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| 1 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 2 | Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome显示文摘Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic interventions. Cardamonin(CDN), the major active ingredient of the traditional Chinese medicinal herb Alpinia katsumadai, has exerted an excellent anti-inflammatory activity, but the mechanism underlying this role is not fully understood. Here, we show that CDN blocks canonical and noncanonical NLRP3 inflammasome activation triggered by multiple stimuli. Moreover, the suppression of CDN on inflammasome activation is specific to NLRP3, not to NLRC4 or AIM2 inflammasome. Besides, the inhibitory effect is not dependent on the expression of NF-κB-mediated inflammasome precursor proteins. We also demonstrate that CDN suppresses the NLRP3 inflammasome through blocking ASC oligomerization and speckle formation in a dose-dependent manner.Importantly, CDN improves the survival of mice suffering from lethal septic shock and attenuates IL-1βproduction induced by LPS in vivo, which is shown to be NLRP3 dependent. In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases. | Zhilei Wang Guang Xu Yuan Gao Xiaoyan Zhan Nan Qin Shubin Fu Ruisheng Li Ming Niu Jiabo Wang Youping Liu Xiaohe Xiao Zhaofang Bai | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 19 |
| 3 | 生物合理设计光系统Ⅱ抑制剂研究(Ⅱ)3-苯甲氨基-2-氰基-3-甲硫基丙烯酸乙酯的晶体及分子结构显示文摘合成了具有良好光合作用抑制活性的标题化合物,测定了其晶体结构.确定了该类化合物的顺反构型,阐明了苯环与氨基间亚甲基对化合物抑制活性的重要作用,解释了氨基氢与酯羰基氧间没有形成氢键的原因. | LIU Hua Yin *, YANG Guang Fu, LU Rong Jian, TAN Hui Fen, YANG Hua Zheng (The Institute of Elemento Organic Chemistry, National Elemento Organic Chemistry Key Laboratory, Nankai University, Tianjin, 300071) LAI Lu Hua (The Institute of Physical Chemist | 1998 | 高等学校化学学报1998，19，6： | 10 |
| 4 | A Novel Semiconductor CIGS Photovoltaic Material and Thin-Film ED Technology显示文摘In order to achieve low cost high efficiency thin film solar cells,a novel Semiconductor Photovoltaic (PV) active material CuIn 1-x Ga x Se 2 (CIGS) and thin film Electro Deposition (ED) technology is explored.Firstly,the PV materials and technologies is investigated,then the detailed experimental processes of CIGS/Mo/glass structure by using the novel ED technology and the results are reported.These results shows that high quality CIGS polycrystalline thin films can be obtained by the ED method,in which the polycrystalline CIGS is definitely identified by the (112),(204,220) characteristic peaks of the tetragonal structure,the continuous CIGS thin film layers with particle average size of about 2μm of length and around 1 6μm of thickness.The thickness and solar grade quality of CIGS thin films can be produced with good repeatability.Discussion and analysis on the ED technique,CIGS energy band and sodium (Na) impurity properties,were also performed.The alloy CIGS exhibits not only increasing band gap with increasing x ,but also a change in material properties that is relevant to the device operation.The beneficial impurity Na originating from the low cost soda lime glass substrate becomes one prerequisite for high quality CIGS films.These novel material and technology are very useful for low cost high efficiency thin film solar cells and other devices. | ZHENG Guang fu 1,YANG Hong xing 1,MAN Cheuk ho 1,WONG Wing lok 2, AN Da wei 1 and John BURNETT 1(1 Centre for Development of Solar Energy Technology,Department of Building Services Engineering, The Hong Kong Polytechnic University,Hong Kong,C | 2001 | Journal of Semiconductors2001，22，11： | 10 |
