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| 1 | Predictive factors for the local recurrence and distant metastasis of phyllodes tumors of the breast: a retrospective analysis of 192 cases at a single center显示文摘The local recurrence rate of phyllodes tumors of the breast varies widely among different subtypes, and distant metastasis is associated with poor survival. This study aimed to identify factors that are predictive of local recurrence-free survival(LRFS), distant metastasis-free survival(DMFS), and overall survival(OS) in patients with phyllodes tumors of the breast. Clinical data of all patients with a phyllodes tumor of the breast(n = 192) treated at Sun Yat-sen University Cancer Center between March 1997 and December 2012 were reviewed. The Pearson χ2 test was used to investigate the relationship between clinical features of patients and histotypes of tumors. Univariate and multivariate Cox regression analyses were performed to identify factors that are predictive of LRFS, DMFS, and OS. In total, 31(16.1%) patients developed local recurrence, and 12(6.3%) developed distant metastasis. For the patients who developed local recurrence, the median age at the diagnosis of primary tumor was 33 years(range, 17-56 years), and the median size of primary tumor was 6.0 cm(range, 0.8-18 cm). For patients who developed distant metastasis, the median age at the diagnosis of primary tumor was 46 years(range, 24-68 years), and the median size of primary tumor was 5.0 cm(range, 0.8-18 cm). In univariate analysis, age, size, hemorrhage, and margin status were found to be predictive factors for LRFS(P = 0.009, 0.024, 0.004, and 0.001, respectively), whereas histotype, epithelial hyperplasia, margin status, and local recurrence were predictors of DMFS(P = 0.001, 0.007, 0.007, and < 0.001, respectively). In multivariate analysis, independent prognostic factors for LRFS included age [hazard ratio(HR) = 3.045, P = 0.005], tumor size(HR = 2.668, P = 0.013), histotype(HR = 1.715, P = 0.017), and margin status(HR = 4.530, P< 0.001). Histotype(DMFS: HR = 4.409, P = 0.002; OS: HR = 4.194, P = 0.003) and margin status(DMFS: HR = 2.581, P = 0.013; OS: HR = 2.507, P = 0.020) were independent predictors of both DMFS and OS. In this cohort, younger age, a larger tumor size, a higher tumor grade, and positive margins were associated with lower rates of LRFS. Histotype and margin status were found to be independent predictors of DMFS and OS. | Jing Wei Yu-Ting Tan Yu-Cen Cai Zhong-Yu Yuan Dong Yang Shu-Sen Wang Rou-Jun Peng Xiao-Yu Teng Dong-Geng Liu Yan-Xia Shi | 2014 | Chinese Journal of Cancer2014，33，10： | 18 |
| 2 | Fabrication of homogeneously dispersed graphene/Al composites by solution mixing and powder metallurgy显示文摘Graphene-reinforced aluminum(Al) matrix composites were successfully prepared via solution mixing and powder metallurgy in this study. The mechanical properties of the composites were studied using microhardness and tensile tests. Compared to the pure Al alloy, the graphene/Al composites showed increased strength and hardness. A tensile strength of 255 MPa was achieved for the graphene/Al composite with only 0.3 wt% graphene, which has a 25% increase over the tensile strength of the pure Al matrix. Raman spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, and transmission electron microscopy were used to investigate the morphologies, chemical compositions, and microstructures of the graphene and the graphene/Al composites. On the basis of fractographic evidence, a relevant fracture mechanism is proposed. | Xiang Zeng Jie Teng Jin-gang Yu Ao-shuang Tan Ding-fa Fu Hui Zhang | 2018 | International Journal of Minerals,Metallurgy and Materials2018，25，1： | 13 |
