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| 1 | Overexpression of TaNAC69 Leads to Enhanced Transcript Levels of Stress Up-Regulated Genes and Dehydration Tolerance in Bread Wheat显示文摘NAC 蛋白质是植物特定的抄写因素并且充实,成员们在对干旱应力的植物反应包含了。在这研究,我们用 Affymetrix 小麦染色体数组数据集和量的 RTPCR 在面包小麦分析了 TaNAC69 的表达式侧面。TaNAC69 表示断然与对不能生活、关於生命的压力的小麦回答被联系并且密切与很多个压力被相关起来调整的基因。在转基因的小麦的 TaNAC69 的功能的分析证明干旱可诱导的 HvDhn4s 倡导者导致了的一棵大麦驾驶的 TaNAC69 在转基因的线的叶子和根标记 TaNAC69 的干旱可诱导的 overexpression。HvDhn4s : 更生产的 TaNAC69 转基因的线在联合的温和的盐应力和水限制条件下面射击生物资源,在聚乙烯下面的有的更长的根和更多根生物资源导致乙二醇的脱水。有 TaNAC69 的组成的 overexpression 的转基因的线的分析证明提高的表示几个压力铺平起来调整的基因。DNA 有约束力的试金表明 TaNAC69 和它的米饭相当或相同的事物(ONAC131 ) 能够到三米饭基因的倡导者元素的绑定(chitinase, ZIM,和 glyoxalase 我) 并且 Arabidopsis glyoxalase 我家庭基因,它是 TaNAC69 起来调整的压力基因的相当或相同的事物。这些数据建议 TaNAC69 涉及调整应力起来调整的基因和小麦改编到干旱应力。 | Gang-Ping Xue Heather M. Way Terese Richardson Janneke Drenth Priya A. Joyce C.Lynne Mclntyre | 2011 | Molecular Plant2011，4，4： | 25 |
| 2 | Evaluation of hepatic cystic lesions显示文摘Hepatic cysts are increasingly found as a mere coincidence on abdominal imaging techniques, such as ultrasonography (USG), computed tomography (CT) and magnetic resonance imaging (MRI). These cysts often present a diagnostic challenge. Therefore, we performed a review of the recent literature and developed an evidence-based diagnostic algorithm to guide clinicians in characterising these lesions. Simple cysts are the most common cystic liver disease, and diagnosis is based on typical USG characteristics. Serodiagnostic tests and microbubble contrast-enhanced ultrasound (CEUS) are invaluable in differentiating complicated cysts, echinococcosis and cystadenoma/cystadenocarcinoma when USG, CT and MRI show ambiguous findings. Therefore, serodiagnostic tests and CEUS reduce the need for invasive procedures. Polycystic liver disease (PLD) is arbitrarily defined as the presence of > 20 liver cysts and can present as two distinct genetic disorders: autosomal dominant polycystic kidney disease (ADPKD) and autosomal dominant polycystic liver disease (PCLD). Although genetic testing for ADPKD and PCLD is possible, it is rarely performed because it does not affect the therapeutic management of PLD. USG screening of the liver and both kidneys combined with extensive family history taking are the cornerstone of diagnostic decision making in PLD. In conclusion, an amalgamation of these recent advances results in a diagnostic algorithm that facilitates evidence-based clinical decision making. | Marten A Lantinga Tom JG Gevers Joost PH Drenth | 2013 | World Journal of Gastroenterology2013，19，23： | 12 |
| 3 | 复杂并发症产生在简单并且 polycystic 肝包囊显示文摘 Liver cysts are common,affecting 5%-10% of the population.Most are asymptomatic,however 5% of patients develop symptoms,sometimes due to complications and will require intervention.There is no consensus on their management because complications are so uncommon.The aim of this study was to perform a collected review of how a series of complications were managed at our institutions.Six different patients presenting with rare complications of liver cysts were obtained from Hepatobiliary Units in the United Kingdom and The Netherlands.History and radiological imaging were obtained from case notes and computerised radiology.As a result,1 patient admitted with inferior vena cava obstruction was managed by cyst aspiration and lanreotide;1 patient with common bile duct obstruction was first managed by endoscopic retrograde cholangiopancreatography and stenting,followed by open fenestration;1 patient with ruptured cysts and significant medical co-morbidities was managed by percutaneous drainage;1 patient with portal vein occlusion and varices was managed by open liver resection;1 patient with infected cysts was treated with intravenous antibiotics and is