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| 1 | Effect of cholecystokinin and secretin on contractile activity of isolated gastric muscle strips in guinea pigs显示文摘AIM To study the effect of cholecystokinin-octapeptide(CCK-8)and secretin on contractileactivity of isolated gastric muscle strips inguinea pigs.METHODS Each isolated gastric muscle stripwas suspended in a tissue chamber containing5 mL Krebs solution constantly warmed by waterjacked at 37℃ and supplied with a mixed gas of95% O2 and 5% CO2 After incubating for lhunder 1 g tension,varied concentrations of CCK-8 and secretin were added respectively in thetissue chamber and the contractile response wasmeasured isometrically on ink-writing recorders.RESULTS CCK-8 could increase①all regionalcircular and longitudinal muscular tension at rest(fundus LM 19.7%±2.1%,P<0.01;fundus CM16.7%±2.2%,P<0.01;gastric body LM 16.8%±2.3%,P<0.01;body CM 12.7%±2.6%,P<0.01;antrum LM 12.3%±1.3%,P<0.01;antrum CM 16.7%±4.5%,P<0.01;pylous CM12.7%±5.0%,P<0.05);②contractilefrequencies of body LM,both LM and CM ofantrum and pylorus CM(5.1/min±0.2/min to5.6/min±0.2/min,5.9/min±0.2/min to 6.6/min±0.l/min,5.4/min±0.3/min to 6.3/min±0.4/rain,1.3/min±0.2/min to 2.3/min±0.3/min,respectively,P<0.05);③the mean contractileamplitude of antral circular muscle(58.6%±18.4%,P<0.05)and ④the motility index ofpylorus CM(145.0%±23.8%,P<0.01),butdecrease the mean contractile amplitude ofgastric body and antral LM(-10.3%±3.3%,-10.5%±4.6%,respectively,P<0.05).All the CCK-8 effects were not blocked by atropine orindomethacin.Secretin had no effect on gastricsmooth muscle activity.CONCLUSION CCK-8 possessed bothexcitatory and inhibitory action on contractileactivity of different regions of stomach in guineapigs.Its action was not mediated via cholinergicM receptor and endogenous prostagiandinreceptor, | Li W Zheng TZ Qu SY | 2000 | World Journal of Gastroenterology2000，6，1： | 13 |
| 2 | 三结构域蛋白27通过降解转化生长因β活化激酶1结合蛋白2/3减轻肝缺血再灌注损伤显示文摘【据Hepatology 2021年2月报道】题:三结构域蛋白27通过降解转化生长因β活化激酶1结合蛋白2/3减轻肝缺血再灌注损伤(作者Chen SY等)肝缺血再灌注(IR)损伤是肝移植术后器官功能障碍的主要原因,其主要涉及炎症反应和细胞凋亡等过程。作为调控多种细胞炎症和凋亡的关键介质,三结构域蛋白27(TRIM27)在肝IR损伤中的作用值得研究。 | CHEN SY ZHANG HP LI J 陈三洋 | 2021 | 临床肝胆病杂志2021，37，6： | 11 |
| 3 | Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light. | lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu | 2017 | Science Bulletin2017，62，21： | 6 |
| 4 | 桑螵蛸脂类提取物对铜绿假单胞菌的抗菌活性和抗生物膜作用(英文)显示文摘目的:探究桑螵蛸脂类提取物的成分及对铜绿假单胞菌的抗菌和抗生物膜作用。创新点:中国传统中药桑螵蛸一直广泛应用于肾病的治疗,在抗菌领域未见报道,本实验首次证明桑螵蛸脂类提取物对铜绿假单胞菌有明显的抗菌和抗生物膜作用。方法:采用气相色谱-质谱联用技术,测定桑螵蛸脂质提取物的化学成分及其相对比例。采用纸片扩散法和琼脂平板稀释法观察桑螵蛸脂类提取物对铜绿假单胞菌的抑菌效应并测定最小抑制浓度(MIC)。采用结晶紫染色法和扫描电镜(SEM)进行抑制生物被膜的试验。结论:桑螵蛸脂类提取物中含有16种化合物,最丰富的成分分别是倍半萜类化合物、单萜和微量芳香族化合物。桑螵蛸脂类提取物对铜绿假单胞菌的MIC为4 mg/ml,对铜绿假单胞菌生物被膜的抑制作用明显。 | Wen-dong WANG Nan-nan ZHANG Warren CHANDA Min LIU Syed Riaz ud DIN Yun-peng DIAO Lei LIU Jing CAO Xiao-li WANG Xing-yun LI An-hong NING Min HUANG Min-tao ZHONG | 2018 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2018，19，5： | 6 |
| 5 | Microstructure and Mechanical Property of in-situ Al-Cu/TiC Composites显示文摘An approach named direct reaction synthesis (DRS) has been developed to fabricate particulate composites with an extremely fine reinforcement size. ID situ Al matrix composites were fabri-cated by DRS. Extensive analysis of the composites microstructure using SEM and TEM identify that the reinforcement formed during the DRS process is Ti carbide (TiC) particle, generally less than 1.0 μm. The reacted, semisolid extruded samples exhibit a homogeneous distribution of fine TiC particles in Al-Cu matrix, Mechanical property evaluation of the composites has revealed a very high tensile strength relative to the matrix alloy. Fractographic analysis indicates ductile failure although the ductility and strength are limited by the presence of coarse titanium aluminides (Al3Ti). | Zhang, EL Zeng, SY Yang, B Li, QC Ma, MZ | 1998 | Journal of Materials Science & Technology1998，14，3： | 6 |