| 3 | 急诊经皮冠状动脉介入治疗与远端血栓保护装置PercuSurge Guardwire联合治疗急性心肌梗死(英文)显示文摘目的 评价远端血栓保护装置PercuSurgeGuardwire在急性心肌梗死 (AMI)的高危急诊经皮冠状动脉介入 (PCI)治疗中预防远端血栓栓塞并发症的临床疗效及安全性。方法 92例AMI患者为研究对象 ,其中 4 7例在急诊PCI过程中联合应用PercuSurgeGuardwire装置(PercuSurge组 ) ,平均年龄 (6 1 4± 7 1)岁 ;另 4 5例进行常规无PercuSurgeGuardwire保护的急诊PCI (对照组 ) ,平均年龄 (6 4 9± 8 3)岁。比较两组急诊PCI术后即刻冠状动脉TIMI血流及院内、 30天主要心脏不良事件发生率。结果 全部病例均成功植入血管支架并放置PercuSurgeGuardwire保护装置。平均阻滞球囊直径 (4 5± 0 5 )mm ,平均阻滞时间 (8 7± 5 9)min。PercuSurge组术后TIMI 3级血流率显著高于对照组 (95 74与 86 6 7% ,P <0 0 5 ) ,无血流事件发生率显著降低 (0 %与 6 6 7% ,P <0 0 5 )。并发症包括 :血管夹层 1例 (2 13% ) ,远端小血管血栓栓塞 1例 (2 13% )。随访全部患者 ,PercuSurge组院内及 30天心脏不良事件发生率均显著低于对照组 (分别为 2 13%与13 33% ,2 13%与 8 89% ,P值均小于 0 0 5 )。结论 联合应用PercuSurgeGuarwire远端保护装置在AMI患者的急诊PCI过程中可安全有效地预防远端血栓栓塞并发症的发生 。 | 李浪 刘唐威 Tan Huay Cheem Lim Yean Teng | 2004 | 中华急诊医学杂志2004，13，9： | 12 |
| 4 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 5 | Mesoporous silica nanorods intrinsically doped with photosensitizers as a multifunctional drug carrier for combination therapy of cancer显示文摘Mesoporous 硅石 nanoparticles (MSN ) 由于他们的大表面区域,悦耳的尺寸,灵巧的修正和可观的 biocompatibility 作为药交货搬运人在最近的年里吸引了巨大的注意。在这个工作,我们制作内在地与使分子具有感光性被做的 MSN 的一种有趣的类型,氯 e6 (Ce6 ) 。由增加在硅石矩阵内做的 Ce6 的数量, MSN 的形态学从范围改变到像杆的形状,这被发现。获得的做 Ce6 的 mesoporous 硅石 nanorods (CMSNR ) 不仅能为光力学的治疗,而且罐头生产汗衫氧也与由利用他们的 mesoporous 结构装载能力的高药用作一个药交货平台。比作球形的 nanoparticles,有更大的方面比率的 CMSNR 由癌症房间显示出许多更快的举起,这被发现。与作为模型药采用的 doxorubicin (纪录影片) ,联合光力学并且化疗被执行,在 vitro 并且在 vivo 完成 synergistic 反肿瘤效果。我们的学习介绍一个基于 MSN 的药交货平台的一个新图案,它内在地荧光灯、有能力用作一个光力学的代理人,为未来答应癌症的指导成像的联合治疗。 | Guangbao Yang Hua Gong Xiaoxin Qian Pengli Tan Zhiwei Li Teng Liu Jingjing Liu Youyong Li Zhuang Liu | 2015 | Nano Research2015，8，3： | 11 |
| 6 | First Imported Case of SARS-CoV-2 Omicron Subvariant BA.5—Shanghai Municipality,China,May 13,2022显示文摘On April 27,2022,an international flight KL857 from Amsterdam,the Netherlands arrived at Pudong International Airport,Shanghai Municipality.Passengers were transferred to the quarantine hotel for a routine 14-day medical observation in Songjiang District and regularly tested for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).One of the passengers(a 37-year-old Chinese male)was reported positive and diagnosed as a mild case on April 29.The case set out from Uganda(flight KL535)on April 25 and transferred at Amsterdam,the Netherlands on April 26 and Seoul,the Republic of Korea(KL857)on April 27.The patient has been vaccinated in four doses against coronavirus disease 2019(COVID-19)(Beijing Institute of Biological Products Co.,Ltd)in China and Uganda.After diagnosis,he was transferred to Shanghai Public Health Clinical Center for treatment.He recovered after treatment and was discharged on May 12. | Hui Jiang Changcheng Wu Wenbo Xu Hongyou Chen Fanghao Fang Min Chen Chaonan Wang Lingyue Yuan Huanyu Wu Zheng Teng Jinyuan Guo Yaxu Zheng Xihong Lyu Xuefei Qiao Guizhen Wu Wenjie Tan Xi Zhang | 2022 | China CDC weekly2022，4，30： | 10 |
