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	题名	作者	年代	出处	被引量
1	Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound显示文摘AIM:To evaluate whether contrast enhanced ultrasound(CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer.METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal cancer underwent CEUS before treatment(CEUS date 1) and before the second(CEUS date 2) and fourth(CEUS date 3) cycle of bevacizumab based chemotherapy.Three parameters [PEAK,Time to peak(TTP) and RISE RATE]were correlated with radiological response.RESULTS:For neoadjuvant purpose a reduction of tumour mass was required to assume clinical response.Based on these response criteria there was a significant(P < 0.001) correlation in TTP between metastases of responders(9.08 s) and non-responders(14.76 s) archived on CEUS date 1.By calculating a standardized quotient(metastases divided by normal liver tissue) we were able to define a cut off,predicting response with a sensitivity of 92.3 % and a specificity of 100 %.To reflect a palliative intention only those patients with progressive disease were classified as non-responders.In this stetting TTP was also significantly(P < 0.01) different between responders and non-responders.In contrast,Peak and Rise rate did not show any significant difference between responder and non-responder.CONCLUSION:CEUS might serve as a surrogate marker to predict treatment response in patients with metastasized colorectal cancer who receive antiangiogenic therapy.	Ramin Schirin-Sokhan Ron Winograd Christoph Roderburg Jhenee Bubenzer Nicole Cabral do ó Dorothee Guggenberger Hartmut Hecker Christian Trautwein Jens J W Tischendorf	2012	World Journal of Gastroenterology2012，18，6：	16
2	Role of circulating microRNAs in liver diseases显示文摘MicroRNAs(miRNAs) are small RNAs regulate gene expression by inhibiting the turnover of their target mRNAs. In the last years, it became apparent that miRNAs are released into the circulation and circulating miRNAs emerged as a new class of biomarkers for various diseases. In this review we summarize available data on the role of circulating miRNAs in the context of acute and chronic liver diseases including hepatocellular and cholangiocellular carcinoma. Data from animal models are compared to human data and current challenges in the field of miRNAs research are discussed.	Sven H Loosen Florian Schueller Christian Trautwein Sanchari Roy Christoph Roderburg	2017	World Journal of Hepatology2017，9，12：	7
3	Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis显示文摘	Christoph Roderburg Gerd‐Willem Urban Kira Bettermann Mihael Vucur Henning Zimmermann Sabine Schmidt J?rn Janssen Christiane Koppe Percy Knolle Mirco Castoldi Frank Tacke Christian Trautwein Tom Luedde	2011	Hepatology2011，，1：	3
4	Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis显示文摘	Roderburg C Urban GW Bettermann K		0，，：	1
5	The fractalkine receptor CX3CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes显示文摘	Karlmark KR Zimmermann HW Roderburg C	2010	Hepatology2010，52，5：	1
6	Circulating mi- croRNA-150 serum levels predict survival in patients with critical illness and sepsis显示文摘	Roderburg C Luedde M Vargas Cardenas D	2013	PLoS One2013，8，54：	1
7	Mi-cro -RNA profiling reveals a role for miR -29 in human and mu-rine liver fibrosis显示文摘	RODERBURG C URBAN GW BETTERMANN K	2011	Hepatology2011，53，1：	1
8	Circulating microRNAs as markers of liver in- flammation, fibrosis and cancer 显示文摘	Roderburg C Luedde T	2014	J Hepatol2014，61，6：	1
9	Micro-RNA profilingreveals a role for miR-29 in human and murine liver fibrosis显示文摘	Roderburg C Urban GW Bettermann K	2011	Hep-atology2011，53，1：	1
10	Circulating mieroRNA-150 serum levels predict survival in patients with critical illness and sepsis显示文摘	Roderburg C Luedde M Cardenas D	2013	PLoS one2013，8，54：	1
11	Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis显示文摘	Roderburg C Urban GW Bettermann K	2011	Hepatology2011，35，1：	1
12	The role of the gut micro-biome in the development and progression of liver cirrhosis and hepatocellu- lar carcinoma显示文摘	RODERBURG C LUEDDE T	2014	Gut Microbes2014，，4：	1
13	U6 is un-suitable for normalization of serum miRNA levels in patientswith sepsis or liver fibrosis显示文摘	BENZ F RODERBURG C CARDENAS DV	2013	Exp Mol Med2013，45，：	1
14	Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis显示文摘	Roderburg C Urban GW Bettermann K Vucur M Zimmermann H Schmidt S	2011	Hepatology2011，53，1：	1
15	Micro-RNA profi- ling reveals a role for miR-29 in human and murine liver fibrosis 显示文摘	Roderburg C Urban GW Bettermann K	2011	Hepatology2011，53，1：	1
16	Serum concentrations of A Proliferation-Inducing Ligand(APRIL)are elevated in sepsis and predict mortality in critically ill patients显示文摘	Roderburg C Koch A Tacke F	2013	J Crit Care2013，28，5：	1
17	miR-133a Mediates TGF-β-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis显示文摘	Roderburg C Luedde M Vargas Cardenas D Vucur M Mollnow T Zimmermann HW	2013	J Hepatol2013，58，4：	1
18	Miero-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR- 652 in liver cirrhosis 显示文摘	Roderburg C Mollnow T Bongaerts B	2012	PLoS One2012，7，32：	1
19	Levels of circulating miR- 133a are elevated in sepsis and predict mortality in critically ill patients 显示文摘	Tacke F Roderburg C Benz F	2014	Crit Care Med2014，42，5：	1
20	MicroRNA profiling re- veals a role for miR -29 in human and murine liver fibrosis显示文摘	Roderburg C Urban GW Bettermann K	2011	Hepa- tology2011，53，1：	1

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