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| 1 | Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma显示文摘瞄准:与肝细胞癌(HCC ) 从病人分析树枝状的房间(DC ) 的显型和功能以便在这疾病理解他们的角色。方法:骨髓的的树枝状的房间在 HCC 病人的外部血被枚举。从外部血的天真、刺激的骨髓的的树枝状的房间上的 CD80, CD83, CD86 和 HLA 医生表示被分析。骨髓的的树枝状的房间从外部血被孤立,他们的功能被测试。吞噬作用用 FITC 葡聚糖祷告被分析,肽特殊刺激,在多形核白细胞 dI:dC 之上刺激 allogeneic T 房间和 cytokines 的分泌物的能力被测试。结果:骨髓的的树枝状的房间与 HCC 在病人被减少。在 CD80, CD83, CD86 和 HLA 医生表示的差别都没从 HCC 病人和健康控制在天真、刺激的骨髓的的树枝状的房间上被发现。肽 specific T 房间的正常吞噬作用或刺激与一个损害 allo-stimulatory 能力和减少的 IL-12 分泌物相对照被观察。结论:在病人的 mDCs 的损害 IL-12 生产能导致建议指导治疗可以提高的那 IL-12 的天真的 T 房间的一个损害 stimulatory 能力在 HCC 病人的肿瘤 specific 免疫者回答。 | Lars A Ormandy Anatol Frber Tobias Cantz Susanne Petrykowska Heiner Wedemeyer Monique Hrning Frank Lehner Michael P Manns Firouzeh Korangy Tim F Greten | 2006 | World Journal of Gastroenterology2006，12，20： | 12 |
| 2 | Carboxylesterases in lipid metabolism: From mouse to human显示文摘哺乳动物的 carboxylesterases 水解大量 xenobiotic 和内长的混合物,包括类脂化合物酉旨。在类脂化合物新陈代谢的 carboxylesterases 和在 vivo 的精力动态平衡的生理的函数被基因操作和化学抑制在鼠标,并且在 vitro 表明了通过(在上) 表达式,表达式击倒、化学在许多房间的抑制。最近的研究进展揭示了 carboxylesterases 的关联到象肥胖那样的新陈代谢的疾病和脂肪肝疾病,建议这些酶可能是为新陈代谢的混乱的处理的潜在的目标。以便翻译现出症状之前的潜的研究在细胞并且到在老鼠之间的 carboxylesterases 的人和人的老鼠模型需要被阐明。这评论在鼠标和人的结构和功能介绍并且讨论研究进步在类脂化合物新陈代谢和新陈代谢的混乱的这些酶的 carboxylesterases,和角色。 | Jihong Lian Randal Nelson Richard Lehner | 2018 | Protein & Cell2018，9，2： | 6 |
| 3 | Investigating soil moisture–climate interactions in a changing climate: A review显示文摘 | Sonia I. Seneviratne Thierry Corti Edouard L. Davin Martin Hirschi Eric B. Jaeger Irene Lehner Boris Orlowsky Adriaan J. Teuling | 2010 | Earth Science Reviews2010，，3： | 3 |
| 4 | 动态^(18)F-FDG PET定量分析用于骨病变鉴别诊断显示文摘目的 评价18F 脱氧葡萄糖 (FDG)PET在骨骼病变中的诊断价值。方法 研究对象为40例原发性骨骼病变患者。所有患者在注射示踪剂后立即开始动态PET采集 ,持续 6 0min。对动态PET图像进行半定量分析 ,分别计算平均和最大标准摄取值 (SUVaver和SUVmax) ,病灶SUV/肌肉SUV比值 (T/M) ,病灶 6 0minSUV/ 30minSUV比值 (SUVaver 60 /3 0min和SUVmax 60 /3 0min)等。采用Patlak作图分析法对动态图像数据进行拟合计算 ,得出摄入常数 (Ki) ,计算FDG代谢率 (MRFDG)。根据接受器工作特性曲线 (ROC)确定各定量指标的诊断阈值 ,并比较其鉴别良恶性病变的灵敏度和特异性。结果 经病理检查证实恶性病变 2 1例 ,良性病变 19例。恶性病变的MRFDG和SUV值高于良性病变 ,但各种指标的数值分布均存在交叉重叠。SUVaver与MRFDG呈正相关 (r=0 6 7)。以SUV值≥ 1 8作为阈值时 ,鉴别良恶性病变的灵敏度和特异性分别为 85 0 %和 82 4% ,以MRFDG(1 1)为阈值时的灵敏度 (82 4% )与SUV相近 ,而特异性 (92 9% )较高。同时采用SUV(1 8)和SUVaver 60 /3 0min(1 1)作为鉴别标准时 ,较之单独采用SUV特异性可改善为 93 3% ,灵敏度略有降低 (81 3% )。结论 骨骼良恶性病变之间存在葡萄糖代谢率差异。单用静态FDGPET获取SUV值不能很好鉴? | 吴华 Antonia Dimitrakopoulou-Strauss Thomas O-Heichel Burkhard Lehner Ludger Bernd Volker Ewerbeck Cyrill Burger Ludwig G Strauss | 2002 | 中华核医学杂志2002，22，2： | 3 |
| 5 | Observation of Offshore Wind Farm Wakes by Spaceborne Synthetic Aperture Radar显示文摘In this paper,studies on offshore wind farm wakes observed by spaceborne synthetic aperture radar(SAR)are reviewed mainly based on our previous research.Particularly,we focus on investigating wind wakes and tidal current wakes observed by spaceborne SAR of Terra SAR-X,Gaofen-3 and Radarsat-2 in high spatial resolution,in two offshores wind farms,i.e.,the Alpha Ventus in the