| 7 | Sequential organ failure assessment score is superior to other prognostic indices in acute pancreatitis显示文摘BACKGROUND Acute pancreatitis(AP)is a common surgical condition,with severe AP(SAP)potentially lethal.Many prognostic indices,including;acute physiology and chronic health evaluation II score(APACHE II),bedside index of severity in acute pancreatitis(BISAP),Glasgow score,harmless acute pancreatitis score(HAPS),Ranson’s score,and sequential organ failure assessment(SOFA)evaluate AP severity and predict mortality.AIM To evaluate these indices'utility in predicting severity,intensive care unit(ICU)admission,and mortality.METHODS A retrospective analysis of 653 patients with AP from July 2009 to September 2016 was performed.The demographic,clinical profile,and patient outcomes were collected.SAP was defined as per the revised Atlanta classification.Values for APACHE II score,BISAP,HAPS,and SOFA within 24 h of admission were retrospectively obtained based on laboratory results and patient evaluation recorded on a secure hospital-based online electronic platform.Data with<10%missing data was imputed via mean substitution.Other patient information such as demographics,disease etiology,and patient outcomes were also derived from electronic medical records.RESULTS The mean age was 58.7±17.5 years,with 58.7%males.Gallstones(n=404,61.9%),alcohol(n=38,5.8%),and hypertriglyceridemia(n=19,2.9%)were more common aetiologies.81(12.4%)patients developed SAP,20(3.1%)required ICU admission,and 12(1.8%)deaths were attributed to SAP.Ranson’s score and APACHE-II demonstrated the highest sensitivity in predicting SAP(92.6%,80.2%respectively),ICU admission(100%),and mortality(100%).While SOFA and BISAP demonstrated lowest sensitivity in predicting SAP(13.6%,24.7%respectively),ICU admission(40.0%,25.0%respectively)and mortality(50.0%,25.5%respectively).However,SOFA demonstrated the highest specificity in predicting SAP(99.7%),ICU admission(99.2%),and mortality(98.9%).SOFA demonstrated the highest positive predictive value,positive likelihood ratio,diagnostic odds ratio,and overall accuracy in predicting SAP,ICU admission,and mortality.SOFA and Ranson’s score demonstrated the highest area under receiver-operator curves at 48 h in predicting SAP(0.966,0.857 respectively),ICU admission(0.943,0.946 respectively),and mortality(0.968,0.917 respectively).CONCLUSION The SOFA and 48-h Ranson’s scores accurately predict severity,ICU admission,and mortality in AP,with more favorable statistics for the SOFA score. | Thomas Zheng Jie Teng Jun Kiat Thaddaeus Tan Samantha Baey Sivaraj K Gunasekaran Sameer P Junnarkar Jee Keem Low Cheong Wei Terence Huey Vishal G Shelat | 2021 | World Journal of Critical Care Medicine2021，10，6： | 9 |
