|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mercury in aquatic fauna contamination:A systematic review on its dynamics and potential health risks显示文摘Mercury is an important pollutant,released into aquatic ecosystems both naturally and by anthropogenic action.This element is transferred to aquatic organisms in different ways,causing potential health risks.In addition,mercury can be accumulated by humans,especially through the consumption of contaminated food.This systematic review aims to present mercury pathways,the major routes through which this element reaches the aquatic environment and its transformations until becoming available to living animals,leading to bioaccumulation and biomagnification phenomena.The key biotic and abiotic factors affecting such processes,the impact of mercury on animal and human health and the issue of seafood consumption as a source of chronic mercury contamination are also addressed.A total of 101 articles were retrieved from a standardized search on three databases(PubMed,Emabse,and Web of Science),in addition to 28 other studies not found on these databases but considered fundamental to this review(totaling 129 articles).Both biotic and abiotic factors display fundamental importance in mediating mercurial dynamics,i.e.,muscle tropism,and salinity,respectively.Consequently,mercurial contamination in aquatic environments affects animal health,especially the risk of extinction species and also on human health,with methylmercury the main mercury species responsible for acute and chronic symptomatology. | Paloma de Almeida Rodrigues Rafaela Gomes Ferrari Luciano Neves dos Santos Carlos Adam Conte Junior | 2019 | Journal of Environmental Sciences2019，31，10： | 6 |
| 2 | Association of Helicobacter pylori infection and giardiasis: Results from a study of surrogate markers for fecal exposure among children显示文摘AIM: To investigate whether Helicobacter pylori (H pykori)infection is associated with hepatitis A virus (HAV) infection, presence of enteroparasites, and other surrogates of fecal exposure.METHODS: We conducted a cross-sectional study in 121 children consecutively admitted at a pediatric hospital inSalvador, Brazil.H pylori and HAV infection were identified by the presence of serum antibodies. Stool specimens were examined for the presence of ova and parasites. A structured questionnaire inquiring about sanitary conditions and life style was applied to each subject. RESULTS: Fifty-one of the 121 children (42.1%) werefound to be seropositive for H pylori, and 45 (37.2%) for HAV. The seroprevalence ofHpyloriand HAV both increased significantly with age. Cross-tabulation of data showed that 26 (21.5%) were seropositive and 51 (42.1%) were negative for bothHpyloriand HAV antibodies (χ2 = 7.18,OR = 2.8, CI 1.30-5.97). The age adjusted OR for an HAV-infected child being H pylori positive was 2.3 (CI1.02-5.03). The agreement between H pylori and HAVseropositivity was fair (κ = 0.24). After controlling for possible confounding, the variables remaining independently associated with seropositivity to H pyloriwere age,presence of Giardia lamblia in feces (OR = 3.2, 95%CI, 1.1-9.5) and poor garbage disposal quality (OR = 2.4,95%CI, 1.1-5.1).CONCLUSION: Our data suggest that H pylori infection is associated with surrogate markers of fecal exposure. Thus, we conclude that the fecal-oral route is relevant in the transmission of HP among children in an urban setting of a developing country. The association observed between G. lamblia and H pylori infection may have several explanations. Further studies to investigate this relationship are warranted. | Edson Duarte Moreira Jr Victor Bastos Nassri Rafaela Sousa Santos Junísia Ferraz Matos Wilson Andrade de Carvalho Célia Stolve Silvani Círia Santana e Sant'Ana | 2005 | World Journal of Gastroenterology2005，11，18： | 3 |
| 3 | Behavior of materials for earth and rockfill dams:Perspective from unsaturated soil mechanics显示文摘The basis of the design of earth and rockfill dams is focused on ensuring the stability of the structure under a set of conditions expected to occur during its life.Combined mechanical and hydraulic conditions must be considered since pore pressures develop during construction,after impoundment and in drawdown.Other instability phenomena caused by transient flow and internal erosion must be considered.The prediction of the hydromechanical behavior of traditional and non-traditional materials used in the construction of dams is therefore fundamental.The materials used for dam’s construction cover a wide range from clayey materials to rockfill.In a broad sense they are compacted materials and therefore unsaturated materials.A summary of the current level of knowledge on the behavior of traditional materials used in the construction of dams is presented in the paper.Regular compacted materials(with a significant clay fraction),rockfill and compacted soft rocks are studied with more detail.The latter are non-traditional materials.They are analysed because their use,as well as the use of mixtures of soil and rock,is becoming more necessary for sustainability reasons. | Eduardo E.ALONSO Rafaela CARDOSO | 2010 | Frontiers of Structural and Civil Engineering2010，4，1： | 3 |
