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| 1 | DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination显示文摘 | Weihua Qin Patricia Wolf Nan Liu Stephanie Link Martha Smets Federica La Mastra Ignasi Forne Garwin Pichler David Horl Karin Fellinger Fabio Spada Ian Marc Bonapace Axel Imhof Hartmann Harz Heinrich Leonhardt | 2015 | Cell Research2015，25，8： | 5 |
| 2 | CREMa overexpression decreases IL-2 production,induces a TH17 phenotype and accelerates autoimmunity显示文摘Dear Editor,External cytokines produced by cells of the innate immune system induce the dif-ferentiation of CD4+T cells into helper T cell subsets with distinct functions and cytokine profiles.Apart from TH1 and TH2 cells a third subset of helper T cells has been described,which is characterized by increased expression of IL-17A,IL-17F,IL-21 and IL-22(TH17 cells). | Ralph Lippe Kim Ohl Georg Varga Thomas Rauen Jose C.Crispin Yuang-Taung Juang Stefanie Kuerten Frank Tacke Marc Wolf Kirsten Roebrock Thomas Vogl Eva Verjans Nora Honke Jan Ehrchen Dirk Foell Boris Skryabin Norbert Wagner George C.Tsokos Johannes Roth Klaus Tenbrock | 2012 | Journal of Molecular Cell Biology2012，4，2： | 2 |
| 3 | A Short Amino-Terminal Part of Arabidopsis Phytochrome A Induces Constitutive Photomorphogenic Response显示文摘Phytochrome A (phyA ) 是在 Arabidopsis thaliana 察觉到的 far-red 光的主导的光敏电阻器。phyA 在发信号的变白的幼苗,和导致光的 phyA 的细胞质在高水平积累被一个复杂规章的网络调停。这包括光 -- 并且进在 vivo 的原子核的本国的 phyA 的 FHY1/FHL 蛋白质依赖者 translocation。phyA (PHYA406 ) 的短 N 终端碎片对 phenocopy 足够,这也被显示出在 vitro 的这个高度调整的细胞的过程。为了测试这 N 终端的生物活动,在 planta phyA 碎裂,我们生产了表示 PHYA406YFP 的转基因的 phyA-201 植物(黄荧光灯蛋白质) DD, PHYA406YFPDDNLS (原子本地化信号) ,和 PHYA406YFPDDNES (原子出口信号) 熔化蛋白质。这里,我们报导 PHYA406YFPDD 被进口进原子核,而 PHYA406YFPDDNLS 和 PHYA406YFPDDNES 显示期望的组成的本地化模式,这进程部分是轻依赖者的。我们的结果证明这些截断的 phyA 蛋白质是轻马厩的,当局部性时,他们在他们的原子核,和两个都不触发组成的象 photomorphogenic 一样回答导致合适的 phyA 发信号。我们证明在 vitro 并且在 vivo PHYA406, Pfr 和 Pr 绑 COP1, photomorphogenesis 的一个一般抑压者,并且在原子身体与它共同本地化。因此,我们断定在 planta,截断的 PHYA406 蛋白质以一种光无关的方式在原子核使 COP1 失去活性。 | Andra's Viczia'n E'va Ada'm Iris Wolf Ja'nos Bindics Stefan Kircher Marc Heijde Roman Ulm Eberhard Scha'fer Ferenc Nagy | 2012 | Molecular Plant2012，5，3： | 2 |
| 4 | Icnemia/reperfusion-induced INF-gup-regulation involvement of IL-12 and IL-18显示文摘 | Daemen MARC van't Veer C Wolfs TGAM | 1999 | Immunol1999，162，： | 1 |
| 5 | A Mutation in VPS35 , Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease显示文摘 | Alexander Zimprich Anna Benet-Pagès Walter Struhal Elisabeth Graf Sebastian H. Eck Marc N. Offman Dietrich Haubenberger Sabine Spielberger Eva C. Schulte Peter Lichtner Shaila C. Rossle Norman Klopp Elisabeth Wolf Klaus Seppi Walter Pirker Stefan Presslau | 2011 | The American Journal of Human Genetics2011，，1： | 1 |
| 6 | Wild- tpe KRAS is required for panitumumab efficacy in patients with meta- static colorectal cancer显示文摘 | Rafael G Amado Michael Wolf Marc Peeters | 2008 | J Clin Onco12008，26，： | 1 |
| 7 | Surgical Ablation of Atrial Fibrillation显示文摘 | A. Marc Gillinov Randall K. Wolf | 2005 | Progress in Cardiovascular Diseases2005，，3： | 1 |
| 8 | Metabolic Activation of Intrahepatic CD8 + T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes显示文摘 | Monika Julia Wolf Arlind Adili Kira Piotrowitz Zeinab Abdullah Yannick Boege Kerstin Stemmer Marc Ringelhan Nicole Simonavicius Michèle Egger Dirk Wohlleber Anna Lorentzen Claudia Einer Sabine Schulz Thomas Clavel Ulrike Protzer Christoph Thiele Hans Zisc | 2014 | Cancer Cell2014，，4： | 1 |
| 9 | Remote sensing of the urban heat island effect across biomes in the continental USA显示文摘 | Marc L. Imhoff Ping Zhang Robert E. Wolfe Lahouari Bounoua | 2009 | Remote Sensing of Environment2009，，3： | 1 |