| 8 | A review on photo-thermal catalytic conversion of carbon dioxide显示文摘The conversion of carbon dioxide into value-added products is of great industrial and environmental interest. However, as carbon dioxide is relatively stable, the input energy required for this conversion is a significant limiting factor in the system's performance. By utilising energy from the sun, through a range of key routes, this limitation can be overcome. In this review, we present a comprehensive and critical overview of the potential routes to harvest the sun's energy, primarily through solar-thermal technologies and plasmonic resonance effects. Focusing on the localised heating approach, this review shortlists and compares viable catalysts for the photo-thermal catalytic conversion of carbon dioxide.Further, the pathways and potential products of different carbon dioxide conversion routes are outlined with the reverse water gas shift,methanation, and methanol synthesis being of key interest. Finally, the challenges in implementing such systems and the outlook to the future are detailed. | Ee Teng Kho Tze Hao Tan Emma Lovell Roong Jien Wong Jason Scott Rose Amal | 2017 | Green Energy & Environment2017，2，3： | 7 |
| 9 | Eogenetic Karst in Interbedded Carbonates and Evaporites and Its Impact on Hydrocarbon Reservoir: A New Case from Middle Triassic Leikoupo Formation in Sichuan Basin, Southwest China显示文摘Karst in interbedded carbonates and evaporites has been reported to have important and complex impacts on reservoir. It is significant for exploration and karst geology. Here, we report such a new case from Middle Triassic Leikoupo Formation of Sichuan Basin, Southwest China. Stratigraphic incompleteness and the occurrence of unconformity provide evidence for the presence of eogenetic karst. Under the impact of this eogenetic karst, residual weathered and solution-collapse breccia, solution pores and silicification and dedolomitization have been observed. Classic stratigraphic zonation of karst is not readily distinguishable, which is ascribed to the stratigraphic collapse of carbonate rocks resulting from the dissolution of evaporites by lateral subsurface fluid flow. In terms of impact on reservoir quality, karst can generally improve the initial physical property of the porous layers in theory. However, subsurface fluid flow dissolved the evarporitic beds and facilitated the collapse of overlying strata. As a consequence, the lateral continuity of the reservoirs would be destroyed, and relatively high-quality reservoirs can only be developed with little collapse of overlying strata, reflecting reservoir heterogeneities. This may be a general feature of reservoir formation under the impact of karst in interbedded carbonates and evaporites. | Hong Liu Xiucheng Tan Ling Li Xiong Ding Jian Cao Guang Yang Teng Ma | 2019 | Journal of Earth Science2019，30，5： | 5 |
| 10 | Electrically controllable laser frequency combs in graphene-fibre microresonators显示文摘Laser frequency combs emitting ultrafast pulses of light,at equidistantly discrete frequencies,are cornerstones of modern information networks.In recent years,the generation of soliton combs in microcavities with ultrahighquality factors has established microcombs as out-oflaboratory tools.However,the material and geometry of a laser cavity,which determine comb formation,are difficult to electrically tune.Such dynamic control can further enrich the diversity of comb outputs and help to actively stabilize them. | Chenye Qin Kunpeng Jia Qianyuan Li Teng Tan Xiaohan Wang Yanhong Guo Shu-Wei Huang Yuan Liu Shining Zhu Zhenda Xie Yunjiang Rao Baicheng Yao | 2020 | Light(Science & Applications)2020，9，1： | 5 |
