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| 1 | Helicobacter pylori and pregnancy-related disorders显示文摘Helicobacter pylori(H.pylori)infection is investigated in gastric diseases even during pregnancy.In particular,this Gram-negative bacterium seems to be associated with hyperemesis gravidarum,a severe form of nausea and vomiting during pregnancy.During the last decade,the relationship among H.pylori and several extra-gastric diseases strongly emerged in literature.The correlation among H.pylori infection and pregnancy-related disorders was mainly focused on iron deficiency anemia,thrombocytopenia,fetal malformations,miscarriage,pre-eclampsia and fetal growth restriction.H.pylori infection may have a role in the pathogenesis of various pregnancy-related disorders through different mechanisms:depletion of micronutrients(iron and vitamin B12)in maternal anemia and fetal neural tube defects;local or systemic induction of pro-inflammatory cytokines release and oxidative stress in gastrointestinal disorders and pre-eclampsia;cross-reaction between specific anti-H.pylori antibodies and antigens localized in placental tissue and endothelial cells(preeclampsia,fetal growth restriction,miscarriage).Since H.pylori infection is most likely acquired before pregnancy,it is widely believed that hormonal and immunological changes occurring during pregnancy could activate latent H.pylori with a negative impact not only on maternal health(nutritional deficiency,organ injury,death),but also on the fetus(insufficient growth,malformation,death)and sometime consequences can be observed later in life.Another important issue addressed by investigators was to determine whether it is possible to transmit H.pylori infection from mother to child and whether maternal anti-H.pylori antibodies could prevent infant’s infection.Studies on novel diagnostic and therapeutic methods for H.pylori are no less important,since these are particularly sensitive topics in pregnancy conditions.It could be interesting to study the possible correlation between H.pylori infection and other pregnancy-related diseases of unknown etiology,such as gestational diabetes mellitus,obstetric cholestasis and spontaneous preterm delivery.Since H.pylori infection is treatable,the demonstration of its causative role in pregnancy-related disorders will have important social-economic implications. | Simona Cardaropoli Alessandro Rolfo Tullia Todros | 2014 | World Journal of Gastroenterology2014，20，3： | 12 |
| 2 | Helicobacter pylori's virulence and infection persistence define pre-eclampsia complicated by fetal growth retardation显示文摘AIM: To better understand the pathogenic role of Helicobacter pylori (H. pylori) in pre-eclampsia (PE), and whether it is associated or not with fetal growth retardation (FGR). METHODS: Maternal blood samples were collected from 62 consecutive pregnant women with a diagnosis of PE and/or FGR, and from 49 women with uneventful pregnancies (controls). Serum samples were evaluated by immunoblot assay for presence of specific antibodies against H. pylori antigens [virulence: cytotoxin-associated antigen A (CagA); ureases; heat shock protein B; flagellin A; persistence: vacuolating cytotoxin A (VacA)]. Maternal complete blood count and liver enzymes levels were assessed at delivery by an automated analyzer. RESULTS: A significantly higher percentage of H. pyloriseropositive women were found among PE cases (85.7%) compared to controls (42.9%, P < 0.001). There were no differences between pregnancies complicated by FGR without maternal hypertension (46.2%) and controls. Importantly, persistent and virulent infections (VacA/ CagA seropositive patients, intermediate leukocyte blood count and aspartate aminotransferase levels) were exclusively associated with pre-eclampsia complicated by FGR, while virulent but acute infections (CagA positive/ VacA negative patients, highest leukocyte blood count and aspartate aminotransferase levels) specifically correlated with PE without FGR. CONCLUSION: Our data strongly indicate that persistent and virulent H. pylori infections cause or contribute to PE complicated by FGR, but not to PE without feto-placental compromise. | Simona Cardaropoli Alessandro Rolfo Annalisa Piazzese Antonio Ponzetto Tullia Todros | 2011 | World Journal of Gastroenterology2011，17，47： | 9 |