| 10 | Translational Control of Cell Division by Elongator显示文摘 | Fanelie Bauer Akihisa Matsuyama Julie Candiracci Marc Dieu Judith Scheliga Dieter A. Wolf Minoru Yoshida Damien Hermand | 2012 | Cell Reports2012，，5： | 1 |
| 11 | The influence of major depression and its treatment on heart rate variability and pupillary light reflex parameters显示文摘 | Karl-Jürgen B?r Wolf Greiner Thomas Jochum Marc Friedrich Gerd Wagner Heinrich Sauer | 2004 | Journal of Affective Disorders2004，，2： | 1 |
| 12 | Ischemic stroke in young adults: classification and risk factors显示文摘 | Anastasios Chatzikonstantinou Marc E. Wolf Michael G. Hennerici | 2012 | Journal of Neurology2012，，4： | 1 |
| 13 | An overview of acute stroke therapy: past,present, and future 显示文摘 | Marc F Wolf S | 2000 | Arch Intern Med2000，160，： | 1 |
| 14 | Video-assisted bilateral pulmonary vein isolation and left atrial appendage exclusion for atrial fibrillation显示文摘 | Randall K. Wolf E. William Schneeberger Robert Osterday Doug Miller Walter Merrill John B. Flege A. Marc Gillinov | 2005 | The Journal of Thoracic and Cardiovascular Surgery2005，，3： | 1 |
| 15 | 活化的RET和ROS:肺腺癌新的驱动基因显示文摘ROS1和RET的基因重排是新发现的肺腺癌驱动基因,各自突变频率约为1%。肺腺癌中RET和ROS1基因重排与其他已知的驱动基因几乎没有重叠,成为独立的新的肺腺癌分子亚型。肺腺癌中ROS1和RET突变基因的临床病理学特征已经阐明,体外实验也证实数种多靶点受体激酶抑制剂能抑制含ROS1和RET突变基因的非小细胞肺癌(non-small cell lung cancer,NSCLC)细胞系。而临床研究显示MET/ALK/ROS抑制剂克唑替尼在ROS1突变阳性的肺癌患者中疗效显著。目前,正开展一些针对肺腺癌ROS1和RET基因的各种激酶抑制剂的早期临床试验。针对这些基因突变的新的肺腺癌亚群的个体化治疗极有可能在不久的将来作为常规的临床治疗措施。 | Marc Bos Masyar Gardizi Hans-Ulrich Schidhaus Reinhard Buettner Juergen Wolf 王允芬(译) 宋勇(审校) | 2014 | 临床与病理杂志2014，34，2： | 0 |
| 16 | Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma:Real-life Data on Liver Disease,Treatment and Prognosis显示文摘Background and Aims:Hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(iCCA)have common features and differences.This real-life study investigated their characteristics,treatment modalities,and prognoses.Methods:This retrospective comparative study was performed in 1,075 patients seen at one tertiary center between January 2008 and December 2020.Overall survival(OS)was estimated by the Kaplan-Meier method.Subclassification of iCCAs after histological and radiological review,and molecular profiling was performed.Results:HCCs patients were more likely to have early-stage disease than iCCA patients.iCCA patients were more likely to be female,especially those patients without cirrhosis(43%vs.17%).Cirrhosis was prominent among HCC patients(89%vs.34%),but no difference in underlying liver disease among cirrhotic patients was found.OS of HCC patients was 18.4(95%CI:6.4,48.3)months,that of iCCA patients was 7.0(95%CI:3.4,20.1)months.OS of Barcelona Clinic Liver Cancer C HCC patients was 7.8(95%CI:4.3,14.2)months,that of advanced/metastatic iCCA patients was 8.5(95%CI:5.7,12.3)months.In patients treated with sorafenib,OS was longer in HCC patients who received subsequent tyrosine kinase inhibitor therapies.No significant OS difference was found between iCCA patients with and without cirrhosis or according to histological subtype.A targetable molecular alteration was detected in 50%of the iCCA patients.Conclusions:In this French series,cirrhosis was common in iCCA,which showed etiological factors comparable to those of HCC,implying a distinct oncogenic pathway.Both entities had a dismal prognosis at advanced stages.However,systemic therapies sequencing in HCC and molecular profiling in iCCA offer new insights. | Xavier Adhoute Olivia Pietri Guillaume Pénaranda Thomas Wolf Patrick Beaurain Olivier Monnet Arthur Laquière Justine Bonomini Frédéric Neumann Olivier Levrel Jean-Pascal Buono Xavier Hanna Paul Castellani HervéPerrier Marc Bourliere Rodolphe Anty | 2023 | Journal of Clinical and Translational Hepatology2023，11，5： | 0 |
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