| 11 | 远端保护装置FilterWire EX^(TM)在冠状动脉旁路移植术后大隐静脉桥病变介入治疗中的临床效果显示文摘目的 远端血栓栓塞是冠状动脉旁路移植术后大隐静脉桥的介入治疗过程中常见的并发症,本研究在大隐静脉桥病变的介入治疗中应用新颖的FilterWire EXTM远端保护装置,评价其临床疗效与安全性。方法 选择73例冠状动脉旁路移植术后大隐静脉桥病变患者为研究对象。其中39例患者在FiherWire EXTM的保护下行介入治疗(FilterWire EXTM组),而另34例患者进行无保护的常规介入治疗(对照组)。比较两组患者介入治疗前后的FIMI血流,院内及30 d心脏不良事件发生率。结果 Filter-Wire EXTM在全部病例均成功释放。FiherWire EXTM组经皮冠状动脉介入治疗后TIMI3级血流发生率显著高于对照组(89.74%比76.47%,P<0.05),“无血流”(TIMI 0/1级血流)或“慢血流”(TIMI 2级血流)发生率显著低于对照组(分别为2.56%比8.82%及7.69%比14.70%,P<0.05),院内及30 d心脏不良事件发生率均显著降低(7.69%比17.65%及5.13%比14.71%,P<0.05);未见与装置有关的并发症。结论 在大隐静脉桥病变的介入治疗中联合应用FilterWire EXTM远端保护装置可安全有效,简便易行地预防远端血栓栓塞并发症的发生,显著降低患者院内及30 d心脏不良事件发生率。 | 李浪 Tan Huay Cheem Teo Swee Guan Lim Yean Teng | 2004 | 中华心血管病杂志2004，32，7： | 4 |
| 12 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 13 | RP11-40C6.2 Inactivates Hippo Signaling by Attenuating YAP1 Ubiquitylation in Hepatitis B Virus-associated Hepatocellular Carcinoma显示文摘Background and Aims:Chronic hepatitis caused by hepatitis B virus(HBV)infection is a leading cause of hepatocellular carcinoma(HCC).We investigated the roles of oncogenic HBV infection-associated long noncoding RNAs in HCC.Methods:Bioinformatics analysis of data from the Cancer Genome Atlas(TCGA)was performed to screen potential oncogenic HBV-related lncRNAs.Next,we assessed their expression in clinical samples and investigated their correlation with clinical characteristics.The detailed oncogenic effects were analyzed by performing in vitro and in vivo studies.Results:RP11-40C6.2,an HBV infection-related lncRNA,was identified by analysis of the TCGA–Liver Hepatocellular Carcinoma database.Gene Set Enrichment Analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis of differentially expressed genes revealed a strong association of RP11-40C6.2 with the Hippo signaling pathway.RP11-40C6.2 was overexpressed in HCC patients with HBV infection compared to those without HBV infection.RP11-40C6.2 transcription showed a positive association with HBV-X protein(HBx),but not HBV core protein(HBc)expression,both of which are carcinogenic proteins.Luciferase gene reporter and ChIP assays revealed that YAP1/TAZ/TEADs complex enhanced RP11-40C6.2 transcription by binding to its promoter area.RP11-40C6.2 showed oncogenic characteristics in HCC cell lines and in animal models that were mediated via activation of YAP1.In vitro ubiquitylation assay revealed that RP11-40C6.2 can promote the stabilization of YAP1 by stopping phosphorylation at its s127 residue and further stopping its degradation through binding to 14-3-3.Conclusions:RP11-40C6.2 is an HBV infection-related lncRNA that exerts its oncogenic effects by targeting the Hippo signaling pathway. | Han Zhuo Chen Wu Junwei Tang Feihong Zhang Zhenggang Xu Dongwei Sun Yue Teng Zhongming Tan | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 3 |
| 14 | Mirror-twin induced bicrystalline InAs nanoleaves显示文摘在这研究,像叶子的一个维的 InAs nanostructures 被 metalorganic 化学药品蒸汽免职方法种。详细结构的描述建议 nanoleaves 包含相对低精力 { 122 } 或 { 133 } 镜子双胞胎充当他们作为叶柄连接 nanoleaves 和他们的内在的底的中肋和狭窄的节。重要地,镜子双胞胎以晶体学和极性导致孪生的结构的相同侧面的生长,它为侧面的对称的 nanoleaves 的形成是必要的。nanoleaves 的形成被催化剂精力最小化驾驶,这被发现了。这研究提供制作半导体 nanoleaf 在自然发现的叶的 biomimic。 | Mun Teng Soo Kun Zheng Qiang Gao Hark Hoe Tan Chennupati Jagadish Jin Zou | 2016 | Nano Research2016，9，3： | 2 |
