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| 1 | Beyond the stomach: An updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment显示文摘Helicobacter pylori(H. pylori) is an extremely common, yet underappreciated, pathogen that is able to alter host physiology and subvert the host immune response, allowing it to persist for the life of the host. H. pylori is the primary cause of peptic ulcers and gastric cancer. In the United States, the annual cost associated with peptic ulcer disease is estimated to be $6 billion and gastric cancer kills over 700000 people per year globally. The prevalence of H. pylori infection remains high(> 50%) in much of the world, although the infection rates are dropping in some developed nations. The drop in H. pylori prevalence could be a double-edged sword, reducing the incidence of gastric diseases while increasing the risk of allergies and esophageal diseases. The list of diseases potentially caused by H. pylori continues to grow; however, mechanistic explanations of how H. pylori could contribute to extragastric diseases lag far behind clinical studies. A number of host factors and H. pylori virulence factors act in concert to determine which individuals are at the highest risk of disease. These include bacterial cytotoxins and polymorphisms in host genes responsible for directing the immune response. This review discusses the latest advances in H. pylori pathogenesis, diagnosis, and treatment. Up-todate information on correlations between H. pylori and extragastric diseases is also provided. | Traci L Testerman James Morris | 2014 | World Journal of Gastroenterology2014，20，36： | 47 |
| 2 | 幽门螺杆菌感染相关胃外疾病研究进展显示文摘H .pylori 是消化性溃疡、慢性胃炎、MALT 淋巴瘤的主要病因。流行病学调查发现,全世界近1/2的人感染H .pylori。随着对 H .pylori 研究的不断深入,发现H .pylori感染不仅与胃部疾病有关,还在许多胃肠外疾病(如心脑血管疾病、血液系统疾病、神经系统疾病等)的发生、发展中起关键性作用。现对H .pylori 与胃外相关疾病的研究进展进行综述。 | 高仕霖 张连峰 时永全 | 2016 | 中华消化杂志2016，36，1： | 20 |
| 3 | Helicobacter pylori and pregnancy-related disorders显示文摘Helicobacter pylori(H.pylori)infection is investigated in gastric diseases even during pregnancy.In particular,this Gram-negative bacterium seems to be associated with hyperemesis gravidarum,a severe form of nausea and vomiting during pregnancy.During the last decade,the relationship among H.pylori and several extra-gastric diseases strongly emerged in literature.The correlation among H.pylori infection and pregnancy-related disorders was mainly focused on iron deficiency anemia,thrombocytopenia,fetal malformations,miscarriage,pre-eclampsia and fetal growth restriction.H.pylori infection may have a role in the pathogenesis of various pregnancy-related disorders through different mechanisms:depletion of micronutrients(iron and vitamin B12)in maternal anemia and fetal neural tube defects;local or systemic induction of pro-inflammatory cytokines release and oxidative stress in gastrointestinal disorders and pre-eclampsia;cross-reaction between specific anti-H.pylori antibodies and antigens localized in placental tissue and endothelial cells(preeclampsia,fetal growth restriction,miscarriage).Since H.pylori infection is most likely acquired before pregnancy,it is widely believed that hormonal and immunological changes occurring during pregnancy could activate latent H.pylori with a negative impact not only on maternal health(nutritional deficiency,organ injury,death),but also on the fetus(insufficient growth,malformation,death)and sometime consequences can be observed later in life.Another important issue addressed by investigators was to determine whether it is possible to transmit H.pylori infection from mother to child and whether maternal anti-H.pylori antibodies could prevent infant’s infection.Studies on novel diagnostic and therapeutic methods for H.pylori are no less important,since these are particularly sensitive topics in pregnancy conditions.It could be interesting to study the possible correlation between H.pylori infection and other pregnancy-related diseases of unknown etiology,such as gestational diabetes mellitus,obstetric cholestasis and spontaneous preterm delivery.Since H.pylori infection is treatable,the demonstration of its causative role in pregnancy-related disorders will have important social-economic implications. | Simona Cardaropoli Alessandro Rolfo Tullia Todros | 2014 | World Journal of Gastroenterology2014，20，3： | 12 |