| 6 | Evaluation of sugar and organic acid composition and their levels in highbush blueberries from two regions of China显示文摘Sweet and sour are the most important taste of blueberries,and they are produced by sugar and acid,respectively.Their contributions to the taste depend not only on the levels of sugar and acid,but also on the types and relative proportions of sugar and acid.Therefore,it is very important to evaluate the composition and levels of sugar and acid in blueberries.Regional differences and variety diversity also affect the sugar and acid characteristics of fruits.Therefore,this study selected two main producing regions in northern China(Weihai and Yingkou)to examine the sugar and acid characteristics of 11 common blueberry cultivars.The indexes measured included soluble sugars,organic acids,soluble solid content and titratable acidity.The results showed that glucose and fructose were the major sugars,and citric acid and quinic acid were the major organic acids.Correlation analysis showed that glucose,fructose,and sucrose were positively correlated with total sugar content;the citric acid content was positively correlated with the titratable acidity and total organic acids.Titratable acidity,glucose,fructose,sucrose,total sugar content,citric acid,shikimic acid and total acid content of the blueberries varied significantly between regions(P<0.05).In general,compared with Weihai blueberries,Yingkou blueberries had higher sugar content and lower acid content.The results of this study may provide useful references for the evaluation of sweet and sour flavors and cultivar selection of blueberries. | ZHANG Jia NIE Ji-yun LI Jing ZHANG Hui LI Ye Saqib FAROOQ Syed Asim Shah BACHA WANG Jie | 2020 | Journal of Integrative Agriculture2020，19，9： | 6 |
| 7 | Kudo's pit pattern classification for colorectal neoplasms:A meta-analysis显示文摘AIM:To analyze the current available evidence of Kudo's pit pattern classification for diagnosing colorectal neoplasms.METHODS:A search was performed on Pubmed/Embase to identify studies reporting the outcomes of the pit pattern classification in colorectal polyps.Retrieved records were evaluated and selected by two independent investigators.The number of patients,polyps and diagnostic performance of Kudo’s pit pattern classification were retrieved from suitable studies.Pooled sensitivities and specificities were calculated using fixed or random effect models according to their heterogeneity.Publication bias was evaluated using funnel plot,Egger’s test,and Begg’s test.Sensitivity analysis was performed by omitting one study at a time and selecting a subgroup consisting of 11 magnifying chromoendoscopy studies.RESULTS:20 eligible studies were included in which a total of 5111 colorectal lesions in 3418 patients were identified for the differentiation of neoplastic and nonneoplastic polyps.Pit pattern classification in all the studies of mucosal patterns with magnification resulted in a pooled sensitivity of 89.0%(95%CI:85.2-91.9)and pooled specificity of 85.7%(95%CI:81.3-89.2)and the area under the SROC curve was 0.9354.There was significant publication bias(P=0.038 and 0.006 for sensitivity and specificity using Egger’s test,P=0.035and 0.139 for sensitivity and specificity using Begg’s test,respectively).No single study significantly affected the pooled result,and the magnifying chromoendoscopy subgroup yielded a sensitivity of 92.7%(95%CI:89.2-95.2)and specificity of 87.3%(95%CI:81.6-91.4).CONCLUSION:Kudo’s pit pattern classification is an accurate diagnostic method for the differentiation of neoplastic colorectal lesions.Publication bias is significant in the current available literature. | Ming Li Syed Mohsin Ali Syeda Umm-a-OmarahGilani Jing Liu Yan-Qing Li Xiu-Li Zuo | 2014 | World Journal of Gastroenterology2014，20，35： | 5 |
