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| 1 | Helicobacter pylori and pregnancy-related disorders显示文摘Helicobacter pylori(H.pylori)infection is investigated in gastric diseases even during pregnancy.In particular,this Gram-negative bacterium seems to be associated with hyperemesis gravidarum,a severe form of nausea and vomiting during pregnancy.During the last decade,the relationship among H.pylori and several extra-gastric diseases strongly emerged in literature.The correlation among H.pylori infection and pregnancy-related disorders was mainly focused on iron deficiency anemia,thrombocytopenia,fetal malformations,miscarriage,pre-eclampsia and fetal growth restriction.H.pylori infection may have a role in the pathogenesis of various pregnancy-related disorders through different mechanisms:depletion of micronutrients(iron and vitamin B12)in maternal anemia and fetal neural tube defects;local or systemic induction of pro-inflammatory cytokines release and oxidative stress in gastrointestinal disorders and pre-eclampsia;cross-reaction between specific anti-H.pylori antibodies and antigens localized in placental tissue and endothelial cells(preeclampsia,fetal growth restriction,miscarriage).Since H.pylori infection is most likely acquired before pregnancy,it is widely believed that hormonal and immunological changes occurring during pregnancy could activate latent H.pylori with a negative impact not only on maternal health(nutritional deficiency,organ injury,death),but also on the fetus(insufficient growth,malformation,death)and sometime consequences can be observed later in life.Another important issue addressed by investigators was to determine whether it is possible to transmit H.pylori infection from mother to child and whether maternal anti-H.pylori antibodies could prevent infant’s infection.Studies on novel diagnostic and therapeutic methods for H.pylori are no less important,since these are particularly sensitive topics in pregnancy conditions.It could be interesting to study the possible correlation between H.pylori infection and other pregnancy-related diseases of unknown etiology,such as gestational diabetes mellitus,obstetric cholestasis and spontaneous preterm delivery.Since H.pylori infection is treatable,the demonstration of its causative role in pregnancy-related disorders will have important social-economic implications. | Simona Cardaropoli Alessandro Rolfo Tullia Todros | 2014 | World Journal of Gastroenterology2014，20，3： | 12 |
| 2 | Helicobacter pylori's virulence and infection persistence define pre-eclampsia complicated by fetal growth retardation显示文摘AIM: To better understand the pathogenic role of Helicobacter pylori (H. pylori) in pre-eclampsia (PE), and whether it is associated or not with fetal growth retardation (FGR). METHODS: Maternal blood samples were collected from 62 consecutive pregnant women with a diagnosis of PE and/or FGR, and from 49 women with uneventful pregnancies (controls). Serum samples were evaluated by immunoblot assay for presence of specific antibodies against H. pylori antigens [virulence: cytotoxin-associated antigen A (CagA); ureases; heat shock protein B; flagellin A; persistence: vacuolating cytotoxin A (VacA)]. Maternal complete blood count and liver enzymes levels were assessed at delivery by an automated analyzer. RESULTS: A significantly higher percentage of H. pyloriseropositive women were found among PE cases (85.7%) compared to controls (42.9%, P < 0.001). There were no differences between pregnancies complicated by FGR without maternal hypertension (46.2%) and controls. Importantly, persistent and virulent infections (VacA/ CagA seropositive patients, intermediate leukocyte blood count and aspartate aminotransferase levels) were exclusively