| 5 | Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity显示文摘Psoraleae Fructus(PF)is a well-known traditional herbal medicine in China,and it is widely used for osteoporosis,vitiligo,and other diseases in clinical settings.However,liver injury caused by PF and its preparations has been frequently reported in recent years.Our previous studies have demonstrated that PF could cause idiosyncratic drug-induced liver injury(IDILI),but the mechanism underlying its hepatotoxicity remains unclear.This paper reports that bavachin isolated from PF enhances the specific stimuli-induced activation of the NLRP3 inflammasome and leads to hepatotoxicity.Bavachin boosts the secretion of IL-ip and caspase-1 caused by ATP or nigericin but not those induced by poly(I:C),monosodium urate crystal,or intracellular lipopolysaccharide.Bavachin does not affect AIM2 or NLRC4 inflammasome activation.Mechanistically,bavachin specifically increases the production of nigericin-induced mitochondrial reactive oxygen species among the most important upstream events in the activation of the NLRP3 inflammasome.Bavachin increases the levels of aspartate transaminase and alanine aminotransferase in serum and hepatocyte injury accompanied by the secretion of IL-ip via a mouse model of lipopolysaccharide-mediated susceptibility to IDILI.These results suggest that bavachin specifically enhances the ATP-or nigericin-induced activation of the NLRP3 inflammasome.Bavachin also potentially contributes to PF-induced idiosyncratic hepatotoxicity.Moreover,bavachin and PF should be evaded among patients with diseases linked to the ATP-or nigericin-mediated activation of the NLRP3 inflammasome,which may be a dangerous factor for liver injury. | Nan Qin Guang Xu Yan Wang Xiaoyan Zhan Yuan Gao Zhilei Wang Shubin Fu Wei Shi Xiaorong Hou Chunyu Wang Ruisheng Li Yan Liu Jiabo Wang Haiping Zhao Xiaohe Xiao Zhaofang Bai | 2021 | Frontiers of Medicine2021，15，4： | 9 |
| 6 | Geochemical characteristics and applications of 18α(H)-neohopanes and 17α(H)-diahopanes显示文摘Distributions and geochemical significances of 18α(H)-neohopanes and of 17α(H)-diahopanes in oils from west Xialiaohe depression of the Bohai Bay Basin have been studied. Relative abundance of 18α(H)-neohopanes and of 17α(H)-diahopanes can be effectively used as maturity parameters, in a range of medium-high mature stage, based on consideration on sedimentary-organic facies of source rocks. With a dual geochemical significance of maturity and sedimentary-organic facies, neohopane and diahopane parameters can be well used in oil-source correlation and in petroleum population division. Formation, primary concentration and preservation of precursors of rearranged hopanes are closely related to depositional conditions such as Eh-pH and clays content. A series of probable diahopanes (series D) was detected in the oils, which exhibits a similar distribution pattern and geochemical behavior as that of 17α(H)-diahopanes (series B). | WANG Chunjiang, FU Jiamo, SHENG Guoying, XIAO Qianhua, LI Jinyou, ZHANG Yali & PIAO Mingzhi1. Slate Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences. Guang/hou 510640, China 2. Department of Geosciences, Petroleum University, Beijing 102200, China 3. Institute of Petroleum Exploration and Exploitation, Liaohe Bureau of Petroleum Exploration, Panjin 240000, China | 2000 | Chinese Science Bulletin2000，45，19： | 9 |
| 7 | Synergistic effects of elevated homocysteine level and abnormal blood lipids on the onset of stroke显示文摘Hyperhomocysteinemia and abnormal blood lipids are independent risk factors for stroke.However,whether both factors exert a synergistic effect in the onset of stroke remains unclear.The present study is a retrospective analysis of 2 089 cases of stroke and 2 089 control cases of simple intervertebral disk protrusion using a paired multivariate logistic regression method.Adjusting for known confounding variables including the patients’age,gender,smoking status,alcohol consumption status,patient and family medical history,and clinical biochemical indices,elevated homocysteine level was related to