| 8 | Comparative transcriptome analysis of different nitrogen responses in low-nitrogen sensitive and tolerant maize genotypes显示文摘Although previous researches have greatly increased our general knowledge on plant responses to nitrogen(N)stress,a comprehensive understanding of the different responses in crop genotypes is still needed.This study evaluated 304 maize accessions for low-N tolerance under field conditions,and selected the low-N sensitive Ye478 and low-N tolerant Qi319 for further investigations.After a 5-day low-N treatment,the typical N-deficient phenotype with yellowing older leaves was observed in Ye478 but not in Qi319.After the 5-day low-N stress,16 RNA libraries from leaf and root of Ye478 and Qi319 were generated.The differentially expressed genes(DEGs)in the root of Qi319 up-regulated by special N deficiency were mainly enriched in energy-related metabolic pathways,including tricarboxylic acid metabolic process and nicotinamide metabolic process.Consistent with yellowing older leaves only observed in Ye478,the special N deficiency-responsive DEGs related to thylakoid,chloroplast,photosynthetic membrane,and chloroplast stroma pathways were repressed by low-N stress in Ye478.A total of 216 transcription factors(TFs),including ZmNLP5,were identified as special N deficiencyresponsive TFs between Qi319 and Ye478,indicating the importance of transcriptional regulation of N stress-responsive pathway in different tolerance to low-N stress between crop genotypes.In addition,15 miRNAs were identified as DEGs between Qi319 and Ye478.Taken together,this study contributes to the understanding of the genetic variations and molecular basis of low-N tolerance in maize. | DU Qing-guo YANG Juan Shah Syed Muhammad Sadiq YANG Rong-xin YU Jing-juan LI Wen-xue | 2021 | Journal of Integrative Agriculture2021，20，8： | 5 |
| 9 | Application of Rayleigh Light Scattering Spectroscopy to the Determination of Proteins Using Bromo-Pyrogallol Red显示文摘The binding of bromo-Pyrogallol red (BPR) to proteins is accompamed by the enhancement of Rayleigh light scattering at 332nm. and based on this. a new quantitative protein assay method is put forward. | Ma, CQ Li, KA Tong, SY | 1997 | Chinese Chemical Letters1997，8，1： | 5 |
| 10 | The Patatin-Containing Phospholipase A pPLAIIα Modulates Oxylipin Formation and Water Loss in Arabidopsis thaliana显示文摘patatin 相关的 phospholipase A (pPLA ) 水解膜 glycerolipids 将生产 monoacyl 混合物和免费的丰满的酸。Phospholipids 被 pPLAII 在 sn-1 和 sn-2 劈开包括那些包含的 oxophytodienoic 酸,位置,和 galactolipids 能也用作底层。pPLAII 的脱离减少了 lysophosphatidylcholine 和 lysophosphatidylethanolamine 层次,而是增加的免费的亚麻酸的酸。pPLAII 缺乏的植物显示了 jasmonic 酸和甲基的高水平 jasmonate,以及 oxylipin-biosynthetic 中介 13-hydroperoxylinolenic 酸和比酸的 12-oxophytodienoic 野类型(WT ) 植物。涉及 oxylipin 生产的基因的表示比在 WT 植物在 pPLAII 缺乏的异种也是更高的。变异的植物比 WT 植物更快速失去了水。WT 和变异的植物的 stomata 对 abscisic 酸同样作出回应。响应干燥,异种和 WT 叶子以一样的率生产了 abscisic 酸,,但是,在干燥的 4h 以后, jasmonic 酸水平比 WT 离开的在异种是高得多的。这些结果显示 pPLAII 否定地调整 oxylipin 生产并且从膜在氧化地修改的丰满的酸的移动建议一个角色。 | Wen-Yu Yang Yong Zheng Sung Chul Bahn Xiang-Qing Pan Mao-Yin Li Hieu Sy Vu Mary R.Roth Brad Scheu Ruth Welt Yue-Yun Hong Xue-Min Wang | 2012 | Molecular Plant2012，5，2： | 5 |
