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| 1 | MicroRNA in rectal cancer显示文摘In rectal cancer,one of the most common cancers worldwide,the proper staging of the disease determines the subsequent therapy.For those with locally advancedrectal cancer,a neoadjuvant chemoradiotherapy(CRT) is recommended before any surgery.However,response to CRT ranges from complete response(responders) to complete resistance(non-responders).To date we are not able to separate in advance the first group from the second,due to the absence of a valid biomarker.Therefore all patients receive the same therapy regardless of whether they reap benefits.On the other hand almost all patients receive a surgical resection after the CRT,although a watch-and-wait procedure or an endoscopic resection might be sufficient for those who responded well to the CRT.Being highly conserved regulators of gene expression,micro RNAs(mi RNAs) seem to be promising candidates for biomarkers.Many studies have been analyzing the mi RNAs expressed in rectal cancer tissue to determine a specific mi RNA profile for the ailment.Unfortunately,there is only a small overlap of identified mi RNAs between different studies,posing the question as to whether different methods or differences in tissue storage may contribute to that fact or if the results simply are not reproducible,due to unknown factors with undetected influences on mi RNA expression.Other studies sought to find mi RNAs which correlate to clinical parameters(tumor grade,nodal stage,metastasis,survival) and therapy response.Although several mi RNAs seem to have an impact on the response to CRT or might predict nodal stage,there is still only little overlap between different studies.We here aimed to summarize the current literature on rectal cancer and mi RNA expression with respect to the different relevant clinical parameters. | azadeh azizian jens gruber b michael ghadimi jochen gaedcke | 2016 | World Journal of Gastrointestinal Oncology2016，8，5： | 3 |
| 2 | STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo显示文摘 | Melanie Spitzner Birte Roesler Christian Bielfeld Georg Emons Jochen Gaedcke Hendrik A. Wolff Margret Rave‐Fr?nk Frank Kramer Tim Beissbarth Julia Kitz Jürgen Wienands B. Michael Ghadimi Reinhard Ebner Thomas Ried Marian Grade | 2014 | Int J Cancer2014，，4： | 2 |
| 3 | Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g显示文摘 | Junius Salendo Melanie Spitzner Frank Kramer Xin Zhang Peter Jo Hendrik A. Wolff Julia Kitz Silke Kaulfu? Tim Bei?barth Matthias Dobbelstein Michael Ghadimi Marian Grade Jochen Gaedcke | 2013 | Radiotherapy and Oncology2013，，： | 2 |
| 4 | Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g<!-- MicroRNA chemoradiosensitivity signature -->显示文摘 | Junius Salendo Melanie Spitzner Frank Kramer Xin Zhang Peter Jo Hendrik A. Wolff Julia Kitz Silke Kaulfu? Tim Bei?barth Matthias Dobbelstein Michael Ghadimi Marian Grade Jochen Gaedcke | 2013 | Radiotherapy and Oncology2013，，： | 2 |
| 5 | Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer显示文摘 | Geng Zhang Peijun He Hanson Tan Anuradha Budhu Jochen Gaedcke B. Michael Ghadimi Thomas Ried Harris G. Yfantis Dong H. Lee Anirban Maitra Nader Hanna H. Richard Alexander S. Perwez Hussain | 2013 | Clinical Cancer Research2013，，18： | 1 |
| 6 | The mesopancreas is the primary site for R1 resection in pancreatic head cancer: rele- vance for clinical trials显示文摘 | Gaedcke J Gunawan B Grade M | 2010 | Langenbecks Arch Surg2010，395，4： | 1 |
| 7 | The mesopancreas is the primary site for R1 resection in pancreatic head cancer: relevance for clinical trials显示文摘 | Gaedcke J Gunawan B Grade M | 2010 | Langenbecks Arch Surg2010，395，4： | 1 |
| 8 | The rectal cancer microR- NAome-microRNA expression in rectal cancer and matched normal mucosa显示文摘 | Gaedcke J Grade M Carnps J | 2012 | Clin Cancer Res2012，18，18： | 1 |
| 9 | Investigation of the pharmaceutical and pharmacological equivalence of different hawthorn extracts 显示文摘 | VERLING W BRAND N GAEDCKE F | 2003 | Phytomedicine2003，10，1： | 1 |
| 10 | Investigation of the phar- maceutical and pharmacological equivalence of different hawthorn extracts 显示文摘 | Vierling W Brand N Gaedcke F | 2003 | Phytomedicine2003，，10： | 1 |
| 11 | The rectal cancer microRNAome-microRNA expression in rectal cancer and matched normal mucosa显示文摘 | Gaedcke J Grade M Camps J | 2012 | Clin Cancer Res2012，18，18： | 1 |
| 12 | The mesopancreas is the primary site for R1 resection in pancreatic head eancer :relevance for clinical trials显示文摘 | Gaedcke J Gunawan B Grade M | 2010 | Langenbecks Arch Surg2010，395，4： | 1 |
| 13 | The rectal cancer microRNAome-microRNA expression in rectal cancer and matched normal mucosa显示文摘 | Gaedcke J Grade M Camps J | 2012 | Clin Cancer Res2012，18，18： | 1 |
| 14 | The mesopancreas is the primary site for Rl resection in pancreatic head cancer: relevance for clinical trials显示文摘 | Gaedcke r Gunawan B Grade M | 2010 | Langenbecks Arch Surg2010，395，4： | 1 |
| 15 | Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis显示文摘 | KaulfuβS Burfeind P Gaedcke J | 2009 | Molecular Cancer Therapeutics2009，8，4： | 1 |
| 16 | The molecular basis of chemoradiosensitivity in rectal cancer: implications for personalized therapies 显示文摘 | Grade M Wolff HA Gaedcke J | 2012 | Langenbecks Arch Surg2012，397，： | 1 |
| 17 | Dual silencing of insulin-like growth factor-Ⅰ receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis显示文摘 | Kaulfuss S Burfeind P Gaedcke J | 2009 | Mol Cancer Ther2009，8，4： | 1 |
| 18 | The mesopancreas is the primary site for R1 resection in pancreatic head cancer: rel- evance for clinical trials显示文摘 | Gaedcke J Gunawan B Grade M | 2010 | Langenbecks Arch Surg2010，395，： | 1 |
| 19 | K-ras and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy显示文摘 | Gaedcke J GradeM Jung K | 2010 | Radiother Oncol2010，94，1： | 1 |
| 20 | Rectal cancer: current status of multimodal therapy--when and how显示文摘 | Gaedcke J Liersch T Hess C | 2011 | Zentralbl Chir2011，136，4： | 1 |
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