| 3 | A Prospective Policy Development to Increase Split-Liver Transplantation for 2 Adult Recipients: Results of a 12-Year Multicenter Collaborative Study显示文摘 | Paolo Aseni Tullia Maria De Feo Luciano De Carlis Umberto Valente Michele Colledan Umberto Cillo Giorgio Rossi Vincenzo Mazzaferro Matteo Donataccio Nicola De Fazio Enzo Andorno Patrizia Burra | 2014 | Annals of Surgery2014，，1： | 3 |
| 4 | Growth Factor Regulation of Autophagy and Cell Survival in the Absence of Apoptosis显示文摘 | Julian J. Lum Daniel E. Bauer Mei Kong Marian H. Harris Chi Li Tullia Lindsten Craig B. Thompson | 2005 | Cell2005，，2： | 3 |
| 5 | Antibodies Anti‐Caga Cross‐React with Trophoblast Cells: A Risk Factor for Pre‐Eclampsia?显示文摘 | Francesco Franceschi Nicoletta Di Simone Silvia D’Ippolito Roberta Castellani Fiorella Di Nicuolo Giovanni Gasbarrini Yoshio Yamaoka Tullia Todros Giovanni Scambia Antonio Gasbarrini | 2012 | Helicobacter2012，，6： | 2 |
| 6 | DNA and RNA binding properties of an arginine-based ' Extended Chiral Box' Peptide Nucleic Acid显示文摘 | Alessandro C Tullia T Roberto C | | 0，，02： | 1 |
| 7 | Food analysis and food authentication by peptide nucleic acidPNA)-based technologies显示文摘 | Stefano S Roberto C Tullia T | | 0，，01： | 1 |
| 8 | Endoscopic CO laser excision for Tis, T1, and T2 glottic carcinomas: Cure rate and prognostic factors显示文摘 | Giorgio Peretti Piero Nicolai Luca Oscar Redaelli de Zinis Marco Berlucchi Tullia Bazzana Filippo Bertoni Antonino Roberto Antonelli | 2000 | Otolaryngology - Head and Neck Surgery2000，，1： | 1 |
| 9 | Analysis of green tea catechins: comparative study between HPLC and HPCE显示文摘 | MATTEO B MARCO P TULLIA G Y | 2003 | Food Chemistry2003，81，4： | 1 |
| 10 | Accompanying symptoms and psychiatric comorbidity in migraine and tension-type headache patients显示文摘 | Franco Mongini Eugenia Rota Andrea Deregibus Luca Ferrero Giuseppe Migliaretti Franco Cavallo Tullia Mongini Andrea Novello | 2006 | Journal of Psychosomatic Research2006，，4： | 1 |
| 11 | tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c 显示文摘 | Tullia L Vamsi K | 2000 | Denes Dev2000，14，： | 1 |
| 12 | Fifteen years and 382 extended right grafts from in situ split livers in a multicenter study: Are these still extended criteria liver grafts?显示文摘 | Umberto Maggi Tullia M. De Feo Enzo Andorno Umberto Cillo Luciano De Carlis Michele Colledan Patrizia Burra Nicola De Fazio Giorgio Rossi | 2015 | Liver Transpl2015，，4： | 1 |
| 13 | Rate evolution of benzonitrile nitration under heterogenenous conditions 显示文摘 | Roberto A Tullia A Vincenzo C | 1994 | J Chem Tech Biotechnol1994，61，： | 1 |
| 14 | Three-dimensional hydrogeological modeling application to the Alvera mudslide (Cortina d'Ampezzo,Italy)显示文摘 | Tullia Bonnomi Angelo Cavallin | 1999 | Geomorphology1999，30，： | 1 |
| 15 | Phenotypic Analysis of Prostate-Infiltrating Lymphocytes Reveals TH17andTregS-kewing显示文摘 | Karen Sandell Sfanos Tullia C Bruno Charles H Maris | 2008 | Clinical Cancer Research2008，14，11： | 1 |
| 16 | BCL-2, BCL-X L Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis显示文摘 | Emily H.-Y.A Cheng Michael C Wei Solly Weiler Richard A Flavell Tak W Mak Tullia Lindsten Stanley J Korsmeyer | 2001 | Molecular Cell2001，，3： | 1 |
| 17 | The microbial degradation of silk: a laboratory investigation显示文摘 | Annamaria S Maria R Tullia M | 1998 | International Biodeterioration &Biode - gradation1998，42，4： | 1 |
| 18 | Phenol content related to antioxidant and antimicrobial activities of Passiflora spp. extracts显示文摘 | Alessandra Bendini Lorenzo Cerretani Luca Pizzolante Tullia Gallina Toschi Flavia Guzzo Stefania Ceoldo Andrea Maria Marconi Filippo Andreetta Marisa Levi | 2006 | European Food Research and Technology2006，，1： | 1 |
| 19 | Relative contributions of psychotic symptoms and insight to quality of life in stable schizophrenia显示文摘 | Paola R Filomena C Tullia M | | 0，，08： | 1 |
| 20 | Analysis of green tea catechins: comparative study between HPLC and HPCE显示文摘 | Matteo Bonoli Marco PeliIlo Tullia Gallina Toschi | 2003 | 81(4):631-6382003，81，4： | 1 |
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