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| 1 | Incidence and mortality of acute and chronic pancreatitis in the Netherlands:A nationwide record-linked cohort study for the years 1995-2005显示文摘AIM:To analyze trends in incidence and mortality of acute pancreatitis(AP) and chronic pancreatitis(CP) in the Netherlands and for international standard populations.METHODS:A nationwide cohort is identified through record linkage of hospital data for AP and CP,accumulated from three nationwide Dutch registries:the hospital discharge register,the population register,and the death certificate register.Sex-and age-group specific incidence rates of AP and CP are defined for the period 2000-2005 and mortality rates of AP and CP for the period 1995-2005.Additionally,incidence and mortality rates over time are reported for Dutch and international(European and World Health Organization) standard populations.RESULTS:Incidence of AP per 100000 persons per year increased between 2000 and 2005 from 13.2(95%CI:12.6-13.8) to 14.7(95%CI:14.1-15.3).Incidence of AP for males increased from 13.8(95%CI:12.9-14.7) to 15.2(95%CI:14.3-16.1),for females from 12.7(95%CI:11.9-13.5) to 14.2(95%CI:13.4-15.1).Irregular patterns over time emerged for CP.Overall mean incidence per 100000 persons per year was 1.77,for males 2.16,and for females 1.4.Mortality for AP fluctuated during 1995-2005 between 6.9 and 11.7 per million persons per year and was almost similar for males and females.Concerning CP,mortality for males fluctuated between 1.1(95%CI:0.6-2.3) and 4.0(95%CI:2.8-5.8),for females between 0.7(95%CI:0.3-1.6) and 2.0(95%CI:1.2-3.2).Incidence and mortality of AP and CP increased markedly with age.Standardized rates were lowest for World Health Organization standard population.CONCLUSION:Incidence of AP steadily increased while incidence of CP fluctuated.Mortality for both AP and CP remained fairly stable.Patient burden and health care costs probably will increase because of an ageing Dutch population. | BW Marcel Spanier Marco J Bruno Marcel GW Dijkgraaf | 2013 | World Journal of Gastroenterology2013，19，20： | 20 |
| 2 | The role of mechanotransduction versus hypoxia during simulated orthodontic compressive strain——an in vitro study of human periodontal ligament fibroblasts显示文摘During orthodontic tooth movement(OTM)mechanical forces trigger pseudo-inflammatory,osteoclastogenic and remodelling processes in the periodontal ligament(PDL)that are mediated by PDL fibroblasts via the expression of various signalling molecules.Thus far,it is unknown whether these processes are mainly induced by mechanical cellular deformation(mechanotransduction)or by concomitant hypoxic conditions via the compression of periodontal blood vessels.Human primary PDL fibroblasts were randomly seeded in conventional six-well cell culture plates with O2-impermeable polystyrene membranes and in special plates with gas-permeable membranes(Lumox?,Sarstedt),enabling the experimental separation of mechanotransducive and hypoxic effects that occur concomitantly during OTM.To simulate physiological orthodontic compressive forces,PDL fibroblasts were stimulated mechanically at 2 g·cm?2 for 48 h after 24 h of pre-incubation.We quantified the cell viability by MTT assay,gene expression by quantitative real-time polymerase chain reaction(RT-qPCR)and protein expression by western blot/enzyme-linked immunosorbent assays(ELISA).In addition,PDL-fibroblast-mediated osteoclastogenesis(TRAP+cells)was measured in a 72-h coculture with RAW264.7 cells.The expression of HIF-1α,COX-2,PGE2,VEGF,COL1A2,collagen and ALPL,and the RANKL/OPG ratios at the mRNA/protein levels during PDL-fibroblast-mediated osteoclastogenesis were significantly elevated by mechanical loading irrespective of the oxygen supply,whereas