awaiting liver transplantation.The final patient with a simple liver cyst mimicking a hydatid was managed by open liver resection.In conclusion,complications of cystic liver disease are rare,and we have demonstrated in this series that both operative and non-operative strategies have defined roles in management.The mainstays of treatment are either aspiration/sclerotherapy or,alternatively laparoscopic fenestration.Medical management with somatostatin analogues is a potentially new and exciting treatment option but requires further study. | Christian Macutkiewicz Ricci Plastow Melissa Chrispijn Rafik Filobbos Basil A Ammori David J Sherlock Joost PH Drenth Derek A O’Reilly | 2012 | World Journal of Hepatology2012，4，12： | 10 |
| 4 | Cytomegalovirus in inflammatory bowel disease: Asystematic review显示文摘AIM: To identify definitions of cytomegalovirus(CMV) infection and intestinal disease, in inflammatory bowel disease(IBD), to determine the prevalence associated with these definitions.METHODS: We conducted a systematic review and interrogated Pub Med, EMBASE and Cochrane for literature on prevalence and diagnostics of CMV infection and intestinal disease in IBD patients. As medical headings we used 'cytomegalovirus' OR 'CMV' OR 'cytomegalo virus' AND 'inflammatory bowel disease' OR 'IBD' OR 'ulcerative colitis' OR 'colitis ulcerosa' OR 'Crohn's disease'. Both Me SH-terms and free searches were performed. We included all types of English-language(clinical) trials concerning diagnostics and prevalence of CMV in IBD.RESULTS: The search strategy identified 924 citations, and 52 articles were eligible for inclusion. We identified 21 different definitions for CMV infection, 8 definitions for CMV intestinal disease and 3 definitions for CMV reactivation. Prevalence numbers depend on used definition, studied population and region. The highest prevalence for CMV infection was found when using positive serum PCR as a definition, whereas for CMV intestinal disease this applies to the use of tissue PCR > 10 copies/mg tissue. Most patients with CMV infection and intestinal disease had steroid refractory disease and came from East Asia.CONCLUSION: We detected multiple different definitions used for CMV infection and intestinal disease in IBD patients, which has an effect on prevalence numbers and eventually on outcome in different trials. | Tessa EH Römkens Geert J Bulte Loes HC Nissen Joost PH Drenth | 2016 | World Journal of Gastroenterology2016，22，3： | 6 |
| 5 | Prevention of overuse: A view on upper gastrointestinal endoscopy显示文摘Many upper gastrointestinal(GI) endoscopies worldwide are performed for inappropriate indications. This overuse of healthcare negatively affects healthcare quality and puts pressure on endoscopy services. Dyspepsia is one of the most common inappropriate indications for upper GI endoscopy as diagnostic yield is low. Reasons for untimely referral are: unfamiliarity with dyspepsia guidelines,uncertainty about etiology of symptoms, and therapy failure. Unfiltered openaccess referrals feed upper GI endoscopy overuse. This review highlights strategies applied to diminish use of upper GI endoscopies for dyspepsia. First,we describe the impact of active guideline implementation. We found improved guideline adherence, but resistance was encountered in the process. Secondly, we show several forms of clinical assessment. While algorithm use reduced upper GI endoscopy volume, effects of referral assessment of individual patients were minor. A third strategy proposed Helicobacter pylori test and treat for all dyspeptic patients. Many upper GI endoscopies can be avoided using this strategy, but outcomes may be prevalence dependent. Lastly, empirical treatment with Proton pump inhibitors achieved symptom relief for dyspepsia and avoided upper GI endoscopies in about two thirds of patients. Changing referral behavior is complex as contributing factors are manifold. A collaboration of multiple strategies is most likely to succeed. | Judith J de Jong Marten A Lantinga Joost PH Drenth | 2019 | World Journal of Gastroenterology2019，25，2： | 3 |