associated with pre-eclampsia complicated by FGR, while virulent but acute infections (CagA positive/ VacA negative patients, highest leukocyte blood count and aspartate aminotransferase levels) specifically correlated with PE without FGR. CONCLUSION: Our data strongly indicate that persistent and virulent H. pylori infections cause or contribute to PE complicated by FGR, but not to PE without feto-placental compromise. | Simona Cardaropoli Alessandro Rolfo Annalisa Piazzese Antonio Ponzetto Tullia Todros | 2011 | World Journal of Gastroenterology2011，17，47： | 9 |
| 3 | Antibodies Anti‐Caga Cross‐React with Trophoblast Cells: A Risk Factor for Pre‐Eclampsia?显示文摘 | Francesco Franceschi Nicoletta Di Simone Silvia D’Ippolito Roberta Castellani Fiorella Di Nicuolo Giovanni Gasbarrini Yoshio Yamaoka Tullia Todros Giovanni Scambia Antonio Gasbarrini | 2012 | Helicobacter2012，，6： | 2 |
| 4 | Increased levels of macrophage migration inhibitory factor (MIF) in pre- eelampsia显示文摘 | TODROS T BONTEMPO S PICCOL1 E | 2005 | Eur J Obstet Gynecol Reprod Biol2005，123，2： | 1 |
| 5 | Doppler indices in the umbilical arteries:influence of vessel curvature induced by bladder filling显示文摘 | Balbis S Gaglioti P Todros T | | 0，，12： | 1 |
| 6 | Contuncal anomalies inprenatal life 显示文摘 | Paladini D Rustico MA Todros T | 1996 | Ultrasound Obstet Gynecol1996，8，4： | 1 |
| 7 | Hepatic involvement in larva migrans of Toxocara canis : report of a case with pathological and radiological findings 显示文摘 | Leone N Baronio M Todros L | 2006 | Digestive and Liver Disease2006，38，7： | 1 |
| 8 | macrophage migration inhibitory factor in human pregnancy and labor显示文摘 | Ietta F Todros T Tice0ni C | 2002 | Am J Reprod Immunol2002，48，6： | 1 |
| 9 | Fetal short femur length in the second trimester and the outcome of pregnancy 显示文摘 | TODROS T MASSARENTI I GAGI IOTI P | 2004 | BJOG2004，111，： | 1 |
| 10 | Increased levels of macrophage migration inhibitory factor (MIF) in preeclampsia显示文摘 | Todros T Bontempo S Piccoli E | 2005 | Eur J Obstet Gynecol Reprod Biol2005，123，： | 1 |
| 11 | Accuracy of routine ultra- sonography in screening heart disease prenatally显示文摘 | Todros T Faggiano F Chiappa E | 2007 | Prenat Diagn2007，17，： | 1 |
| 12 | Copper ( Ⅱ )-neocuproine as colour reagent for some biologically thios: spectrophotometric determination of cysteine, penicillamine, glutathione, and 6-mercaptopurine 显示文摘 | Besada A Todros N S Gawargious Y A | 1989 | Mikrichim Acta1989，，： | 1 |
| 13 | Laparoscopic myomectomyand subsequent pregnancy results in 54 patients显示文摘 | Seinera P Farina C Todros T | 2000 | HumReprod2000，15，9： | 1 |
| 14 | Macrophage migration in-hibitory factor in human pregnancy and labor显示文摘 | letta F Todros T Ticconi C | 2002 | Am J Reprod lmmunol2002，48，6： | 1 |
| 15 | Accuracy of routine ultrasonography in screening heart disease prenatally显示文摘 | Todros T Faggiano F Chiappa E | 1997 | Prenat Diagn1997，17，： | 1 |
| 16 | The significance of fetal ventriculomegaly:etiology,short-and-long-term outcomes显示文摘 | Gaglioti P Oberto M Todros T | 2009 | Prenat Diagn2009，29，4： | 1 |
| 17 | Pulmonary stenosis and atresia with intact vent ricular septum during prenatal life 显示文摘 | Todros T Paladini D Chiappa E | 2003 | Ultrasound Obstet Gynecol2003，21，5： | 1 |
| 18 | Blind separation of independent sources using gaussian mixture model显示文摘 | K Todros J Tabrikian | 2007 | IEEE transactions on signal processing2007，55，7： | 1 |
| 19 | A Model of Labor Migration and Urban Un-employment in Less Developed Countries 显示文摘 | TODRO M P | 1969 | The AmericanEconomic Review1969，59，1： | 1 |
| 20 | Accuracy of routine ultrasonography in screening heart disease prenatally显示文摘 | Todros T Faggiano F Chiappa E | | 0，，10： | 1 |
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