the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids showed a 40.9%increase in the risk for stroke compared to patients with normal homocysteine levels and blood lipids(odds ratio 1.409;95%confidence interval1.127–1.761).These results indicate that elevated homocysteine and abnormal blood lipids exert synergistic effects in the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids are predisposed to stroke. | Lu Hao Liming Chen Xiaoyong Sai Zhefeng Liu Guang Yang Rongzeng Yan Lili Wang Caiyun Fu Xuan Xu Zhenzhen Cheng Qiang Wu Shuzhang Li | 2013 | Neural Regeneration Research2013，8，31： | 9 |
| 8 | Conceptual study of lunar-based SAR for global change monitoring显示文摘As an active microwave remote sensing imaging sensor, Synthetic Aperture Radar(SAR) plays an important role in earth observation. Here we establish a SAR system based on the platform of the moon. This will aid large-scale, constant, and long-term dynamic Earth observations to better meet the needs of global change research and to complement the space borne and airborne earth observations. Lunar-based SAR systems have the characteristics of high resolution and wide swath width. The swath width could be thousands of kilometers in the stripe mode and it could cover 40% of earth's surface with 10 meters or even higher spatial resolution in the scanning mode. Using the simplified observation model, here we quantitatively analyze the spatial resolution and coverage area of lunar-based SAR and simulate the observation on the Qinghai-Tibet plateau and the Amazon plain. The results show that this system could provide near 100% daily coverage of the Qinghai-Tibet plateau, whereas 40% to 70% daily coverage of the Amazon plain. Lunar-based SAR could provide large-scale, long-term and stable time series data in order to support future research of global change. | GUO HuaDong DING YiXing LIU Guang ZHANG DaoWei FU WenXue ZHANG Lu | 2014 | Science China Earth Sciences2014，57，8： | 8 |
| 9 | Distribution characteristics of poly-and perfluoroalkyl substances in the Yangtze River Delta显示文摘In this work, a method was developed and optimized for the analysis of polyfluoroalkyl and/or perfluoroalkyl substances(PFASs) content in surface water and sediment samples with high instrumental response and good separation. Surface water and sediment samples were collected from the Yangtze River Delta(YRD) to analyze the distribution characteristics of perfluoroalkyl carboxylic acids(PFCAs), perfluoroalkane sulfonic acids(PFSAs), perfluoroalkyl phosphonic acids(PFPAs), perfluoroalkyl phosphinic acids(PFPiAs), and polyfluoroalkyl phosphoric acid diesters(di PAPs). The results showed that the total concentrations of PFCAs and PFSAs in YRD varied from 31 to 902 ng/L. PFCAs(≥ 11 carbons) and PFSAs(≥ 10 carbons atoms) were not detected in any surface water samples. The mean concentrations of all PFCAs and PFSAs in surface water from the sampling areas decreased in the following order:Yangtze river(191 ng/L) ≈ Taihu lake(189 ng/L) > Huangpu river(122 ng/L) ≈ Qiantang river(120 ng/L) > Jiaxing urban river(100 ng/L). Strong significant(p < 0.05) correlations between the concentrations of many of the compounds were found in the sampling areas, suggesting a common source for these compounds. Only perfluorooctanoic acid(PFOA) was observed in all sediment samples, at concentrations varying from 0.02 to 1.35 ng/g. Finally, detection rates of two di PAPs were only 8% and 10%, respectively and the concentration of di PAPs was two to three times lower compared to PFCAs and PFSAs. | Binghui Zheng Xiaolei Liu Rui Guo Qing Fu Xingru Zhao Shanjun Wang Sheng Chang Xing Wang Mengjiao Geng Guang Yang | 2017 | Journal of Environmental Sciences2017，29，11： | 8 |