| 11 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 12 | A panel of monoclonal antibodies against the prion protein proves that there is no prion protein in human pancreatic ductal epithelial cells显示文摘Prion diseases are a group of neurodegenerative diseases that are fatal. The study of these unique diseases in China is hampered by a lack of resources. Amongst the most important resources for biological study are monoclonal antibodies. Here, we characterize a panel of monoclonal antibodies specific for cellular prion protein by enzyme-linked immunosorbent assay(ELISA), immunofluorescent staining, flow cytometry, and western blotting. We identify several antibodies that can be used for specific applications and we demonstrate that there is no prion protein expression in human pancreatic ductal epithelial cells(HPDC). | Liheng Yang Yan Zhang Lipeng Hu Ying Zhu Man-Sun Sy Chaoyang Li | 2014 | Virologica Sinica2014，29，4： | 3 |
| 13 | 非甾体抗炎药应用中,环氧合酶2、不对称二甲基精氨酸与心血管危害的关系显示文摘已有大规模、安慰剂对照试验确定了非甾体类抗炎药(nonsteroidal anti—inflammatory drugs,NSAIDs)具有心血管危害性:这归因于环氧合酶2(cyclooxygenase,COX-2)的心脏保护产物受到抑制,尤其是前列环素(prostacyclin,PG12)。NSAID降低心脏保护作用的另一种机制可能是通过增强肾脏中甲基精氨酸的形成来限制一氧化氮在整个脉管系统中的作用。 | Ricciotti E Castro C Tang SY Briggs WTE West JA Malik D Rhoades SD Meng H Li X Lahens NF Sparks JA Karlson EW Weljie AM Griffin JL FitzGerald GA6 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 3 |
| 14 | New high-resolution 2D seismic imaging of fluid escape structures in the Makran subduction zone,Arabian Sea显示文摘Seabed fluid escape is active in the Makran subduction zone,Arabian Sea.Based on the new highresolution 2D seismic data,acoustic blanking zones and seafloor mounds are identified.Acoustic blanking zones include three kinds of geometries:Bell-shaped,vertically columnar and tilted zones.The bellshaped blanking zone is characterized by weak and discontinuous reflections in the interior and upbending reflections on the top,interpreted as gas chimneys.Vertically columnar blanking zone is interpreted as side-imaged gas chimneys associated with focused fluid flow and topped by a seafloor anomaly expressed as a localized reflection discontinuity,which may together serve as a vent structure.Tilted acoustic blanking zone could be induced by accretionary thrust activity and rapid sedimentation surrounding slope.Seafloor mounds occur at the sites of bell-shaped acoustic blanking zone and may be associated with the material intrusion.Bottom simulating refectors(BSRs)are widely distributed and exhibit a series of characteristics including diminished amplitude,low continuity as well as local shoaling overlapping with these acoustic blanking zones.The large amount of gases dissociated from the gas hydrates migrated upwards and then arrived at the near-seafloor sediments,followed by the formation of the gas hydrates and hence the seafloor mound. | Bin Liu Jiang-xin Chen Syed Waseem Haider Xi-guang Deng Li Yang Min-liang Duan | 2020 | China Geology2020，3，2： | 3 |
| 15 | A Study on the Reaction Mechanism of Bromocresol Green with Bovine Serum Albumin显示文摘AStudyontheReactionMechanismofBromocresolGreenwithBovineSerumAlbuminKenZhu;KeAnLI;ShenYangTONG(ChemistryDepartment,PekingUniv... | Zhu, K Li, KA Tong, SY | 1996 | Chinese Chemical Letters1996，7，11： | 2 |
| 16 | Structural Comparison and Drug Screening of Spike Proteins of Ten SARS-CoV-2 Variants显示文摘SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)has evolved many variants with stronger infectivity and immune evasion than the original strain,including Alpha,Beta,Gamma,Delta,Epsilon,Kappa,lota,Lambda,and 21H strains.Amino acid mutations are enriched in the spike protein of SARS CoV-2.which plays a crucial role in cell infetion.However,the impact of these mutations on protein structure and function is unclear.Understanding the pathophysiology and pandemic feaures of these SARS-CoV-2 