hypoxic conditions had no significant additional effects.The cellular–molecular mediation of OTM by PDL fibroblasts via the expression of various signalling molecules is expected to be predominantly controlled by the application of force(mechanotransduction),whereas hypoxic effects seem to play only a minor role.In the context of OTM,the hypoxic marker HIF-1αdoes not appear to be primarily stabilized by a reduced O2 supply but is rather stabilised mechanically. | Niklas Ullrich Agnes Schroder Jonathan Jantsch Gerrit Spanier Peter Proff Christian Kirschneck | 2019 | International Journal of Oral Science2019，11，4： | 5 |
| 3 | A system for the stlrgical staging of musculoskeletal sarcoma显示文摘 | Enneking WF Spanier SS Goodman MA | 1980 | Clinical Orthopaedics Related Research1980，153，1： | 1 |
| 4 | A system for the surgical staging of the musculoskeletal sarcoma 显示文摘 | Enneking WF Spanier SS Goodman MA | 1980 | Clin Orthop1980，153，1： | 1 |
| 5 | Single-crystalline barium titanate nanowires显示文摘 | Urban J J Spanier J E Ouyang L | 2003 | Adv Mater2003，15，： | 1 |
| 6 | Endotoxin in pooled pericardial blood contributes to the systemic inflammatory response during cardiac surgery显示文摘 | Tector K Schwartz G | 2000 | Perfusion2000，15，5： | 1 |
| 7 | A system for the surgecl staging of musculoskeletal sarcoma显示文摘 | Enneking WF Spanier SS Goodman MA | 1980 | Clin Orthop1980，153，： | 1 |
| 8 | Current approaches to the study of meat flavor quality显示文摘 | Spanier A M | 1992 | Food Science and Human Nutrition1992，29，： | 1 |
| 9 | A system for the surgical staging of musculoskeletal sarcoma: 1980 显示文摘 | Enneking WF Spanier SS Goodman MA | 2003 | Clin Orthop Relat Res2003，，415： | 1 |
| 10 | Delayed postoperative epidural hematoma formation after heparinization in lumbar spine surgery显示文摘 | Spanier D E Stambough J L | 2000 | J Spinal Disord2000，13，1： | 1 |
| 11 | Electrodiagnosis of cervical radiculopathy 显示文摘 | Hakimi K Spanier D | 2013 | Physic Med Rehabil Clin N Am2013，1，： | 1 |
| 12 | Prenatal exposure to bis- phenol A and child wheeze from birth to 3 years of age显示文摘 | Spanier A J Kahn R S Kunselman A R | 2012 | Environ Health Perspect2012，120，6： | 1 |
| 13 | Measuring Dyadic Adjustment: New Scales for Assessing the Quality of Marriage and Similar Dyads 显示文摘 | Spanier G B | 1976 | Journal of Marriage and Family1976，38，1： | 1 |
| 14 | Transcriptional and functional regulation of the intestinal peptide transporter PEPT1显示文摘 | SPANIER B | 2014 | The Journal of Physiology2014，592，5： | 1 |
| 15 | Nutritional management of patientswith acute pancreatitis: a Dutch observa- tional muhicentre study 显示文摘 | Spanier BW Mathus - Vliegen EM Tuynman HA | 2008 | Aliment Pharmacol Ther2008，28，9： | 1 |
| 16 | The hazards of biopsy in patients with malignant primary bone and soft tissue tumors显示文摘 | Mankin HJ Lange TA Spanier SS | | 0，，08： | 1 |
| 17 | Vasopressin deficiency and pressor hypersensitivity in hemodynamically unstable organ donors显示文摘 | Chen JM Cullinane S Spanier TB | 1999 | Circulation1999，100，19： | 1 |
| 18 | Lipid oxi-dation in foods显示文摘 | Vercellotti J R Angelo A J S Spanier A M | 1996 | Critical Reviews in Food Scienceand Nutrition1996，36，3： | 1 |
| 19 | Resveratrol reduces endothelial oxidative stressby modulating the gene expression of superoxide dis-mutase 1 (SOD1),glutathione peroxidase 1 (GPxl )and NADPH oxidase subunit (Nox4 )显示文摘 | Spanier G Xu H Xia N? Tobias S Deng S WojnowskiL | 2009 | J PhysiolPharmacol2009，60，4： | 1 |
| 20 | Resveratrol reduces en- dothelial oxidative stress by modulating the gene ex- pression of super oxide dismutasel (SOD1) gluta thione peroxidasel(GPX1) and nadphoxidase subunit(NOX4)显示文摘 | Spanier G Xu H Xia N | 2009 | J Physiol Pharmaeol2009，60，14： | 1 |
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