| 10 | Characterization of neurovascular compression in facial neuralgia patients by 3D high-resolution MRI and image fusion technique显示文摘Objective:To describe the anatomical characteristics and patterns of neurovascular compression (NVC) in patients suffering trigeminal neuralgia(TN) by 3D high-resolution magnetic resonance imaging(MRI) method and image fusion technique.Methods:The anatomic structure of trigeminal nerve,brain stem and blood vessel was observed in 100 consecutive TN patients by 3D high resolution MRI(3D SPGR,contrast-enhanced T1 3D MP-RAGE and T2/T1 3D FIESTA). The 3D image sources were fused and visualized using 3D DOCTOR software.Results:One or several NVC sites,which usually appeared 0-9.8 mm away from brain stem,were found on the symptomatic side in 93%of the TN cases.Superior cerebellar artery was involved in 76%(71/93) of these cases.The other vessels including antero-inferior cerebellar artery,vertebral artery, basilar artery and veins also contributed to the occurrence of NVC.The NVC sites were found to be located in the proximal segment in 42%of these cases(39/93) and in the distal segment in 45% (42/93).Nerve dislocation or distortion was observed in 32%(30/93).Conclusions:Various 3D high resolution MRI methods combined with the image fusion technique could provide pathologic anatomic information for the diagnosis and treatment of TN. | Jing Chen Zi-Yi Guo Guang Yang Xiong Wang Qing-Yu Tang Yue-Qiong Cheng Yi Guo Shui-Xi Fu Cai-Xiang Chen Xiang-Jun Han | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，6： | 7 |
| 11 | Evaluation of the Sensitivity and Specificity of the New Clinical Diagnostic and Classification Criteria for Kashin-Beck Disease,an Endemic Osteoarthritis,in China显示文摘这研究试图评估敏感和特性新临床诊断并且为用六个临床的标记的 Kashin 山涧疾病(KBD ) 的分类标准:手指的远侧的部分的屈曲,使变形的手指,扩大手指关节,弄短的手指,蹲下来,并且侏儒症。在 Linyou 县的三分之一个张全部的人口被成层的随机的采样取样。调查包括了基线特征并且临床诊断,并且新标准的敏感和特性被评估。我们鉴别 3,459 个 KBD 病人, 69 早有上演 KBD, 1,952 有的舞台我, 1,132 有的阶段 II,和 306 有的阶段 III。分类的屏蔽测试作为舞台扩大了手指关节我 KBD 与 0.978 和 0.045 的敏感和特性,分别地。分别地,弄短的手指作为阶段 II KBD 被分类,与 0.969 和 0.844 的敏感和特性,侏儒症分别地与 0.951 和 0.992 的敏感和特性作为阶段 III KBD 被分类。连续屏蔽测试表明 KBD 的新临床的分类分类阶段与 0.949, 0.945,和 0.925 的敏感和 0.967, 0.970,和 0.993 的特性我, II,和 III KBD 分别地。屏蔽测试表明扩大手指关节,弄短的手指,和侏儒症是为有高敏感和特性的 KBD 的临床的诊断和分类的适当标记。 | YU Fang Fang PING Zhi Guang YAO Chong WANG Zhi Wen WANG Fu Qi GUO Xiong | 2017 | Biomedical and Environmental Sciences2017，30，2： | 6 |
| 12 | Genetic Diversity and Population Structure for the Conservation of Giant Spiny Frog(Quasipaa spinosa)Using Microsatellite Loci and Mitochondrial DNA显示文摘The giant spiny frog(Quasipaa spinosa) is an endangered species with a relatively small distribution limited to southern China and Northern Vietnam. This species is becoming increasingly threatened because of over-exploitation and habitat degradation. This study provides data on the genetic diversity and population genetic structure of the giant spiny frog to facilitate the further development of effective conservation recommendations for this economically important but threatened species. We examined 10 species-specific microsatellite loci and Cyt b genes(562 bp) collected from 13 wild populations across the entire range of this species. Results of 10 microsatellite loci analysis showed a generally high level of genetic diversity. Moreover, the genetic differentiation among all 12 populations was moderate to large(overall F_(ST) = 0.1057). A total of 51 haplotypes were identified for Cyt b, which suggests high haplotype nucleotide diversities. Phylogeographic and population structure analyses using both DNA markers suggested that the wild giant spiny frog can be divided into four distinct major clades, i.e., Northern Vietnam, Western China, Central China, and Eastern China. The clades with significant genetic divergence are reproductively isolated, as evidenced by a high number of private alleles and strong incidence of failed amplification in microsatellite loci. Our research, coupled with other studies, suggests that Q. spinosa might be a species complex within which no detectable morphological variation has been revealed. The four phylogenetic clades and some subclades with distinct geographical distribution should be regarded as independent management units for conservation purposes. | Danna YU Rongquan ZHENG Qinfang LU Guang YANG Yao FU Yun ZHANG | 2016 | Asian Herpetological Research2016，7，2： | 5 |
