|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Novel concepts in radiation-induced cardiovascular disease显示文摘Radiation-induced cardiovascular disease(RICVD) is the most common nonmalignant cause of morbidity and mortality among cancer survivors who have undergone mediastinal radiation therapy(RT).Cardiovascular complications include effusive or constrictive pericarditis,cardiomyopathy,valvular heart disease,and coronary/vascular disease.These are pathophysiologically distinct disease entities whose prevalence varies depending on the timing and extent of radiation exposure to the heart and great vessels.Although refinements in RT dosimetry and shielding will inevitably limit future cases of RICVD,the increasing number of long-term cancer survivors,including those treated with older higher-dose RT regimens,will ensure a steady flow of afflicted patients for the foreseeable future.Thus,there is a pressing need for enhanced understanding of the disease mechanisms,and improved detection methods and treatment strategies.Newly characterized mechanisms responsible for the establishment of chronic fibrosis,such as oxidative stress,inflammation and epigenetic modifications,are discussed and linked to potential treatments currently under study.Novel imaging modalities may serve as powerful screening tools in RICVD,and recent research and expert opinion advocating their use is introduced.Data arguing for the aggressive use of percutaneous interventions,such as transcutaneous valve replacement and drug-eluting stents,are examined and considered in the context of prior therapeutic approaches.RICVD and its treatment options are the subject of a rich and dynamic body of research,and patients who are at risk or suffering from this disease will benefit from the care of physicians with specialty expertise in the emerging field of cardiooncology. | Jason R Cuomo Gyanendra K Sharma Preston D Conger Neal L Weintraub | 2016 | World Journal of Cardiology2016，8，9： | 17 |
| 2 | S100B protein in the gut:The evidence for enteroglial-sustained intestinal inflammation显示文摘Glial cells in the gut represent the morphological and functional equivalent of astrocytes and microglia in the central nervous system (CNS). In recent years, the role of enteric glial cells (EGCs) has extended from that of simple nutritive support for enteric neurons to that of being pivotal participants in the regulation of inflammatory events in the gut. Similar to the CNS astrocytes, the EGCs physiologically express the S100B protein that exerts either trophic or toxic effects depending on its concentration in the extracellular milieu. In the CNS, S100B overexpression is responsible for the initiation of a gliotic reaction by the release of pro-inflammatory mediators, which may have a deleterious effect on neighboring cells. S100B-mediated pro-inflammatory effects are not limited to the brain: S100B overexpression is associated with the onset and maintenance of inflammation in the human gut too. In this review we describe the major features of EGCs and S100B protein occurring in intestinal inflammation deriving from such. | Carla Cirillo Giovanni Sarnelli Giuseppe Esposito Fabio Turco Luca Steardo Rosario Cuomo | 2011 | World Journal of Gastroenterology2011，17，10： | 16 |
| 3 | Irritable bowel syndrome and food interaction显示文摘Irritable bowel syndrome(IBS) is one of the most common gastrointestinal disorders in Western countries. Despite the high prevalence of this disorders, the therapeutic management of these patients is often unsatisfactory. A number of factors have been suggested to be involved in the pathogenesis of IBS, including impaired motility and sensitivity, increased permeability, changes in the gut microbiome and alterations in the brain-gut axis. Also food seems to play a critical role: the most of IBS patients report the onset or the exacerbation of their symptoms after the meals. Recently, an increasing attention has been paid to the role of food in IBS. In this review we summarize the most recent evidences about the role of diet on IBS symptoms. A diet restricted in fermentable, poorly absorbed carbohydrates and sugar alcohols has beneficial effects on IBS symptoms. More studies are needed to improve our knowledge about the relationship between food and IBS. However, in the foreseeable future, dietary strategies will represent one of the key tools in the therapeutic management of patients with IBS. | Rosario Cuomo Paolo reozzi Francesco Paolo Zito Valentina Passananti Giovanni De Carlo Giovanni Sarnelli | 2014 | World Journal of Gastroenterology2014，20，27： | 11 |