North Sea and the one near Donghai bridge in the East China Sea.Representing examples of wind wakes and tidal current wakes observed by SAR in the two farms are presented and compared.A preliminary statistical analysis on morphology of wind feature downstream Alpha Ventus is presented as well.Besides these studies on wind wakes generated by a single offshore wind farm,we show an example of wakes downstream multiple wind farms in the North Sea to demonstrate'cluster'effect of multiple offshore wind farms on sea wind. | Xiaoming LI Susanne LEHNER | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 2 |
| 6 | High-Density Lipoprotein Transport Through Aortic Endothelial Cells Involves Scavenger Receptor BI and ATP-Binding Cassette Transporter G1显示文摘 | Lucia Rohrer Pascale M. Ohnsorg Marc Lehner Franziska Landolt Franz Rinninger Arnold von Eckardstein | 2009 | Circulation Research2009，，10： | 2 |
| 7 | Diets enriched in trans -11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome显示文摘 | M. Miriam Jacome-Sosa Faye Borthwick Rabban Mangat Richard Uwiera Martin J. Reaney Jianheng Shen Ariel D. Quiroga René L. Jacobs Richard Lehner Spencer D. Proctor | 2014 | The Journal of Nutritional Biochemistry2014，，： | 2 |
| 8 | A three-channel microcomputer system for segmentation and characterization of the phonocardiogram显示文摘 | Lehner RJ Rangayyan RM | 1987 | IEEE Trans Biomedical Eng1987，34，6： | 2 |
| 9 | Replacement of the proximal humerus with MUTARS tumor endoprostheses显示文摘 | P. Raiss S. Kinkel U. Sauter T. Bruckner B. Lehner | 2009 | European Journal of Surgical Oncology2009，，4： | 2 |
| 10 | Mapping of liver-enriched transcription factors in the human intestine显示文摘AIM: To investigate the gene expression pattern of hepatocyte nuclear factor 6 (HNF6) and other liverenriched transcription factors in various segments of the human intestine to better understand the differentiation of the gut epithelium. METHODS: Samples of healthy duodenum and jejunum were obtained from patients with pancreatic cancer whereas ileum and colon was obtained from patients undergoing right or left hemicolectomy or (recto)sigmoid or rectal resection. All surgical specimens were subjected to histopathology. Excised tissue was shock-frozen and analyzed for gene expression of liver-enriched transcription factors by semiquantitative reverse transcription polymerase chain and compared to the human colon carcinoma cell line Caco-2. Protein expression of major liver-enriched transcription factors was determined by Western blotting while the DNA binding of HNF6 was investigated by electromobility shift assays. RESULTS: The gene expression patterning of liverenriched transcription factors differed in the various segments of the human intestine with HNF6 gene expression being most abundant in the duodenum (P < 0.05) whereas expression of the zinc finger protein GATA4 and of the HNF6 target gene ALDH3A1 was most abundant in the jejunum (P < 0.05). Likewise, expression