| 13 | A stochastic method for convective storm identification,tracking and nowcasting显示文摘对流暴风雨鉴定,追踪并且现在扔方法是迎着严重对流天气的重要现在扔方法论之一。在严重对流盒子中,例如暴风雨形状或快速的速度变化,存在方法是,追踪并且现在扔结果容易的提供未得到满足的暴风雨鉴定。克服这些困难,这篇论文建议一条新奇途径识别,轨道和对流暴风雨的短期的预报(扔的现在) 。一个数学基于形态学的暴风雨鉴定方法被采用它能在暴风雨的簇精确地识别暴风雨房间。至于困难的追踪问题,顺序的蒙特卡罗(SMC ) 方法被利用简化追踪的过程。它处理暴风雨失踪的盒子内在地对处理复杂裂口和兼并不仅合适,而且有能力察觉。为了提供暴风雨的更多的精确预报,放,这个方法拿跨关联的方法的优点。质、量的评估显示出建议途径的效率和坚韧性。 | Lei Han Shengxue Fu Guang Yang Hongqing Wang Yongguang Zheng Yingjing Lin | 2008 | Progress in Natural Science:Materials International2008，18，12： | 5 |
| 14 | CONCEPT, DISTRIBUTION LAW AND FORMATION MACHANISM OF INLAND SALINE ALKALINE WETLAND─ ─ Taking Songliao Plain for Example显示文摘The paper, taking Songliao Plain for example, studied the concept, distribution law and formation mechanism of inland saline alkaline wetland. The inland saline alkaline wetland is distributed over the inland region of arid or semi arid climate; it is the wet or slightly stagnant environment, forming saline alkaline soil and salt vegetation and making the geogra phical environment fonming complex with an ecosystem of saline alkaline wetland. The laws of zone nature and non zone nature control the distribution of the inland saline alkaline wetland that extensively spreads in north part of China and other countries. The inland saline alkaline wetland is formed jointly by atmosphere, hydrosphere, lithosphere and biosphere including intellectual sphere. Under the special condition, the artificial activity is possibly the key function. In order to improve the human environment, it is a great duty confronting the whole world to rationally transform the inland saline alkaline wetland. Therefore, we presented an anti inland theory to promote the environment transformation. | SUN Guang you1, LUO Xin zheng2 , YI Fu ke1 , ZHANG Xiao ping1 (1.Changchun Institute of Geography, the Chinese Academy of Sciences,Changchun 130021,P.R.China 2.Institute of Geography, Academy of Henan Province, Zhengzhou 450052,P.R.China) | 2000 | Chinese Geographical Science2000，10，3： | 5 |
| 15 | Research on global change scientific satellites显示文摘Global change now poses a severe threat to the survival and development of mankind.Large-scale,real-time,highly accurate Earth observation from space has become a key technology used to observe global change.China is one of the most influential countries affecting and being affected by global change,yet it has no scientific satellite for global change research so far.Developing global change scientific satellites not only would meet an important demand of China,but also would be a valuable contribution to the world.By analyzing the mechanisms of space-based observation of variables sensitive to global change,this paper explores the concept of global change scientific satellites,and proposes a series of global change scientific satellites to establish a scientific observation system for global environmental change monitoring from space. | GUO HuaDong FU WenXue LI XinWu CHEN Pei LIU Guang LI Zhen WANG Cheng DONG Qing LEI LiPing BAI LinYan LIU QingJie | 2014 | Science China Earth Sciences2014，57，2： | 5 |