| 4 | 内视镜的诊断,管理和食道的疾病的监视策略上的更改显示文摘 In the last few decades, upper gastrointestinal endoscopy has become the most complementary test for investigation of esophageal diseases. Its accessibility and safety guarantee wide clinical utilization in patients with suspected benign and malignant diseases of the esophagus. Recent technological advances in endoscopic imaging and tissue analysis obtained from the esophagus have been useful to better understand and manage highly relevant diseases such as gastroesophageal reflux disease, eosinophilic esophagitis and esophageal cancer. Using endoscopy to elucidate esophageal disorders in children has been another field of intensive and challenging research. This editorial highlights the latest advances in the endoscopic management of esophageal diseases, and focuses on Barrett’s esophagus, esophageal cancer, eosinophilic esophagitis, as well as esophageal disorders in the pediatric population. | Fernando Fornari Rafaela Wagner | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，4： | 3 |
| 5 | Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms显示文摘AIM: To determine the association of Helicobacter pylori (H pylori) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA+ was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP)and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA+ status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA+ (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as well as PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA+ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population. | Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud | 2008 | World Journal of Gastroenterology2008，14，42： | 2 |
| 6 | Solid-state fermentation technology and innovation for the production of agricultural and animal feed bioproducts显示文摘It has now passed more than forty years since solid-state fermentation(SSF)research developments have gained importance for the scientific community.After so many years,numerous processes and equipment for SSF were studied and designed focusing on the production of different commercially relevant bioproducts such as enzymes,fermented food,such as Chinese daqu and koji,organic acids,pigments,phenolic compounds,aromas,biosorbents and so many others.However,no review paper has been focused yet specifically on agricultural and animal feed bioproducts obtained through SSF techniques.This review comprises the description of agricultural sub-products that have been employed in most important developed pro-cesses concerning the production of animal feed products and agricultural products such as spores,probiotics,biofungicides,bioinsecticides and other biopesticides,biofertilizers and plant growth hormones.Major designed SSF bioreactors are also described and the most important related cases of successful employment of the technique are reported.Finally,a summary of patents and innovations regarding SSF products and processes in this area is presented,showing that the main involved countries are China,South Korea,India and the USA.It is clear that the interest in this theme is increasing and that scientific and technological developments are still needed. | Luciana P.S.Vandenberghe Ashok Pandey Julio C.Carvalho Luiz A.J.Letti Adenise L.Woiciechowski Susan G.Karp Vanete Thomaz-Soccol Walter J.Martinez-Burgos Rafaela O.Penha Leonardo W.Herrmann Amanda O.Rodrigues Carlos R.Soccol | 2021 | Systems Microbiology and Biomanufacturing2021，1，2： | 2 |
| 7 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 8 | Emerging and neglected zoonoses in transplant population显示文摘Zoonoses represent a problem of rising importance in the transplant population.A close relationship and changes between human,animal and environmental health(“One Health”concept)significantly influence the transmission and distribution of zoonotic diseases.The aim of this manuscript is to perform a narrative review of the published literature on emerging and neglected zoonoses in the transplant population.Many reports on donor-derived or naturally acquired(re-)emerging arboviral infections such as dengue,chikungunya,West Nile,tick-borne encephalitis and Zika virus infection have demonstrated atypical or more complicated clinical course in immunocompromised hosts.Hepatitis E virus has emerged as a serious problem