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| 1 | Effect of garlic and garlic-green tea mixture on serum lipids in MNNG-induced experimental gastriccarcinoma and precancerous lesion显示文摘EfectofgarlicandgarlicgreenteamixtureonserumlipidsinMNNGinducedexperimentalgastriccarcinomaandprecancerouslesionSUQi,LUOZh... | SU Qi, LUO Zhao Yang, TENG Hua, YUN Wei Dong, Li Yi Qing and HE Xin E Institute of Oncology, Hengyang Medical College, Hengyang 421001, Hunan Province, China | 1998 | World Journal of Gastroenterology1998，4，1： | 4 |
| 2 | The Alzheimer's disease-associated gene TREML2 modulates inflammation by regulating microglia polarization and NLRP3 inflammasome activation显示文摘Triggering receptor expressed on myeloid cells-like 2(TREML2)is a newly identified susceptibility gene for Alzheimer's disease(AD).It encodes a microglial inflammation-associated receptor.To date,the potential role of mic roglial TREML2 in neuroinflammation in the context of AD remains unclear.In this study,APP/PS1 mice were used to investigate the dynamic changes of TREML2 levels in brain during AD progression.In addition,lipopolysaccharide(LPS)stimulation of primary microglia as well as a lentivirus-mediated TREML2 overexpression and knockdown were employed to explore the role of TREML2 in neuroinflammation in the context of AD.Our res ults show that TREML2 levels gradually increased in the brains of AP P/PS1 mice during disease progression.LPS stimulation of primary microglia led to the release of inflammato ry cytokines including interleukin-1β,inte rleukin-6,and tumor necrosis factor-a in the culture medium.The LPS-induced mic roglial release of inflammatory cytokines was enhanced by TREML2 overexpression and was attenuated by TREML2 knoc kdown.LPS increased the levels of mic roglial M1-type polarization marker inducible nitric oxide synthase.This effect was enhanced by TREML2 overexpression and ameliorated by TREML2 knockdown.Furthermore,the levels of microglial M2-type polarization markers CD206 and ARG1 in the primary microglia were reduced by TREML2 overexpression and elevated by TREML2 knockdown.LPS stimulation increased the levels of NLRP3 in primary microglia.The LPS-induced increase in NLRP3 was further elevated by TREML2 overexpression and alleviated by TREML2 knockdown.In summary,this study provides the first evidence that TREML2 modulates inflammation by regulating microglial polarization and NLRP3 inflammasome activation.These findings reveal the mechanisms by which TREML2 regulates microglial inflammation and suggest that TREML2 inhibition may represent a novel therapeutic strategy for AD. | Si-Yu Wang Xin-Xin Fu Rui Duan Bin Wei Hai-Ming Cao Yan E Shuai-Yu Chen Ying-Dong Zhang Teng Jiang | 2023 | Neural Regeneration Research2023，18，2： | 2 |
| 3 | Neuropsychiatric sym-ptoms are associated with progression from mild cognitive impairment to Alzheimer's disease显示文摘 | Teng E Lu PH Cummings JL | 2007 | Dement Geriatr Cogn Disord2007，24，4： | 1 |
| 4 | Aging activates adipogenic and suppresses osteogenic programs in mesen-chymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways 显示文摘 | Moerman E J Teng K Lipschitz DA | 2004 | Aging Cell2004，3，6： | 1 |
| 5 | Downregulation of proapoptotic proteins Bax and Bcl-X (S) in p53 overexpressing hepatocellular carcinomas 显示文摘 | BEERHEIDE W TAN Y J TENG E | 2000 | Biochem Biophys Res Commun2000，273，1： | 1 |
| 6 | Chemisorption of nitric oxide on char: 1 Reversible nitric oxide sorption 显示文摘 | TENG H SUUBERG E M | 1993 | J Phys Chem1993，97，47： | 1 |
| 7 | Cleavage of proBDNF by tPA/plasmin is essential forlong-term hippocampal plasticity 显示文摘 | PANG PT TENG H K ZAITSEV E | 2004 | Science2004，306，5695： | 1 |
| 8 | Effect of film-hole shape on turbine-blade heat-transfer coefficient distribution 显示文摘 | TENG S HAN J C POINSATTE P E | 2001 | Jour- nal of Thermophysics and Heat Transfer2001，15，3： | 1 |
| 9 | Chitosan/nanohydroxyapatite compo- site membranes via dynamic filtration for guided bone regenera- tion 显示文摘 | Teng S Lee E Yoon B | 2009 | Journal of Biomedical Materials Research Part A2009，88，3： | 1 |
| 10 | Studies on the reduction of nitric oxide by carbon: The NO-carbon gasification reaction显示文摘 | Suuberg E M Calo J M | 1992 | Energy and Fuels1992，6，： | 1 |
| 11 | Effect of stocking density on the growth of estuary grouper, Epinephelus salmoides Maxwell,cultured in foating net-cages显示文摘 | Teng S K Chua T E | 1978 | Aquaculture1978，15，： | 1 |
| 12 | Hybrid testing of lum- bar CHARITE discs versus fusions显示文摘 | Panjabi M Malcolmson G Teng E | 2007 | Spine (Phila Pa 1976)2007，32，9： | 1 |
| 13 | Do cytokeratin positive only sentinel lymph nodes warrant complete axillary lymph node dissection in patients with invasive breast cancer? 显示文摘 | Teng S Dupont E McCann C | 2000 | Am Surg2000，66，6： | 1 |
| 14 | Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2显示文摘 | LI B RH(E)AUME C TENG A | 2007 | Genesis2007，45，5： | 1 |
| 15 | Effects of feeding frequency on the growth of young Estuary grouper, Epinephelus tauvina(Forskal) ,cultured in floating net-cages显示文摘 | Chua T E Teng S K | 1978 | Aquaculture1978，14，1： | 1 |
| 16 | Retailer's Economic Order Quantity when the Supplier Offers Conditionally Permissible Delay in Payments Link to Order Quantity显示文摘 | Chen S C Cárdenas-Barrón L E Teng J T | 2014 | International Journal of Production Economics2014，，155： | 1 |
| 17 | Multi-objective simulation-based evolutionary algorithm for an aircraft spare parts allocation problem显示文摘 | Lee L H Chew E P Teng S | 2008 | European Journal of Operational Research2008，112，2： | 1 |
| 18 | The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue显示文摘 | Park K I Teng Y D Snyder E Y | | 0，，11： | 1 |
| 19 | Purification and characterization of extrocellular proteases produced by a clinical isolate and a laboratory strain of Pseudomonas aeruginosa 显示文摘 | JENSEN S E PHILLIPPE L TENG TSENG J | 1980 | Journal ofMicrobiology1980，26，： | 1 |
| 20 | Release Kinetics Studies of Aromatic Molecules into Water from Block Polymer Micelles显示文摘 | Teng Y Morrison M E Munk P | 1998 | Macromolecules1998，31，11： | 1 |
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