| 4 | Outcome of nonerosive gastro-esophageal reflux disease patients with pathological acid exposure显示文摘AIM: To assess the management and outcome of nonerosive gastro-esophageal reflux disease (NERD) patients who were identified retrospectively, after a 5-year follow-up.METHODS: We included patients with gastro-esophageal reflux disease (GERD) symptoms who had a negative endoscopy result and pathological 24-h esophageal pH-monitoring while off therapy. We interviewed them after an average period of 5 years (range 3.5-7 years) by means of a structured questionnaire to assess presence of GERD symptoms, related therapy, updated en-doscopic data and other features. We assessed predictors of esophagitis development by means of univariate and multivariate statistical analysis.RESULTS: 260 patients (137 women) were included. Predominant GERD symptoms were heartburn andregurgitation in 103/260 (40%). 70% received a maintenance treatment, which was proton pump inhibitor (PPI) in 55% of cases. An average number of 1.5 symptomatic relapses per patient/year of follow-up were observed. A progression to erosive gastro-esophageal reflux disease (ERD) was found in 58/193 (30.0%) of patients undergoing repeat endoscopy; 72% of these were Los Angeles grade A-B. CONCLUSION: This study shows that progression to ERD occurs in about 5% of NERD cases per year, despite therapy. Only two factors consistently and independently influence progression: smoking and absence of PPI therapy. | Fabio Pace Stefano Pallotta Gianpiero Manes Annalisa de Leone Patrizia Zentilin Luigi Russo Vincenzo Savarino Matteo Neri Enzo Grossi Rosario Cuomo | 2009 | World Journal of Gastroenterology2009，15，45： | 8 |
| 5 | Present and future of metastatic colorectal cancer treatment: A review of new candidate targets显示文摘In the last two decades, great efforts have been made in the treatment of metastatic colorectal cancer(m CRC) due to the approval of new target agents for cytotoxic drugs. Unfortunately, a large percentage of patients present with metastasis at the time of diagnosis or relapse after a few months. The complex molecular heterogeneity of this disease is not completely understood; to date, there is a lack of predictive biomarkers that can be used to select subsets of patients who may respond to target drugs. Only the RAS-mutation status is used to predict resistance to anti-epidermal growth factor receptor agents in patients with m CRC. In this review, we describe approved targeted therapies for the management of metastatic m CRC and discuss new candidate targets on the horizon. | Giulia Martini Teresa Troiani Claudia Cardone Pietropaolo Vitiello Vincenzo Sforza Davide Ciardiello Stefania Napolitano Carminia Maria Della Corte Floriana Morgillo Antonio Raucci Antonio Cuomo Francesco Selvaggi Fortunato Ciardiello Erika Martinelli | 2017 | World Journal of Gastroenterology2017，23，26： | 7 |
| 6 | Eosinophilic esophagitis: From pathophysiology to treatment显示文摘Eosinophilic esophagitis(Eo E) is a chronic immune disease, characterized by a dense eosinophilic infiltrate in the esophagus, leading to bolus impaction and refluxlike symptoms. Traditionally considered a pediatric disease, the number of adult patients with Eo E is continuously increasing, with a relatively higher incidence in western countries. Dysphagia and food impaction represent the main symptoms complained by patients, but gastroesophageal reflux-like symptoms may also be present. Esophageal biopsies are mandatory for the diagnosis of Eo E, though clinical manifestations and proton pump inhibitors responsiveness must be taken into consideration. The higher prevalence of Eo E in patients suffering from atopic diseases suggests a common background with allergy, however both the etiology and pathophysiology are not completely understood. Elimination diets are considered the firstline therapy in children, but this approach appears less effective in adults patients, who often require steroids; despite medical treatments, Eo E is complicated in some cases by esophageal stricture and stenosis, that require additional endoscopic treatments. This review summarizes the evidence on Eo E pathophysiology and illustrates the safety and efficacy of the most recent medical and endoscopic treatments. | Alessandra D’Alessandro Dario Esposito Marcella Pesce Rosario Cuomo Giovanni Domenico De Palma Giovanni Sarnelli | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 4 |
| 7 | Microbiota in health and irritable bowel syndrome: current knowledge, perspectives and therapeutic options显示文摘 | Leonilde Bonfrate Jan Tack Ignazio Grattagliano Rosario Cuomo Piero Portincasa | 2013 | Scandinavian Journal of Gastroenterology2013，，9： | 3 |
