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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Adjuvant chemotherapy for intrahepatic cholangiocarcinoma: approaching clinical practice consensus?显示文摘Background:Intrahepatic cholangiocarcinoma(ICC)is rare with limited evidence-based guidelines.This retrospective study evaluates the use of chemotherapy in patients with resected ICC.Methods:The Surveillance Epidemiology and End Results(SEER)program database was used to identify patients with resected ICC.Patients were stratified by date of diagnosis(2000-2004,2005-2009,2010-2014),T,and N stage.Multivariable logistic regression models identified predictors of chemotherapy use.Kaplan-Meier and Cox proportional hazard models were used to identify survival trends.Results:One thousand and two hundred twenty-three patients met inclusion criteria.Chemotherapy utilization increased over time(33%to 41%,P≤0.05).Chemotherapy use increased in lymph node(LN)positive patients[32%to 60%in 2010-2014;(P≤0.05)and T3/T4 disease(40%to 60%in 2010-2014;P≤0.01)],but not in patients with LN negative or T1/T2 disease.LN positivity was associated with utilization of chemotherapy in 2005-2009 and 2010-2014.Overall survival increased from 32 to 41 months(P≤0.05).In LN positive patients,chemotherapy was associated with a decreased hazard ratio of death(P≤0.05)and T3/T4 disease was associated with an increased hazard ratio of death(P≤0.05).Conclusions:Adjuvant chemotherapy use in ICC has increased.More LN positive or patients with T3/T4 tumors are receiving chemotherapy,which may explain the improvement in overall survival. | Ariella M.Altman Scott Kizy Schelomo Marmor Jane Y.C.Hui Todd M.Tuttle Eric H.Jensen Jason W.Denbo | 2020 | Hepatobiliary Surgery and Nutrition2020，9，5： | 10 |
| 3 | A review on photo-thermal catalytic conversion of carbon dioxide显示文摘The conversion of carbon dioxide into value-added products is of great industrial and environmental interest. However, as carbon dioxide is relatively stable, the input energy required for this conversion is a significant limiting factor in the system's performance. By utilising energy from the sun, through a range of key routes, this limitation can be overcome. In this review, we present a comprehensive and critical overview of the potential routes to harvest the sun's energy, primarily through solar-thermal technologies and plasmonic resonance effects. Focusing on the localised heating approach, this review shortlists and compares viable catalysts for the photo-thermal catalytic conversion of carbon dioxide.Further, the pathways and potential products of different carbon dioxide conversion routes are outlined with the reverse water gas shift,methanation, and methanol synthesis being of key interest. Finally, the challenges in implementing such systems and the outlook to the future are detailed. | Ee Teng Kho Tze Hao Tan Emma Lovell Roong Jien Wong Jason Scott Rose Amal | 2017 | Green Energy & Environment2017，2，3： | 7 |
| 4 | 抗生素耐药性环境中产生和转移的人类健康风险评估(HHRA)显示文摘[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生'热点区域'的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ARB)产生;b)在相关的环境组成部分的'热点区域'中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ARB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ARB的HHRA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHRA,并使风险管理者了解环境抗生素耐药性。 | Nicholas J.Ashbolt Alejandro Amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anja Coors Rita Finley William H.Gaze Thomas Heberer John R.Lawrence D.G.Joakim Larsson Scott A.McEwen James J.Ryan Jens Schnfeld Peter Silley Jason R.Snape Christel Van den Eede Edward Topp 王晓宇 张伊人 操仪 | 2014 | 环境与职业医学2014，31，2： | 3 |