variants requires knowledge of the spike protein structures.Here,we obtained the spike protein structures of 10 main globally endemic SARS CoV-2 strains using AlphaFold2.The clustering analysis based on structural similarity revealed the unique features of the mainly pandemic SARS CoV-2 Delta variants.indicating that structural clusters can reflect the current characteristics of the epidemic more accurately than those based on the protein sequence.The analysis of the binding afinities of ACE2-RBD,antibody-NTD,and antibody-RBD complexes in the different variants revealed that the recognition of antibodies against SI NTD and RBD was decreased in the variants,especally the Delta variant compared with the original strain,which may induce the immune evasion of SARS-CoV-2 variants.Furthermore,by virtual screening the ZINC database against a high-accuracy predicted structure of Delta spike protein and experimental validation,we identified multiple compounds that target S1 NTD and RBD,which might contribute towards the development of clinical anti-SARS-CoV-2 medicines.Our findings provided a basic foundation for future in vitro and in vivo investigations that might speed up the development of potential therapies for the SARS-CoV-2 va riants. | Qiangzhen Yang Xuemin Jian Ali Alamdar Shah Syed Aamir Fahira Chenxiang Zheng zijia Zhu Ke Wang Jinmai Zhang Yangin Wen Zhiqiang Li Dun Pan Tingting Lu Zhuo Wang Yongyong Shi | 2022 | Research2022，，2： | 2 |
| 17 | The Scorpion Venom Peptide Smp76 Inhibits Viral Infection by Regulating Type-Ⅰ Interferon Response显示文摘Dengue virus(DENV) and Zika virus(ZIKV) have spread throughout many countries in the developing world and infect millions of people every year, causing severe harm to human health and the economy. Unfortunately, there are few effective vaccines and therapies available against these viruses. Therefore, the discovery of new antiviral agents is critical.Herein, a scorpion venom peptide(Smp76) characterized from Scorpio maurus palmatus was successfully expressed and purified in Escherichia coli BL21(DE3). The recombinant Smp76(rSmp76) was found to effectively inhibit DENV and ZIKV infections in a dose-dependent manner in both cultured cell lines and primary mouse macrophages. Interestingly,rSmp76 did not inactivate the viral particles directly but suppressed the established viral infection, similar to the effect of interferon(IFN)-b. Mechanistically, rSmp76 was revealed to upregulate the expression of IFN-b by activating interferon regulatory transcription factor 3(IRF3) phosphorylation, enhancing the type-Ⅰ IFN response and inhibiting viral infection.This mechanism is significantly different from traditional virucidal antimicrobial peptides(AMPs). Overall, the scorpion venom peptide Smp76 is a potential new antiviral agent with a unique mechanism involving type-Ⅰ IFN responses,demonstrating that natural AMPs can enhance immunity by functioning as immunomodulators. | Zhenglin Ji Fangfang Li Zhiqiang Xia Xingchen Guo Minjun Gao Fang Sun Yuting Cheng Yingliang Wu Wenxin Li Syed Abid Ali Zhijian Cao | 2018 | Virologica Sinica2018，33，6： | 2 |
| 18 | Ocular flmgal isolates and antifungal susceptibility in northern China 显示文摘 | Sun XG Wang ZX Wang ZQ Luo SY Li R | 2007 | Am J Ophthalmol2007，143，： | 1 |
| 19 | Airway assessment by volumetric computed tomography in snorers and subjects with obstructive sleep apnea in a Far-East Asian population(Chinese)显示文摘 | Chen NH Li KK Li SY | 2002 | Laryngoscope2002，112，4： | 1 |
| 20 | Dicer is essential for mouse development 显示文摘 | Benrstein E Kim SY Carmell MA Murchison EP Alcorn H Li MZ | 2003 | Nat Genet2003，35，3： | 1 |
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