| 16 | Characteristics of neurovascular compression in facial neuralgia patients by 3D high-resolution MRI and fusion technology显示文摘Objective:To evaluate the anatomical characteristics and patterns of neurovascular compression in patients suffering trigeminal neuralgia,using 3D high-resolution magnetic resonance imaging methods and fusion technologies.Methods:The analysis of the anatomy of the facial nerve,brain stem and the vascular structures related to this nerve was made in 100 consecutive patients for TN.3D high resolution MRI studies(3D SPGR,T1 enhanced 3D MP-RAGE and T2/T1 3D FIESTA) simultaneous visualization were used to assessed using the software 3D DOCTOR. Results:In 93 patients(93%),there were one or several locals of neurovascular compression (NVC).The superior cerebellar artery was involved in 71 cases(76%),the other vessels including the antero-inferior cerebellar artery,the basilar artery,the vertebral artery,and some venous structures.The mean distance between NVC and nerve origin site in the brainstem was(3.76±2.90) mm).In 39 patients(42%),the vascular compression was located proximally and in 42(45%) the compression was located distally.Nerve dislocation or distortion by the vessel was observed in 30 cases(32%).Conclusions:This 3D high resolution MRI and image fusion technology could be useful for diagnostic and therapeutic decisions in TN. | Zi-Yi Guo Jing Chen Guang Yang Qian-Yu Tang Cai-Xiang Chen Shui-Xi Fu Dan Yu | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 5 |
| 17 | Pandemonium Breaks Out:Disruption of Salicylic Acid-Mediated Defense by Plant Pathogens显示文摘Salicylic acid (SA) or 2-hydroxybenoic acid is a phenolic plant hormone that plays an essential role in plant defense against biotrophic and semi-biotrophic pathogens. In Arabidopsis, SA is synthesized from chorismate in the chloroplast through the ICS1 (isochorismate synthase I) pathway during pathogen infectioru The transcription co-activator NPR1 (Non-Expresser of Pathogenesis-Related Gene 1), as the master regulator of SA signaling, interacts with transcription factors to induce the expression of anti-microbial PR (Pathogenesis-Related) genes. To establish successful in fections, plant bacterial, oomycete, fun gal, and viral pathogens have evolved at least three major strategies to disrupt SA-mediated defense? The first strategy is to reduce SA accumulation directly by converting SA into its inactive derivatives. The second strategy is to interrupt SA biosynthesis by targeting the ICS1 pathway. In the third major strategy, plant pathogens deploy different mechanisms to interfere with SA downstream signaling. The wide array of strategies deployed by plant pathogens highlights the crucial role of disruption of SA-mediated plant defense in plant pathogenesis. A deeper understanding of this topic will greatly expand our knowledge of how plant pathogens cause diseases and consequently pave the way for the development of more effective ways to corn trol these diseases. | Guang Qi Jian Chen Ming Chang Huan Chen Katherine Hall John Korin Fengquan Liu Daowen Wang Zheng Qing Fu | 2018 | Molecular Plant2018，11，12： | 5 |
| 18 | Progress in bionic information processing techniques for an electronic nose based on olfactory models显示文摘As a novel bionic analytical technique, an electronic nose, inspired by the mechanism of the biological olfactory system and integrated with modern sensing technology, electronic technology and pattern recognition technology, has been widely used in many areas. Moreover, recent basic research findings in biological olfaction combined with computational neuroscience promote its development both in methodology and application. In this review, the basic information processing principle of biological olfaction and artificial olfaction are summarized and compared, and four olfactory models and their applications to electronic noses are presented. Finally, a chaotic olfactory neural network is detailed and the utilization of several biologically oriented learning rules and its spatiotemporal dynamic propties for electronic noses are discussed. The integration of various phenomena and their mechanisms for biological olfaction into an electronic nose context for information processing will not only make them more bionic, but also perform better than conventional methods. However, many problems still remain, which should be solved by further cooperation between theorists and engineers. | LI Guang FU Jun ZHANG Jia ZHENG JunBao | 2009 | Chinese Science Bulletin2009，54，4： | 4 |
