 | Bruegge C J Val S Diner D J | 2014 | Earth Observing Systems2014，9218，92： | 1 |
| 10 | Expression analysis of the Ara-bidopsis peroxidase multigenic family显示文摘 | VALéRIO L DE MEYER M PENEL C | 2004 | Phytochemistry2004，65，10： | 1 |
| 11 | The application of pH-stat leaching tests to assess the pH-dependent release of trace metals from soils, sediments and waste materials显示文摘 | Val~rie C Rudy S | 2008 | Journal of Hazardous Materials2008，158，： | 1 |
| 12 | Coercivity and induced magnetic anisotropy by stress and/or field annealing in Fe-and Co-based (Finemet-type) amorphous alloys显示文摘 | MIGUEL C ZHUKOV A DEL VAL J J | 2005 | J Magn Magn Mater2005，294，： | 1 |
| 13 | Systemic Delivery of Parathyroid Hormone (1-34) Using Inhalation Dry Powders in Rats显示文摘 | Valérle C Francis V Roger KV | 2003 | J Pharm Sci2003，92，5： | 1 |
| 14 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 1 |
| 15 | Kallikrein-Related Peptidase 14 Acts on Proteinase-Activated Receptor 2 to Induce Signaling Pathway in Colon Cancer Cells显示文摘 | Valérie Gratio Céline Loriot G. Duke Virca Katerina Oikonomopoulou Francine Walker Eleftherios P. Diamandis Morley D. Hollenberg Dalila Darmoul | 2011 | The American Journal of Pathology2011，，5： | 1 |
| 16 | Induction of mesenchymal/epithelial marker expression in human amniotic fluid stem cel s显示文摘 | Siegel N Val i A Fuchs C | | 0，，06： | 1 |
| 17 | The effects of dietary supplementation of methionine on genomic stability and p53 gene promoter methylation in rats显示文摘 | Cátia Lira Do Amaral Rafaela de Barros e Lima Bueno Regislaine Valéria Burim Regina Helena Costa Queiroz Maria de Lourdes Pires Bianchi Lusania Maria Greggi Antunes | 2011 | MutRes-Genetic Toxicology and Environmental Mutagenesis2011，，1： | 1 |
| 18 | Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial显示文摘 | Jeremy Chataway Nadine Schuerer Ali Alsanousi Dennis Chan David MacManus Kelvin Hunter Val Anderson Charles R M Bangham Shona Clegg Casper Nielsen Nick C Fox David Wilkie Jennifer M Nicholas Virginia L Calder John Greenwood Chris Frost Richard Nicholas | 2014 | The Lancet2014，，： | 1 |
| 19 | Effect of washing hands with soap on diarrhoea risk in the community: a systematic review 显示文摘 | Val C Sandy C | 2003 | Lancet Infect Dis2003，3，： | 1 |
| 20 | Gravity inversion of a discontinuous relief stabilized by weighted smoothness constraints on depth显示文摘 | Val rica C F | 1999 | Geophysics1999，64，5： | 1 |
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