| 8 | 对上面的胃肠的道的活动性混乱的基因贡献显示文摘 Motility disorders of the upper gastrointestinal tract encompass a wide range of different diseases. Esophageal achalasia and functional dyspepsia are representative disorders of impaired motility of the esophagus and stomach, respectively. In spite of their variable prevalence, what both diseases have in common is poor knowledge of their etiology and pathophysiology. There is some evidence showing that there is a genetic predisposition towards these diseases, especially for achalasia. Many authors have investigated the possible genes involved, stressing the autoimmune or the neurological hypothesis, but there is very little data available. Similarly, studies supporting a post-infective etiology, based on an altered immune response in susceptible individuals, need to be validated. Further association studies can help to explain this complex picture and find new therapeutic targets. The aim of this review is to summarize current knowledge of genetics in motility disorders of the upper gastrointestinal tract, addressing how genetics contributes to the development of achalasia and functional dyspepsia respectively. | Giovanni Sarnelli Alessandra D’Alessandro Marcella Pesce Ilaria Palumbo Rosario Cuomo | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，4： | 3 |
| 9 | Symptom Patterns and Pathophysiological Mechanisms in Dyspeptic Patients with and Without Helicobacter pylori显示文摘 | Giovanni Sarnelli Rosario Cuomo Jozef Janssens Jan Tack | 2003 | Digestive Diseases and Sciences2003，，12： | 2 |
| 10 | Circuit implementation of synchronization chaos with applications to communications 显示文摘 | Cuomo K M Oppenheim A V | 1993 | Int Bifurcation Chaos1993，，3： | 2 |
| 11 | Circuit implementation of synchronized chaos with application to communications显示文摘 | CUOMO K M OPPENHEIM A V | 1993 | Phys Rev Lett1993，71，1： | 2 |
| 12 | Compromised nutritional status in patients with end-stage liver disease:Role of gut microbiota显示文摘Background: Patients with end-stage liver disease(ESLD) have a compromised nutritional status because of the liver crucial role in regulating metabolic homeostasis and energy balance.Data sources: A systematic review of literature based on extensive relevant articles published from 2001 to 2017 in English in Pub Med database was performed by searching keywords such as liver disease, nonalcoholic liver disease, alcoholic liver disease, malnutrition, epigenetics, gut microbiota, and probiotics.Results: Liver transplantation would be one eligible therapy for ESLD patients, even if, the clinical outcome is negatively influenced by malnutrition and/or infections. The malnutrition is a condition of nutrient imbalance with a high incidence in ESLD patients. An accurate evaluation of nutritional status could be fundamental for reducing complications and prolonging the survival of ESLD patients including those undergoing liver transplantation. In addition, the interaction among nutrients, diet and genes via epigenetics has emerged as a potential target to reduce the morbidity and mortality in ESLD patients. The malnutrition induces changes in gut microbiota causing dysbiosis with a probable translocation of bacteria and/or pathogen-derived factors from the intestine to the liver. Gut microbiota contribute to the progression of chronic liver diseases as well as hepatocellular carcinoma. The administration of probiotics modulating gut microbiota could improve all chronic liver diseases.Conclusions: This review provides an update on malnutrition status linked to epigenetics and the potential benefit of some probiotics on the management of ESLD patients. In support of this view and to reveal the constant and growing interest in this field, some clinical trials are reported. | Maria Vasco Rossella Paolillo Concetta Schiano Linda Sommese Oreste Cuomo Claudio Napoli | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，4： | 2 |
| 13 | Diagnostic value of the ration of recovery sysolic blood pressure to peak exercise systolic blood pressure for the detection of coronary artery disease显示文摘 | Acanfora D DeCaprio LC Cuomo S | 1988 | Circulation1988，77，6： | 1 |
| 14 | Developments in broad beam ion source technology and applications显示文摘 | Harper J M E Cuomo J J | 1983 | J Vac Sci Technol A1983，1，2： | 1 |
| 15 | Effect of dynamic myocardial dyssynchrony on mitral regurgitation during supine bicycle exercise stress echoeardiography in patients with idiopathic dilated cardiomyopathy and 'narrow' QRS显示文摘 | D'Andrea A Caso P Cuomo S | 2007 | Eur Heart J2007，28，8： | 1 |
| 16 | Infrared and Raman spectra of the Silicon-hydrogen bonds in amor- phous silicon prepared by glow discharge and sputter- ing显示文摘 | Brodsky M H Cardona M Cuomo J J | 1977 | Phys Rev B1977，16，： | 1 |
| 17 | Radio resource sharing for ad hoc networking with UWB显示文摘 | CUOMO F MARTELLO C BAIOCCHI A | 2002 | IEEE J Sel Areas Commun2002，20，9： | 1 |
| 18 | Technology and applications of broad beam ion sources used in sputtering(Part 2): Application显示文摘 | Harper J M E Cuomo J J | 1982 | J Vac Sci Technol1982，21，3： | 1 |
| 19 | Femoral attachment of the anterior cruciate ligament显示文摘 | Giron F Cuomo P Aglietti P | | 0，，： | 1 |
| 20 | Phase II study with ifosfamide,carboplatin,etoposide (ICE regimen) at intermediate dosage for advanced non small cell lung cancer (NSCLC) 显示文摘 | Preti P Poggi G Cuomo AM | 1998 | J Chemother1998，10，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员