| 6 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 7 | Systematic review: hypomagnesaemia induced by proton pump inhibition显示文摘 | M. W. Hess J. G. J. Hoenderop R. J. M. Bindels J. P. H. Drenth | 2012 | Aliment Pharmacol Ther2012，，5： | 2 |
| 8 | Phyllosticta species associated with freckle disease of banana显示文摘The identity of the casual agent of freckle disease of banana was investigated.The pathogen is generally referred to in literature under its teleomorphic name,Guignardia musae,or that of its purported anamorph,Phyllosticta musarum.Based on morphological and molecular data from a global set of banana specimens,several species were found associated with freckle disease.Phyllosticta maculata(from Southeast Asia and Oceania)is introduced as a new name for Guignardia musae,and an epitype is designated from Australia.Phyllosticta musarum(from India and Thailand)is shown to represent a distinct species,and the name is fixed by designation of an epitype from India.Guignardia stevensii is confirmed as distinct species from Hawaii,while Guignardia musicola from northern Thailand is shown to contain different taxa and is regarded as nomen confusum.Phyllosticta cavendishii is described as a new,widely distributed species,appearing primarily on Cavendish,but also on non-Cavendish banana cultivars. | Mee-Hua Wong Pedro W.Crous Juliane Henderson Johannes Z.Groenewald Andre Drenth | 2012 | Fungal Diversity2012，，5： | 2 |
| 9 | Germline mutations in PRKCSH are associated with autosomal dominant polycystic liver disease显示文摘 | Drenth JP de Morsche RH Smink R | 2003 | Nat Genet2003，33，3： | 2 |
| 10 | Erythromelalgia and erythermalgia : diagnostic differentiation显示文摘 | Drenth JPH Michiels JJ | 1994 | Int J Dermatol1994，33，6： | 1 |
| 11 | The primary erythermalgia-susceptibility gene is located on chromosome 2q31-32显示文摘 | Drenth JP Finley WH Breedveld GJ | 2001 | Am J Hum Genet2001，68，5： | 1 |
| 12 | Classification and diagnosis of erythromelalgia and erythermalgia显示文摘 | Michiels J J Drenth JP Van Genderen PJ | 1995 | lnt J Dermatol1995，34，2： | 1 |
| 13 | Hepatitis C vi- rus infection management in 2012 显示文摘 | VAN GULICK J J LAMERS MH DRENTH JP | 2012 | Panminerva Med2012，54，1： | 1 |
| 14 | Structure of Papain显示文摘 | Drenth J Jansonius J N Koekoek R | 1968 | Nature1968，218，： | 1 |
| 15 | A molecular phylogeny of Phytophthora and related oomycetes显示文摘 | COOKE D E L DRENTH A DUNCAN J M | 2000 | Fungal Genetics and Biology2000，30，： | 1 |
| 16 | Endurancerun increases circulating IL-6 and IL-lra but downregulates ex vivoTNF-alpha and IL-1 beta production显示文摘 | DRENTH J P van UUM S H van DEUREN M | 1995 | J Appl Physiol1995，79，5： | 1 |
| 17 | SCNgA mutations define primary erythermalgia as a neuropathic disorder of voltage gated sodium channels显示文摘 | Drenth JP te Morsche RH Guillet G | 2005 | J Invest Dermatol2005，124，6： | 1 |
| 18 | The heat shock factor family from Triticum aestivum in response to heat and other major abiotic stresses and their role in regulation of heat shock protein genes 显示文摘 | Xue GP Sadat S Drenth J | 2014 | Journal of Ex- perimental Botany2014，65，2： | 1 |
| 19 | Classification and diagnosis of erythromelalgia and erythermalgia显示文摘 | Michiels J J Drenth J | 1995 | Int J Dermatol1995，34，2： | 1 |
| 20 | The primary erythermalgia - susceptibility gene is located on chromosome 2q31 -32 显示文摘 | Drenth JP Finley WH Breedveld GT l | 2001 | Am J Hum Genet2001，68，5： | 1 |
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