| 5 | Nature:研究鉴定出侵袭性胰腺癌细胞及其弱点显示文摘在一项新的研究中,来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植(patient—derived tumorxenograft,PDx)和模式小鼠开展一系列临床前实验,鉴定出一种门卫蛋白(gatekee Perprotein)阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型,并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。 | Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, Maria Nezi, Luigi Corti, Denise Minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal Molin, Marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia Muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, Michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas Maitra, Anirban Roberts, Charles W. M. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda | 2017 | 现代生物医学进展2017，17，14： | 2 |
| 6 | Temperature Responses to Infrared-Loading and Water Table Manipulations in Peatland Mesocosms显示文摘We initiated a multi-factor global change experiment to explore the effects of infrared heat loading (HT) and water table level (WL) treatment on soil temperature (T) in bog and fen peatland mesocosms.We found that the temperature varied highly by year,month,peatland type,soil depth,HT and WL manipulations.The highest effect of HT on the temperature at 25 cm depth was found in June for the bog mesocosms (3.34–4.27 ?C) but in May for the fen mesocosms (2.32–4.33 ?C) over the 2-year study period.The effects of WL in the bog mesocosms were only found between August and January,with the wet mesocosms warmer than the dry mesocosms by 0.48–2.03 °C over the 2-year study period.In contrast,wetter fen mesocosms were generally cooler by 0.16–3.87 °C.Seasonal changes of temperatures elevated by the HT also varied by depth and ecosystem type,with temperature differences at 5 cm and 10 cm depth showing smaller seasonal fluctuations than those at 25 cm and 40 cm in the bog mesocosms.However,increased HT did not always lead to warmer soil,especially in the fen mesocosms.Both HT and WL manipulations have also changed the length of the non-frozen season. | Jiquan Chen Scott Bridgham Jason Keller John Pastor Asko Noormets Jake F.Weltzin | 2008 | Journal of Integrative Plant Biology2008，50，11： | 2 |
| 7 | Harnessing the Beneficial Attributes of Ceria and Titania in a Mixed-Oxide Support for Nickel-Catalyzed Photothermal CO_2 Methanation显示文摘太阳能驱动二氧化碳(CO_2)转化为燃料是解决CO_2减排和快速增长的世界能源需求的理想方案。本文利用光照辐射镍基负载催化剂床层引发加热效应以促进CO_2的转化,研究了不同组成的氧化铈-氧化钛复合氧化物载体及其对光热CO_2转化的影响。提高光热CO_2甲烷化活性的两个至关重要的因素分别是:(1)优化的镍颗粒负载对于高活性催化面积及用于加热催化床层的更高的光吸收能力是必需的;(2)载体上的缺陷位对于促进CO_2吸附及随后的活化是必需的。载体中的钛对维持掺杂氧化钛的氧化铈上的氧空位缺陷起着关键作用。当氧化铈和氧化钛混合比例理想时,再结合高光照吸收以及稳定的还原状态,有利于CO_2吸附及随后高效光热CO_2甲烷化反应的发生。 | Ee Teng Kho Salina Jantarang Zhaoke Zheng Jason Scott Rose Amal | 2017 | Engineering2017，3，3： | 2 |
| 8 | Comparison of vertebroplasty and balloon kyphoplasty for treatment of vertebral compression fractures: a meta-analysis of the literature显示文摘 | Jason C. Eck Dean Nachtigall S. Craig Humphreys Scott D. Hodges | 2008 | The Spine Journal2008，，3： | 2 |
| 9 | Comparison of Posterior and Transforaminal Approaches to Lumbar Interbody Fusion显示文摘 | S. Craig Humphreys Scott D. Hodges Avinash G. Patwardhan Jason C. Eck R. Bryan Murphy and Laurie A. Covington | 2001 | Spine2001，，5： | 2 |
| 10 | Transgastric endoscopic peritoneoscopy does not require decontamination of the stomach in humans显示文摘 | Vimal K. Narula Lynn C. Happel Kevin Volt Simon Bergman Jason C. Roland Rebecca Dettorre David B. Renton Kevin M. Reavis Bradley J. Needleman Dean J. Mikami E. Christopher Ellison W. Scott Melvin Jeffrey W. Hazey | 2009 | Surgical Endoscopy2009，，6： | 2 |
