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| 1 | Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?显示文摘Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma(HCC) since 2007 and numerous studieshave investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC. | Giorgia Marisi Alessandro Cucchetti Paola Ulivi Matteo Canale Giuseppe Cabibbo Leonardo Solaini Francesco G Foschi Serena De Matteis Giorgio Ercolani Martina Valgiusti Giovanni L Frassineti Mario Scartozzi Andrea Casadei Gardini | 2018 | World Journal of Gastroenterology2018，24，36： | 14 |
| 2 | Practical review for diagnosis and clinical management of perihilar cholangiocarcinoma显示文摘Cholangiocarcinoma(CCC)is the most aggressive malignant tumor of the biliary tract.Perihilar CCC(pCCC)is the most common CCC and is burdened by a complicated diagnostic iter and its anatomical location makes surgical approach burden by poor results.Besides its clinical presentation,a multimodal diagnostic approach should be carried on by a tertiary specialized center to avoid missdiagnosis.Preoperative staging must consider the extent of liver resection to avoid post-surgical hepatic failure.During staging iter,magnetic resonance can obtain satisfactory cholangiographic images,while invasive techniques should be used if bile duct samples are needed.Consistently,to improve diagnostic potential,bile duct drainage is not necessary in jaundice,while it is indicated in refractory cholangitis or when liver hypertrophy is needed.Once resecability criteria are identified,the extent of liver resection is secondary to the longitudinal spread of CCC.While in the past type IV pCCC was not considered resectable,some authors reported good results after their treatment.Conversely,in selected unresectable cases,liver transplantation could be a valuable option.Adjuvant chemotherapy is the standard of care for resected patients,while neoadjuvant approach has growing evidences.If curative resection is not achieved,radiotherapy can be added to chemotherapy.This multistep curative iter must be carried on in specialized centers.Hence,the aim of this review is to highlight the main steps and pitfalls of the diagnostic and therapeutic approach to pCCC with a peculiar attention to type IV pCCC. | Daniele Dondossola Michele Ghidini Francesco Grossi Giorgio Rossi Diego Foschi | 2020 | World Journal of Gastroenterology2020，26，25： | 9 |
| 3 | Acetaldehyde Inhibits PPARγ via H 2 O 2 -Mediated c-Abl Activation in Human Hepatic Stellate Cells显示文摘 | Elisabetta Ceni David W. Crabb Marco Foschi Tommaso Mello Mirko Tarocchi Valentino Patussi Luca Moraldi Renato Moretti Stefano Milani Calogero Surrenti Andrea Galli | 2006 | Gastroenterology2006，，4： | 2 |
| 4 | Confidence in linear spectral unmixing of single pixels显示文摘 | Petrou Maria Foschi Patricia G | 1999 | IEEE Transactions on Geoscience and Remote Sensing1999，37，1： | 1 |
| 5 | Soluble CD30 serum level in HCV-positive chronic active hepatitis: a surrogate marker of disease activity 显示文摘 | Foschi FG Gramenzi A Castelli E | 2000 | Cytokine2000，12，6： | 1 |
| 6 | An inverse reliability method and its application显示文摘 | LI H FOSCHI R O | 1998 | Structural Safety1998，20，3： | 1 |
| 7 | Graft materials and bone marrow stromal cells in bone tissue engineering显示文摘 | Foschi F Conserva E Pera P | 2012 | J Biomater Appl2012，26，8： | 1 |
| 8 | Alpha-l-Thymosin and transcatheter arterial chemoembolization in hepatocellular carcinoma patients: A preliminary experience 显示文摘 | Foschi FG Gastelli E | 1998 | Hepato Gastroenterology1998，45，19： | 1 |
| 9 | Oxygen free radicals interact with indomethacin to cause gastrointestinal injury显示文摘 | Del Soldato P Foschi D Benoni G | | 0，，05： | 1 |
| 10 | Depression after stroke:an investigation through catamnesis显示文摘 | Angeleri VA Foschi N | 1997 | J Clin Psychiatry1997，58，6： | 1 |
| 11 | Object - oriented finite element analysis 显示文摘 | FORD B W R FOSCHI R O STIENER S F | 1990 | Computers and Structures1990，35，： | 1 |
| 12 | Probability distribution of intensity attenuations for Colombia and Western Venezuela显示文摘 | Prieto J A Foschi R 0 Ventura C E | 2011 | Bulletin ofSeismological Society of America2011，101，2： | 1 |
| 13 | Object oriented finite element analysis显示文摘 | FORDE B W R FOSCHI R O STIEMER S F | 1990 | Computers&Structures1990，34，3： | 1 |
| 14 | Objeet-oriented finite element analysis显示文摘 | FORDE B W R FOSCHI R O STIEMER S F | 1990 | Computers & Structures1990，34，3： | 1 |
| 15 | The mechanisms of blood vessel closure in humans by the application of ultrasonic energy显示文摘 | Foschi D Cellerino P Corsi F | 2002 | Surg Endosc2002，16，5： | 1 |
| 16 | Acetaldehyde inhibits PPARgamma via H202 -mediated c- Abl activation in hu- man hepatic stellate cells显示文摘 | Ceni E Crabb DW Foschi M | 2006 | Gastroenterology2006，131，： | 1 |
| 17 | Effects of high tempera- tures on functional response of hemocytes in the clam Chamelea gallina 显示文摘 | Monari M Matozzo V Foschi J | 2007 | Fish Shellfish Immunology2007，22，12： | 1 |
| 18 | Effects of intramural administration of Botulinum Toxin A on gastric emptying and eating capacity in obese patients显示文摘 | Foschi D Lazzaroni M Sangaletti O | | 0，，： | 1 |
| 19 | Risk factors for prostate cancer in men aged less than 60 years: a case control study from Italy显示文摘 | Gallus S Foschi R Talamini R | 2007 | Urology2007，70，6： | 1 |
| 20 | The mechanisms of blood vessel closure in humans by the application of ultrasonic ener-gy显示文摘 | FOSCHI D CELLERINO P CORSI F | 2002 | Surg Endosc2002，16，5： | 1 |
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