| 4 | 幽门螺旋杆菌与妊娠相关疾病的临床研究进展显示文摘幽门螺旋杆菌(Hp)感染一直是胃肠道疾病研究的热点。研究发现,Hp与妊娠的多种疾病均存在一定的关系。妊娠阶段的Hp感染不仅会带来胃肠道的疾病,如妊娠剧吐,同时也能导致缺铁性贫血、胎儿畸形、流产、子痫前期及FGR。这些妊娠相关疾病对于产妇、胎儿、新生儿甚至母体远期的生命和健康构成了潜在的威胁。由于Hp感染的可治愈性,研究Hp与其他未知病因的妊娠相关疾病(如妊娠期糖尿病,妊娠期肝内胆汁淤积症和自发性早产)之间可能存在的关系,阐明其在相关疾病中所起的作用将会带来巨大的社会和经济影响。 | 兰萌 姜倩 杜超 王培萍 韩磊 | 2015 | 现代妇产科进展2015，24，6： | 8 |
| 5 | Can Helicobacter pylori infection influence human reproduction?显示文摘Helicobacter pylori(H.pylori)infection could be associated with extra-digestive diseases.Here,we report the evidences concerning the decrease in reproductive potential occurring in individuals infected by H.pylori,especially by strains expressing CagA.This infection is more prevalent in individuals with fertility disorders.Infected women have anti-H.pylori antibodies in cervical mucus and follicular fluid that may decrease sperm motility and cross react immunologically with spermatozoa,conceivably hampering the oocyte/sperm fusion.Infection by CagA positive organisms enhances the risk of preeclampsia,which is a main cause of foetus death.These findings are supported by the results of experimental infections of pregnant mice,which may cause reabsorption of a high number of foetuses and alter the balance between Th1 and Th2 cell response.Infected men have decreased sperm motility,viability and numbers of normally shaped sperm and augmented systemic levels of inflammatory cytokines,such as TNF-α,which may damage spermatozoa.In countries where parasitic infestation is endemic,detrimental effects of infection upon spermatozoa may not occur,because the immune response to parasites could determine a switch from a predominant Th1 type to Th2 type lymphocytes,with production of anti-inflammatory cytokines.In conclusion,the evidences gathered until now should be taken into consideration for future studies aiming to explore the possible role of H.pylori infection on human reproduction. | Elena Moretti Natale Figura Giulia Collodel Antonio Ponzetto | 2014 | World Journal of Gastroenterology2014，20，19： | 6 |
| 6 | 幽门螺旋杆菌感染与子痫前期的关系显示文摘幽门螺旋杆菌是最常见的消化道致病菌,参与急性胃肠炎、消化性溃疡、胃肠肿瘤等胃肠道疾病的发生发展,与胃肠外疾病也有密切联系。研究发现,幽门螺旋杆菌感染与子痫前期存在明确的流行病学因果关系,特别是细胞毒素相关基因A(cytotoxin-associated gene A,cagA)阳性的幽门螺旋杆菌菌株诱导产生的抗cagA抗体可与滋养层细胞发生免疫反应导致滋养细胞浸润异常。此外,幽门螺旋杆菌感染引起的炎症反应、脂质代谢异常可造成血管内皮功能异常,导致子痫前期。本文将对幽门螺旋杆菌感染与子痫前期的关系作一综述。 | 余婷 彭芸花 | 2020 | 协和医学杂志2020，11，5： | 5 |
| 7 | 幽门螺杆菌感染对子痫前期发病及母儿结局的影响显示文摘目的:探讨幽门螺杆菌感染对孕妇子痫前期发病及母儿结局的影响。方法:随机选择284例孕周>20周的孕妇分为幽门螺杆菌感染阴性组和幽门螺杆菌感染阳性组。跟踪观察、记录子痫前期(轻度子痫、重度子痫)发病及母儿结局(胎盘早剥、产后大出血、胎儿窘迫、围产儿死亡、胎盘重量、1 min新生儿Apgar评分、胎龄及新生儿体重)情况,进行比较分析。结果:281例(阴性组148例,阳性组133例)纳入统计。除胎盘早剥、产后大出血、胎儿窘迫、围产儿死亡率外,阴性组与阳性组的轻度子痫、重度子痫、胎盘重量、1 min Apgar评分、胎龄及新生儿体重差异均有统计学意义(均P<0.05),阴性组母儿结局优于阳性组。幽门螺杆菌感染与轻度子痫发病、重度子痫发病呈正相关(均P<0.05);幽门螺杆菌感染与胎盘重量、1 min Apgar评分、胎龄及新生儿体重均呈负相关(均P<0.05)。结论:幽门螺杆菌感染与孕妇子痫前期发病有密切的关系,幽门螺杆菌感染对母儿结局具有不良的影响。 | 黄素静 | 2016 | 现代医学2016，44，5： | 2 |
| 8 | 感染因素与子痫前期发生相关性的研究进展显示文摘子痫前期是妊娠期特有疾病,多种学说试图阐明其发病机制,但均不能完全解释该病的发生发展。近年来有学者提出感染因素在子痫前期发生发展过程中可能起到一定的作用。本文对可能引起子痫前期发生的致病微生物进行综述,阐述其证据及可能的发病机制,主要病原体包括人巨细胞病毒、新型冠状病毒、乙型肝炎病毒、幽门螺杆菌、引起牙周炎细菌、解脲支原体、肺炎衣原体及疟疾等。 | 郝文静 邹丽颖 | 2022 | 妇儿健康导刊2022，1，4： | 0 |
| 9 | Protection from Preeclampsia显示文摘 | Antonio Ponzetto Natale Figura Annalisa Santucci | 2018 | Chinese Medical Journal2018，，9： | 0 |
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