of FOXA2 and the splice variants 2 and 4 of HNF4α were most abundantly expressed in the jejunum (P < 0.05). Essentially, expression of transcription factors declined from the duodenum towards the colon with the most abundant expression in the jejunum and less in the ileum. The expression of HNF6 and of genes targeted by this factor, i.e. neurogenin 3 (NGN3) was most abundant in the jejunum followed by the ileum and the colon while DNA binding activity of HNF4α and of NGN3 was conf irmed by electromobility shift assays to an optimized probe. Furthermore, Western blotting provided evidence of the expression of several liver-enriched transcription factors in cultures of colon epithelial cells, albeit at different levels. CONCLUSION: We describe significant local and segmental differences in the expression of liver-enriched transcription factors in the human intestine which impact epithelial cell biology of the gut. | Frank Lehner Ulf Kulik Juergen Klempnauer Juergen Borlak | 2010 | World Journal of Gastroenterology2010，16，31： | 2 |
| 11 | Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers显示文摘 | Reeves MB MacAry PA Lehner PJ | 2005 | Proc Natl Acad Sci USA2005，102，11： | 1 |
| 12 | Cytokeratin 8 protects from hepatotoxicity and its ratio to cytokeratln 18 determines the ability of hepatocytes to form mallory bodies显示文摘 | ZATLOUKAL K STUMPTNER C LEHNER M | 2000 | Am J Pathol2000，156，4： | 1 |
| 13 | Microbiological, epidemiological and food safety aspects of Enterobacter sakazakii 显示文摘 | Lehner A Stephan R | 2004 | Food Pro2004，67，12： | 1 |
| 14 | Develop- ment of a multiplex and semi-nested PCR assay for detection of Yersinia enterocolitica and Aeromonas hydrophila in rawmilk显示文摘 | YESIM Z O LEHNER A WAGNER M | 2000 | Food Microbiol2000，17，： | 1 |
| 15 | In search of antisense显示文摘 | Lavorgna G Dahary D Lehner B | 2004 | Trends Biochem Sci2004，29，2： | 1 |
| 16 | Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers显示文摘 | Reeves MB MacAry PA Lehner PJ | 2005 | Proc Natl Acad Sci USA2005，102，11： | 1 |
| 17 | Es-x/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes显示文摘 | Ko K W Erickson B Lehner R | 2009 | Biochim Biophys Acta2009，1791，12： | 1 |
| 18 | First experiences with negative pressure wound therapy and instillation in the treat- ment of infected orthopaedic implants: a clinical observational study 显示文摘 | Lehner B Fleisehmann W Beeker R | 2011 | Int Orthop2011，35，9： | 1 |
| 19 | The amount of viable and dyssynchronous myocardium is associated with response to cardiac resynehronization therapy:initial clinical results u sing multiparametric ECG-gated FDG PET 显示文摘 | Lehner S Uebleis C Schtitler F | 2013 | Eur J Nucl Med Mol Imaging2013，40，12： | 1 |
| 20 | Vapor growth and characterization of pyrite ( FeS2 ) doped with Co, Ni and As: variations in semiconducting properties 显示文摘 | S W Lehner K S Savage J C Ayers | 2006 | Journal of Crystal Growth2006，286，： | 1 |
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