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| 1 | Role of matricellular proteins in cardiac tissue remodeling after myocardial infarction显示文摘After onset of myocardial infarction(MI),the left ventricle(LV) undergoes a continuum of molecular,cellular,and extracellular responses that result in LV wall thinning,dilatation,and dysfunction.These dynamic changes in LV shape,size,and function are termed cardiac remodeling.If the cardiac healing after MI does not proceed properly,it could lead to cardiac rupture or maladaptive cardiac remodeling,such as further LV dilatation and dysfunction,and ultimately death.Although the precise molecular mechanisms in this cardiac healing process have not been fully elucidated,this process is strictly coordinated by the interaction of cells with their surrounding extracellular matrix(ECM) proteins.The components of ECM include basic structural proteins such as collagen,elastin and specialized proteins such as fibronectin,proteoglycans and matricellular proteins.Matricellular proteins are a class of non-structural and secreted proteins that probably exert regulatory functions through direct binding to cell surface receptors,other matrix proteins,and soluble extracellular factors such as growth factors and cytokines.This small group of proteins,which includesosteopontin,thrombospondin-1/2,tenascin,periostin,and secreted protein,acidic and rich in cysteine,shows a low level of expression in normal adult tissue,but is markedly upregulated during wound healing and tissue remodeling,including MI.In this review,we focus on the regulatory functions of matricellular proteins during cardiac tissue healing and remodeling after MI. | Yutaka Matsui Junko Morimoto Toshimitsu Uede | 2010 | World Journal of Biological Chemistry2010，1，5： | 7 |
| 2 | Swine-origin influenza-virus-induced acute lung injury:Novel or classical pathogenesis?显示文摘Influenza viruses are common respiratory pathogens in humans and can cause serious infection that leads to the development of pneumonia.Due to their hostrange diversity,genetic and antigenic diversity,and potential to reassort genetically in vivo,influenza A viruses are continual sources of novel influenza strains that lead to the emergence of periodic epidemics and outbreaks in humans.Thus,newly emerging viral diseases are always major threats to public health.In March 2009,a novel influenza virus suddenly emerged and caused a worldwide pandemic.The novel pandemic influenza virus was genetically and antigenically distinct from previous seasonal human influenza A/H1N1 viruses;it was identified to have originated from pigs,and further genetic analysis revealed it as a subtype of A/H1N1,thus later called a swine-origin influenza virus A/H1N1.Since the novel virus emerged,epidemiological surveys and research on experimental animal models have been conducted,and characteristics of the novel influenza virus have been determined but the exact mechanisms of pulmonary pathogenesis remain to be elucidated.In this editorial,we summa-rize and discuss the recent pandemic caused by the novel swine-origin influenza virus A/H1N1 with a focus on the mechanism of pathogenesis to obtain an insight into potential therapeutic strategies. | Naoyoshi Maeda Toshimitsu Uede | 2010 | World Journal of Biological Chemistry2010，1，5： | 3 |
| 3 | Osteopontin as a potential diagnostic biomarker for ovarian cancer 显示文摘 | Kim JH Skates SJ Uede T | 2002 | JAMA2002，3287，13： | 1 |
| 4 | Immunologic self-toleranced maintained by CD25+CD4+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4 显示文摘 | Tagami T Yamazaki S Uede T Shimizu J Sakaguchi N Mak TW Sakaguchi S | 2000 | J Exp Med2000，192，2： | 1 |
| 5 | Vascular endothelial growth factor and osteopontin in stage I lung adenocarcinoma 显示文摘 | Shijubo N Uede T Kon S | 1999 | Am J Respir Crit Care Med1999，160，4： | 1 |
| 6 | Pathogenesis of hyponatremia following subarachnoid haemorrhage due to ruptured cerebral aneurysm显示文摘 | KUROCAWA Y UEDE T | 1996 | Surg Neurol1996，46，5： | 1 |
| 7 | Vascular endo thelial growth factor and osteopontin in lumor biology显示文摘 | Shijubo N Uede T Kon S Nagata M Abe S | 2000 | Crit Rev Oncog2000，11，： | 1 |
| 8 | Blockade of macrophage migration inhibitory factor amel-iorates experimental autoimmune myocarditis显示文摘 | Matsui Y Okamoto H Jia N Akino M Uede T Kitabatake A | 2004 | J Mol CellCardiol2004，37，： | 1 |
| 9 | Vascular endothelial growth factor and osteopontin in stage I lung adenocarcinoma显示文摘 | Shijubo N Uede T Kon S | 1999 | Am J Respir Crit Care Med1999，160，4： | 1 |
| 10 | Expression of a multidrug-resis-tance gene in human tumors and tissues显示文摘 | Fojo A T Uede K Slamon D J | 1987 | Proc Natl Acad Sci USA1987，84，1： | 1 |
| 11 | Prevention of experimental autoimmune uveoretinitis by blockade of osteopontin with small interfering RNA显示文摘 | Daiju Iwata Mizuki Kitamura Nobuyoshi Kitaichi Yoshinari Saito Shigeyuki Kon Kenichi Namba Junko Morimoto Akiko Ebihara Hirokuni Kitamei Kazuhiko Yoshida Susumu Ishida Shigeaki Ohno Toshimitsu Uede Kazunori Onoé Kazuya Iwabuchi | 2009 | Experimental Eye Research2009，，1： | 1 |
| 12 | Diagnosis of ruptured and unruptured cerebral aneurys with three-dimensional CT angiography (3D-CTA) 显示文摘 | Tanabe S Ohtaki M Uede T | 1995 | No Shinkei Geka1995，23，9： | 1 |
| 13 | Significant improvement of visual functions after removal of an intracranial giant optic nerve glioma revealing exophytic growth: case report 显示文摘 | Tong Z Wanibuchi M Uede T | 2006 | Neurosurgery2006，58，79： | 1 |
| 14 | Effective Display of Metallothionein Tandem Repeats on the Bioadsorption of Cadmium Ion显示文摘 | Kuroda K Ued M | 2006 | Applied Microbiology and Biotechnology2006，70，4： | 1 |
| 15 | Osteopontin,intrinsic tissue regulator of intractable inflammatory diseases显示文摘 | Uede T | 2011 | Pathol Int2011，61，5： | 1 |
| 16 | 查看详情显示文摘 | Uede M | | 0，，： | 1 |
| 17 | 查看详情显示文摘 | Uede M | | 0，，： | 1 |
| 18 | Osteopontin as a potential diagnostic biomarker for ovarian cancer显示文摘 | Kim JH Skates S J Uede T | 2002 | JAMA2002，287，13： | 1 |
| 19 | Vascular endothelial growth factor and osteopontin in stage Ⅰ lung adenocarcinoma 显示文摘 | Shijubo N Uede T Kon S | 1999 | Am J Respir Crit Care Med1999，160，4： | 1 |
| 20 | Vascular endothelial grvwth factor and osteopontin in stage I lung adenoeareinoma显示文摘 | Uede T Kon S | 1999 | Am J Respir Crit Care Med1999，160，4： | 1 |
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