| 15 | Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial显示文摘It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart disease.Here,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and placebo.After performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by DII.Furthermore,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol metabolism.We assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear regression.Our study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target drug.Modular methods facilitate the discovery of network pharmacologicalmechanisms and the advancement of precision medicine.(ClinicalTrials.gov identifier:NCTO1681316). | Jun Liu Dan-Dan Li Wei Dong Yu-Qi Liu Yang Wu Da-Xuan Tang Fu-Chun Zhang Meng Qiu Qi Hua Jing-Yu He Jun Li Bai Du Ting-Hai Du Lin-Lin Niu Xue-Jun Jiang Bo Cui Jiang-Bin Chen Yang-Gan Wang Hai-Rong Wang Qin Yu Jing He Yi-Lin Mao Xiao-Fang Bin Yue Deng Yu-Dan Tian Qing-Hua Han Da-Jin Liu Li-Qin Duan Ming-Jun Zhao Cui-Ying Zhang Hai-Ying Dai Ze-Hua Li Ying Xiao You-Zhi Hu Xiao-Yu Huang Kun Xing Xin Jiang Chao-Feng Liu Jing An Feng-Chun Li Tao Tao Jin-Fa Jiang Ying Yang Yao-Rong Dong Lei Zhang Guang Fu Ying Li Shu-Wei Huang Li-Ping Dou Lan-Jun Sun Ying-Qiang Zhao Jie Li Yun Xia Jun Liu Fan Liu Wen-Jin He Ying Li Jian-Cong Tan Yang Lin Ya-Bin Zhou Jian-Fei Yang Guo-Qing Ma Hui-Jun Chen He-Ping Liu Zong-Wu Liu Jian-Xiong Liu Xiao-Jia Luo Xiao-Hong Bin Ya-Nan Yu Hai-Xia Dang Bing Li Fei Teng Wang-Min Qiao Xiao-Long Zhu Bing-Wei Chen Qi-Guang Chen Chun-Ti Shen Yong-Yan Wang Yun-Dai Chen Zhong Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 2 |
| 16 | 紫杉醇洗脱支架在冠心病介入治疗中的临床应用显示文摘目的观察紫杉醇洗脱支架(商品名TAXUS)治疗冠心病的疗效及安全性。方法选择77例冠心病患者,包括36例稳定型心绞痛、40例急性冠状动脉综合征、1例急性心肌梗死,对其92处病变(1处A型病变.91处B型和C型病变)植入92枚TAXUS。于术后住院期间、术后30日及12个月检查手术部位再狭窄及心脏不良事件。结果全部病例成功植入TAXUS;术前靶病变狭窄程度为(77±10)%,术后残余狭窄程度为(6.2±0.8)%;目标血管的参考直径及长度分别为(3.6±0.4)mm和(15.0±2.0)mm,植入支架的平均直径及长度分别为(3.2±0.4)mm和(24±15)mm。术后30日发生支架内再狭窄1例,术后第4日亚急性血栓形成1例,6个月在观察终点发生支架边缘再狭窄1例。再狭窄发生率2.6%,心脏不良事件发生率3.9%,靶血管血运重建率3.3%。结论TAXUS可有效地预防冠心病介入治疗术后再狭窄,心脏不良事件发生率低。 | 李浪 Lim Yean Teng Tan Huay Cheem 刘唐威 | 2005 | 岭南心血管病杂志2005，11，3： | 2 |
| 17 | Substrate-based galvanic replacement reactions carried out on heteroepitaxially formed silver templates显示文摘流电的代替反应广泛地被用来转变驱散的银模板组织进复杂 nanoshell 几何学的答案。这里,我们在这些一样的反应的使用上报导从与内在的单个水晶底层有一种 heteroepitaxial 关系的银模板形成空支持底层的 Au-Ag nanoshells。获得的结构展出 nanohut 几何学,显示出高度悦耳的 plasmonic 性质并且用一种没有平版印刷术的技术作为周期的数组被形成。当从底层搬迁了时转换 nanohuts 在边界与一张槽口作为 nanobowls 出现。学习为利用在地点特定的地点定位的 nanoshells 的基于晶片的设备放地基。 | Kyle D. Gilroy Pouyan Farzinpour Aarthi Sundar Teng Tan Robert A. Hughes Svetlana Neretina | 2013 | Nano Research2013，6，6： | 2 |
| 18 | Genome-Wide Serum microRNA Expression Profiling Identifies Serum Biomarkers for Alzheimer's Disease显示文摘 | Lin Tan Jin-Tai Yu Meng-Shan Tan Qiu-Yan Liu Hui-Fu Wang Wei Zhang Teng Jiang Lan Tan | 2014 | Journal of Alzheimer's Disease2014，，4： | 2 |
| 19 | Atomic Layer Deposition of a MoSz Film显示文摘 | Tan L 14 Liu B Teng J H | 2014 | Nanoscale2014，6，10： | 1 |
| 20 | Downregulation of proapoptotic proteins Bax and Bcl-X (S) in p53 overexpressing hepatocellular carcinomas 显示文摘 | BEERHEIDE W TAN Y J TENG E | 2000 | Biochem Biophys Res Commun2000，273，1： | 1 |
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