| 19 | Association between High Fat-low Carbohydrate Diet Score and Newly Diagnosed Type 2 Diabetes in Chinese Population显示文摘Objective To study the association between high fat-low carbohydrate diet score and newly diagnosed type 2 diabetes in Chinese population. Methods Data about 20 717 subjects aged 45-59 years from the cross-sectional 2002 China National Nutrition and Health Survey were analyzed. High fat-low carbohydrate diet was scored according to the energy of carbohydrate, fat, and protein. Results Of the 20 717 subjects, 1 332 were diagnosed with hyperglycemia and 662 were newly diagnosed with type 2 diabetes. Multivariate adjusted analysis showed that the highest score of type 2 diabetes patients was 2.75 (95% CI: 2.09-3.61). The score of type 2 diabetes patients was 1.87 (95% CI: 1.35-2.58) after further adjustment for their socioeconomic status and physical activity. No significant difference was found in the odds ratio after further adjustment for BMI, blood pressure, lipid level, and energy intake. No evidence was observed for the relation between high fat-low carbohydrate-diet score in type 2 diabetes patients due to high family income, less education, physical activity, overweight, hypertension, high TG, or low HDL level. Conclusion High fat-low carbohydrate diets, far different from traditional Chinese diets, are associated with the high incidence of type 2 diabetes in Chinese population. | HE Yu Na FESKENS EJ LI Yan Ping ZHANG Jian FU Ping MA Guan Sheng YANG Xiao Guang | 2012 | Biomedical and Environmental Sciences2012，25，4： | 4 |
| 20 | Compound LM9,a novel MyD88 inhibitor,efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy显示文摘Mechanisms of cardiomyopathy caused by obesity/hyperlipidemia are complicated.Obesity is usually associated with chronic low-grade inflammation and may lead to the onset and progression of myocardial fbrosis and remodeling.TLR4/MyD88 signaling pathway,as a key regulator of inflammation,plays an important role in the pathogenesis of obesity-induced cardiomyopathy.We previously demonstrated that LM9,a novel MyD88 inhibitor,attenuated inflammatory responses and fbrosis in obesity-induced cardiomyopathy by inhibiting the formation of TLR4/MyD88 complex.In this study,we investigated the protective effects of LM9 on obesity-induced cardiomyopathy in vitro and in vivo.We showed that LM9(5,10uM)significantly attenuates palmitic acid(PA)-induced infammation in mouse peritoneal macrophages,evidenced by decreased expression of proinflammatory genes including TNF-α,IL-6,IL-1β,and ICAM-1.In cardiac-derived H9C2 cell,LM9 treatment suppressed PA-induced inflammation,lipid accumulation,and fbrotic responses.In addition,LM9 treatment also inhibited PA-activated TLR4/MyD88/NF-κB signaling pathway.We further revealed in HEK293 cells that LM9 treatment blocked the TLR4/MyD88 binding and MyD88 homodimer formation.In HFD-fed mice,administration of LM9(5,10 mg/kg,ig,every other days for 8 weeks)dose-dependently alleviated inflammation and fbrosis in heart tissues and decreased serum lipid concentration.In conclusion,this study demonstrates that MyD88 inhibitor LM9 exerts protective effects against obesity-induced cardiomyopathy,suggesting LM9 to be a promising therapeutic candidate drug for the obesity-related cardiac complications. | Xu-yong Zheng Chu-chu Sun Qian Liu Xiao-yao Lu Li-li Fu Guang Liang Xiu-hua Zhang Gao-zhi Chen | 2020 | Acta Pharmacologica Sinica2020，41，8： | 4 |
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