after solid organ transplantation(SOT),leading to diverse extrahepatic manifestations and chronic hepatitis with unfavorable outcomes.Some neglected pathogens such as lymphocytic choriomeningitis virus can cause severe infection with multi-organ failure and high mortality.In addition,ehrlichiosis may be more severe with higher casefatality rates in SOT recipients.Some unusual or severe presentations of borreliosis,anaplasmosis and rickettsioses were also reported among transplant patients.Moreover,toxoplasmosis as infectious complication is a well-recognized zoonosis in this population.Although rabies transmission through SOT transplantation has rarely been reported,it has become a notable problem in some countries.Since the spreading trends of zoonoses are likely to continue,the awareness,recognition and treatment of zoonotic infections among transplant professionals should be imperative. | Anna Mrzljak Rafaela Novak Nenad Pandak Irena Tabain Lucija Franusic Ljubo Barbic Maja Bogdanic Vladimir Savic Danko Mikulic Jadranka Pavicic-Saric Vladimir Stevanovic Tatjana Vilibic-Cavlek | 2020 | World Journal of Transplantation2020，10，3： | 2 |
| 9 | Intraepithelial Effector (CD3 + )/Regulatory (FoxP3 + ) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma显示文摘 | Frank A. Sinicrope Rafaela L. Rego Stephen M. Ansell Keith L. Knutson Nathan R. Foster Daniel J. Sargent | 2009 | Gastroenterology2009，，4： | 2 |
| 10 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 11 | Outcome of isolated antenatal hydronephrosis: a prospective cohort study显示文摘 | Graziela M. Coelho Maria Candida F. Bouzada Alamanda K. Pereira Bruno F. Figueiredo Maria Rafaela S. Leite Danielly S. Oliveira Eduardo A. Oliveira | 2007 | Pediatric Nephrology2007，，10： | 2 |
| 12 | Preconditioning by Sevoflurane Decreases Biochemical Markers for Myocardial and Renal Dysfunction in Coronary Artery Bypass Graft Surgery:Double-blinded,Placebo-controlled,Multicenter Study显示文摘 | Karine J Rafaela da Silva Carlos G | 2003 | Anesthesiology2003，98，6： | 1 |
| 13 | Monitoring the epoxy curing by the dielectric thermal analysis method显示文摘 | Shigue C Y Rafaela G S Baldan C A | 2004 | IEEE Trans Appl Superconduct2004，4，2： | 1 |
| 14 | Evaluation of chemical mediators and cellular response during acute and chronic gut inflammatory response induced by dextran sodium sulfate in mice显示文摘 | Allisson Freire Bento Daniela Ferraz Pereira Leite Rodrigo Marcon Rafaela Franco Claudino Rafael Cypriano Dutra Maíra Cola Alessandra Cadete Martini Jo?o B. Calixto | 2012 | Biochemical Pharmacology2012，，11： | 1 |
| 15 | Antioxidant activity in banana peel extracts: Testing extraction conditions and related bioactive compounds显示文摘 | Rafaela Gonz 6 lez-Montelongo M Gloria Lobo M 6 nica Gonz 6 lez | 2010 | Food Chemistry2010，，3： | 1 |
| 16 | Bifid pancreatic tail as cause of acute pancreatitis显示文摘We present a case of a 22-year-old woman with recurrent episodes of acute pancreatitis.The patient had no known risk factors such as history of alcoholism,smoking,pre-existing medical conditions,family members with pancreatitis,autoimmune disease or regular use of medications.During the last episode,an amylase peak(1175 U/L)and increased inflammatory markers were detected,along with ultrasonographic confirmation of acute pancreatic inflammation,with no biliary dilatation or cholelithiasis. | Hanna Rafaela Ferreira Dalla Pria Rafael Andrade Santiago Fernanda Garozzo Velloni Giuseppe D’ippolito | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，5： | 1 |
| 17 | The effect of extraction temperature, time and number of steps on the antioxidant capacity of methanolic banana peel extracts 显示文摘 | Rafaela GonzAlez-Montelongo M Gloria Lobo M6nica Gonzalez | 2010 | Separation and Purification Technology2010，71，： | 1 |
| 18 | Facies-related diagenesis and multiphase siderite cementation and dissolu- tion in the reservoir sandstones of the Khatatba Formation, Egypt western desert 显示文摘 | Carlos R Rafaela M Karl R Permanyer A | 2001 | J Sediment Res2001，71，3： | 1 |
| 19 | Prolonged ingestion of ovalbumin diet by Ova sensitized mice suppresses mBSA-induced arthritis显示文摘 | Maria de Lourdes Meirelles Noviello Nathália Vieira Batista Luana Pereira Antunes Dourado Rafaela Vaz Sousa Pereira André Gustavo Oliveira Gustavo Batista Menezes Denise Carmona Cara | 2013 | Cellular Immunology2013，，： | 1 |
| 20 | The effects of dietary supplementation of methionine on genomic stability and p53 gene promoter methylation in rats显示文摘 | Cátia Lira Do Amaral Rafaela de Barros e Lima Bueno Regislaine Valéria Burim Regina Helena Costa Queiroz Maria de Lourdes Pires Bianchi Lusania Maria Greggi Antunes | 2011 | MutRes-Genetic Toxicology and Environmental Mutagenesis2011，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员