| 11 | The use of a standardized Chinese herbal formula in patients with advanced lung cancer:a feasibility study显示文摘Objective: Increasing numbers of cancer patients are using Chinese herbs(CHs). However, differences among prior studies make it difficult to draw firm conclusions about the clinical usefulness of any specific CH formula. The primary objective of this study was to establish the acceptability of taking a standardized CH formula for patients with advanced lung cancer. The secondary objective was to identify any toxicities attributable to this CH formula and to measure changes in quality of life.Methods: A single-arm, prospective study of a 6-week intervention with a selected CH formula in15 patients with stage 4 nonsmall-cell lung cancer(NSCLC, Seventh American Joint Committee on Cancer TNM staging system).Results: Patients with advanced lung cancer were interested in using the CH formula. Completion(93%)and adherence(98%) levels were very high and most patients perceived the CH treatment as easy to take and were willing to take the CHs used in the study again if it was available. About half of the patients reported adverse events, all of which were mild(Grade 1 or 2) and only a small minority(8%) were potentially related to CHs. No biochemical or hematological evidence of toxicity was observed. Overall, there were improvement in quality of life, and reduced feelings of tiredness and sleepiness.Conclusion: This study provides preliminary evidence that short-term use of a carefully selected and prepared CH formula in patients with stage 4 NSCLC is acceptable and safe. | Goulnar Kasymjanova Anh-Thi Tran Victor Cohen Carmela Pepe Lama Sakr David Small Jason Scott Agulnik Robert Thomas Jagoe | 2018 | Journal of Integrative Medicine2018，16，6： | 2 |
| 12 | Incorporation of polarization into the DIRSIG synthetic image generation model 显示文摘 | Jason P M eyers John R Schott Scott D Brown | 2002 | Proceedings of SPIE(S0277-786X)2002，4816，： | 1 |
| 13 | Characterization of Crash-Induced Thoracic Loading Resulting in Pulmonary Contusion显示文摘 | F Scott Gayzik R Shayn Martin H Clay Gabler J Jason Hoth Stefan M. Duma J Wayne Meredith Joel D. Stitzel | 2009 | The Journal of Trauma: Injury, Infection, and Critical Care2009，，3： | 1 |
| 14 | Clarifying the role of silver deposits on titania for the photocatalyt- ic mineralization of organic compounds显示文摘 | Hoany Tran Jason Scott Ken Chiang | 2006 | Journal of Photochemistry and Photobiology: A2006，183，： | 1 |
| 15 | A comparison of stages IB1 and IB2 cervical cancers treated with radical hysterectomy. Is size the real difference?显示文摘 | Teresa L. Rutledge Scott A. Kamelle Todd D. Tillmanns Natalie S. Gould Jason D. Wright David E. Cohn Thomas J. Herzog Janet S. Rader Michael A. Gold Gary A. Johnson Joan L. Walker Robert S. Mannel D. Scott McMeekin | 2004 | Gynecologic Oncology2004，，1： | 1 |
| 16 | A method for determining the free (unbound) concentration of ten beta - laetam antibiotics in human plasma using high performance liquid chro- matography with ultraviolet detection显示文摘 | Scott E Briscoe Brett C McWhinney Jeffrey Lipman Jason A | 2012 | Journal of Chromatography B2012，907，： | 1 |
| 17 | Nest predation increases with parental activity: separating nest site and parental activity effects显示文摘 | Martin Thomas E. Scott Jason Menge Chris | 2000 | 2000 (1459)2000，，1459： | 1 |
| 18 | Marketspace or Marketplace? Online Information Search and Channel Outcomes in Auto Retailing显示文摘 | Jason Kuruzovich Siva Viswanathan Ritu Agarwal Sanjay Gosain Scott Weitzman | 2008 | Information Systems Research2008，，2： | 1 |
| 19 | How Climate and Vegetation Influence the fire Regime of the Alaskan Boreal Biome: The Holocene Perspective显示文摘 | Feng Sheng Hu Linda B. Brubaker Daniel G. Gavin Philip E. Higuera Jason A. Lynch T. Scott Rupp Willy Tinner | 2006 | Mitigation and Adaptation Strategies for Global Change2006，，4： | 1 |
| 20 | Short-Run demand and uncertainty o{ outcome in major league baseball显示文摘 | SCOTT TAINSKY JASON WINFREE | 2010 | Rev Industrial Organization2010，37，3： | 1 |
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